Rendering of the source text

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="gupta_model_2007" name="gupta_model_2007">

<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
<section id="sec_status">
    <title>Model Status</title>
    <para>This particular version of the model has a single stress and recreates the shapes of the graphs in figure 4 of the paper.  This CellML model runs in both COR and OpenCell.  The units have been checked and they are consistent.  The equations are based on the scaled set in the paper (9-12) and the concentrations of the hormones are therefore dimensionless. For this reason the CellML model doesn't quite recreate the graphs in figure 4 (where the hormones are assigned units of picomolar and nanomolar).
          </para>
  </section>
  <sect1 id="sec_structure">
  <title>Model Structure</title>

<para>
ABSTRACT: BACKGROUND: The body's primary stress management system is the hypothalamic pituitary adrenal (HPA) axis. The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related diseases. RESULTS: We developed a structured model of the HPA axis that includes the glucocorticoid receptor (GR). This model incorporates nonlinear kinetics of pituitary GR synthesis. The nonlinear effect arises from the fact that GR homodimerizes after cortisol activation and induces its own synthesis in the pituitary. This homodimerization makes possible two stable steady states (low and high) and one unstable state of cortisol production resulting in bistability of the HPA axis. In this model, low GR concentration represents the normal steady state, and high GR concentration represents a dysregulated steady state. A short stress in the normal steady state produces a small perturbation in the GR concentration that quickly returns to normal levels. Long, repeated stress produces persistent and high GR concentration that does not return to baseline forcing the HPA axis to an alternate steady state. One consequence of increased steady state GR is reduced steady state cortisol, which has been observed in some stress related disorders such as Chronic Fatigue Syndrome (CFS). CONCLUSION: Inclusion of pituitary GR expression resulted in a biologically plausible model of HPA axis bistability and hypocortisolism. High GR concentration enhanced cortisol negative feedback on the hypothalamus and forced the HPA axis into an alternative, low cortisol state. This model can be used to explore mechanisms underlying disorders of the HPA axis.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability, Shakti Gupta, Eric Aslakson, Brian M. Gurbaxani and Suzanne D. Vernon, 2007,<emphasis>Theoretical Biology and Medical Modelling</emphasis>, volume 4, issue 8.  <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/17300722">PubMed ID: 17300722</ulink>
</para>

<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>model diagram</title>
    </objectinfo>
    <imagedata fileref="gupta_2007.png"/>
  </imageobject>
</mediaobject>
<caption>The HPA axis model has three compartments, namely the hypothalamus, pituitary and adrenals.  External stress triggers CRH secretion by the hypothalamus.  In turn, this signals to the pituitary to release ACTH which stimulates the adrenal gland to release cortisol.  Cortisol binds to the glucocorticoid receptor (R) in the pituitary and has a negative feedback effect on the release of CRH and ACTH.  In addition, the cortisol-receptor complex has a positive feedback effect, promoting further receptor synthesis.</caption>
</informalfigure>
</sect1>
</article>
</documentation> 


   
  <units name="hour">
    <unit multiplier="3600.0" units="second"/>
  </units>
  
  <units name="first_order_rate_constant">
    <unit exponent="-1" units="hour"/>
  </units>
 
  
  <component name="environment">
    <variable cmeta:id="environment_time" name="time" public_interface="out" units="hour"/>
  </component>
  
 
  <component cmeta:id="c" name="c">
    <variable cmeta:id="c_c" initial_value="0.6" name="c" public_interface="out" units="dimensionless"/> 
    
    <variable name="f" units="dimensionless"/>

    <variable name="kcd" public_interface="in" units="first_order_rate_constant"/>
    <variable name="ki1" public_interface="in" units="dimensionless"/>
    <variable name="o" public_interface="in" units="dimensionless"/>
    <variable name="time" public_interface="in" units="hour"/> 
    
    <math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci> c </ci> 
        </apply>
        <apply>
          <minus/> 
          <apply>
            <times/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant"> 1.0 </cn><apply>
            <divide/>
            <apply>
              <plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>  
              <ci> f </ci>
            </apply>
            <apply>
              <plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanomolar"> 1.0 </cn>
              <apply>
                <divide/> 
                <ci> o </ci>
                <ci> ki1 </ci>
              </apply>
            </apply>
		  </apply>
		  </apply>
          <apply>
            <times/>  
            <ci> kcd </ci>
            <ci> c </ci>
          </apply>
        </apply>  
      </apply>
 
      <apply id="f_calculation">
        <eq/>
        <ci> f </ci>
        <piecewise>
          <piece>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <apply>
              <lt/>
              <ci> time </ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 1.0 </cn>
            </apply>
          </piece>
          <otherwise>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.0 </cn>
          </otherwise>
        </piecewise>
      </apply>
    </math> 
  </component>
  
  <component cmeta:id="a" name="a">
    <variable cmeta:id="a_a" initial_value="0.055" name="a" public_interface="out" units="dimensionless"/> 
    
    <variable name="kad" public_interface="in" units="first_order_rate_constant"/>
    <variable name="ki2" public_interface="in" units="first_order_rate_constant"/>
    <variable name="c" public_interface="in" units="dimensionless"/>
    <variable name="o" public_interface="in" units="dimensionless"/>
    <variable name="r" public_interface="in" units="dimensionless"/>
    <variable name="time" public_interface="in" units="hour"/> 
    
    <math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci> a </ci> 
        </apply>
        <apply>
          <minus/> 
          <apply>
            <divide/>
            <ci> c </ci>
            <apply>
              <plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanomolar"> 1.0 </cn>
              <apply>
                <divide/>
                <apply>
                  <times/> 
                  <ci> o </ci>
                  <ci> r </ci>
                </apply>
                <ci> ki2 </ci>
              </apply>
            </apply>
          </apply>
          <apply>
            <times/>  
            <ci> kad </ci>
            <ci> a </ci>
          </apply>
        </apply>  
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="r" name="r">
    <variable cmeta:id="r_r" initial_value="0.08" name="r" public_interface="out" units="dimensionless"/> 
    
    <variable name="kcr" public_interface="in" units="first_order_rate_constant"/>
    <variable name="krd" public_interface="in" units="first_order_rate_constant"/>
    <variable name="k" public_interface="in" units="dimensionless"/>
    <variable name="o" public_interface="in" units="dimensionless"/>
    <variable name="time" public_interface="in" units="hour"/> 
    
    <math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci> r </ci> 
        </apply>
        <apply>
          <minus/>
          <apply>
            <plus/> 
            <apply>
              <divide/>
              <apply>
                <power/>
                <apply>
                  <times/>
                  <ci> o </ci>
                  <ci> r </ci>
                </apply>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
              </apply>
              <apply>
                <times/>
				<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 1.0 </cn>
				<apply>
                <plus/>
                <ci> k </ci>
                <apply>
                  <power/>
                  <apply>
                    <times/>
                    <ci> o </ci>
                    <ci> r </ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
                </apply>
				</apply>
              </apply>
            </apply>
            <ci> kcr </ci>
          </apply>
          <apply>
            <times/>  
            <ci> krd </ci>
            <ci> r </ci>
          </apply>
        </apply>  
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="o" name="o">
    <variable cmeta:id="o_o" initial_value="0.055" name="o" public_interface="out" units="dimensionless"/> 
    
    <variable name="a" public_interface="in" units="dimensionless"/>
    <variable name="time" public_interface="in" units="hour"/> 
    
    <math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci> o </ci> 
        </apply>
        <apply>
          <times/>
		  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant"> 1.0 </cn>
		  <apply>
            <minus/> 
            <ci> a </ci>
            <ci> o </ci>
		  </apply> 
        </apply>  
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="reaction_constants" name="reaction_constants">
    <variable initial_value="0.1" name="ki1" public_interface="out" units="dimensionless"/>
    <variable initial_value="0.1" name="ki2" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="1.0" name="kcd" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="10.0" name="kad" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.001" name="k" public_interface="out" units="dimensionless"/>
    <variable initial_value="0.05" name="kcr" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.9" name="krd" public_interface="out" units="first_order_rate_constant"/>
  </component>
  
