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<article>
  <articleinfo>
  <title>Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, The university of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
           This CellML model runs in both OpenCell and COR to reproduce the published results. The value for the variable 'Ca_o' in the component 'calcium_current' can be altered to 0, 2.5, 5 or 7.5 mM to reproduce figures 5 a,b,c,d, respectively.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: The extracellular calcium concentration has interesting effects on bursting of pancreatic beta-cells. The mechanism underlying the extracellular Ca2+ effect is not well understood. By incorporating a low-threshold transient inward current to the store-operated bursting model of Chay, this paper elucidates the role of the extracellular Ca2+ concentration in influencing electrical activity, intracellular Ca2+ concentration, and the luminal Ca2+ concentration in the intracellular Ca2+ store. The possibility that this inward current is a carbachol-sensitive and TTX-insensitive Na+ current discovered by others is discussed. In addition, this paper explains how these three variables respond when various pharmacological agents are applied to the store-operated model.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Effects of extracellular Calcium on Electrical Bursting and Intracellular and Luminal Calcium Oscillations in Insulin Secreting Pancreatic Beta-Cells, Teresa Ree Chay, 1997, 
            <emphasis>Biophysical Journal</emphasis>
          , 73, 1673-1688.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9284334&amp;dopt=Abstract">PubMed ID: 9284334</ulink>  
</para>



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      <title>diagram of the mitochondrial Ca2+ handling model</title>
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    <imagedata fileref="chay_1997.png"/>
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</mediaobject>
<caption>A schematic representation of the current and fluxes captured by the Chay 1997 pancreatic beta-cell model.  This diagram shows the plasma membrane currents associated with burst and spike oscillations: the fast current, I<subscript>fast</subscript>; the calcium current, I <subscript>Ca<superscript>2+</superscript>
            </subscript>; the cationic nonselective inward current, I<subscript>NS</subscript>; the delayed-rectifying K<superscript>+</superscript> current, I<subscript>K(dr)</subscript>, the calcium-sensitive K<superscript>+</superscript> current, I<subscript>K(Ca)</subscript>; the ATP-sensitive K<superscript>+</superscript> current, I<subscript>K(ATP)</subscript>; and the Na<superscript>+</superscript> leak current, I<subscript>Na(L)</subscript>.  The ER intracellular Ca<superscript>2+</superscript> store is also shown with its associated transmembrane calcium fluxes: calcium release, J<subscript>rel</subscript>; and calcium uptake by the Ca<superscript>2+</superscript>-ATPase, J<subscript>pump</subscript>.</caption>
</informalfigure>

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  <rdf:Description rdf:about="rdf:#ece923a6-30c1-47a9-b3b1-3909eda215f2">
    <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James Lawson</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#d42f3492-3ace-4f88-b29a-67b923201a1e">
    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#adedec42-59c5-4dad-8f6c-177511d9560d"/>
    <rdf:value>Added more metadata.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#1df83312-5912-493b-8df9-acad7a980fbc"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#9ce2cfb8-26d1-4434-a964-2ec9582e1204">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#f0b2acc8-21ca-4887-9cbf-715041bcbc45">
    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#272ea005-0b0b-45fb-a45a-3f7efecb9fea"/>
    <rdf:value>Added cmeta:id's to several variables to allow their use by a session file. (PCEnv does this automatically when a session of a model is exported and the model file saved.)</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#c3e37a47-326f-4f3c-81bc-def220c86f52"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#b87b0808-5081-44e3-9bde-1b28762f3c10">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#0c711e21-217a-4caf-ab74-c759ffaf1c48">
    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#bc06bd16-6e67-4d77-a80d-2be26c39d66a"/>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Effects of extracellular calcium on electrical bursting and                      intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells</dc:title>
    <bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">73</bqs:volume>
    <bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">1673</bqs:first_page>
    <bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#3f00c2b6-0292-4510-9d7a-5d1656bedfff"/>
    <dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#12a2d14a-4cbc-4962-8793-966a6b2cee3a"/>
    <bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">1688</bqs:last_page>
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    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#ece923a6-30c1-47a9-b3b1-3909eda215f2"/>
    <rdf:value>This model runs in PCEnv and COR and is able to reproduce the figures presented in the Chay 1997 paper. This version has a PCEnv session file associated with it. 

