/* There are a total of 13 entries in the algebraic variable array. There are a total of 9 entries in each of the rate and state variable arrays. There are a total of 19 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is S1 in component S1 (millimolar). * CONSTANTS[0] is Jo in component glucose_influx_rate (flux). * ALGEBRAIC[3] is v1 in component v1 (flux). * STATES[1] is S2 in component S2 (millimolar). * ALGEBRAIC[4] is v2 in component v2 (flux). * STATES[2] is S3 in component S3 (millimolar). * ALGEBRAIC[5] is v3 in component v3 (flux). * ALGEBRAIC[10] is v8 in component v8 (flux). * STATES[3] is S4 in component S4 (millimolar). * ALGEBRAIC[6] is v4 in component v4 (flux). * STATES[4] is S5 in component S5 (millimolar). * ALGEBRAIC[7] is v5 in component v5 (flux). * STATES[5] is S6 in component S6 (millimolar). * ALGEBRAIC[9] is v6 in component v6 (flux). * ALGEBRAIC[12] is J in component S6_flux_rate_across_the_plasma_membrane (flux). * STATES[6] is S6_ex in component S6_ex (millimolar). * CONSTANTS[1] is phi in component S6_ex (dimensionless). * ALGEBRAIC[11] is v9 in component v9 (flux). * STATES[7] is A3 in component A3 (millimolar). * ALGEBRAIC[8] is v7 in component v7 (flux). * CONSTANTS[2] is A in component A (millimolar). * ALGEBRAIC[0] is A2 in component A (millimolar). * STATES[8] is N2 in component N2 (millimolar). * CONSTANTS[3] is N in component N (millimolar). * ALGEBRAIC[1] is N1 in component N (millimolar). * CONSTANTS[4] is K_i in component v1 (millimolar). * CONSTANTS[5] is k_1 in component v1 (second_order_rate_constant). * CONSTANTS[6] is n in component v1 (dimensionless). * ALGEBRAIC[2] is f_A3 in component v1 (dimensionless). * CONSTANTS[7] is k_2 in component v2 (first_order_rate_constant). * CONSTANTS[8] is k_GAPDH_plus in component v3 (second_order_rate_constant). * CONSTANTS[9] is k_GAPDH_minus in component v3 (second_order_rate_constant). * CONSTANTS[10] is k_PGK_plus in component v3 (second_order_rate_constant). * CONSTANTS[11] is k_PGK_minus in component v3 (second_order_rate_constant). * CONSTANTS[12] is k_4 in component v4 (second_order_rate_constant). * CONSTANTS[13] is k_5 in component v5 (first_order_rate_constant). * CONSTANTS[14] is k_6 in component v6 (second_order_rate_constant). * CONSTANTS[15] is k_7 in component v7 (first_order_rate_constant). * CONSTANTS[16] is k_8 in component v8 (second_order_rate_constant). * CONSTANTS[17] is k_9 in component v9 (first_order_rate_constant). * CONSTANTS[18] is k in component S6_flux_rate_across_the_plasma_membrane (first_order_rate_constant). * RATES[0] is d/dt S1 in component S1 (millimolar). * RATES[1] is d/dt S2 in component S2 (millimolar). * RATES[2] is d/dt S3 in component S3 (millimolar). * RATES[3] is d/dt S4 in component S4 (millimolar). * RATES[4] is d/dt S5 in component S5 (millimolar). * RATES[5] is d/dt S6 in component S6 (millimolar). * RATES[6] is d/dt S6_ex