  
  <connection>
    <map_components component_1="c" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="a" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="r" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="o" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="c" component_2="o"/>
    <map_variables variable_1="o" variable_2="o"/>
  </connection>

  <connection>
    <map_components component_1="a" component_2="o"/>
    <map_variables variable_1="o" variable_2="o"/>
    <map_variables variable_1="a" variable_2="a"/>
  </connection>

  <connection>
    <map_components component_1="a" component_2="c"/>
    <map_variables variable_1="c" variable_2="c"/>
  </connection>
  
  <connection>
    <map_components component_1="a" component_2="r"/>
    <map_variables variable_1="r" variable_2="r"/>
  </connection>

  <connection>
    <map_components component_1="r" component_2="o"/>
    <map_variables variable_1="o" variable_2="o"/>
  </connection>
  
  <connection>
    <map_components component_1="c" component_2="reaction_constants"/>
    <map_variables variable_1="kcd" variable_2="kcd"/>
    <map_variables variable_1="ki1" variable_2="ki1"/>
  </connection>
  
  <connection>
    <map_components component_1="a" component_2="reaction_constants"/>
    <map_variables variable_1="kad" variable_2="kad"/>
    <map_variables variable_1="ki2" variable_2="ki2"/>
  </connection>

  <connection>
    <map_components component_1="r" component_2="reaction_constants"/>
    <map_variables variable_1="kcr" variable_2="kcr"/>
    <map_variables variable_1="krd" variable_2="krd"/>
    <map_variables variable_1="k" variable_2="k"/>
  </connection>
  

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Bag rdf:about="rdf:#f85d4fa7-dd97-46c3-a2ba-b6471ff8999e">
    <rdf:li>glucocorticoid receptor</rdf:li>
    <rdf:li>cortisol</rdf:li>
    <rdf:li>endocrine</rdf:li>
    <rdf:li>HPA axis</rdf:li>
    <rdf:li>hypothalamus</rdf:li>
    <rdf:li>hpa axis</rdf:li>
  </rdf:Bag>
  <rdf:Seq rdf:about="rdf:#68037546-ec70-4bac-bd6c-660bad2f0609">
    <rdf:li rdf:resource="rdf:#5969f797-e449-42f0-b000-18277246f486"/>
    <rdf:li rdf:resource="rdf:#b4fdc3db-5a08-4f17-9616-e4c84c35b549"/>
    <rdf:li rdf:resource="rdf:#a397ed0b-de3e-424e-ad3b-02925ab3dfe4"/>
    <rdf:li rdf:resource="rdf:#28706648-32b8-464b-b119-64f2e1d6d229"/>
  </rdf:Seq>
  <rdf:Description rdf:about="">
    <dc:title>Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability: where a single stress is applied to the model</dc:title>
	  <dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">The University of Auckland, Auckland Bioengineering Institute</dc:publisher>
    <cmeta:comment rdf:resource="rdf:#419a1313-fa6b-414b-95a3-7faaa9215314"/>
    <dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#960e3353-a75e-4600-abbc-9e15aaaec2b2"/>
    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#cd480843-85e4-49af-b1be-e39066d11302"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#41e80e95-e75c-4fda-aeae-9503344e41eb">
    <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#a397ed0b-de3e-424e-ad3b-02925ab3dfe4">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#1be78e94-17b4-43e1-9644-cd543a457faa"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#73cbe600-aec4-49f9-a4b6-1a68fa6fb975">
    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#68037546-ec70-4bac-bd6c-660bad2f0609"/>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability</dc:title>
    <bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">4</bqs:volume>
    <bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#"/>
    <bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#e24471cf-1d31-413f-ae5e-5256f4752e13"/>
    <dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#60c510ea-2004-4b33-9d73-c23c046811d9"/>
    <bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#e3a736ad-f06b-4c45-825c-2200b53256df">
    <vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
    <vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgunit>
  </rdf:Description>
  <rdf:Description rdf:about="#gupta_model_2007">
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
        Gupta et al's 2007 hypothalamic pituitary adrenal axis model.
      </dc:title>
    <cmeta:bio_entity>hypothalamic pituitary adrenal axis</cmeta:bio_entity>
    <cmeta:comment rdf:resource="rdf:#90032e84-be09-49cd-b592-e3ab1c83c21f"/>
    <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#72ea7f0d-6f59-48a4-a6a2-3f835bf6fc00"/>
    <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#d4ef2931-2786-4e7b-b980-cfe9248a9a1f"/>
  </rdf:Description>
  <rdf:Description rdf:about="#c">
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">CRH</dcterms:alternative>
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">corticotropin releasing hormone</dcterms:alternative>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">c</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="#a">
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">ACTH</dcterms:alternative>
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">adrenocorticotropic hormone</dcterms:alternative>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">a</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#28706648-32b8-464b-b119-64f2e1d6d229">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#1d790a57-963a-4267-a178-1f6795a75058"/>
  </rdf:Description>
  <rdf:Description rdf:about="#o">
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">cortisol</dcterms:alternative>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">o</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#5969f797-e449-42f0-b000-18277246f486">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#67e3b6d7-ed02-4d02-a62c-c6020ec0c3e3"/>
  </rdf:Description>
  <rdf:Description rdf:about="#r">
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">GR</dcterms:alternative>
    <dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">glucocorticoid receptor</dcterms:alternative>
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">r</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#ea0ad739-753b-49ce-aead-18f8a79d0185">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#cd480843-85e4-49af-b1be-e39066d11302">
    <vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#e3a736ad-f06b-4c45-825c-2200b53256df"/>
    <vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#7b9105ef-448d-4853-868e-c09e0a00bf5f"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#ea0ad739-753b-49ce-aead-18f8a79d0185"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#90032e84-be09-49cd-b592-e3ab1c83c21f">
    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#f2ee7d35-65dc-4aa8-8eb0-2207a943a2b3"/>
    <rdf:value>This is the CellML description of Gupta et al's 2007 hypothalamic pituitary adrenal axis model.  The value of f - the stress input - has been defined such that it is short to give the results in Figure 4 of the original publication.</rdf:value>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#960e3353-a75e-4600-abbc-9e15aaaec2b2">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-05-28T00:00:00+00:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#7b9105ef-448d-4853-868e-c09e0a00bf5f">
    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
    <rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#f2ee7d35-65dc-4aa8-8eb0-2207a943a2b3">
    <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#e7beb6f9-e76e-4792-ad9e-1af81e6a79db">
    <bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
    <rdf:value rdf:resource="rdf:#f85d4fa7-dd97-46c3-a2ba-b6471ff8999e"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#de6edd1c-17e3-42a4-bc66-3ea4640e0d01">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Eric</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Aslakson</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#67e3b6d7-ed02-4d02-a62c-c6020ec0c3e3">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Shakti</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Gupta</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#e24471cf-1d31-413f-ae5e-5256f4752e13">
    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Theoretical Biology and Medical Modelling</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#b4fdc3db-5a08-4f17-9616-e4c84c35b549">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#de6edd1c-17e3-42a4-bc66-3ea4640e0d01"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#419a1313-fa6b-414b-95a3-7faaa9215314">
    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#41e80e95-e75c-4fda-aeae-9503344e41eb"/>
    <rdf:value/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#d4ef2931-2786-4e7b-b980-cfe9248a9a1f">
    <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#e7beb6f9-e76e-4792-ad9e-1af81e6a79db"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#1be78e94-17b4-43e1-9644-cd543a457faa">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Brian</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Gurbaxani</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">M</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#60c510ea-2004-4b33-9d73-c23c046811d9">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-02-14</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#72ea7f0d-6f59-48a4-a6a2-3f835bf6fc00">
    <bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">17300722</bqs:Pubmed_id>
    <bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#73cbe600-aec4-49f9-a4b6-1a68fa6fb975"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#1d790a57-963a-4267-a178-1f6795a75058">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Suzanne</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Vernon</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">D</vCard:Other>
  </rdf:Description>
</rdf:RDF>
</model>