Korzeniewski, Zoladz, 2001

Model Status

This model is valid CellML but is overconstrained.

Model Structure

Oxidative phosphorylation in mitochondria is the main process responsible for the synthesis of ATP in most animal tissues under most conditions. The energy required for ATP synthesis in the mitochondria is released by substrate dehydrogenation in the TCA cycle and in the beta-oxidation of fatty acids. These substrate dehydrogenations are coupled to the reduction of the co-enzymes NAD+ or FAD in the mitochondrial matrix. The reduced forms of these co-enzymes (NADH and FADH2) are reoxidised by molecular oxygen using a series of electron carriers on the inner membrane known as the respiratory chain (see below).

In 1991, Bernard Korzeniewski and Wojciech Froncisz published a dynamic model of oxidative phosphorylation in isolated mitochondria. This model was further modified in 1992, in 1996 it was adapted to be specific to intact hepatocytes and in 2001 a model was developed for oxidative phosphorylation in mammalian skeletal muscle.

The complete original paper references are cited below:

An extended dynamic model of oxidative phosphorylation, Bernard Korzeniewski and Wojciech Froncisz, 1991, Biochimica et Biophysica Acta. 1060, 210-223. PubMed ID: 1657162

Simulation of oxidative phosphorylation in hepatocytes, Bernard Korzeniewski, 1996, Biophysical Chemistry , 58, 215-224. (A PDF version of the article is available to subscribers on the ScienceDirect website.) PubMed ID: 8820407

A model of oxidative phosphorylation in mammalian skeletal muscle, Bernard Korzeniewski and Jerzy A. Zoladz, 2001, Biophysical Chemistry , 92, 17-34. (The full text (HTML) and PDF versions of the article are available on the ScienceDirect website.) PubMed ID: 11527576

The raw CellML description of the oxidative phosphorylation model can be downloaded in various formats as described in . For an example of a more complete documentation of another real reaction pathway, see The Bhalla Iyengar EGF Pathway Model, 1999.

A rendering of oxidative phosphorylation. Metabolites are represented by rounded rectangles, catalysts are represented by ellipses and reactions and metabolite translocations are represented by arrows.

In CellML, models are thought of as connected networks of discrete components. These components may correspond to physiologically separated regions or chemically distinct objects, or may be useful modelling abstractions. This model has 62 components representing chemically distinct objects (metabolites, enzymes and reactions) and two components defined for modeling convenience; global variables which stores the universal variable time, and cell which defines a number of cell specific features. Because this model has so many components, its CellML rendering would be complex. For an example of a CellML rendering of a reaction pathway see The Bhalla Iyengar EGF Pathway Model, 1999.