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/* There are a total of 1 entries in the algebraic variable array. There are a total of 20 entries in each of the rate and state variable arrays. There are a total of 17 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is Py in component Py (nanomolar). * STATES[1] is Zn in component Zn (nanomolar). * STATES[2] is Py1 in component Py1 (nanomolar). * CONSTANTS[0] is r3 in component model_parameters (third_order_rate_constant). * CONSTANTS[1] is r4 in component model_parameters (first_order_rate_constant). * STATES[3] is Dw in component Dw (nanomolar). * STATES[4] is Qw2 in component Qw2 (nanomolar). * CONSTANTS[2] is k_1 in component model_parameters (first_order_rate_constant). * CONSTANTS[3] is k1a in component model_parameters (second_order_rate_constant). * STATES[5] is Qw1 in component Qw1 (nanomolar). * STATES[6] is Rw in component Rw (nanomolar). * CONSTANTS[4] is k2 in component model_parameters (second_order_rate_constant). * CONSTANTS[5] is k_2 in component model_parameters (first_order_rate_constant). * ALGEBRAIC[0] is k3 in component model_parameters (first_order_rate_constant). * STATES[7] is Mw in component Mw (nanomolar). * STATES[8] is Px in component Px (nanomolar). * STATES[9] is Px1 in component Px1 (nanomolar). * STATES[10] is Dz in component Dz (nanomolar). * STATES[11] is Qz4 in component Qz4 (nanomolar). * CONSTANTS[6] is r1 in component model_parameters (second_order_rate_constant). * CONSTANTS[7] is r2 in component model_parameters (first_order_rate_constant). * CONSTANTS[8] is k1b in component model_parameters (second_order_rate_constant). * STATES[12] is Qz2 in component Qz2 (nanomolar). * CONSTANTS[9] is k1 in component model_parameters (second_order_rate_constant). * STATES[13] is Tp in component Tp (nanomolar). * STATES[14] is Tp1 in component Tp1 (nanomolar). * CONSTANTS[10] is r5 in component model_parameters (second_order_rate_constant). * CONSTANTS[11] is r6 in component model_parameters (first_order_rate_constant). * STATES[15] is Qz1 in component Qz1 (nanomolar). * STATES[16] is Rz in component Rz (nanomolar). * CONSTANTS[12] is k2a in component model_parameters (second_order_rate_constant). * STATES[17] is Qz3 in component Qz3 (nanomolar). * STATES[18] is Qz5 in component Qz5 (nanomolar). * CONSTANTS[13] is k2b in component model_parameters (second_order_rate_constant). * CONSTANTS[14] is k2c in component model_parameters (second_order_rate_constant). * STATES[19] is Mz in component Mz (nanomolar). * CONSTANTS[15] is td0 in component model_parameters (second). * CONSTANTS[16] is td in component model_parameters (second). * RATES[0] is d/dt Py in component Py (nanomolar). * RATES[2] is d/dt Py1 in component Py1 (nanomolar). * RATES[3] is d/dt Dw in component Dw (nanomolar). * RATES[6] is d/dt Rw in component Rw (nanomolar). * RATES[5] is d/dt Qw1 in component Qw1 (nanomolar). * RATES[4] is d/dt Qw2 in component Qw2 (nanomolar). * RATES[7] is d/dt Mw in component Mw (nanomolar). * RATES[8] is d/dt Px in component Px (nanomolar). * RATES[9] is d/dt Px1 in component Px1 (nanomolar). * RATES[13] is d/dt Tp in component Tp (nanomolar). * RATES[14] is d/dt Tp1 in component Tp1 (nanomolar). * RATES[1] is d/dt Zn in component Zn (nanomolar). * RATES[10] is d/dt Dz in component Dz (nanomolar). * RATES[16] is d/dt Rz in component Rz (nanomolar). * RATES[15] is d/dt Qz1 in component Qz1 (nanomolar). * RATES[12] is d/dt Qz2 in component Qz2 (nanomolar). * RATES[17] is d/dt Qz3 in component Qz3 (nanomolar). * RATES[11] is d/dt Qz4 in component Qz4 (nanomolar). * RATES[18] is d/dt Qz5 in component Qz5 (nanomolar). * RATES[19] is d/dt Mz in component Mz (nanomolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 25.0; STATES[1] = 10000.0; STATES[2] = 0.0; CONSTANTS[0] = 4.41E10; CONSTANTS[1] = 9E-3; STATES[3] = 4.0; STATES[4] = 0.0; CONSTANTS[2] = 0.9; CONSTANTS[3] = 1.0; STATES[5] = 0.0; STATES[6] = 50.0; CONSTANTS[4] = 0.02; CONSTANTS[5] = 0.3; STATES[7] = 0.0; STATES[8] = 50.0; STATES[9] = 0.0; STATES[10] = 2.0; STATES[11] = 0.0; CONSTANTS[6] = 2.73E2; CONSTANTS[7] = 3.437E-4; CONSTANTS[8] = 1.253E-2; STATES[12] = 0.0; CONSTANTS[9] = 0.025; STATES[13] = 10000.0; STATES[14] = 0.0; CONSTANTS[10] = 3E4; CONSTANTS[11] = 1.506E-2; STATES[15] = 0.0; STATES[16] = 100.0; CONSTANTS[12] = 0.00005; STATES[17] = 0.0; STATES[18] = 0.0; CONSTANTS[13] = 0.0002; CONSTANTS[14] = 0.0037; STATES[19] = 0.0; CONSTANTS[15] = 1800.0; CONSTANTS[16] = 2700; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = CONSTANTS[1]*STATES[2] - CONSTANTS[0]*pow(STATES[1], 2.00000)*STATES[0]; RATES[2] = ( CONSTANTS[0]*pow(STATES[1], 2.00000)*STATES[0]+ CONSTANTS[2]*STATES[4]) - ( CONSTANTS[1]*STATES[2]+ CONSTANTS[3]*STATES[3]*STATES[2]); RATES[4] = CONSTANTS[3]*STATES[3]*STATES[2] - CONSTANTS[2]*STATES[4]; RATES[8] = ( CONSTANTS[7]*STATES[9]+ CONSTANTS[2]*STATES[11]) - ( CONSTANTS[6]*STATES[1]*STATES[8]+ CONSTANTS[8]*STATES[10]*STATES[8]); RATES[9] = ( CONSTANTS[6]*STATES[1]*STATES[8]+ CONSTANTS[2]*STATES[12]) - ( CONSTANTS[7]*STATES[9]+ CONSTANTS[9]*STATES[10]*STATES[9]); RATES[13] = CONSTANTS[11]*STATES[14] - CONSTANTS[10]*STATES[1]*STATES[13]; RATES[14] = CONSTANTS[10]*STATES[1]*STATES[13] - CONSTANTS[11]*STATES[14]; RATES[1] = ( CONSTANTS[7]*STATES[9]+ CONSTANTS[11]*STATES[14]) - ( CONSTANTS[6]*STATES[1]*STATES[8]+ CONSTANTS[10]*STATES[1]*STATES[13]); ALGEBRAIC[0] = (VOI>=0.00000&&VOI<CONSTANTS[15] ? 0.00000 : VOI>=CONSTANTS[15]&&VOI<CONSTANTS[16] ? 0.0110000 : 0.0/0.0); RATES[3] = ( CONSTANTS[2]*STATES[4]+ ALGEBRAIC[0]*STATES[5]+ CONSTANTS[5]*STATES[5]) - ( CONSTANTS[3]*STATES[3]*STATES[2]+ CONSTANTS[4]*STATES[3]*STATES[6]); RATES[6] = ( ALGEBRAIC[0]*STATES[5]+ CONSTANTS[5]*STATES[5]) - CONSTANTS[4]*STATES[3]*STATES[6]; RATES[5] = CONSTANTS[4]*STATES[3]*STATES[6] - ( ALGEBRAIC[0]*STATES[5]+ CONSTANTS[5]*STATES[5]); RATES[7] = ALGEBRAIC[0]*STATES[5]; RATES[10] = ( CONSTANTS[2]*STATES[12]+ ALGEBRAIC[0]*STATES[15]+ CONSTANTS[5]*STATES[15]+ CONSTANTS[2]*STATES[11]) - ( CONSTANTS[8]*STATES[10]*STATES[8]+ CONSTANTS[9]*STATES[10]*STATES[9]+ CONSTANTS[12]*STATES[10]*STATES[16]); RATES[16] = ( ALGEBRAIC[0]*STATES[15]+ CONSTANTS[5]*STATES[15]+ ALGEBRAIC[0]*STATES[17]+ CONSTANTS[5]*STATES[17]+ ALGEBRAIC[0]*STATES[18]+ CONSTANTS[5]*STATES[18]) - ( CONSTANTS[12]*STATES[10]*STATES[16]+ CONSTANTS[13]*STATES[11]*STATES[16]+ CONSTANTS[14]*STATES[12]*STATES[16]); RATES[15] = CONSTANTS[12]*STATES[10]*STATES[16] - ( ALGEBRAIC[0]*STATES[15]+ CONSTANTS[5]*STATES[15]); RATES[12] = ( CONSTANTS[9]*STATES[10]*STATES[9]+ ALGEBRAIC[0]*STATES[17]+ CONSTANTS[5]*STATES[17]) - ( CONSTANTS[2]*STATES[12]+ CONSTANTS[14]*STATES[12]*STATES[16]); RATES[17] = CONSTANTS[14]*STATES[12]*STATES[16] - ( ALGEBRAIC[0]*STATES[17]+ CONSTANTS[5]*STATES[17]); RATES[11] = ( CONSTANTS[8]*STATES[10]*STATES[8]+ ALGEBRAIC[0]*STATES[18]+ CONSTANTS[5]*STATES[18]) - ( CONSTANTS[2]*STATES[11]+ CONSTANTS[13]*STATES[11]*STATES[16]); RATES[18] = CONSTANTS[13]*STATES[11]*STATES[16] - ( ALGEBRAIC[0]*STATES[18]+ CONSTANTS[5]*STATES[18]); RATES[19] = ALGEBRAIC[0]*STATES[15]+ ALGEBRAIC[0]*STATES[17]+ ALGEBRAIC[0]*STATES[18]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (VOI>=0.00000&&VOI<CONSTANTS[15] ? 0.00000 : VOI>=CONSTANTS[15]&&VOI<CONSTANTS[16] ? 0.0110000 : 0.0/0.0); }