/* There are a total of 2 entries in the algebraic variable array. There are a total of 15 entries in each of the rate and state variable arrays. There are a total of 21 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is Arg in component Arg (micromolar). * ALGEBRAIC[0] is S in component Arg (flux). * STATES[1] is Fe3 in component Fe3 (micromolar). * STATES[2] is Fe3_Arg in component Fe3_Arg (micromolar). * STATES[3] is Fe2_Arg in component Fe2_Arg (micromolar). * STATES[4] is Fe2 in component Fe2 (micromolar). * CONSTANTS[0] is k1 in component model_constants (second_order_rate_constant). * CONSTANTS[1] is k_1 in component model_constants (first_order_rate_constant). * CONSTANTS[2] is k4 in component model_constants (second_order_rate_constant). * CONSTANTS[3] is k_4 in component model_constants (first_order_rate_constant). * STATES[5] is Fe3_NO in component Fe3_NO (micromolar). * STATES[6] is Fe2_NO in component Fe2_NO (micromolar). * CONSTANTS[4] is O2 in component model_constants (micromolar). * STATES[7] is Fe3_NOHA in component Fe3_NOHA (micromolar). * STATES[8] is NOHA in component NOHA (micromolar). * CONSTANTS[5] is k2 in component model_constants (first_order_rate_constant). * CONSTANTS[6] is k13 in component model_constants (second_order_rate_constant). * CONSTANTS[7] is k14 in component model_constants (first_order_rate_constant). * CONSTANTS[8] is k8 in component model_constants (first_order_rate_constant). * CONSTANTS[9] is k_8 in component model_constants (second_order_rate_constant). * CONSTANTS[10] is k3 in component model_constants (first_order_rate_constant). * STATES[9] is Fe2_NOHA in component Fe2_NOHA (micromolar). * CONSTANTS[11] is k9 in component model_constants (first_order_rate_constant). * CONSTANTS[12] is k_9 in component model_constants (second_order_rate_constant). * STATES[10] is Fe3_O2_Arg in component Fe3_O2_Arg (micromolar). * CONSTANTS[13] is k5 in component model_constants (second_order_rate_constant). * CONSTANTS[14] is k_5 in component model_constants (first_order_rate_constant). * CONSTANTS[15] is k6 in component model_constants (first_order_rate_constant). * CONSTANTS[16] is k7 in component model_constants (first_order_rate_constant). * STATES[11] is Fe3_O2_NOHA in component Fe3_O2_NOHA (micromolar). * CONSTANTS[17] is k_10 in component model_constants (first_order_rate_constant). * CONSTANTS[18] is k10 in component model_constants (second_order_rate_constant). * CONSTANTS[19] is k11 in component model_constants (first_order_rate_constant). * CONSTANTS[20] is k12 in component model_constants (first_order_rate_constant). * STATES[12] is NO in component NO (micromolar). * ALGEBRAIC[1] is dNOdt in component NO (flux). * STATES[13] is citrulline in component citrulline (micromolar). * STATES[14] is NO3 in component NO3 (micromolar). * RATES[0] is d/dt Arg in component Arg (micromolar). * RATES[1] is d/dt Fe3 in component Fe3 (micromolar). * RATES[2] is d/dt Fe3_Arg in component Fe3_Arg (micromolar). * RATES[4] is d/dt Fe2 in component Fe2 (micromolar). * RATES[3] is d/dt Fe2_Arg in component Fe2_Arg (micromolar). * RATES[10] is d/dt Fe3_O2_Arg in component Fe3_O2_Arg (micromolar). * RATES[7] is d/dt Fe3_NOHA in component Fe3_NOHA (micromolar). * RATES[9] is d/dt Fe2_NOHA in component Fe2_NOHA (micromolar). * RATES[11] is d/dt Fe3_O2_NOHA in component Fe3_O2_NOHA (micromolar). * RATES[5] is d/dt Fe3_NO in component Fe3_NO (micromolar). * RATES[6] is d/dt Fe2_NO in component Fe2_NO (micromolar). * RATES[12] is d/dt NO in component NO (micromolar). * RATES[13] is d/dt citrulline in component citrulline (micromolar). * RATES[14] is d/dt NO3 in component NO3 (micromolar). * RATES[8] is d/dt NOHA in component NOHA (micromolar). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 100.0; STATES[1] = 0.045; STATES[2] = 0.0; STATES[3] = 0.0; STATES[4] = 0.0; CONSTANTS[0] = 0.1; CONSTANTS[1] = 0.1; CONSTANTS[2] = 1.89; CONSTANTS[3] = 11.4; STATES[5] = 0.0; STATES[6] = 0.0; CONSTANTS[4] = 172.0; STATES[7] = 0.0; STATES[8] = 0.0; CONSTANTS[5] = 0.91; CONSTANTS[6] = 0.033; CONSTANTS[7] = 53.9; CONSTANTS[8] = 0.1; CONSTANTS[9] = 0.1; CONSTANTS[10] = 0.91; STATES[9] = 0.0; CONSTANTS[11] = 11.4; CONSTANTS[12] = 1.89; STATES[10] = 0.0; CONSTANTS[13] = 2.58; CONSTANTS[14] = 98.0; CONSTANTS[15] = 12.6; CONSTANTS[16] = 0.91; STATES[11] = 0.0; CONSTANTS[17] = 89.9; CONSTANTS[18] = 3.33; CONSTANTS[19] = 29.4; CONSTANTS[20] = 0.91; STATES[12] = 0.0; STATES[13] = 0.0; STATES[14] = 0.0; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[4] = 0.1001; RATES[3] = 0.1001; RATES[10] = 0.1001; RATES[7] = 0.1001; RATES[9] = 0.1001; RATES[11] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[12] = 0.1001; RATES[13] = 0.1001; RATES[14] = 0.1001; RATES[8] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ( CONSTANTS[1]*STATES[2]+ CONSTANTS[3]*STATES[3]+ALGEBRAIC[0]) - ( CONSTANTS[0]*STATES[0]*STATES[1]+ CONSTANTS[2]*STATES[0]*STATES[4]); resid[1] = RATES[1] - ( CONSTANTS[1]*STATES[2]+ CONSTANTS[7]*STATES[5]+ CONSTANTS[6]*STATES[6]*CONSTANTS[4]+ CONSTANTS[8]*STATES[7]) - ( CONSTANTS[0]*STATES[0]*STATES[1]+ CONSTANTS[5]*STATES[1]+ CONSTANTS[9]*STATES[8]*STATES[1]); resid[2] = RATES[2] - CONSTANTS[0]*STATES[1]*STATES[0] - ( CONSTANTS[1]*STATES[2]+ CONSTANTS[10]*STATES[2]); resid[3] = RATES[4] - ( CONSTANTS[5]*STATES[1]+ CONSTANTS[3]*STATES[3]+ CONSTANTS[11]*STATES[9]) - ( CONSTANTS[2]*STATES[4]*STATES[0]+ CONSTANTS[12]*STATES[4]*STATES[8]); resid[4] = RATES[3] - ( CONSTANTS[10]*STATES[2]+ CONSTANTS[14]*STATES[10]+ CONSTANTS[2]*STATES[4]*STATES[0]) - ( CONSTANTS[13]*STATES[3]*CONSTANTS[4]+ CONSTANTS[3]*STATES[3]); resid[5] = RATES[10] - CONSTANTS[13]*STATES[3]*CONSTANTS[4] - ( CONSTANTS[15]*STATES[10]+ CONSTANTS[14]*STATES[10]); resid[6] = RATES[7] - ( CONSTANTS[15]*STATES[10]+ CONSTANTS[9]*STATES[1]*STATES[8]) - ( CONSTANTS[16]*STATES[7]+ CONSTANTS[8]*STATES[7]); resid[7] = RATES[9] - ( CONSTANTS[16]*STATES[7]+ CONSTANTS[17]*STATES[11]+ CONSTANTS[12]*STATES[4]*STATES[8]) - ( CONSTANTS[11]*STATES[9]+ CONSTANTS[18]*STATES[9]*CONSTANTS[4]); resid[8] = RATES[11] - CONSTANTS[18]*STATES[9]*CONSTANTS[4] - ( CONSTANTS[19]*STATES[11]+ CONSTANTS[17]*STATES[11]); resid[9] = RATES[5] - CONSTANTS[19]*STATES[11] - ( CONSTANTS[7]*STATES[5]+ CONSTANTS[20]*STATES[5]); resid[10] = RATES[6] - CONSTANTS[20]*STATES[5] - CONSTANTS[6]*STATES[6]*CONSTANTS[4]; resid[11] = RATES[12] - CONSTANTS[7]*STATES[5]; resid[12] = RATES[13] - CONSTANTS[19]*STATES[11]; resid[13] = RATES[14] - CONSTANTS[6]*STATES[6]*CONSTANTS[4]; resid[14] = RATES[8] - ( CONSTANTS[8]*STATES[7]+ CONSTANTS[11]*STATES[9]) - ( CONSTANTS[9]*STATES[1]*STATES[8]+ CONSTANTS[12]*STATES[4]*STATES[8]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[7]*STATES[5]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[0]*STATES[0]*STATES[1]+ CONSTANTS[2]*STATES[0]*STATES[4]) - ( CONSTANTS[1]*STATES[2]+ CONSTANTS[3]*STATES[3]); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[11] = 1.0; SI[12] = 1.0; SI[13] = 1.0; SI[14] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }