/* There are a total of 0 entries in the algebraic variable array. There are a total of 33 entries in each of the rate and state variable arrays. There are a total of 80 entries in the constant variable array. */ /* * VOI is time in component environment (s). * CONSTANTS[0] is kf1 in component PI3K (second_order_rate_constant). * CONSTANTS[1] is kb1 in component PI3K (first_order_rate_constant). * CONSTANTS[2] is kf2 in component PI3K (second_order_rate_constant). * CONSTANTS[3] is kb2 in component PI3K (first_order_rate_constant). * CONSTANTS[4] is kf3 in component PI3K (first_order_rate_constant). * CONSTANTS[5] is kb3 in component PI3K (first_order_rate_constant). * CONSTANTS[6] is kf34 in component PI3K (first_order_rate_constant). * CONSTANTS[7] is kb34 in component PI3K (first_order_rate_constant). * CONSTANTS[8] is V4 in component PI3K (flux). * CONSTANTS[9] is k4 in component PI3K (nm). * CONSTANTS[10] is kf5 in component PI3K (second_order_rate_constant). * CONSTANTS[11] is kb5 in component PI3K (first_order_rate_constant). * CONSTANTS[12] is kf6 in component PI3K (first_order_rate_constant). * CONSTANTS[13] is kb6 in component PI3K (first_order_rate_constant). * CONSTANTS[14] is kf7 in component PI3K (first_order_rate_constant). * CONSTANTS[15] is kb7 in component PI3K (first_order_rate_constant). * CONSTANTS[16] is kf8 in component PI3K (first_order_rate_constant). * CONSTANTS[17] is kb8 in component PI3K (second_order_rate_constant). * CONSTANTS[18] is kf9 in component PI3K (first_order_rate_constant). * CONSTANTS[19] is kb9 in component PI3K (second_order_rate_constant). * CONSTANTS[20] is V10 in component PI3K (flux). * CONSTANTS[21] is k10 in component PI3K (nm). * CONSTANTS[22] is kf23 in component PI3K (second_order_rate_constant). * CONSTANTS[23] is kb23 in component PI3K (first_order_rate_constant). * CONSTANTS[24] is kf24 in component PI3K (first_order_rate_constant). * CONSTANTS[25] is kb24 in component PI3K (first_order_rate_constant). * CONSTANTS[26] is kf25 in component PI3K (first_order_rate_constant). * CONSTANTS[27] is kb25 in component PI3K (second_order_rate_constant). * CONSTANTS[28] is V26 in component PI3K (flux). * CONSTANTS[29] is k26 in component PI3K (nm). * STATES[0] is R in component PI3K (nm). * STATES[1] is Shc in component PI3K (nm). * STATES[2] is PI3K in component PI3K (nm). * STATES[3] is HRG in component PI3K (nm). * STATES[4] is R_HRG in component PI3K (nm). * STATES[5] is R_HRG2 in component PI3K (nm). * STATES[6] is Internalisation in component PI3K (nm). * STATES[7] is RP in component PI3K (nm). * STATES[8] is R_Shc in component PI3K (nm). * STATES[9] is R_ShP in component PI3K (nm). * STATES[10] is ShP in component PI3K (nm). * STATES[11] is R_ShGS in component PI3K (nm). * STATES[12] is ShGS in component PI3K (nm). * STATES[13] is GS in component PI3K (nm). * STATES[14] is R_PI3K in component PI3K (nm). * STATES[15] is R_PI3Kstar in component PI3K (nm). * STATES[16] is PI3Kstar in component PI3K (nm). * CONSTANTS[30] is two in component PI3K (dimensionless). * STATES[17] is RasGTP in component RasGDPtoRasGTP (nm). * CONSTANTS[31] is kf11 in component RasGDPtoRasGTP (first_order_rate_constant). * CONSTANTS[32] is k11 in component RasGDPtoRasGTP (nm). * CONSTANTS[33] is V12 in component RasGDPtoRasGTP (flux). * CONSTANTS[34] is k12 in component RasGDPtoRasGTP (nm). * STATES[18] is RasGDP in component RasGDPtoRasGTP (nm). * STATES[19] is Akt_PIPP in component Akt (nm). * STATES[20] is RAF_star in component RAF (nm). * CONSTANTS[35] is kf13 in component RAF (first_order_rate_constant). * CONSTANTS[36] is k13 in component RAF (nm). * CONSTANTS[37] is kf14 in component RAF (first_order_rate_constant). * CONSTANTS[38] is k14 in component RAF (nm). * CONSTANTS[39] is E in component RAF (nm). * STATES[21] is RAF in component RAF (nm). * STATES[22] is MEKP in component MEK (nm). * STATES[23] is MEKPP in component MEK (nm). * CONSTANTS[40] is kf27 in component Akt (first_order_rate_constant). * CONSTANTS[41] is k27 in component Akt (nm). * CONSTANTS[42] is V28 in component Akt (flux). * CONSTANTS[43] is k28 in component Akt (nm). * CONSTANTS[44] is kf29 in component Akt (second_order_rate_constant). * CONSTANTS[45] is kb29 in component Akt (first_order_rate_constant). * CONSTANTS[46] is V30 in component Akt (flux). * CONSTANTS[47] is k30 in component Akt (nm). * CONSTANTS[48] is kf31 in component Akt (first_order_rate_constant). * CONSTANTS[49] is k31 in component Akt (nm). * CONSTANTS[50] is V32 in component Akt (flux). * CONSTANTS[51] is k32 in component Akt (nm). * CONSTANTS[52] is kf33 in component Akt (first_order_rate_constant). * CONSTANTS[53] is k33 in component Akt (nm). * CONSTANTS[54] is k16 in component Akt (nm). * CONSTANTS[55] is k18 in component Akt (nm). * STATES[24] is P in component Akt (nm). * STATES[25] is PIP3 in component Akt (nm). * STATES[26] is Akt in component Akt (nm). * STATES[27] is Akt_PIP3 in component Akt (nm). * STATES[28] is Akt_PIP in component Akt (nm). * CONSTANTS[56] is PP2A in component Akt (nm). * CONSTANTS[57] is one in component Akt (dimensionless). * CONSTANTS[58] is PP2A in component MEK (nm). * STATES[29] is MEK in component MEK (nm). * CONSTANTS[59] is kf15 in component MEK (first_order_rate_constant). * CONSTANTS[60] is k15 in component MEK (nm). * CONSTANTS[61] is kf16 in component MEK (first_order_rate_constant). * CONSTANTS[62] is k16 in component MEK (nm). * CONSTANTS[63] is kf17 in component MEK (first_order_rate_constant). * CONSTANTS[64] is k17 in component MEK (nm). * CONSTANTS[65] is kf18 in component MEK (first_order_rate_constant). * CONSTANTS[66] is k18 in component MEK (nm). * CONSTANTS[67] is k31 in component MEK (nm). * CONSTANTS[68] is k33 in component MEK (nm). * CONSTANTS[69] is one in component MEK (dimensionless). * CONSTANTS[70] is MKP3 in component ERK (nm). * STATES[30] is ERK in component ERK (nm). * STATES[31] is ERKP in component ERK (nm). * STATES[32] is ERKPP in component ERK (nm). * CONSTANTS[71] is kf19 in component ERK (first_order_rate_constant). * CONSTANTS[72] is k19 in component ERK (nm). * CONSTANTS[73] is kf20 in component ERK (first_order_rate_constant). * CONSTANTS[74] is k20 in component ERK (nm). * CONSTANTS[75] is kf21 in component ERK (first_order_rate_constant). * CONSTANTS[76] is k21 in component ERK (nm). * CONSTANTS[77] is kf22 in component ERK (first_order_rate_constant). * CONSTANTS[78] is k22 in component ERK (nm). * CONSTANTS[79] is one in component ERK (dimensionless). * RATES[0] is d/dt R in component PI3K (nm). * RATES[3] is d/dt HRG in component PI3K (nm). * RATES[4] is d/dt R_HRG in component PI3K (nm). * RATES[5] is d/dt R_HRG2 in component PI3K (nm). * RATES[7] is d/dt RP in component PI3K (nm). * RATES[6] is d/dt Internalisation in component PI3K (nm). * RATES[8] is d/dt R_Shc in component PI3K (nm). * RATES[1] is d/dt Shc in component PI3K (nm). * RATES[9] is d/dt R_ShP in component PI3K (nm). * RATES[13] is d/dt GS in component PI3K (nm). * RATES[10] is d/dt ShP in component PI3K (nm). * RATES[11] is d/dt R_ShGS in component PI3K (nm). * RATES[12] is d/dt ShGS in component PI3K (nm). * RATES[14] is d/dt R_PI3K in component PI3K (nm). * RATES[2] is d/dt PI3K in component PI3K (nm). * RATES[15] is d/dt R_PI3Kstar in component PI3K (nm). * RATES[16] is d/dt PI3Kstar in component PI3K (nm). * RATES[18] is d/dt RasGDP in component RasGDPtoRasGTP (nm). * RATES[17] is d/dt RasGTP in component RasGDPtoRasGTP (nm). * RATES[21] is d/dt RAF in component RAF (nm). * RATES[20] is d/dt RAF_star in component RAF (nm). * RATES[24] is d/dt P in component Akt (nm). * RATES[25] is d/dt PIP3 in component Akt (nm). * RATES[26] is d/dt Akt in component Akt (nm). * RATES[27] is d/dt Akt_PIP3 in component Akt (nm). * RATES[28] is d/dt Akt_PIP in component Akt (nm). * RATES[19] is d/dt Akt_PIPP in component Akt (nm). * RATES[29] is d/dt MEK in component MEK (nm). * RATES[22] is d/dt MEKP in component MEK (nm). * RATES[23] is d/dt MEKPP in component MEK (nm). * RATES[30] is d/dt ERK in component ERK (nm). * RATES[32] is d/dt ERKPP in component ERK (nm). * RATES[31] is d/dt ERKP in component ERK (nm). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.0012; CONSTANTS[1] = 0.00076; CONSTANTS[2] = 0.01; CONSTANTS[3] = 0.1; CONSTANTS[4] = 1; CONSTANTS[5] = 0.01; CONSTANTS[6] = 0.001; CONSTANTS[7] = 0; CONSTANTS[8] = 62.5; CONSTANTS[9] = 50; CONSTANTS[10] = 0.1; CONSTANTS[11] = 1; CONSTANTS[12] = 20; CONSTANTS[13] = 5; CONSTANTS[14] = 60; CONSTANTS[15] = 546; CONSTANTS[16] = 2040; CONSTANTS[17] = 15700; CONSTANTS[18] = 40.8; CONSTANTS[19] = 0; CONSTANTS[20] = 0.0154; CONSTANTS[21] = 340; CONSTANTS[22] = 0.1; CONSTANTS[23] = 2; CONSTANTS[24] = 9.85; CONSTANTS[25] = 0.0985; CONSTANTS[26] = 45.8; CONSTANTS[27] = 0.047; CONSTANTS[28] = 2620; CONSTANTS[29] = 3680; STATES[0] = 80; STATES[1] = 1000; STATES[2] = 10; STATES[3] = 10; STATES[4] = 0; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0; STATES[10] = 0; STATES[11] = 0; STATES[12] = 0; STATES[13] = 10; STATES[14] = 0; STATES[15] = 0; STATES[16] = 0; CONSTANTS[30] = 2; STATES[17] = 0; CONSTANTS[31] = 0.222; CONSTANTS[32] = 0.181; CONSTANTS[33] = 0.289; CONSTANTS[34] = 0.0571; STATES[18] = 120; STATES[19] = 0.0; STATES[20] = 100; CONSTANTS[35] = 1.53; CONSTANTS[36] = 11.7; CONSTANTS[37] = 0.00673; CONSTANTS[38] = 8.07; CONSTANTS[39] = 7; STATES[21] = 0; STATES[22] = 0; STATES[23] = 0; CONSTANTS[40] = 16.9; CONSTANTS[41] = 39.1; CONSTANTS[42] = 17000; CONSTANTS[43] = 9.02; CONSTANTS[44] = 507; CONSTANTS[45] = 234; CONSTANTS[46] = 20000; CONSTANTS[47] = 80000; CONSTANTS[48] = 0.107; CONSTANTS[49] = 4.35; CONSTANTS[50] = 20000; CONSTANTS[51] = 80000; CONSTANTS[52] = 0.211; CONSTANTS[53] = 12; CONSTANTS[54] = 2200; CONSTANTS[55] = 60; STATES[24] = 800; STATES[25] = 0; STATES[26] = 10; STATES[27] = 0; STATES[28] = 0; CONSTANTS[56] = 11.4; CONSTANTS[57] = 1; CONSTANTS[58] = 11.4; STATES[29] = 120; CONSTANTS[59] = 3.5; CONSTANTS[60] = 317; CONSTANTS[61] = 0.058; CONSTANTS[62] = 2200; CONSTANTS[63] = 2.9; CONSTANTS[64] = 317; CONSTANTS[65] = 0.058; CONSTANTS[66] = 60; CONSTANTS[67] = 4.35; CONSTANTS[68] = 12; CONSTANTS[69] = 1; CONSTANTS[70] = 2.4; STATES[30] = 1000; STATES[31] = 0; STATES[32] = 0; CONSTANTS[71] = 9.5; CONSTANTS[72] = 146000; CONSTANTS[73] = 0.3; CONSTANTS[74] = 160; CONSTANTS[75] = 16; CONSTANTS[76] = 146000; CONSTANTS[77] = 0.27; CONSTANTS[78] = 60; CONSTANTS[79] = 1; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = - CONSTANTS[0]*STATES[0]*STATES[3]+ CONSTANTS[1]*STATES[4]; RATES[3] = - CONSTANTS[0]*STATES[0]*STATES[3]+ CONSTANTS[1]*STATES[4]; RATES[4] = ( CONSTANTS[0]*STATES[0]*STATES[3] - CONSTANTS[1]*STATES[4]) - CONSTANTS[30]*( CONSTANTS[2]*STATES[4]*STATES[4] - CONSTANTS[3]*STATES[5]); RATES[5] = (( CONSTANTS[2]*STATES[4]*STATES[4] - CONSTANTS[3]*STATES[5]) - ( CONSTANTS[4]*STATES[5] - CONSTANTS[5]*STATES[7]))+( CONSTANTS[8]*STATES[7])/(CONSTANTS[9]+STATES[7]); RATES[7] = (((((( CONSTANTS[4]*STATES[5] - CONSTANTS[5]*STATES[7]) - ( CONSTANTS[8]*STATES[7])/(CONSTANTS[9]+STATES[7])) - ( CONSTANTS[10]*STATES[7]*STATES[1] - CONSTANTS[11]*STATES[8]))+( CONSTANTS[16]*STATES[9] - CONSTANTS[17]*STATES[12]*STATES[7])) - ( CONSTANTS[22]*STATES[7]*STATES[2] - CONSTANTS[23]*STATES[14]))+( CONSTANTS[26]*STATES[15] - CONSTANTS[27]*STATES[7]*STATES[16])) - ( CONSTANTS[6]*STATES[7] - CONSTANTS[7]*STATES[6]); RATES[6] = CONSTANTS[6]*STATES[7] - CONSTANTS[7]*STATES[6]; RATES[8] = ( CONSTANTS[10]*STATES[7]*STATES[1] - CONSTANTS[11]*STATES[8]) - ( CONSTANTS[12]*STATES[8] - CONSTANTS[13]*STATES[9]); RATES[1] = - ( CONSTANTS[10]*STATES[7]*STATES[1] - CONSTANTS[11]*STATES[8])+( CONSTANTS[20]*STATES[10])/(CONSTANTS[21]+STATES[10]); RATES[9] = ( CONSTANTS[12]*STATES[8] - CONSTANTS[13]*STATES[9]) - ( CONSTANTS[14]*STATES[9] - CONSTANTS[15]*STATES[11]); RATES[13] = - ( CONSTANTS[14]*STATES[9] - CONSTANTS[15]*STATES[11])+( CONSTANTS[18]*STATES[12] - CONSTANTS[19]*STATES[13]*STATES[10]); RATES[10] = ( CONSTANTS[18]*STATES[12] - CONSTANTS[19]*STATES[13]*STATES[10]) - ( CONSTANTS[20]*STATES[10])/(CONSTANTS[21]+STATES[10]); RATES[11] = ( CONSTANTS[14]*STATES[9] - CONSTANTS[15]*STATES[11]) - ( CONSTANTS[16]*STATES[9] - CONSTANTS[17]*STATES[12]*STATES[7]); RATES[12] = ( CONSTANTS[16]*STATES[9] - CONSTANTS[17]*STATES[12]*STATES[7]) - ( CONSTANTS[18]*STATES[12] - CONSTANTS[19]*STATES[13]*STATES[10]); RATES[14] = ( CONSTANTS[22]*STATES[7]*STATES[2] - CONSTANTS[23]*STATES[14]) - ( CONSTANTS[24]*STATES[14] - CONSTANTS[25]*STATES[15]); RATES[2] = - ( CONSTANTS[22]*STATES[7]*STATES[2] - CONSTANTS[23]*STATES[14])+( CONSTANTS[28]*STATES[16])/(CONSTANTS[29]+STATES[16]); RATES[15] = ( CONSTANTS[24]*STATES[14] - CONSTANTS[25]*STATES[15]) - ( CONSTANTS[26]*STATES[15] - CONSTANTS[27]*STATES[7]*STATES[16]); RATES[16] = ( CONSTANTS[26]*STATES[15] - CONSTANTS[27]*STATES[7]*STATES[16]) - ( CONSTANTS[28]*STATES[16])/(CONSTANTS[29]+STATES[16]); RATES[18] = - (( CONSTANTS[31]*STATES[12]*STATES[18])/(CONSTANTS[32]+STATES[18]))+( CONSTANTS[33]*STATES[17])/(CONSTANTS[34]+STATES[17]); RATES[17] = ( CONSTANTS[31]*STATES[12]*STATES[18])/(CONSTANTS[32]+STATES[18]) - ( CONSTANTS[33]*STATES[17])/(CONSTANTS[34]+STATES[17]); RATES[21] = ( CONSTANTS[37]*(STATES[19]+CONSTANTS[39])*STATES[20])/(CONSTANTS[38]+STATES[20]) - ( CONSTANTS[35]*STATES[17]*STATES[21])/(CONSTANTS[36]+STATES[21]); RATES[20] = - (( CONSTANTS[37]*(STATES[19]+CONSTANTS[39])*STATES[20])/(CONSTANTS[38]+STATES[20]))+( CONSTANTS[35]*STATES[17]*STATES[21])/(CONSTANTS[36]+STATES[21]); RATES[24] = ( CONSTANTS[42]*STATES[25])/(CONSTANTS[43]+STATES[25]) - ( CONSTANTS[40]*STATES[16]*STATES[24])/(CONSTANTS[41]+STATES[24]); RATES[25] = (- (( CONSTANTS[42]*STATES[25])/(CONSTANTS[43]+STATES[25]))+( CONSTANTS[40]*STATES[16]*STATES[24])/(CONSTANTS[41]+STATES[24])) - ( CONSTANTS[44]*STATES[25]*STATES[26] - CONSTANTS[45]*STATES[27]); RATES[26] = - ( CONSTANTS[44]*STATES[25]*STATES[26] - CONSTANTS[45]*STATES[27]); RATES[27] = (( CONSTANTS[44]*STATES[25]*STATES[26] - CONSTANTS[45]*STATES[27]) - ( CONSTANTS[46]*STATES[27])/( CONSTANTS[47]*(CONSTANTS[57]+STATES[28]/CONSTANTS[51])+STATES[27]))+( CONSTANTS[48]*CONSTANTS[56]*STATES[28])/( CONSTANTS[49]*(CONSTANTS[57]+STATES[22]/CONSTANTS[54]+STATES[23]/CONSTANTS[55]+STATES[19]/CONSTANTS[53])+STATES[28]); RATES[28] = ((( CONSTANTS[46]*STATES[27])/( CONSTANTS[47]*(CONSTANTS[57]+STATES[28]/CONSTANTS[51])+STATES[27]) - ( CONSTANTS[48]*CONSTANTS[56]*STATES[28])/( CONSTANTS[49]*(CONSTANTS[57]+STATES[22]/CONSTANTS[54]+STATES[23]/CONSTANTS[55]+STATES[19]/CONSTANTS[53])+STATES[28])) - ( CONSTANTS[50]*STATES[28])/( CONSTANTS[51]*(CONSTANTS[57]+STATES[27]/CONSTANTS[47])+STATES[28]))+( CONSTANTS[52]*CONSTANTS[56]*STATES[19])/( CONSTANTS[53]*(CONSTANTS[57]+STATES[22]/CONSTANTS[54]+STATES[23]/CONSTANTS[55]+STATES[28]/CONSTANTS[49])+STATES[19]); RATES[19] = ( CONSTANTS[50]*STATES[28])/( CONSTANTS[51]*(CONSTANTS[57]+STATES[27]/CONSTANTS[47])+STATES[28]) - ( CONSTANTS[52]*CONSTANTS[56]*STATES[19])/( CONSTANTS[53]*(CONSTANTS[57]+STATES[22]/CONSTANTS[54]+STATES[23]/CONSTANTS[55]+STATES[28]/CONSTANTS[49])+STATES[19]); RATES[29] = - (( CONSTANTS[59]*STATES[20]*STATES[29])/( CONSTANTS[60]*(CONSTANTS[69]+STATES[22]/CONSTANTS[64])+STATES[29]))+( CONSTANTS[61]*CONSTANTS[58]*STATES[22])/( CONSTANTS[62]*(CONSTANTS[69]+STATES[23]/CONSTANTS[66]+STATES[28]/CONSTANTS[67]+STATES[19]/CONSTANTS[68])+STATES[22]); RATES[22] = ((( CONSTANTS[59]*STATES[20]*STATES[29])/( CONSTANTS[60]*(CONSTANTS[69]+STATES[22]/CONSTANTS[64])+STATES[29]) - ( CONSTANTS[61]*CONSTANTS[58]*STATES[22])/( CONSTANTS[62]*(CONSTANTS[69]+STATES[23]/CONSTANTS[66]+STATES[28]/CONSTANTS[67]+STATES[19]/CONSTANTS[68])+STATES[22])) - ( CONSTANTS[63]*STATES[20]*STATES[22])/( CONSTANTS[64]*(CONSTANTS[69]+STATES[29]/CONSTANTS[60])+STATES[22]))+( CONSTANTS[65]*CONSTANTS[58]*STATES[23])/( CONSTANTS[66]*(CONSTANTS[69]+STATES[22]/CONSTANTS[62]+STATES[28]/CONSTANTS[67]+STATES[19]/CONSTANTS[68])+STATES[23]); RATES[23] = ( CONSTANTS[63]*STATES[20]*STATES[22])/( CONSTANTS[64]*(CONSTANTS[69]+STATES[29]/CONSTANTS[60])+STATES[22]) - ( CONSTANTS[65]*CONSTANTS[58]*STATES[23])/( CONSTANTS[66]*(CONSTANTS[69]+STATES[22]/CONSTANTS[62]+STATES[28]/CONSTANTS[67]+STATES[19]/CONSTANTS[68])+STATES[23]); RATES[30] = - (( CONSTANTS[71]*STATES[23]*STATES[30])/( CONSTANTS[72]*(CONSTANTS[79]+STATES[31]/CONSTANTS[76])+STATES[30]))+( CONSTANTS[73]*CONSTANTS[70]*STATES[31])/( CONSTANTS[74]*(CONSTANTS[79]+STATES[32]/CONSTANTS[78])+STATES[31]); RATES[32] = ( CONSTANTS[75]*STATES[23]*STATES[31])/( CONSTANTS[76]*(CONSTANTS[79]+STATES[30]/CONSTANTS[72])+STATES[31]) - ( CONSTANTS[77]*CONSTANTS[70]*STATES[32])/( CONSTANTS[78]*(CONSTANTS[79]+STATES[31]/CONSTANTS[74])+STATES[32]); RATES[31] = ((( CONSTANTS[71]*STATES[23]*STATES[30])/( CONSTANTS[72]*(CONSTANTS[79]+STATES[31]/CONSTANTS[76])+STATES[30]) - ( CONSTANTS[73]*CONSTANTS[70]*STATES[31])/( CONSTANTS[74]*(CONSTANTS[79]+STATES[32]/CONSTANTS[78])+STATES[31])) - ( CONSTANTS[75]*STATES[23]*STATES[31])/( CONSTANTS[76]*(CONSTANTS[79]+STATES[30]/CONSTANTS[72])+STATES[31]))+( CONSTANTS[77]*CONSTANTS[70]*STATES[32])/( CONSTANTS[78]*(CONSTANTS[79]+STATES[31]/CONSTANTS[74])+STATES[32]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { }