/* There are a total of 16 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 37 entries in the constant variable array. */ /* * VOI is time in component environment (hour). * CONSTANTS[0] is T_a in component model_parameters (celsius). * CONSTANTS[1] is T_b in component model_parameters (celsius). * CONSTANTS[2] is delta_T in component model_parameters (celsius). * CONSTANTS[3] is kinc in component model_parameters (W_per_kg_C2). * CONSTANTS[4] is tdose1 in component model_parameters (hour). * CONSTANTS[5] is tdose2 in component model_parameters (hour). * CONSTANTS[6] is tdose3 in component model_parameters (hour). * ALGEBRAIC[5] is M_c in component M_c (W_per_kg). * CONSTANTS[7] is t_day in component M_c (hour). * CONSTANTS[8] is t_night in component M_c (hour). * ALGEBRAIC[1] is tprime in component M_c (second). * CONSTANTS[9] is day_length in component M_c (second). * CONSTANTS[35] is M_day in component M_day (W_per_kg). * ALGEBRAIC[3] is M_night in component M_night (W_per_kg). * STATES[0] is M in component M (W_per_kg). * CONSTANTS[10] is km in component M (per_hour). * STATES[1] is T in component T (celsius). * CONSTANTS[11] is c in component T (kJ_per_kg_C). * ALGEBRAIC[0] is k in component k (W_per_kg_C). * STATES[2] is BR in component k (dimensionless). * CONSTANTS[12] is pEtot in component k (dimensionless). * CONSTANTS[13] is kR in component k (per_day). * CONSTANTS[14] is AMT_dose in component k (mg_per_kg). * CONSTANTS[15] is pEf1 in component k (per_day). * CONSTANTS[16] is pEs1 in component k (kg_per_day_mg). * CONSTANTS[17] is pEf2 in component k (per_day). * CONSTANTS[18] is pEs2 in component k (kg_per_day_mg). * CONSTANTS[19] is pEf3 in component k (per_day). * CONSTANTS[20] is pEs3 in component k (kg_per_day_mg). * ALGEBRAIC[13] is E_slow in component k (per_day). * ALGEBRAIC[15] is E_fast in component k (per_day). * CONSTANTS[30] is f2_drug in component k (W_per_kg_C). * CONSTANTS[34] is kb in component kb (W_per_kg_C). * ALGEBRAIC[2] is f_prime in component M_night (dimensionless). * ALGEBRAIC[6] is gNsTs1 in component gNT (dimensionless). * ALGEBRAIC[9] is gNsTs2 in component gNT (dimensionless). * ALGEBRAIC[12] is gNsTs3 in component gNT (dimensionless). * ALGEBRAIC[7] is gNfTf1 in component gNT (dimensionless). * ALGEBRAIC[10] is gNfTf2 in component gNT (dimensionless). * ALGEBRAIC[14] is gNfTf3 in component gNT (dimensionless). * CONSTANTS[29] is T_day in component T_day (celsius). * CONSTANTS[32] is T_night in component T_night (celsius). * CONSTANTS[21] is M_b in component kb (W_per_kg). * CONSTANTS[22] is t_prime in component M_night (hour). * CONSTANTS[23] is alpha in component M_night (per_hour). * CONSTANTS[24] is delta_high_dose in component M_night (dimensionless). * CONSTANTS[36] is M_night_baseline in component M_night (W_per_kg). * CONSTANTS[25] is Ns in component gNT (dimensionless). * CONSTANTS[26] is Nf in component gNT (dimensionless). * CONSTANTS[27] is Ts in component gNT (day). * CONSTANTS[28] is Tf in component gNT (day). * ALGEBRAIC[4] is X1 in component gNT (day). * ALGEBRAIC[8] is X2 in component gNT (day). * ALGEBRAIC[11] is X3 in component gNT (day). * CONSTANTS[31] is Kf in component gNT (per_day). * CONSTANTS[33] is Ks in component gNT (per_day). * RATES[0] is d/dt M in component M (W_per_kg). * RATES[1] is d/dt T in component T (celsius). * RATES[2] is d/dt BR in component k (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 21.0; CONSTANTS[1] = 38.0; CONSTANTS[2] = 1.57; CONSTANTS[3] = 0.0258; CONSTANTS[4] = 24.0; CONSTANTS[5] = 72.0; CONSTANTS[6] = 120.0; CONSTANTS[7] = 17.5; CONSTANTS[8] = 6.73; CONSTANTS[9] = 86400; STATES[0] = 3.5; CONSTANTS[10] = 1.1375; STATES[1] = 38.785; CONSTANTS[11] = 3.47; STATES[2] = 0.0; CONSTANTS[12] = 0.144; CONSTANTS[13] = 5.35; CONSTANTS[14] = 3.0; CONSTANTS[15] = 1.0; CONSTANTS[16] = 0.2; CONSTANTS[17] = 3.57; CONSTANTS[18] = 2.43; CONSTANTS[19] = 8.0; CONSTANTS[20] = 50.0; CONSTANTS[21] = 3.0; CONSTANTS[22] = 45.12; CONSTANTS[23] = 0.2229166; CONSTANTS[24] = 