Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 67 entries in the algebraic variable array.
There are a total of 17 entries in each of the rate and state variable arrays.
There are a total of 46 entries in the constant variable array.
*/
/*
* VOI is time in component environment (millisecond).
* STATES[0] is V in component membrane (millivolt).
* CONSTANTS[0] is R in component membrane (joule_per_mole_kelvin).
* CONSTANTS[1] is T in component membrane (kelvin).
* CONSTANTS[2] is F in component membrane (coulomb_per_millimole).
* CONSTANTS[3] is Cm in component membrane (microF).
* CONSTANTS[4] is V_c in component membrane (micrometre3).
* ALGEBRAIC[50] is i_K1 in component inward_rectifier_potassium_current (picoA_per_picoF).
* ALGEBRAIC[57] is i_to in component transient_outward_current (picoA_per_picoF).
* ALGEBRAIC[51] is i_Kr in component rapid_time_dependent_potassium_current (picoA_per_picoF).
* ALGEBRAIC[52] is i_Ks in component slow_time_dependent_potassium_current (picoA_per_picoF).
* ALGEBRAIC[55] is i_CaL in component L_type_Ca_current (picoA_per_picoF).
* ALGEBRAIC[58] is i_NaK in component sodium_potassium_pump_current (picoA_per_picoF).
* ALGEBRAIC[53] is i_Na in component fast_sodium_current (picoA_per_picoF).
* ALGEBRAIC[54] is i_b_Na in component sodium_background_current (picoA_per_picoF).
* ALGEBRAIC[59] is i_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF).
* ALGEBRAIC[56] is i_b_Ca in component calcium_background_current (picoA_per_picoF).
* ALGEBRAIC[61] is i_p_K in component potassium_pump_current (picoA_per_picoF).
* ALGEBRAIC[60] is i_p_Ca in component calcium_pump_current (picoA_per_picoF).
* ALGEBRAIC[0] is i_Stim in component membrane (picoA_per_picoF).
* CONSTANTS[5] is stim_start in component membrane (millisecond).
* CONSTANTS[6] is stim_period in component membrane (millisecond).
* CONSTANTS[7] is stim_duration in component membrane (millisecond).
* CONSTANTS[8] is stim_amplitude in component membrane (picoA_per_picoF).
* ALGEBRAIC[13] is E_Na in component reversal_potentials (millivolt).
* ALGEBRAIC[26] is E_K in component reversal_potentials (millivolt).
* ALGEBRAIC[35] is E_Ks in component reversal_potentials (millivolt).
* ALGEBRAIC[44] is E_Ca in component reversal_potentials (millivolt).
* CONSTANTS[9] is P_kna in component reversal_potentials (dimensionless).
* CONSTANTS[10] is K_o in component potassium_dynamics (millimolar).
* CONSTANTS[11] is Na_o in component sodium_dynamics (millimolar).
* STATES[1] is K_i in component potassium_dynamics (millimolar).
* STATES[2] is Na_i in component sodium_dynamics (millimolar).
* CONSTANTS[12] is Ca_o in component calcium_dynamics (millimolar).
* STATES[3] is Ca_i in component calcium_dynamics (millimolar).
* CONSTANTS[13] is g_K1 in component inward_rectifier_potassium_current (nanoS_per_picoF).
* ALGEBRAIC[49] is xK1_inf in component inward_rectifier_potassium_current (dimensionless).
* ALGEBRAIC[47] is alpha_K1 in component inward_rectifier_potassium_current (dimensionless).
* ALGEBRAIC[48] is beta_K1 in component inward_rectifier_potassium_current (dimensionless).
* CONSTANTS[14] is g_Kr in component rapid_time_dependent_potassium_current (nanoS_per_picoF).
* STATES[4] is Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless).
* STATES[5] is Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless).
* ALGEBRAIC[1] is xr1_inf in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless).
* ALGEBRAIC[14] is alpha_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless).
