Model Mathematics

Component: environment

Component: total_calcium

Ca_Pr = Ca_tot - Ca_cyt + rho_ER beta_ER Ca_ER + rho_m beta_m Ca_m

Component: total_protein

Pr = Pr_tot - Ca_Pr

Component: cytosolic_calcium

dd time Ca_cyt = J_ch + J_leak + J_out + k_minus Ca_Pr - J_pump + J_in + k_plus Ca_cyt Pr

Component: ER_calcium

dd time Ca_ER = beta_ER rho_ER J_pump - J_ch + J_leak

Component: mitochondrial_calcium

dd time Ca_m = beta_m rho_m J_in - J_out

Component: ATP_dependent_Ca_uptake_into_the_ER

J_pump = k_pump Ca_cyt

Component: Ca_efflux_from_the_ER

J_ch = k_ch Ca_cyt 2.0 K1 2.0 + Ca_cyt 2.0 Ca_ER - Ca_cyt

Component: Ca_leak_flux_from_the_ER

J_leak = k_leak Ca_ER - Ca_cyt

Component: mitochondrial_Ca_uptake

J_in = k_in Ca_cyt 8.0 K2 8.0 + Ca_cyt 8.0

Component: mitochondrial_Ca_release

J_out = k_out Ca_cyt 2.0 K3 2.0 + Ca_cyt 2.0 + k_m Ca_m