The session shows three electrophysiological graphs (x-axis is time in seconds): membrane potential (mV), intracellular cytosolic calcium and intracellular (luminal / endoplasmic reticulum) calcium. The value for the variable 'Ca_o' in the component 'calcium_current' can be altered to 0, 2.5, 5 or 7.5 mM to reproduce figures 5 a,b,c,d, respectively.</rdf:value>
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  <rdf:Description rdf:about="rdf:#092f5120-d5e6-42cb-802c-44e04672abe8">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#$szI6R1">
    <ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$tzI6R1"/>
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  <rdf:Description rdf:about="rdf:#ac28220c-dc7d-4675-a1f8-e96ab61711c1">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Teresa</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Chay</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Ree</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#54dc0efc-e194-433f-9ad9-cc28c0acf72b">
    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
    <rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#ff9885dd-8329-4566-90ce-9cb51418006c">
    <vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#b6ea36ce-7211-433b-b3c4-73bb7b83af1f"/>
    <vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#54dc0efc-e194-433f-9ad9-cc28c0acf72b"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#9ce2cfb8-26d1-4434-a964-2ec9582e1204"/>
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    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#58390b2b-86cc-4d41-a65f-ae3dbfa61add"/>
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    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#3ee27592-159c-4faa-9c7a-22d32346dc0b"/>
    <rdf:value>Added publication date information.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#c963df5c-bb43-490d-baa3-587ac6d67bb0"/>
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  <rdf:Description rdf:about="rdf:#463030a1-9c73-4da9-9b90-71263df03307">
    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#e5070e94-6bd9-4e8d-a860-997bc55aac36"/>
    <rdf:value>Units checked, curated.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#4f813ce0-f7d1-4d70-a28b-fa9487d2abf9"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#$tzI6R1">
    <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
    <rdf:first rdf:resource="rdf:#$uzI6R1"/>
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  <rdf:Description rdf:about="rdf:#$uzI6R1">
    <ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">100</ns7:endingValue>
    <ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">1000000</ns7:nonstandard-pointDensity>
    <ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.01</ns7:maximumStepSize>
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  <rdf:Description rdf:about="rdf:#12a2d14a-4cbc-4962-8793-966a6b2cee3a">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">1997-09</dcterms:W3CDTF>
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  <rdf:Description rdf:about="rdf:#6bfba5f6-415b-466a-aff1-49fd37869b6e">
    <bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
    <rdf:value rdf:resource="rdf:#a2cc4365-2f2f-4903-9cbc-dc863978ea00"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#0855ba44-9c92-4224-8182-c79ef9d998e0">
    <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#6bfba5f6-415b-466a-aff1-49fd37869b6e"/>
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  <rdf:Description rdf:about="rdf:#c3e37a47-326f-4f3c-81bc-def220c86f52">
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#9957dbbd-a1b4-40c7-b49e-502606ec0c36"/>
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  <rdf:Description rdf:about="rdf:#8180d95a-0164-47c3-bb69-9939c6a0c5ec">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Autumn</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Cuellar</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">A</vCard:Other>
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  <rdf:Description rdf:about="rdf:#d6aeccde-f29c-47e6-b2d6-7cf9e8e3523a">
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#092f5120-d5e6-42cb-802c-44e04672abe8"/>
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  <rdf:Description rdf:about="rdf:#c963df5c-bb43-490d-baa3-587ac6d67bb0">
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#8180d95a-0164-47c3-bb69-9939c6a0c5ec"/>
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</model>