The University of Auckland, Bioengineering Institute
c.lloyd@auckland.ac.nz
Karagiannis
Emmanouil
D
This is the CellML description of Vempati et al.'s 2007 biochemical model of the matrix metalloproteinase 9 activation and inhibition.
Tr
trypsin
angiogenesis
signal transduction
MMP
systems biology
TIMP
MMP9
MMP3
biochemical kinetics
Tr_pM9_T1
trypsin-proMMP9-TIMP1
matrix metalloproteinase-9-tissue inhibitor of metalloproteinase-1 complex
M9_T1
MMP9-TIMP1
M3_pM9
MMP3-proMMP9
matrix metalloproteinase-3-promatrix metalloproteinase-9 complex
pM9
proMMP9
promatrix metalloproteinase-9
100000
144000
37585
282
37596
A Biochemical Model of Matrix Metalloproteinase 9 Activation and Inhibition
Vempati et al.'s 2007 biochemical model of the matrix metalloproteinase 9 activation and inhibition.
MMP3-proMMP9-TIMP1
M3_pM9_T1
matrix metalloproteinase-3-promatrix metalloproteinase-9-tissue inhibitor of metalloproteinase-1 complex
This cellML model is known to run in both PCEnv and COR to recreate the results in the published paper. The units have been checked and they are consistent. Please note that many of the figures in the paper are complex and requite special simulation conditions. This particular CellMl model represents the basic core model presented in the paper. Initial conditions can be modified to generate more complex results. We thank the model author Prakash Vempati for his assistance in getting this CellML model to run.
S
Popel
Aleksander
17848556
pM9_T1
proMMP9-TIMP1
promatrix metalloproteinase-9-tissue inhibitor of metalloproteinase-1 complex
proMMP9-TIMP1-MMP3
pM9_T1_M3
Catherine
May
Lloyd
M9
MMP9
matrix metalloproteinase-9
Tr_pM9
trypsin-proMMP9
2008-07-08T00:00:00+00:00
MMP3-proMMP9-TIMP1-MMP3
M3_pM9_T1_M3
M3
MMP3
matrix metalloproteinase-3
T1
TIMP1
tissue inhibitor of metalloproteinase-1
Prakasht
Vempati
Catherine Lloyd
keyword
inactivated MMP9-TIMP1
inactivated matrix metalloproteinase-9-tissue inhibitor of metalloproteinase-1 complex
M9_T1_star
Auckland Bioengineering Institute
The University of Auckland
MMP9-TIMP1-MMP3
M9_T1_M3
The Journal of Biological Chemistry
Tr_pM9_T1_M3
trypsin-proMMP9-TIMP1-MMP3
MMP3-TIMP1
matrix metalloproteinase-3-tissue inhibitor of metalloproteinase-1 complex
M3_T1
Catherine Lloyd
2007-12-28