/* There are a total of 15 entries in the algebraic variable array. There are a total of 10 entries in each of the rate and state variable arrays. There are a total of 38 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is ATP_cyt in component ATP_cyt (micromolar). * ALGEBRAIC[5] is J_hyd in component J_hyd (flux). * ALGEBRAIC[12] is J_CKMM in component J_CKMM (flux). * ALGEBRAIC[7] is J_diff_ATP in component J_diff_ATP (flux). * CONSTANTS[0] is V_cyt in component fractional_volumes (dimensionless). * STATES[1] is ADP_cyt in component ADP_cyt (micromolar). * ALGEBRAIC[8] is J_diff_ADP in component J_diff_ADP (flux). * STATES[2] is PCr_cyt in component PCr_cyt (micromolar). * ALGEBRAIC[9] is J_diff_PCr in component J_diff_PCr (flux). * STATES[3] is Cr_cyt in component Cr_cyt (micromolar). * ALGEBRAIC[10] is J_diff_Cr in component J_diff_Cr (flux). * STATES[4] is Pi_cyt in component Pi_cyt (micromolar). * ALGEBRAIC[11] is J_diff_Pi in component J_diff_Pi (flux). * STATES[5] is ATP_ims in component ATP_ims (micromolar). * ALGEBRAIC[13] is J_CKMi in component J_CKMi (flux). * ALGEBRAIC[14] is J_syn in component J_syn (flux). * CONSTANTS[1] is V_ims in component fractional_volumes (dimensionless). * STATES[6] is ADP_ims in component ADP_ims (micromolar). * STATES[7] is PCr_ims in component PCr_ims (micromolar). * STATES[8] is Cr_ims in component Cr_ims (micromolar). * STATES[9] is Pi_ims in component Pi_ims (micromolar). * ALGEBRAIC[0] is Den_MMCK in component J_CKMM (dimensionless). * CONSTANTS[2] is Kia in component J_CKMM (micromolar). * CONSTANTS[3] is Kb in component J_CKMM (micromolar). * CONSTANTS[4] is Kib in component J_CKMM (micromolar). * CONSTANTS[31] is KIb in component J_CKMM (micromolar). * CONSTANTS[32] is Kc in component J_CKMM (micromolar). * CONSTANTS[5] is Kic in component J_CKMM (micromolar). * CONSTANTS[6] is Kd in component J_CKMM (micromolar). * CONSTANTS[7] is Kid in component J_CKMM (micromolar). * CONSTANTS[8] is Vmax_MM_f in component J_CKMM (flux). * CONSTANTS[9] is Vmax_MM_b in component J_CKMM (flux). * ALGEBRAIC[1] is Den_MiCK in component J_CKMi (dimensionless). * CONSTANTS[10] is Kia in component J_CKMi (micromolar). * CONSTANTS[11] is Kb in component J_CKMi (micromolar). * CONSTANTS[12] is Kib in component J_CKMi (micromolar). * CONSTANTS[33] is KIb in component J_CKMi (micromolar). * CONSTANTS[34] is Kc in component J_CKMi (micromolar). * CONSTANTS[13] is Kic in component J_CKMi (micromolar). * CONSTANTS[14] is Kd in component J_CKMi (micromolar). * CONSTANTS[15] is Kid in component J_CKMi (micromolar). * CONSTANTS[16] is Vmax_Mi_f in component J_CKMi (flux). * CONSTANTS[17] is Vmax_Mi_b in component J_CKMi (flux). * ALGEBRAIC[4] is H_ATPmax in component J_hyd (flux). * CONSTANTS[18] is J_hyd_basis_1 in component J_hyd (flux). * CONSTANTS[19] is J_hyd_basis_2 in component J_hyd (flux). * CONSTANTS[20] is freq_1 in component J_hyd (dimensionless). * CONSTANTS[21] is freq_2 in component J_hyd (dimensionless). * CONSTANTS[35] is t_cycle_1 in component J_hyd (second). * CONSTANTS[36] is t_cycle_2 in component J_hyd (second). * ALGEBRAIC[3] is t_cycle in component J_hyd (second). * CONSTANTS[22] is nb_of_cycles_1 in component J_hyd (dimensionless). * CONSTANTS[37] is duration_1 in component J_hyd (second). * ALGEBRAIC[2] is ltime in component J_hyd (second). * ALGEBRAIC[6] is Den_syn in component J_syn (dimensionless). * CONSTANTS[23] is KPi in component J_syn (micromolar). * CONSTANTS[24] is KADP in component J_syn (micromolar). * CONSTANTS[25] is V_max_syn in component J_syn (flux). * CONSTANTS[26] is PS_tot_ATP in component J_diff_ATP (first_order_rate_constant). * CONSTANTS[27] is PS_tot_ADP in component J_diff_ADP (first_order_rate_constant). * CONSTANTS[28] is PS_tot_PCr in component J_diff_PCr (first_order_rate_constant). * CONSTANTS[29] is PS_tot_Cr in component J_diff_Cr (first_order_rate_constant). * CONSTANTS[30] is PS_tot_Pi in component J_diff_Pi (first_order_rate_constant). * RATES[0] is d/dt ATP_cyt in component ATP_cyt (micromolar). * RATES[1] is d/dt ADP_cyt in component ADP_cyt (micromolar). * RATES[2] is d/dt PCr_cyt in component PCr_cyt (micromolar). * RATES[3] is d/dt Cr_cyt in component Cr_cyt (micromolar). * RATES[4] is d/dt Pi_cyt in component Pi_cyt (micromolar). * RATES[5] is d/dt ATP_ims in component ATP_ims (micromolar). * RATES[6] is d/dt ADP_ims in component ADP_ims (micromolar). * RATES[7] is d/dt PCr_ims in component PCr_ims (micromolar). * RATES[8] is d/dt Cr_ims in component Cr_ims (micromolar). * RATES[9] is d/dt Pi_ims in component Pi_ims (micromolar). * There are a total of 9 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 5912.77; CONSTANTS[0] = 0.75; STATES[1] = 64; STATES[2] = 5000; STATES[3] = 10500; STATES[4] = 913; STATES[5] = 5912.77; CONSTANTS[1] = 0.0625; STATES[6] = 39; STATES[7] = 5000; STATES[8] = 10500; STATES[9] = 910; CONSTANTS[2] = 9.0E2; CONSTANTS[3] = 1.55E4; CONSTANTS[4] = 3.49E4; CONSTANTS[5] = 2.224E2; CONSTANTS[6] = 1.67E3; CONSTANTS[7] = 4.73E3; CONSTANTS[8] = 1.144E4; CONSTANTS[9] = 4.804E4; CONSTANTS[10] = 7.5E2; CONSTANTS[11] = 5.2E3; CONSTANTS[12] = 2.88E4; CONSTANTS[13] = 2.048E2; CONSTANTS[14] = 5.0E2; CONSTANTS[15] = 1.6E3; CONSTANTS[16] = 8.82E2; CONSTANTS[17] = 3.704E3; CONSTANTS[18] = 4.865e2; CONSTANTS[19] = 6.276e2; CONSTANTS[20] = 135; CONSTANTS[21] = 220; CONSTANTS[22] = 5; CONSTANTS[23] = 8E2; CONSTANTS[24] = 25; CONSTANTS[25] = 1.504E4; CONSTANTS[26] = 13.3; CONSTANTS[27] = 13.3; CONSTANTS[28] = 155.0; CONSTANTS[29] = 155.0; CONSTANTS[30] = 194.0; CONSTANTS[31] = CONSTANTS[4]; CONSTANTS[32] = ( CONSTANTS[5]*CONSTANTS[6])/CONSTANTS[7]; CONSTANTS[33] = CONSTANTS[12]; CONSTANTS[34] = ( CONSTANTS[13]*CONSTANTS[14])/CONSTANTS[15]; CONSTANTS[35] = 60.0000/CONSTANTS[20]; CONSTANTS[36] = 60.0000/CONSTANTS[21]; CONSTANTS[37] = CONSTANTS[22]*CONSTANTS[35]; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - (ALGEBRAIC[7] - (ALGEBRAIC[5]+ALGEBRAIC[12]))/CONSTANTS[0]; resid[1] = RATES[1] - (ALGEBRAIC[8]+ALGEBRAIC[5]+ALGEBRAIC[12])/CONSTANTS[0]; resid[2] = RATES[2] - (ALGEBRAIC[9]+ALGEBRAIC[12])/CONSTANTS[0]; resid[3] = RATES[3] - (ALGEBRAIC[10] - ALGEBRAIC[12])/CONSTANTS[0]; resid[4] = RATES[4] - (ALGEBRAIC[11]+ALGEBRAIC[5])/CONSTANTS[0]; resid[5] = RATES[5] - (ALGEBRAIC[14] - (ALGEBRAIC[7]+ALGEBRAIC[13]))/CONSTANTS[1]; resid[6] = RATES[6] - (ALGEBRAIC[13] - (ALGEBRAIC[14]+ALGEBRAIC[8]))/CONSTANTS[1]; resid[7] = RATES[7] - (ALGEBRAIC[13] - ALGEBRAIC[9])/CONSTANTS[1]; resid[8] = RATES[8] - - (ALGEBRAIC[13]+ALGEBRAIC[10])/CONSTANTS[1]; resid[9] = RATES[9] - - (ALGEBRAIC[14]+ALGEBRAIC[11])/CONSTANTS[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[4] = (CONDVAR[2]<=0.00000 ? 6.00000*CONSTANTS[18] : 6.00000*CONSTANTS[19]); ALGEBRAIC[3] = (CONDVAR[1]<=0.00000 ? CONSTANTS[35] : CONSTANTS[36]); ALGEBRAIC[2] = (CONDVAR[0]<=0.00000 ? VOI - CONSTANTS[35]*floor(VOI/CONSTANTS[35]) : (VOI - CONSTANTS[37]) - CONSTANTS[36]*floor((VOI - CONSTANTS[37])/CONSTANTS[36])); ALGEBRAIC[5] = (CONDVAR[3]>=0.00000&&CONDVAR[4]<0.00000 ? (( ALGEBRAIC[4]*ALGEBRAIC[2])/ALGEBRAIC[3])*6.00000 : CONDVAR[5]>=0.00000&&CONDVAR[6]<0.00000 ? ALGEBRAIC[4]*(1.00000 - 6.00000*(ALGEBRAIC[2]/ALGEBRAIC[3] - 1.00000/6.00000)) : CONDVAR[7]>=0.00000&&CONDVAR[8]<0.00000 ? 0.00000 : 0.0/0.0); ALGEBRAIC[7] = CONSTANTS[26]*(STATES[5] - STATES[0]); ALGEBRAIC[8] = CONSTANTS[27]*(STATES[6] - STATES[1]); ALGEBRAIC[9] = CONSTANTS[28]*(STATES[7] - STATES[2]); ALGEBRAIC[10] = CONSTANTS[29]*(STATES[8] - STATES[3]); ALGEBRAIC[11] = CONSTANTS[30]*(STATES[9] - STATES[4]); ALGEBRAIC[0] = 1.00000+STATES[3]/CONSTANTS[4]+STATES[2]/CONSTANTS[7]+ STATES[0]*(1.00000/CONSTANTS[2]+STATES[3]/( CONSTANTS[2]*CONSTANTS[3]))+ STATES[1]*(1.00000/CONSTANTS[5]+STATES[2]/( CONSTANTS[7]*CONSTANTS[32])+STATES[3]/( CONSTANTS[5]*CONSTANTS[31])); ALGEBRAIC[12] = ( CONSTANTS[8]*(( STATES[0]*STATES[3])/( CONSTANTS[2]*CONSTANTS[3])) - CONSTANTS[9]*(( STATES[1]*STATES[2])/( CONSTANTS[5]*CONSTANTS[6])))/ALGEBRAIC[0]; ALGEBRAIC[1] = 1.00000+STATES[8]/CONSTANTS[12]+STATES[7]/CONSTANTS[15]+ STATES[5]*(1.00000/CONSTANTS[10]+STATES[8]/( CONSTANTS[10]*CONSTANTS[11]))+ STATES[6]*(1.00000/CONSTANTS[13]+STATES[7]/( CONSTANTS[15]*CONSTANTS[34])+STATES[8]/( CONSTANTS[13]*CONSTANTS[33])); ALGEBRAIC[13] = ( CONSTANTS[16]*(( STATES[5]*STATES[8])/( CONSTANTS[10]*CONSTANTS[11])) - CONSTANTS[17]*(( STATES[6]*STATES[7])/( CONSTANTS[13]*CONSTANTS[14])))/ALGEBRAIC[1]; ALGEBRAIC[6] = 1.00000+STATES[6]/CONSTANTS[24]+STATES[9]/CONSTANTS[23]+( STATES[6]*STATES[9])/( CONSTANTS[24]*CONSTANTS[23]); ALGEBRAIC[14] = CONSTANTS[25]*(( STATES[6]*STATES[9])/( CONSTANTS[23]*CONSTANTS[24]*ALGEBRAIC[6])); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[37]; CONDVAR[1] = VOI - CONSTANTS[37]; CONDVAR[2] = VOI - CONSTANTS[37]; CONDVAR[3] = ALGEBRAIC[2] - 0.00000; CONDVAR[4] = ALGEBRAIC[2] - (1.00000/6.00000)*ALGEBRAIC[3]; CONDVAR[5] = ALGEBRAIC[2] - (1.00000/6.00000)*ALGEBRAIC[3]; CONDVAR[6] = ALGEBRAIC[2] - (1.00000/3.00000)*ALGEBRAIC[3]; CONDVAR[7] = ALGEBRAIC[2] - (1.00000/3.00000)*ALGEBRAIC[3]; CONDVAR[8] = ALGEBRAIC[2] - ALGEBRAIC[3]; }