* ALGEBRAIC[27] is beta_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless).
* ALGEBRAIC[36] is tau_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (millisecond).
* ALGEBRAIC[2] is xr2_inf in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless).
* ALGEBRAIC[15] is alpha_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless).
* ALGEBRAIC[28] is beta_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless).
* ALGEBRAIC[37] is tau_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (millisecond).
* CONSTANTS[15] is g_Ks in component slow_time_dependent_potassium_current (nanoS_per_picoF).
* STATES[6] is Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless).
* ALGEBRAIC[3] is xs_inf in component slow_time_dependent_potassium_current_Xs_gate (dimensionless).
* ALGEBRAIC[16] is alpha_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless).
* ALGEBRAIC[29] is beta_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless).
* ALGEBRAIC[38] is tau_xs in component slow_time_dependent_potassium_current_Xs_gate (millisecond).
* CONSTANTS[16] is g_Na in component fast_sodium_current (nanoS_per_picoF).
* STATES[7] is m in component fast_sodium_current_m_gate (dimensionless).
* STATES[8] is h in component fast_sodium_current_h_gate (dimensionless).
* STATES[9] is j in component fast_sodium_current_j_gate (dimensionless).
* ALGEBRAIC[4] is m_inf in component fast_sodium_current_m_gate (dimensionless).
* ALGEBRAIC[17] is alpha_m in component fast_sodium_current_m_gate (dimensionless).
* ALGEBRAIC[30] is beta_m in component fast_sodium_current_m_gate (dimensionless).
* ALGEBRAIC[39] is tau_m in component fast_sodium_current_m_gate (millisecond).
* ALGEBRAIC[5] is h_inf in component fast_sodium_current_h_gate (dimensionless).
* ALGEBRAIC[18] is alpha_h in component fast_sodium_current_h_gate (per_millisecond).
* ALGEBRAIC[31] is beta_h in component fast_sodium_current_h_gate (per_millisecond).
* ALGEBRAIC[40] is tau_h in component fast_sodium_current_h_gate (millisecond).
* ALGEBRAIC[6] is j_inf in component fast_sodium_current_j_gate (dimensionless).
* ALGEBRAIC[19] is alpha_j in component fast_sodium_current_j_gate (per_millisecond).
* ALGEBRAIC[32] is beta_j in component fast_sodium_current_j_gate (per_millisecond).
* ALGEBRAIC[41] is tau_j in component fast_sodium_current_j_gate (millisecond).
* CONSTANTS[17] is g_bna in component sodium_background_current (nanoS_per_picoF).
* CONSTANTS[18] is g_CaL in component L_type_Ca_current (litre_per_farad_second).
* STATES[10] is d in component L_type_Ca_current_d_gate (dimensionless).
* STATES[11] is f in component L_type_Ca_current_f_gate (dimensionless).
* STATES[12] is fCa in component L_type_Ca_current_fCa_gate (dimensionless).
* ALGEBRAIC[7] is d_inf in component L_type_Ca_current_d_gate (dimensionless).
* ALGEBRAIC[20] is alpha_d in component L_type_Ca_current_d_gate (dimensionless).
* ALGEBRAIC[33] is beta_d in component L_type_Ca_current_d_gate (dimensionless).
* ALGEBRAIC[42] is gamma_d in component L_type_Ca_current_d_gate (millisecond).
* ALGEBRAIC[45] is tau_d in component L_type_Ca_current_d_gate (millisecond).
* ALGEBRAIC[8] is f_inf in component L_type_Ca_current_f_gate (dimensionless).
* ALGEBRAIC[21] is tau_f in component L_type_Ca_current_f_gate (millisecond).
* ALGEBRAIC[9] is alpha_fCa in component L_type_Ca_current_fCa_gate (dimensionless).
* ALGEBRAIC[22] is beta_fCa in component L_type_Ca_current_fCa_gate (dimensionless).
* ALGEBRAIC[34] is gama_fCa in component L_type_Ca_current_fCa_gate (dimensionless).
* ALGEBRAIC[43] is fCa_inf in component L_type_Ca_current_fCa_gate (dimensionless).
* CONSTANTS[45] is tau_fCa in component L_type_Ca_current_fCa_gate (millisecond).
* ALGEBRAIC[46] is d_fCa in component L_type_Ca_current_fCa_gate (per_millisecond).
* CONSTANTS[19] is g_bca in component calcium_background_current (nanoS_per_picoF).
* CONSTANTS[20] is g_to in component transient_outward_current (nanoS_per_picoF).
* STATES[13] is s in component transient_outward_current_s_gate (dimensionless).
* STATES[14] is r in component transient_outward_current_r_gate (dimensionless).
* ALGEBRAIC[10] is s_inf in component transient_outward_current_s_gate (dimensionless).
* ALGEBRAIC[23] is tau_s in component transient_outward_current_s_gate (millisecond).
* ALGEBRAIC[11] is r_inf in component transient_outward_current_r_gate (dimensionless).
* ALGEBRAIC[24] is tau_r in component transient_outward_current_r_gate (millisecond).
* CONSTANTS[21] is P_NaK in component sodium_potassium_pump_current (picoA_per_picoF).
* CONSTANTS[22] is K_mk in component sodium_potassium_pump_current (millimolar).
* CONSTANTS[23] is K_mNa in component sodium_potassium_pump_current (millimolar).
* CONSTANTS[24] is K_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF).
* CONSTANTS[25] is K_sat in component sodium_calcium_exchanger_current (dimensionless).
* CONSTANTS[26] is alpha in component sodium_calcium_exchanger_current (dimensionless).
* CONSTANTS[27] is gamma in component sodium_calcium_exchanger_current (dimensionless).
* CONSTANTS[28] is Km_Ca in component sodium_calcium_exchanger_current (millimolar).
* CONSTANTS[29] is Km_Nai in component sodium_calcium_exchanger_current (millimolar).
* CONSTANTS[30] is g_pCa in component calcium_pump_current (picoA_per_picoF).
* CONSTANTS[31] is K_pCa in component calcium_pump_current (millimolar).
* CONSTANTS[32] is g_pK in component potassium_pump_current (nanoS_per_picoF).
* STATES[15] is Ca_SR in component calcium_dynamics (millimolar).
* ALGEBRAIC[62] is i_rel in component calcium_dynamics (millimolar_per_millisecond).
* ALGEBRAIC[63] is i_up in component calcium_dynamics (millimolar_per_millisecond).
* ALGEBRAIC[64] is i_leak in component calcium_dynamics (millimolar_per_millisecond).
* STATES[16] is g in component calcium_dynamics (dimensionless).
* CONSTANTS[33] is tau_g in component calcium_dynamics (millisecond).
* ALGEBRAIC[12] is g_inf in component calcium_dynamics (dimensionless).
* CONSTANTS[34] is a_rel in component calcium_dynamics (millimolar_per_millisecond).
* CONSTANTS[35] is b_rel in component calcium_dynamics (millimolar).
* CONSTANTS[36] is c_rel in component calcium_dynamics (millimolar_per_millisecond).
* CONSTANTS[37] is K_up in component calcium_dynamics (millimolar).
* CONSTANTS[38] is V_leak in component calcium_dynamics (per_millisecond).
* CONSTANTS[39] is Vmax_up in component calcium_dynamics (millimolar_per_millisecond).
* ALGEBRAIC[65] is Ca_i_bufc in component calcium_dynamics (dimensionless).
* ALGEBRAIC[66] is Ca_sr_bufsr in component calcium_dynamics (dimensionless).
* CONSTANTS[40] is Buf_c in component calcium_dynamics (millimolar).
* CONSTANTS[41] is K_buf_c in component calcium_dynamics (millimolar).
* CONSTANTS[42] is Buf_sr in component calcium_dynamics (millimolar).
* CONSTANTS[43] is K_buf_sr in component calcium_dynamics (millimolar).
* CONSTANTS[44] is V_sr in component calcium_dynamics (micrometre3).
* ALGEBRAIC[25] is d_g in component calcium_dynamics (per_millisecond).
* RATES[0] is d/dt V in component membrane (millivolt).
* RATES[4] is d/dt Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless).
* RATES[5] is d/dt Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless).
* RATES[6] is d/dt Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless).
* RATES[7] is d/dt m in component fast_sodium_current_m_gate (dimensionless).
* RATES[8] is d/dt h in component fast_sodium_current_h_gate (dimensionless).
* RATES[9] is d/dt j in component fast_sodium_current_j_gate (dimensionless).
* RATES[10] is d/dt d in component L_type_Ca_current_d_gate (dimensionless).
* RATES[11] is d/dt f in component L_type_Ca_current_f_gate (dimensionless).
* RATES[12] is d/dt fCa in component L_type_Ca_current_fCa_gate (dimensionless).
* RATES[13] is d/dt s in component transient_outward_current_s_gate (dimensionless).
* RATES[14] is d/dt r in component transient_outward_current_r_gate (dimensionless).
* RATES[16] is d/dt g in component calcium_dynamics (dimensionless).
* RATES[3] is d/dt Ca_i in component calcium_dynamics (millimolar).
* RATES[15] is d/dt Ca_SR in component calcium_dynamics (millimolar).
* RATES[2] is d/dt Na_i in component sodium_dynamics (millimolar).
* RATES[1] is d/dt K_i in component potassium_dynamics (millimolar).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = -86.2;
CONSTANTS[0] = 8314.472;
CONSTANTS[1] = 310;
CONSTANTS[2] = 96485.3415;
CONSTANTS[3] = 0.185;
CONSTANTS[4] = 0.016404;
CONSTANTS[5] = 10;
CONSTANTS[6] = 1000;
CONSTANTS[7] = 1;
CONSTANTS[8] = 52;
CONSTANTS[9] = 0.03;
CONSTANTS[10] = 5.4;
CONSTANTS[11] = 140;
STATES[1] = 138.3;
STATES[2] = 11.6;
CONSTANTS[12] = 2;
STATES[3] = 0.0002;
CONSTANTS[13] = 5.405;
CONSTANTS[14] = 0.096;
STATES[4] = 0;
STATES[5] = 1;
CONSTANTS[15] = 0.062;
STATES[6] = 0;
CONSTANTS[16] = 14.838;
STATES[7] = 0;
STATES[8] = 0.75;
STATES[9] = 0.75;
CONSTANTS[17] = 0.00029;
CONSTANTS[18] = 0.000175;
STATES[10] = 0;
STATES[11] = 1;
STATES[12] = 1;
CONSTANTS[19] = 0.000592;
CONSTANTS[20] = 0.294;
STATES[13] = 1;
STATES[14] = 0;
CONSTANTS[21] = 1.362;
CONSTANTS[22] = 1;
CONSTANTS[23] = 40;
CONSTANTS[24] = 1000;
CONSTANTS[25] = 0.1;
CONSTANTS[26] = 2.5;
CONSTANTS[27] = 0.35;
CONSTANTS[28] = 1.38;
CONSTANTS[29] = 87.5;
CONSTANTS[30] = 0.825;
CONSTANTS[31] = 0.0005;
CONSTANTS[32] = 0.0146;
STATES[15] = 0.2;
STATES[16] = 1;
CONSTANTS[33] = 2;
CONSTANTS[34] = 0.016464;
CONSTANTS[35] = 0.25;
CONSTANTS[36] = 0.008232;
CONSTANTS[37] = 0.00025;
CONSTANTS[38] = 8e-5;
CONSTANTS[39] = 0.000425;
CONSTANTS[40] = 0.15;
CONSTANTS[41] = 0.001;
CONSTANTS[42] = 10;
CONSTANTS[43] = 0.3;
CONSTANTS[44] = 0.001094;
CONSTANTS[45] = 2.00000;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000));
ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000));
RATES[11] = (ALGEBRAIC[8] - STATES[11])/ALGEBRAIC[21];
ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/5.00000));
ALGEBRAIC[23] = 85.0000*exp(- pow(STATES[0]+45.0000, 2.00000)/320.000)+5.00000/(1.00000+exp((STATES[0] - 20.0000)/5.00000))+3.00000;
RATES[13] = (ALGEBRAIC[10] - STATES[13])/ALGEBRAIC[23];
ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000));
ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000;
RATES[14] = (ALGEBRAIC[11] - STATES[14])/ALGEBRAIC[24];
ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000)));
ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[33];
RATES[16] = (ALGEBRAIC[12]>STATES[16]&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[25]);
ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000));
ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000));
ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000));
ALGEBRAIC[36] = 1.00000*ALGEBRAIC[14]*ALGEBRAIC[27];
RATES[4] = (ALGEBRAIC[1] - STATES[4])/ALGEBRAIC[36];
ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000));
ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000));
ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000));
ALGEBRAIC[37] = 1.00000*ALGEBRAIC[15]*ALGEBRAIC[28];
RATES[5] = (ALGEBRAIC[2] - STATES[5])/ALGEBRAIC[37];
ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000));
ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2);
ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000));
ALGEBRAIC[38] = 1.00000*ALGEBRAIC[16]*ALGEBRAIC[29];
RATES[6] = (ALGEBRAIC[3] - STATES[6])/ALGEBRAIC[38];
ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000);
ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000));
ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000));
ALGEBRAIC[39] = 1.00000*ALGEBRAIC[17]*ALGEBRAIC[30];
RATES[7] = (ALGEBRAIC[4] - STATES[7])/ALGEBRAIC[39];
ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000);
ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000);
ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000))));
ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]);
RATES[8] = (ALGEBRAIC[5] - STATES[8])/ALGEBRAIC[40];
ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000);
ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? (( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/1.00000)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000);
ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000))));
ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]);
RATES[9] = (ALGEBRAIC[6] - STATES[9])/ALGEBRAIC[41];
ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000));
ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000;
ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000));
ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000));
ALGEBRAIC[45] = 1.00000*ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42];
RATES[10] = (ALGEBRAIC[7] - STATES[10])/ALGEBRAIC[45];
ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000));
ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000));
ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000));
ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000;
ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[45];
RATES[12] = (ALGEBRAIC[43]>STATES[12]&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[46]);
ALGEBRAIC[58] = (( (( CONSTANTS[21]*CONSTANTS[10])/(CONSTANTS[10]+CONSTANTS[22]))*STATES[2])/(STATES[2]+CONSTANTS[23]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[11]/STATES[2]);
ALGEBRAIC[53] = CONSTANTS[16]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[13]);
ALGEBRAIC[54] = CONSTANTS[17]*(STATES[0] - ALGEBRAIC[13]);
ALGEBRAIC[59] = ( CONSTANTS[24]*( exp(( CONSTANTS[27]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[12] - exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[11], 3.00000)*STATES[3]*CONSTANTS[26]))/( (pow(CONSTANTS[29], 3.00000)+pow(CONSTANTS[11], 3.00000))*(CONSTANTS[28]+CONSTANTS[12])*(1.00000+ CONSTANTS[25]*exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))));
RATES[2] = ( - 1.00000*(ALGEBRAIC[53]+ALGEBRAIC[54]+ 3.00000*ALGEBRAIC[58]+ 3.00000*ALGEBRAIC[59])*CONSTANTS[3])/( 1.00000*CONSTANTS[4]*CONSTANTS[2]);
ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[10]/STATES[1]);
ALGEBRAIC[47] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[26]) - 200.000)));
ALGEBRAIC[48] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[26])+100.000))+exp( 0.100000*((STATES[0] - ALGEBRAIC[26]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[26])));
ALGEBRAIC[49] = ALGEBRAIC[47]/(ALGEBRAIC[47]+ALGEBRAIC[48]);
ALGEBRAIC[50] = CONSTANTS[13]*ALGEBRAIC[49]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[57] = CONSTANTS[20]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[51] = CONSTANTS[14]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[35] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[10]+ CONSTANTS[9]*CONSTANTS[11])/(STATES[1]+ CONSTANTS[9]*STATES[2]));
ALGEBRAIC[52] = CONSTANTS[15]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[35]);
ALGEBRAIC[55] = ( (( CONSTANTS[18]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[12]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000);
ALGEBRAIC[44] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[12]/STATES[3]);
ALGEBRAIC[56] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[44]);
ALGEBRAIC[61] = ( CONSTANTS[32]*(STATES[0] - ALGEBRAIC[26]))/(1.00000+exp((25.0000 - STATES[0])/5.98000));
ALGEBRAIC[60] = ( CONSTANTS[30]*STATES[3])/(STATES[3]+CONSTANTS[31]);
ALGEBRAIC[0] = (VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]>=CONSTANTS[5]&&VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[5]+CONSTANTS[7] ? - CONSTANTS[8] : 0.00000);
RATES[0] = (- 1.00000/1.00000)*(ALGEBRAIC[50]+ALGEBRAIC[57]+ALGEBRAIC[51]+ALGEBRAIC[52]+ALGEBRAIC[55]+ALGEBRAIC[58]+ALGEBRAIC[53]+ALGEBRAIC[54]+ALGEBRAIC[59]+ALGEBRAIC[56]+ALGEBRAIC[61]+ALGEBRAIC[60]+ALGEBRAIC[0]);
RATES[1] = ( - 1.00000*((ALGEBRAIC[50]+ALGEBRAIC[57]+ALGEBRAIC[51]+ALGEBRAIC[52]+ALGEBRAIC[61]+ALGEBRAIC[0]) - 2.00000*ALGEBRAIC[58])*CONSTANTS[3])/( 1.00000*CONSTANTS[4]*CONSTANTS[2]);
ALGEBRAIC[62] = (( CONSTANTS[34]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[35], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[36])*STATES[10]*STATES[16];
ALGEBRAIC[63] = CONSTANTS[39]/(1.00000+pow(CONSTANTS[37], 2.00000)/pow(STATES[3], 2.00000));
ALGEBRAIC[64] = CONSTANTS[38]*(STATES[15] - STATES[3]);
ALGEBRAIC[65] = 1.00000/(1.00000+( CONSTANTS[40]*CONSTANTS[41])/pow(STATES[3]+CONSTANTS[41], 2.00000));
RATES[3] = ALGEBRAIC[65]*(((ALGEBRAIC[64] - ALGEBRAIC[63])+ALGEBRAIC[62]) - (( 1.00000*((ALGEBRAIC[55]+ALGEBRAIC[56]+ALGEBRAIC[60]) - 2.00000*ALGEBRAIC[59]))/( 2.00000*1.00000*CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]);
ALGEBRAIC[66] = 1.00000/(1.00000+( CONSTANTS[42]*CONSTANTS[43])/pow(STATES[15]+CONSTANTS[43], 2.00000));
RATES[15] = (( ALGEBRAIC[66]*CONSTANTS[4])/CONSTANTS[44])*(ALGEBRAIC[63] - (ALGEBRAIC[62]+ALGEBRAIC[64]));
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000));
ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000));
ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/5.00000));
ALGEBRAIC[23] = 85.0000*exp(- pow(STATES[0]+45.0000, 2.00000)/320.000)+5.00000/(1.00000+exp((STATES[0] - 20.0000)/5.00000))+3.00000;
ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000));
ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000;
ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000)));
ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[33];
ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000));
ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000));
ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000));
ALGEBRAIC[36] = 1.00000*ALGEBRAIC[14]*ALGEBRAIC[27];
ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000));
ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000));
ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000));
ALGEBRAIC[37] = 1.00000*ALGEBRAIC[15]*ALGEBRAIC[28];
ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000));
ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2);
ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000));
ALGEBRAIC[38] = 1.00000*ALGEBRAIC[16]*ALGEBRAIC[29];
ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000);
ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000));
ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000));
ALGEBRAIC[39] = 1.00000*ALGEBRAIC[17]*ALGEBRAIC[30];
ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000);
ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000);
ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000))));
ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]);
ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000);
ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? (( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/1.00000)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000);
ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000))));
ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]);
ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000));
ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000;
ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000));
ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000));
ALGEBRAIC[45] = 1.00000*ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42];
ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000));
ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000));
ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000));
ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000;
ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[45];
ALGEBRAIC[58] = (( (( CONSTANTS[21]*CONSTANTS[10])/(CONSTANTS[10]+CONSTANTS[22]))*STATES[2])/(STATES[2]+CONSTANTS[23]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[11]/STATES[2]);
ALGEBRAIC[53] = CONSTANTS[16]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[13]);
ALGEBRAIC[54] = CONSTANTS[17]*(STATES[0] - ALGEBRAIC[13]);
ALGEBRAIC[59] = ( CONSTANTS[24]*( exp(( CONSTANTS[27]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[12] - exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[11], 3.00000)*STATES[3]*CONSTANTS[26]))/( (pow(CONSTANTS[29], 3.00000)+pow(CONSTANTS[11], 3.00000))*(CONSTANTS[28]+CONSTANTS[12])*(1.00000+ CONSTANTS[25]*exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))));
ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[10]/STATES[1]);
ALGEBRAIC[47] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[26]) - 200.000)));
ALGEBRAIC[48] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[26])+100.000))+exp( 0.100000*((STATES[0] - ALGEBRAIC[26]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[26])));
ALGEBRAIC[49] = ALGEBRAIC[47]/(ALGEBRAIC[47]+ALGEBRAIC[48]);
ALGEBRAIC[50] = CONSTANTS[13]*ALGEBRAIC[49]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[57] = CONSTANTS[20]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[51] = CONSTANTS[14]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[26]);
ALGEBRAIC[35] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[10]+ CONSTANTS[9]*CONSTANTS[11])/(STATES[1]+ CONSTANTS[9]*STATES[2]));
ALGEBRAIC[52] = CONSTANTS[15]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[35]);
ALGEBRAIC[55] = ( (( CONSTANTS[18]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[12]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000);
ALGEBRAIC[44] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[12]/STATES[3]);
ALGEBRAIC[56] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[44]);
ALGEBRAIC[61] = ( CONSTANTS[32]*(STATES[0] - ALGEBRAIC[26]))/(1.00000+exp((25.0000 - STATES[0])/5.98000));
ALGEBRAIC[60] = ( CONSTANTS[30]*STATES[3])/(STATES[3]+CONSTANTS[31]);
ALGEBRAIC[0] = (VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]>=CONSTANTS[5]&&VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[5]+CONSTANTS[7] ? - CONSTANTS[8] : 0.00000);
ALGEBRAIC[62] = (( CONSTANTS[34]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[35], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[36])*STATES[10]*STATES[16];
ALGEBRAIC[63] = CONSTANTS[39]/(1.00000+pow(CONSTANTS[37], 2.00000)/pow(STATES[3], 2.00000));
ALGEBRAIC[64] = CONSTANTS[38]*(STATES[15] - STATES[3]);
ALGEBRAIC[65] = 1.00000/(1.00000+( CONSTANTS[40]*CONSTANTS[41])/pow(STATES[3]+CONSTANTS[41], 2.00000));
ALGEBRAIC[66] = 1.00000/(1.00000+( CONSTANTS[42]*CONSTANTS[43])/pow(STATES[15]+CONSTANTS[43], 2.00000));
}