2029
2042
96
A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump
A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump: the three-state SERCA model
electrophysiology
calcium dynamics
cardiac
SERCA
Denis
S
Loiselle
A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump: the two-state SERCA model
keyword
2009-03-00 00:00
J
Edmund
Crampin
19254563
cardiac
calcium dynamics
electrophysiology
SERCA
2009-03-05T00:00:00+00:00
This CellML model has been unit checked and is known to run in both PCEnv and COR. This particular version of the CellML model describes the two-state SERCA model and recreates figure 12. In order to recreate this figure we have had to add an additional equation to the model to define the rate of change in ATP. Please also note there are typographical errors in the original paper and [H+] should be raised to the power of n (n=2) for T_Hi and T_Hsr. The value of K-1 should be 2, not 16 as it states in Table 2. And finally, in figure 12 the concetrations of ADP should be 8uM and 20uM rather than 20uM and 40uM.
A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump
2029
2042
96
Catherine Lloyd
This CellML model has been unit checked and is known to run in both PCEnv and COR. This particular version of the CellML model describes the three-state cooperative SERCA model and recreates figure 13. In order to recreate this figure we have had to add an additional equation to the model to define the rate of change in Casr.
Nicolas
Smith
P
Kenneth
Tran
c.lloyd@auckland.ac.nz
keyword
Auckland Bioengineering Institute
The University of Auckland
Biophysical Journal
J
Edmund
Crampin
k.tran@auckland.ac.nz
Catherine Lloyd
2009-03-05T00:00:00+00:00
May
Lloyd
Catherine
Tran
Kenneth
19254563
Biophysical Journal
Auckland Bioengineering Institute
The University of Auckland
Loiselle
Denis
S
P
Smith
Nicolas
Kenneth
Tran
2009-03-00 00:00