Denise
Kirschner
This model has been recoded using the nondimensionalised equations. This was suggested by the author to help with solving the problem, due to its very stiff nature. Some but not all output from the paper can be reproduced by this model. Values of s1 and s2 have been set to zero to represent a non-treatment situation. A value of 0.025 has been given to the variable c, which defines the antigenicity of the tumour, to represent the middle of the range given for this parameter. The model may be re-parameterised to give other relevant outputs, for example, if s1 is greater than 0 while s2 equals 0, the model can simulate adoptive cellular immunotherapy.
This version is known to run in PCEnv and is likely to run in COR, and passes all unit checks (being non-dimensionalised). This version is able to produce some of the figures in the paper. Contact with the model author re: some parameters is pending.
Carl
John
Panetta
Lloyd
Catherine
May
Values of 1.0 and 0.1 have been used for the variables s1 and s2, respectively, which allows this model to run. s1 is a treatment term that represents an external source of effector cells such as LAK or TIL cells. s2 is a treatment term that represents an input of IL2 into the system. The values for these variables are not given in the paper but those given here appear to be reasonable.
The University of Auckland, Auckland Bioengineering Institute
T cell
cytokine
pharmacology
tumour
immunology
t cell
signal transduction
37
252
Modeling immunotherapy of the tumor-immune interaction
235
non-dimensionalized form of variable T - tumour cells
y
Rewrote the model to use the non-dimensionalised equations (given in the paper.) Non-dimensionalized all variables so model will now meet unit tests. Author suggested that NDization helps with solving the model, which is very stiff.
9785481
non-dimensionalized form of variable IL - concentration of the cytokine IL-2 in the single tumour-site compartment
z
1e-6
400
bdf15
1e-6
0.01
1000000
T lymphocyte
Kirschner and Panetta's 1998 mathematical model of the immunotherapy of the tumour-immune interaction.
Lawson
James
Richard
Lawson
Richard
James
2007-08-02T14:17:42+12:00
c.lloyd@auckland.ac.nz
This is the CellML description of Kirschner and Panetta's 1998 mathematical model of the immunotherapy of the tumour-immune interaction.
James Lawson
Journal of Mathematical Biology
keyword
1998-09
Auckland Bioengineering Institute
The University of Auckland
Catherine Lloyd
non-dimensionalized form of T - effector T cells
x
2004-03-28T00:00:00+00:00
2007-08-06T10:50:28+12:00