A phantom bursting mechanism for episodic bursting: modified to include channel noise in the leak current

A phantom bursting mechanism for episodic bursting

Model Status

This CellML model runs in both OpenCell and COR but it does not yet replicate the published results (figure 7 in the original paper) because the model requires a stochastic wiener process to introduce noise into the model. Until stochastic processes can be descibed in CellML "w" in this model has been set to 1.

Model Structure

ABSTRACT: We describe a novel dynamic mechanism for episodic or compound bursting oscillations, in which bursts of electrical impulses are clustered together into episodes, separated by long silent phases. We demonstrate the mechanism for episodic bursting using a minimal mathematical model for "phantom bursting." Depending on the location in parameter space, this model can produce fast, medium, or slow bursting, or in the present case, fast, slow, and episodic bursting. The episodic bursting is modestly robust to noise and to parameter variation, and the effect that noise has on the episodic bursting pattern is quite different from that of an alternate episodic burst mechanism in which the slow envelope is produced by metabolic oscillations. This mechanism could account for episodic bursting produced in endocrine cells or neurons, such as pancreatic islets or gonadotropin releasing neurons of the hypothalamus.s.

The original paper reference is cited below.

A phantom bursting mechanism for episodic bursting, R. Bertram, J. Rhoads and W.P. Cimbora, 2008, Bulletin of Mathematical Biology, 70, 1979-1993. PubMed ID: 18648884

Schematic diagram of the cell model.