1.0; CONSTANTS[25] = 4.0; CONSTANTS[26] = 4.0; CONSTANTS[27] = 2.45; CONSTANTS[28] = 0.368; CONSTANTS[29] = CONSTANTS[1]+CONSTANTS[2]/2.00000; CONSTANTS[30] = 0.00000; CONSTANTS[31] = CONSTANTS[26]/CONSTANTS[28]; CONSTANTS[32] = CONSTANTS[1] - CONSTANTS[2]/2.00000; CONSTANTS[33] = CONSTANTS[25]/CONSTANTS[27]; CONSTANTS[34] = CONSTANTS[21]/(CONSTANTS[1] - CONSTANTS[0]); CONSTANTS[35] = (CONSTANTS[34]+ CONSTANTS[3]*(CONSTANTS[29] - CONSTANTS[1]))*(CONSTANTS[29] - CONSTANTS[0]); CONSTANTS[36] = (CONSTANTS[34]+ CONSTANTS[3]*(CONSTANTS[32] - CONSTANTS[1]))*(CONSTANTS[32] - CONSTANTS[0]); } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[34]+ CONSTANTS[3]*(STATES[1] - CONSTANTS[1]*(1.00000+ CONSTANTS[12]*STATES[2]))+CONSTANTS[30]; RATES[1] = pow(CONSTANTS[11], -1.00000)*(STATES[0] - ALGEBRAIC[0]*(STATES[1] - CONSTANTS[0])); ALGEBRAIC[1] = (int)( VOI*3600.00*1.00000) % (int)(CONSTANTS[9]); ALGEBRAIC[2] = CONSTANTS[24]*pow(1.00000+exp( - CONSTANTS[23]*(VOI - (CONSTANTS[4]+CONSTANTS[22]))), -1.00000); ALGEBRAIC[3] = (1.00000 - ALGEBRAIC[2])*CONSTANTS[36]+ ALGEBRAIC[2]*CONSTANTS[35]; ALGEBRAIC[5] = (ALGEBRAIC[1]/3600.00>=CONSTANTS[8]&&ALGEBRAIC[1]/3600.000.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[4])*pow(ALGEBRAIC[4], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[8] = (VOI - CONSTANTS[5])/24.0000; ALGEBRAIC[9] = (ALGEBRAIC[8]>0.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[8])*pow(ALGEBRAIC[8], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[11] = (VOI - CONSTANTS[6])/24.0000; ALGEBRAIC[12] = (ALGEBRAIC[11]>0.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[11])*pow(ALGEBRAIC[11], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[13] = CONSTANTS[14]*CONSTANTS[18]*(ALGEBRAIC[6]+ALGEBRAIC[9]+ALGEBRAIC[12]); ALGEBRAIC[7] = (ALGEBRAIC[4]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[4])*pow(ALGEBRAIC[4], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[10] = (ALGEBRAIC[8]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[8])*pow(ALGEBRAIC[8], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[14] = (ALGEBRAIC[11]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[11])*pow(ALGEBRAIC[11], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[15] = CONSTANTS[17]*(ALGEBRAIC[7]+ALGEBRAIC[10]+ALGEBRAIC[14]); RATES[2] = ( ALGEBRAIC[2]*(ALGEBRAIC[13]+ALGEBRAIC[15]))*(1.00000 - STATES[2]) - CONSTANTS[13]*STATES[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[34]+ CONSTANTS[3]*(STATES[1] - CONSTANTS[1]*(1.00000+ CONSTANTS[12]*STATES[2]))+CONSTANTS[30]; ALGEBRAIC[1] = (int)( VOI*3600.00*1.00000) % (int)(CONSTANTS[9]); ALGEBRAIC[2] = CONSTANTS[24]*pow(1.00000+exp( - CONSTANTS[23]*(VOI - (CONSTANTS[4]+CONSTANTS[22]))), -1.00000); ALGEBRAIC[3] = (1.00000 - ALGEBRAIC[2])*CONSTANTS[36]+ ALGEBRAIC[2]*CONSTANTS[35]; ALGEBRAIC[5] = (ALGEBRAIC[1]/3600.00>=CONSTANTS[8]&&ALGEBRAIC[1]/3600.000.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[4])*pow(ALGEBRAIC[4], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[8] = (VOI - CONSTANTS[5])/24.0000; ALGEBRAIC[9] = (ALGEBRAIC[8]>0.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[8])*pow(ALGEBRAIC[8], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[11] = (VOI - CONSTANTS[6])/24.0000; ALGEBRAIC[12] = (ALGEBRAIC[11]>0.00000 ? (pow(CONSTANTS[33], CONSTANTS[25])/6.00000)*exp( - CONSTANTS[33]*ALGEBRAIC[11])*pow(ALGEBRAIC[11], CONSTANTS[25] - 1.00000) : 0.00000); ALGEBRAIC[13] = CONSTANTS[14]*CONSTANTS[18]*(ALGEBRAIC[6]+ALGEBRAIC[9]+ALGEBRAIC[12]); ALGEBRAIC[7] = (ALGEBRAIC[4]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[4])*pow(ALGEBRAIC[4], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[10] = (ALGEBRAIC[8]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[8])*pow(ALGEBRAIC[8], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[14] = (ALGEBRAIC[11]>0.00000 ? (pow(CONSTANTS[31], CONSTANTS[26])/6.00000)*exp( - CONSTANTS[31]*ALGEBRAIC[11])*pow(ALGEBRAIC[11], CONSTANTS[26] - 1.00000) : 0.00000); ALGEBRAIC[15] = CONSTANTS[17]*(ALGEBRAIC[7]+ALGEBRAIC[10]+ALGEBRAIC[14]); }