in component S6_ex (millimolar). * RATES[7] is d/dt A3 in component A3 (millimolar). * RATES[8] is d/dt N2 in component N2 (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 1.57981839; CONSTANTS[0] = 50; STATES[1] = 4.8279999; STATES[2] = 0.468657507; STATES[3] = 0.589391932; STATES[4] = 8.210114438; STATES[5] = 0.078042624; STATES[6] = 0.025277594; CONSTANTS[1] = 0.1; STATES[7] = 1.972814237; CONSTANTS[2] = 4; STATES[8] = 0.384873894; CONSTANTS[3] = 1; CONSTANTS[4] = 1; CONSTANTS[5] = 550; CONSTANTS[6] = 4; CONSTANTS[7] = 9.8; CONSTANTS[8] = 323.8; CONSTANTS[9] = 57823.1; CONSTANTS[10] = 76411.1; CONSTANTS[11] = 23.7; CONSTANTS[12] = 80; CONSTANTS[13] = 9.7; CONSTANTS[14] = 2000; CONSTANTS[15] = 28; CONSTANTS[16] = 85.7; CONSTANTS[17] = 80; CONSTANTS[18] = 375; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = pow(1.00000+pow(STATES[7]/CONSTANTS[4], CONSTANTS[6]), - 1.00000); ALGEBRAIC[3] = CONSTANTS[5]*STATES[0]*STATES[7]*ALGEBRAIC[2]; RATES[0] = CONSTANTS[0] - ALGEBRAIC[3]; ALGEBRAIC[4] = CONSTANTS[7]*STATES[1]; RATES[1] = ALGEBRAIC[3] - ALGEBRAIC[4]; ALGEBRAIC[0] = CONSTANTS[2] - STATES[7]; ALGEBRAIC[1] = CONSTANTS[3] - STATES[8]; ALGEBRAIC[5] = ( CONSTANTS[8]*CONSTANTS[10]*STATES[2]*ALGEBRAIC[1]*ALGEBRAIC[0] - CONSTANTS[9]*CONSTANTS[11]*STATES[3]*STATES[7]*STATES[8])/( CONSTANTS[9]*STATES[8]+ CONSTANTS[10]*ALGEBRAIC[0]); ALGEBRAIC[6] = CONSTANTS[12]*STATES[3]*ALGEBRAIC[0]; RATES[3] = ALGEBRAIC[5] - ALGEBRAIC[6]; ALGEBRAIC[7] = CONSTANTS[13]*STATES[4]; RATES[4] = ALGEBRAIC[6] - ALGEBRAIC[7]; ALGEBRAIC[8] = CONSTANTS[15]*STATES[7]; RATES[7] = (ALGEBRAIC[5]+ALGEBRAIC[6]) - ( 2.00000*ALGEBRAIC[3]+ALGEBRAIC[8]); ALGEBRAIC[10] = CONSTANTS[16]*STATES[2]*STATES[8]; RATES[2] = 2.00000*ALGEBRAIC[4] - (ALGEBRAIC[5]+ALGEBRAIC[10]); ALGEBRAIC[9] = CONSTANTS[14]*STATES[5]*STATES[8]; RATES[8] = ALGEBRAIC[5] - (ALGEBRAIC[9]+ALGEBRAIC[10]); ALGEBRAIC[12] = CONSTANTS[18]*(STATES[5] - STATES[6]); RATES[5] = ALGEBRAIC[7] - (ALGEBRAIC[9]+ALGEBRAIC[12]); ALGEBRAIC[11] = CONSTANTS[17]*STATES[6]; RATES[6] = CONSTANTS[1]*ALGEBRAIC[12] - ALGEBRAIC[11]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = pow(1.00000+pow(STATES[7]/CONSTANTS[4], CONSTANTS[6]), - 1.00000); ALGEBRAIC[3] = CONSTANTS[5]*STATES[0]*STATES[7]*ALGEBRAIC[2]; ALGEBRAIC[4] = CONSTANTS[7]*STATES[1]; ALGEBRAIC[0] = CONSTANTS[2] - STATES[7]; ALGEBRAIC[1] = CONSTANTS[3] - STATES[8]; ALGEBRAIC[5] = ( CONSTANTS[8]*CONSTANTS[10]*STATES[2]*ALGEBRAIC[1]*ALGEBRAIC[0] - CONSTANTS[9]*CONSTANTS[11]*STATES[3]*STATES[7]*STATES[8])/( CONSTANTS[9]*STATES[8]+ CONSTANTS[10]*ALGEBRAIC[0]); ALGEBRAIC[6] = CONSTANTS[12]*STATES[3]*ALGEBRAIC[0]; ALGEBRAIC[7] = CONSTANTS[13]*STATES[4]; ALGEBRAIC[8] = CONSTANTS[15]*STATES[7]; ALGEBRAIC[10] = CONSTANTS[16]*STATES[2]*STATES[8]; ALGEBRAIC[9] = CONSTANTS[14]*STATES[5]*STATES[8]; ALGEBRAIC[12] = CONSTANTS[18]*(STATES[5] - STATES[6]); ALGEBRAIC[11] = CONSTANTS[17]*STATES[6]; }