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Lockwood, Ewy, Hermann, Holford, 2006
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Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease
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Model Mathematics
Component based math viewer is available
Component: environment
Component: population_pharmacodynamics_model
S
=
S0
+
alpha
time
+
ADAS_Cog_p
+
PD_CeA
+
epsilon
Component: placebo_response_model
ADAS_Cog_p
=
beta_P
Keq_p
Keq_p
-
Kel_p
ⅇ
-
Kel_p
time
-
ⅇ
-
Keq_p
time
Keq_p
=
ln
2
t_half_eq_p
Kel_p
=
ln
2
t_half_el_p
Component: pharmacokinetic_model
CL
=
2268.0
ⅇ
-
0.0135
age
-
40
smk
Component: drop_out_model
Sv
=
ⅇ
-
0.00145
time
Component: drug_response_model
PD_CeA
=
beta_a
CeA
Component: drug_clearance
d
d
time
CC
=
k_ab
A_in
-
CL
CC
+
CL_ic
CC
-
PC
Vc
d
d
time
PC
=
CL_ic
CC
-
PC
Vp
d
d
time
A_in
=
-
115.44
A_in
Source
Derived from workspace
Lockwood, Ewy, Hermann, Holford, 2006
at changeset
5781efa9e2dd
.
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Creative Commons Attribution 3.0 Unported License
.
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Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease