/* There are a total of 1 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 4 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is x1 in component insulin (nanomolar). * ALGEBRAIC[0] is scatchard in component insulin (dimensionless). * CONSTANTS[0] is k1 in component rate_constants (second_order_rate_constant). * CONSTANTS[1] is k1_ in component rate_constants (first_order_rate_constant). * CONSTANTS[2] is k2_ in component rate_constants (first_order_rate_constant). * STATES[1] is x2 in component unbound_receptor (nanomolar). * STATES[2] is x3 in component single_bound_receptor (nanomolar). * STATES[3] is x4 in component double_bound_receptor (nanomolar). * CONSTANTS[3] is k2 in component rate_constants (second_order_rate_constant). * RATES[0] is d/dt x1 in component insulin (nanomolar). * RATES[1] is d/dt x2 in component unbound_receptor (nanomolar). * RATES[2] is d/dt x3 in component single_bound_receptor (nanomolar). * RATES[3] is d/dt x4 in component double_bound_receptor (nanomolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 1000; CONSTANTS[0] = 1000000; CONSTANTS[1] = 0.0004; CONSTANTS[2] = 0.04; STATES[1] = 0.1; STATES[2] = 0.0; STATES[3] = 0.0; CONSTANTS[3] = 1000000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = (( CONSTANTS[1]*STATES[2] - CONSTANTS[0]*STATES[0]*STATES[1])+ CONSTANTS[2]*STATES[3]) - CONSTANTS[3]*STATES[0]*STATES[2]; RATES[1] = CONSTANTS[1]*STATES[2] - CONSTANTS[0]*STATES[0]*STATES[1]; RATES[2] = (( CONSTANTS[0]*STATES[0]*STATES[1] - CONSTANTS[1]*STATES[2])+ CONSTANTS[2]*STATES[3]) - CONSTANTS[3]*STATES[0]*STATES[2]; RATES[3] = CONSTANTS[3]*STATES[0]*STATES[2] - CONSTANTS[2]*STATES[3]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[2]+STATES[3])/STATES[0]; }