Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 35 entries in the algebraic variable array.
There are a total of 29 entries in each of the rate and state variable arrays.
There are a total of 45 entries in the constant variable array.
*/
/*
* VOI is time in component environment (minute).
* STATES[0] is BMK1 in component BMK1 (micromolar).
* ALGEBRAIC[9] is v10a in component v10 (flux).
* ALGEBRAIC[10] is v10b in component v10 (flux).
* STATES[1] is MRNA in component MRNA (micromolar).
* ALGEBRAIC[28] is v18 in component v18 (flux).
* ALGEBRAIC[30] is v19 in component v19 (flux).
* STATES[2] is NFATc in component NFATc (micromolar).
* ALGEBRAIC[0] is v1 in component v1 (flux).
* ALGEBRAIC[31] is v14 in component v14 (flux).
* ALGEBRAIC[34] is v15 in component v15 (flux).
* STATES[3] is NFATn in component NFATn (micromolar).
* ALGEBRAIC[19] is v16 in component v16 (flux).
* ALGEBRAIC[25] is v17 in component v17 (flux).
* STATES[4] is NFATpc in component NFATpc (micromolar).
* ALGEBRAIC[1] is v2 in component v2 (flux).
* ALGEBRAIC[8] is v9 in component v9 (flux).
* STATES[5] is NFATpn in component NFATpn (micromolar).
* STATES[6] is GSK3betac in component GSK3betac (micromolar).
* ALGEBRAIC[2] is v3 in component v3 (flux).
* ALGEBRAIC[16] is v12a in component v12 (flux).
* ALGEBRAIC[18] is v12b in component v12 (flux).
* ALGEBRAIC[32] is v15a in component v15 (flux).
* ALGEBRAIC[33] is v15b in component v15 (flux).
* STATES[7] is GSK3betan in component GSK3betan (micromolar).
* ALGEBRAIC[21] is v17a in component v17 (flux).
* ALGEBRAIC[23] is v17b in component v17 (flux).
* STATES[8] is CaNc in component CaNc (micromolar).
* ALGEBRAIC[5] is v6 in component v6 (flux).
* STATES[9] is CaNc_star in component CaNc_star (micromolar).
* ALGEBRAIC[3] is v4 in component v4 (flux).
* ALGEBRAIC[6] is v7 in component v7 (flux).
* ALGEBRAIC[12] is v11a in component v11 (flux).
* ALGEBRAIC[13] is v11b in component v11 (flux).
* ALGEBRAIC[22] is v13a in component v13 (flux).
* ALGEBRAIC[24] is v13b in component v13 (flux).
* ALGEBRAIC[26] is v14a in component v14 (flux).
* ALGEBRAIC[29] is v14b in component v14 (flux).
* STATES[10] is CaNn_star in component CaNn_star (micromolar).
* ALGEBRAIC[15] is v16a in component v16 (flux).
* ALGEBRAIC[17] is v16b in component v16 (flux).
* STATES[11] is CaNn in component CaNn (micromolar).
* STATES[12] is CaM in component CaM (micromolar).
* ALGEBRAIC[4] is v5 in component v5 (flux).
* STATES[13] is CaMCa in component CaMCa (micromolar).
* STATES[14] is MCIP in component MCIP (micromolar).
* ALGEBRAIC[11] is v10 in component v10 (flux).
* ALGEBRAIC[14] is v11 in component v11 (flux).
* STATES[15] is MCIPp in component MCIPp (micromolar).
* ALGEBRAIC[20] is v12 in component v12 (flux).
* ALGEBRAIC[27] is v13 in component v13 (flux).
* STATES[16] is MCIPpp in component MCIPpp (micromolar).
* ALGEBRAIC[7] is v8 in component v8 (flux).
* STATES[17] is Comp1 in component Comp1 (micromolar).
* STATES[18] is Comp2 in component Comp2 (micromolar).
* STATES[19] is Comp3 in component Comp3 (micromolar).
* STATES[20] is P1433 in component P1433 (micromolar).
* STATES[21] is MCIP_BMK1 in component MCIP_BMK1 (micromolar).
* STATES[22] is MCIPp_CaNc_star in component MCIPp_CaNc_star (micromolar).
* STATES[23] is MCIPp_GSK3betac in component MCIPp_GSK3betac (micromolar).
* STATES[24] is MCIPpp_CaNc_star in component MCIPpp_CaNc_star (micromolar).
* STATES[25] is NFATpc_CaNc_star in component NFATpc_CaNc_star (micromolar).
* STATES[26] is NFATc_GSK3betac in component NFATc_GSK3betac (micromolar).
* STATES[27] is NFATpn_CaNn_star in component NFATpn_CaNn_star (micromolar).
* STATES[28] is NFATn_GSK3betan in component NFATn_GSK3betan (micromolar).
* CONSTANTS[0] is k29 in component model_parameters (first_order_rate_constant).
* CONSTANTS[1] is k30 in component model_parameters (first_order_rate_constant).
* CONSTANTS[2] is k31 in component model_parameters (first_order_rate_constant).
* CONSTANTS[3] is k32 in component model_parameters (first_order_rate_constant).
* CONSTANTS[4] is k33 in component model_parameters (first_order_rate_constant).
* CONSTANTS[5] is k34 in component model_parameters (first_order_rate_constant).
* CONSTANTS[6] is Ca in component model_parameters (micromolar).
* CONSTANTS[7] is k1 in component model_parameters (fifth_order_rate_constant).
* CONSTANTS[8] is k2 in component model_parameters (first_order_rate_constant).
* CONSTANTS[9] is k3 in component model_parameters (second_order_rate_constant).
* CONSTANTS[10] is k4 in component model_parameters (first_order_rate_constant).
* CONSTANTS[11] is k5 in component model_parameters (second_order_rate_constant).
* CONSTANTS[12] is k6 in component model_parameters (first_order_rate_constant).
* CONSTANTS[13] is k19 in component model_parameters (second_order_rate_constant).
* CONSTANTS[14] is k20 in component model_parameters (first_order_rate_constant).
* CONSTANTS[15] is k27 in component model_parameters (second_order_rate_constant).
* CONSTANTS[16] is k28 in component model_parameters (first_order_rate_constant).
* CONSTANTS[17] is k7 in component model_parameters (second_order_rate_constant).
* CONSTANTS[18] is k8 in component model_parameters (first_order_rate_constant).
* CONSTANTS[19] is k9 in component model_parameters (first_order_rate_constant).
* CONSTANTS[20] is k10 in component model_parameters (second_order_rate_constant).
* CONSTANTS[21] is k11 in component model_parameters (first_order_rate_constant).
* CONSTANTS[22] is k12 in component model_parameters (first_order_rate_constant).
* CONSTANTS[23] is k13 in component model_parameters (second_order_rate_constant).
* CONSTANTS[24] is k14 in component model_parameters (first_order_rate_constant).
* CONSTANTS[25] is k15 in component model_parameters (first_order_rate_constant).
* CONSTANTS[26] is k16 in component model_parameters (second_order_rate_constant).
* CONSTANTS[27] is k17 in component model_parameters (first_order_rate_constant).
* CONSTANTS[28] is k18 in component model_parameters (first_order_rate_constant).
* CONSTANTS[29] is k21 in component model_parameters (second_order_rate_constant).
* CONSTANTS[30] is k22 in component model_parameters (first_order_rate_constant).
* CONSTANTS[31] is k23 in component model_parameters (first_order_rate_constant).
* CONSTANTS[32] is k24 in component model_parameters (second_order_rate_constant).
* CONSTANTS[33] is k25 in component model_parameters (first_order_rate_constant).
* CONSTANTS[34] is k26 in component model_parameters (first_order_rate_constant).
* CONSTANTS[35] is k35 in component model_parameters (second_order_rate_constant).
* CONSTANTS[36] is k36 in component model_parameters (first_order_rate_constant).
* CONSTANTS[37] is k37 in component model_parameters (first_order_rate_constant).
* CONSTANTS[38] is k38 in component model_parameters (second_order_rate_constant).
* CONSTANTS[39] is k39 in component model_parameters (first_order_rate_constant).
* CONSTANTS[40] is k40 in component model_parameters (first_order_rate_constant).
* CONSTANTS[41] is k41 in component model_parameters (first_order_rate_constant).
* CONSTANTS[42] is k42 in component model_parameters (first_order_rate_constant).
* CONSTANTS[43] is t_half in component model_parameters (minute).
* CONSTANTS[44] is k43 in component model_parameters (first_order_rate_constant).
* RATES[0] is d/dt BMK1 in component BMK1 (micromolar).
* RATES[1] is d/dt MRNA in component MRNA (micromolar).
* RATES[2] is d/dt NFATc in component NFATc (micromolar).
* RATES[3] is d/dt NFATn in component NFATn (micromolar).
* RATES[4] is d/dt NFATpc in component NFATpc (micromolar).
* RATES[5] is d/dt NFATpn in component NFATpn (micromolar).
* RATES[6] is d/dt GSK3betac in component GSK3betac (micromolar).
* RATES[7] is d/dt GSK3betan in component GSK3betan (micromolar).
* RATES[8] is d/dt CaNc in component CaNc (micromolar).
* RATES[9] is d/dt CaNc_star in component CaNc_star (micromolar).
* RATES[10] is d/dt CaNn_star in component CaNn_star (micromolar).
* RATES[11] is d/dt CaNn in component CaNn (micromolar).
* RATES[12] is d/dt CaM in component CaM (micromolar).
* RATES[13] is d/dt CaMCa in component CaMCa (micromolar).
* RATES[14] is d/dt MCIP in component MCIP (micromolar).
* RATES[15] is d/dt MCIPp in component MCIPp (micromolar).
* RATES[16] is d/dt MCIPpp in component MCIPpp (micromolar).
* RATES[17] is d/dt Comp1 in component Comp1 (micromolar).
* RATES[18] is d/dt Comp2 in component Comp2 (micromolar).
* RATES[19] is d/dt Comp3 in component Comp3 (micromolar).
* RATES[20] is d/dt P1433 in component P1433 (micromolar).
* RATES[21] is d/dt MCIP_BMK1 in component MCIP_BMK1 (micromolar).
* RATES[22] is d/dt MCIPp_CaNc_star in component MCIPp_CaNc_star (micromolar).
* RATES[23] is d/dt MCIPp_GSK3betac in component MCIPp_GSK3betac (micromolar).
* RATES[24] is d/dt MCIPpp_CaNc_star in component MCIPpp_CaNc_star (micromolar).
* RATES[25] is d/dt NFATpc_CaNc_star in component NFATpc_CaNc_star (micromolar).
* RATES[26] is d/dt NFATc_GSK3betac in component NFATc_GSK3betac (micromolar).
* RATES[27] is d/dt NFATpn_CaNn_star in component NFATpn_CaNn_star (micromolar).
* RATES[28] is d/dt NFATn_GSK3betan in component NFATn_GSK3betan (micromolar).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = 0.012;
STATES[1] = 3.33E-4;
STATES[2] = 2E-5;
STATES[3] = 4.99E-4;
STATES[4] = 4.94E-3;
STATES[5] = 8.01E-5;
STATES[6] = 0.17;
STATES[7] = 0.339;
STATES[8] = 0.91;
STATES[9] = 0.0275;
STATES[10] = 0.0568;
STATES[11] = 0.0057;
STATES[12] = 25.2;
STATES[13] = 7.88E-7;
STATES[14] = 2.15E-4;
STATES[15] = 7.76E-3;
STATES[16] = 0.0798;
STATES[17] = 5.21E-3;
STATES[18] = 0.283;
STATES[19] = 0.014;
STATES[20] = 0.708;
STATES[21] = 2.14E-5;
STATES[22] = 1.07E-4;
STATES[23] = 1.1E-3;
STATES[24] = 1.1E-3;
STATES[25] = 8.15E-5;
STATES[26] = 1.36E-6;
STATES[27] = 2.27E-6;
STATES[28] = 8.46E-5;
CONSTANTS[0] = 0.4;
CONSTANTS[1] = 0.1;
CONSTANTS[2] = 0.1;
CONSTANTS[3] = 0.05;
CONSTANTS[4] = 0.114;
CONSTANTS[5] = 0.0552;
CONSTANTS[6] = 0.2;
CONSTANTS[7] = 5;
CONSTANTS[8] = 100;
CONSTANTS[9] = 2760;
CONSTANTS[10] = 0.072;
CONSTANTS[11] = 50;
CONSTANTS[12] = 0.0567;
CONSTANTS[13] = 0.5;
CONSTANTS[14] = 0.1;
CONSTANTS[15] = 0.4;
CONSTANTS[16] = 0.1;
CONSTANTS[17] = 5;
CONSTANTS[18] = 0.1;
CONSTANTS[19] = 0.5;
CONSTANTS[20] = 0.1;
CONSTANTS[21] = 0.1;
CONSTANTS[22] = 0.1;
CONSTANTS[23] = 0.5;
CONSTANTS[24] = 0.5;
CONSTANTS[25] = 0.1;
CONSTANTS[26] = 0.1;
CONSTANTS[27] = 0.1;
CONSTANTS[28] = 0.1;
CONSTANTS[29] = 0.15;
CONSTANTS[30] = 0.15;
CONSTANTS[31] = 0.15;
CONSTANTS[32] = 0.1;
CONSTANTS[33] = 0.15;
CONSTANTS[34] = 0.1;
CONSTANTS[35] = 0.15;
CONSTANTS[36] = 0.1;
CONSTANTS[37] = 0.2;
CONSTANTS[38] = 0.1;
CONSTANTS[39] = 0.1;
CONSTANTS[40] = 0.1;
CONSTANTS[41] = 0.02;
CONSTANTS[42] = 0.03;
CONSTANTS[43] = 15;
CONSTANTS[44] = 0.03;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[4] = CONSTANTS[7]*STATES[12]*pow(CONSTANTS[6], 4.00000) - CONSTANTS[8]*STATES[13];
RATES[12] = - ALGEBRAIC[4];
ALGEBRAIC[5] = CONSTANTS[9]*STATES[13]*STATES[8] - CONSTANTS[10]*STATES[9];
RATES[8] = - ALGEBRAIC[5];
RATES[11] = - ALGEBRAIC[5];
RATES[13] = ALGEBRAIC[4] - ALGEBRAIC[5];
ALGEBRAIC[6] = CONSTANTS[11]*STATES[9]*STATES[14] - CONSTANTS[12]*STATES[17];
RATES[17] = ALGEBRAIC[6];
ALGEBRAIC[7] = CONSTANTS[13]*STATES[20]*STATES[16] - CONSTANTS[14]*STATES[18];
RATES[18] = ALGEBRAIC[7];
ALGEBRAIC[8] = CONSTANTS[15]*STATES[4]*STATES[20] - CONSTANTS[16]*STATES[19];
RATES[19] = ALGEBRAIC[8];
RATES[20] = - (ALGEBRAIC[7]+ALGEBRAIC[8]);
ALGEBRAIC[9] = CONSTANTS[17]*STATES[14]*STATES[0] - CONSTANTS[18]*STATES[21];
ALGEBRAIC[10] = CONSTANTS[19]*STATES[21];
RATES[0] = ALGEBRAIC[10] - ALGEBRAIC[9];
RATES[21] = ALGEBRAIC[9] - ALGEBRAIC[10];
ALGEBRAIC[12] = CONSTANTS[20]*STATES[15]*STATES[9] - CONSTANTS[21]*STATES[22];
ALGEBRAIC[13] = CONSTANTS[22]*STATES[22];
RATES[22] = ALGEBRAIC[12] - ALGEBRAIC[13];
ALGEBRAIC[3] = CONSTANTS[4]*STATES[9] - CONSTANTS[5]*STATES[10];
ALGEBRAIC[15] = CONSTANTS[35]*STATES[5]*STATES[10] - CONSTANTS[36]*STATES[27];
ALGEBRAIC[17] = CONSTANTS[37]*STATES[27];
RATES[10] = (ALGEBRAIC[3]+ALGEBRAIC[17]) - ALGEBRAIC[15];
ALGEBRAIC[16] = CONSTANTS[23]*STATES[15]*STATES[6] - CONSTANTS[24]*STATES[23];
ALGEBRAIC[18] = CONSTANTS[25]*STATES[23];
RATES[23] = ALGEBRAIC[16] - ALGEBRAIC[18];
RATES[27] = ALGEBRAIC[15] - ALGEBRAIC[17];
ALGEBRAIC[2] = CONSTANTS[2]*STATES[6] - CONSTANTS[3]*STATES[7];
ALGEBRAIC[21] = CONSTANTS[38]*STATES[3]*STATES[7] - CONSTANTS[39]*STATES[28];
ALGEBRAIC[23] = CONSTANTS[40]*STATES[28];
RATES[7] = (ALGEBRAIC[2]+ALGEBRAIC[23]) - ALGEBRAIC[21];
ALGEBRAIC[22] = CONSTANTS[26]*STATES[16]*STATES[9] - CONSTANTS[27]*STATES[24];
ALGEBRAIC[24] = CONSTANTS[28]*STATES[24];
RATES[24] = ALGEBRAIC[22] - ALGEBRAIC[24];
RATES[28] = ALGEBRAIC[21] - ALGEBRAIC[23];
ALGEBRAIC[19] = ALGEBRAIC[15]+ALGEBRAIC[17];
ALGEBRAIC[25] = ALGEBRAIC[21]+ALGEBRAIC[23];
ALGEBRAIC[1] = CONSTANTS[1]*STATES[5];
RATES[5] = ALGEBRAIC[25] - (ALGEBRAIC[1]+ALGEBRAIC[19]);
ALGEBRAIC[11] = ALGEBRAIC[9]+ALGEBRAIC[10];
ALGEBRAIC[14] = ALGEBRAIC[12]+ALGEBRAIC[13];
ALGEBRAIC[20] = ALGEBRAIC[16]+ALGEBRAIC[18];
ALGEBRAIC[27] = ALGEBRAIC[22]+ALGEBRAIC[24];
RATES[15] = (ALGEBRAIC[11]+ALGEBRAIC[27]) - (ALGEBRAIC[14]+ALGEBRAIC[20]);
RATES[16] = ALGEBRAIC[20] - (ALGEBRAIC[7]+ALGEBRAIC[27]);
ALGEBRAIC[28] = CONSTANTS[41]*STATES[3] - CONSTANTS[42]*STATES[1];
ALGEBRAIC[0] = CONSTANTS[0]*STATES[2];
RATES[3] = (ALGEBRAIC[0]+ALGEBRAIC[19]) - (ALGEBRAIC[25]+ALGEBRAIC[28]);
ALGEBRAIC[26] = CONSTANTS[29]*STATES[4]*STATES[9] - CONSTANTS[30]*STATES[25];
ALGEBRAIC[29] = CONSTANTS[31]*STATES[25];
RATES[9] = (ALGEBRAIC[5]+ALGEBRAIC[13]+ALGEBRAIC[24]+ALGEBRAIC[29]) - (ALGEBRAIC[3]+ALGEBRAIC[6]+ALGEBRAIC[12]+ALGEBRAIC[22]+ALGEBRAIC[26]);
RATES[25] = ALGEBRAIC[26] - ALGEBRAIC[29];
ALGEBRAIC[30] = CONSTANTS[44]*STATES[1] - (log(2.00000)/CONSTANTS[43])*STATES[14];
RATES[1] = ALGEBRAIC[30] - ALGEBRAIC[28];
RATES[14] = ALGEBRAIC[14] - (ALGEBRAIC[6]+ALGEBRAIC[11]+ALGEBRAIC[30]);
ALGEBRAIC[32] = CONSTANTS[32]*STATES[2]*STATES[6] - CONSTANTS[33]*STATES[26];
ALGEBRAIC[33] = CONSTANTS[34]*STATES[26];
RATES[6] = (ALGEBRAIC[18]+ALGEBRAIC[33]) - (ALGEBRAIC[2]+ALGEBRAIC[16]+ALGEBRAIC[32]);
RATES[26] = ALGEBRAIC[32] - ALGEBRAIC[33];
ALGEBRAIC[31] = ALGEBRAIC[26]+ALGEBRAIC[29];
ALGEBRAIC[34] = ALGEBRAIC[32]+ALGEBRAIC[33];
RATES[2] = ALGEBRAIC[31] - (ALGEBRAIC[0]+ALGEBRAIC[34]);
RATES[4] = (ALGEBRAIC[1]+ALGEBRAIC[34]) - (ALGEBRAIC[8]+ALGEBRAIC[31]);
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[4] = CONSTANTS[7]*STATES[12]*pow(CONSTANTS[6], 4.00000) - CONSTANTS[8]*STATES[13];
ALGEBRAIC[5] = CONSTANTS[9]*STATES[13]*STATES[8] - CONSTANTS[10]*STATES[9];
ALGEBRAIC[6] = CONSTANTS[11]*STATES[9]*STATES[14] - CONSTANTS[12]*STATES[17];
ALGEBRAIC[7] = CONSTANTS[13]*STATES[20]*STATES[16] - CONSTANTS[14]*STATES[18];
ALGEBRAIC[8] = CONSTANTS[15]*STATES[4]*STATES[20] - CONSTANTS[16]*STATES[19];
ALGEBRAIC[9] = CONSTANTS[17]*STATES[14]*STATES[0] - CONSTANTS[18]*STATES[21];
ALGEBRAIC[10] = CONSTANTS[19]*STATES[21];
ALGEBRAIC[12] = CONSTANTS[20]*STATES[15]*STATES[9] - CONSTANTS[21]*STATES[22];
ALGEBRAIC[13] = CONSTANTS[22]*STATES[22];
ALGEBRAIC[3] = CONSTANTS[4]*STATES[9] - CONSTANTS[5]*STATES[10];
ALGEBRAIC[15] = CONSTANTS[35]*STATES[5]*STATES[10] - CONSTANTS[36]*STATES[27];
ALGEBRAIC[17] = CONSTANTS[37]*STATES[27];
ALGEBRAIC[16] = CONSTANTS[23]*STATES[15]*STATES[6] - CONSTANTS[24]*STATES[23];
ALGEBRAIC[18] = CONSTANTS[25]*STATES[23];
ALGEBRAIC[2] = CONSTANTS[2]*STATES[6] - CONSTANTS[3]*STATES[7];
ALGEBRAIC[21] = CONSTANTS[38]*STATES[3]*STATES[7] - CONSTANTS[39]*STATES[28];
ALGEBRAIC[23] = CONSTANTS[40]*STATES[28];
ALGEBRAIC[22] = CONSTANTS[26]*STATES[16]*STATES[9] - CONSTANTS[27]*STATES[24];
ALGEBRAIC[24] = CONSTANTS[28]*STATES[24];
ALGEBRAIC[19] = ALGEBRAIC[15]+ALGEBRAIC[17];
ALGEBRAIC[25] = ALGEBRAIC[21]+ALGEBRAIC[23];
ALGEBRAIC[1] = CONSTANTS[1]*STATES[5];
ALGEBRAIC[11] = ALGEBRAIC[9]+ALGEBRAIC[10];
ALGEBRAIC[14] = ALGEBRAIC[12]+ALGEBRAIC[13];
ALGEBRAIC[20] = ALGEBRAIC[16]+ALGEBRAIC[18];
ALGEBRAIC[27] = ALGEBRAIC[22]+ALGEBRAIC[24];
ALGEBRAIC[28] = CONSTANTS[41]*STATES[3] - CONSTANTS[42]*STATES[1];
ALGEBRAIC[0] = CONSTANTS[0]*STATES[2];
ALGEBRAIC[26] = CONSTANTS[29]*STATES[4]*STATES[9] - CONSTANTS[30]*STATES[25];
ALGEBRAIC[29] = CONSTANTS[31]*STATES[25];
ALGEBRAIC[30] = CONSTANTS[44]*STATES[1] - (log(2.00000)/CONSTANTS[43])*STATES[14];
ALGEBRAIC[32] = CONSTANTS[32]*STATES[2]*STATES[6] - CONSTANTS[33]*STATES[26];
ALGEBRAIC[33] = CONSTANTS[34]*STATES[26];
ALGEBRAIC[31] = ALGEBRAIC[26]+ALGEBRAIC[29];
ALGEBRAIC[34] = ALGEBRAIC[32]+ALGEBRAIC[33];
}