function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =3; end % There are a total of 2 entries in each of the rate and state variable arrays. % There are a total of 14 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (day)'); LEGEND_CONSTANTS(:,1) = strpad('s in component uninfected (per_day_mm3)'); LEGEND_CONSTANTS(:,2) = strpad('p in component uninfected (per_day)'); LEGEND_CONSTANTS(:,3) = strpad('gamma in component uninfected (per_day)'); LEGEND_CONSTANTS(:,14) = strpad('beta in component uninfected (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('N in component free_virus_particle (dimensionless)'); LEGEND_CONSTANTS(:,5) = strpad('k_1 in component latently_infected (mm3_per_day)'); LEGEND_CONSTANTS(:,6) = strpad('k_2 in component actively_infected (per_day)'); LEGEND_CONSTANTS(:,7) = strpad('k_3 in component latently_infected (per_day)'); LEGEND_CONSTANTS(:,8) = strpad('mu_V in component free_virus_particle (per_day)'); LEGEND_STATES(:,1) = strpad('T_1 in component latently_infected (per_mm3)'); LEGEND_CONSTANTS(:,9) = strpad('mu_b in component actively_infected (per_day)'); LEGEND_STATES(:,2) = strpad('T in component uninfected (per_mm3)'); LEGEND_CONSTANTS(:,10) = strpad('k_4 in component latently_infected (per_day)'); LEGEND_CONSTANTS(:,11) = strpad('T_0 in component latently_infected (per_mm3)'); LEGEND_CONSTANTS(:,12) = strpad('V_0 in component latently_infected (per_mm3)'); LEGEND_CONSTANTS(:,13) = strpad('t_min in component latently_infected (day)'); LEGEND_ALGEBRAIC(:,1) = strpad('T_1_t in component latently_infected (per_mm3)'); LEGEND_ALGEBRAIC(:,2) = strpad('T_2 in component actively_infected (per_mm3)'); LEGEND_ALGEBRAIC(:,3) = strpad('V in component free_virus_particle (per_mm3)'); LEGEND_RATES(:,2) = strpad('d/dt T in component uninfected (per_mm3)'); LEGEND_RATES(:,1) = strpad('d/dt T_1 in component latently_infected (per_mm3)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 10; CONSTANTS(:,2) = 0.01; CONSTANTS(:,3) = 2E-5; CONSTANTS(:,4) = 1000; CONSTANTS(:,5) = 2.4E-5; CONSTANTS(:,6) = 3E-3; CONSTANTS(:,7) = 0.023; CONSTANTS(:,8) = 2.4; STATES(:,1) = 0; CONSTANTS(:,9) = 0.24; STATES(:,2) = 1000; CONSTANTS(:,10) = 2.424; CONSTANTS(:,11) = 1000; CONSTANTS(:,12) = 1E-3; CONSTANTS(:,13) = 2; CONSTANTS(:,14) = (CONSTANTS(:,3)./CONSTANTS(:,7)).*(1.00000+CONSTANTS(:,6)./CONSTANTS(:,9)); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,2) = ((CONSTANTS(:,1)+ CONSTANTS(:,2).*STATES(:,2)) - CONSTANTS(:,3).*power(STATES(:,2), 2.00000)) - ( CONSTANTS(:,7).*CONSTANTS(:,14)+( CONSTANTS(:,4).*CONSTANTS(:,5).*CONSTANTS(:,6))./( CONSTANTS(:,5).*STATES(:,2)+CONSTANTS(:,8))).*STATES(:,2).*STATES(:,1); ALGEBRAIC(:,1) = (( CONSTANTS(:,5).*CONSTANTS(:,11).*CONSTANTS(:,12))./(CONSTANTS(:,10) - CONSTANTS(:,7))).*(exp( - CONSTANTS(:,7).*VOI) - exp( - CONSTANTS(:,10).*VOI)); RATES(:,1) = piecewise({VOI<=CONSTANTS(:,13), ALGEBRAIC(:,1) }, (( CONSTANTS(:,4).*CONSTANTS(:,5).*CONSTANTS(:,6))./( CONSTANTS(:,5).*STATES(:,2)+CONSTANTS(:,8))).*STATES(:,2).*STATES(:,1) - CONSTANTS(:,7).*STATES(:,1)); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = (( CONSTANTS(:,5).*CONSTANTS(:,11).*CONSTANTS(:,12))./(CONSTANTS(:,10) - CONSTANTS(:,7))).*(exp( - CONSTANTS(:,7).*VOI) - exp( - CONSTANTS(:,10).*VOI)); ALGEBRAIC(:,2) = ( CONSTANTS(:,6).*STATES(:,1))./CONSTANTS(:,9); ALGEBRAIC(:,3) = ( CONSTANTS(:,4).*CONSTANTS(:,6).*STATES(:,1))./( CONSTANTS(:,5).*STATES(:,2)+CONSTANTS(:,8)); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end