/* There are a total of 8 entries in the algebraic variable array. There are a total of 1 entries in each of the rate and state variable arrays. There are a total of 10 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * CONSTANTS[0] is BFM in component muscle_O2_delivery (L_per_minute). * CONSTANTS[1] is OVA in component muscle_O2_delivery (mL_per_L). * CONSTANTS[2] is HM in component muscle_O2_delivery (dimensionless). * CONSTANTS[3] is AOM in component muscle_O2_delivery (dimensionless). * CONSTANTS[9] is O2ARTM in component M_O2_blood_supply (mL_per_minute). * ALGEBRAIC[4] is RMO in component delivery_of_O2_to_M_tissues (mL_per_minute). * ALGEBRAIC[5] is PVO in component M_venous_O2_content (mmHg). * CONSTANTS[4] is EXC in component parameter_values (dimensionless). * CONSTANTS[5] is EXCXP2 in component parameter_values (dimensionless). * ALGEBRAIC[6] is OVS in component M_venous_O2_content (dimensionless). * ALGEBRAIC[1] is PMO in component pressure_of_O2_in_M_tissue_cells (mmHg). * ALGEBRAIC[3] is MMO in component metabolic_O2_consumption_by_M_tissue (mL_per_minute). * ALGEBRAIC[2] is P2O in component metabolic_O2_consumption_by_M_tissue (mmHg). * CONSTANTS[6] is OMM in component parameter_values (mL_per_minute). * CONSTANTS[7] is PM5 in component parameter_values (per_mmHg). * ALGEBRAIC[0] is QOM in component volume_of_O2_in_M_tissue (mL). * ALGEBRAIC[7] is DO2M in component volume_of_O2_in_M_tissue (mL_per_minute). * STATES[0] is QOM1 in component volume_of_O2_in_M_tissue (mL). * CONSTANTS[8] is PK2 in component parameter_values (mmHg_per_mL). * RATES[0] is d/dt QOM1 in component volume_of_O2_in_M_tissue (mL). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.989949; CONSTANTS[1] = 204.497; CONSTANTS[2] = 40.0381; CONSTANTS[3] = 1.00002; CONSTANTS[4] = 1; CONSTANTS[5] = 0.17; CONSTANTS[6] = 57.1; CONSTANTS[7] = 30; STATES[0] = 48.0839; CONSTANTS[8] = 0.79167; CONSTANTS[9] = CONSTANTS[1]*CONSTANTS[0]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[0]<0.000100000 ? 0.000100000 : STATES[0]); ALGEBRAIC[1] = CONSTANTS[8]*ALGEBRAIC[0]; rootfind_0(VOI, CONSTANTS, RATES, STATES, ALGEBRAIC, pret); ALGEBRAIC[2] = (ALGEBRAIC[1]>38.0000 ? 38.0000 : ALGEBRAIC[1]); ALGEBRAIC[3] = CONSTANTS[3]*CONSTANTS[6]*CONSTANTS[4]*(1.00000 - pow(38.0001 - ALGEBRAIC[2], 3.00000)/54872.0); ALGEBRAIC[7] = ALGEBRAIC[4] - ALGEBRAIC[3]; RATES[0] = ALGEBRAIC[7]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[0]<0.000100000 ? 0.000100000 : STATES[0]); ALGEBRAIC[1] = CONSTANTS[8]*ALGEBRAIC[0]; ALGEBRAIC[2] = (ALGEBRAIC[1]>38.0000 ? 38.0000 : ALGEBRAIC[1]); ALGEBRAIC[3] = CONSTANTS[3]*CONSTANTS[6]*CONSTANTS[4]*(1.00000 - pow(38.0001 - ALGEBRAIC[2], 3.00000)/54872.0); ALGEBRAIC[7] = ALGEBRAIC[4] - ALGEBRAIC[3]; } void objfunc_0(double *p, double *hx, int m, int n, void *adata) { struct rootfind_info* rfi = (struct rootfind_info*)adata; #define VOI rfi->aVOI #define CONSTANTS rfi->aCONSTANTS #define RATES rfi->aRATES #define STATES rfi->aSTATES #define ALGEBRAIC rfi->aALGEBRAIC #define pret rfi->aPRET ALGEBRAIC[4] = p[0]; ALGEBRAIC[5] = p[1]; ALGEBRAIC[6] = p[2]; hx[0] = ALGEBRAIC[6] - (CONSTANTS[9] - ALGEBRAIC[4])/( CONSTANTS[2]*5.25000*CONSTANTS[0]); hx[1] = ALGEBRAIC[5] - 57.1400*ALGEBRAIC[6]*pow(CONSTANTS[4], CONSTANTS[5]); hx[2] = ALGEBRAIC[4] - (ALGEBRAIC[5] - ALGEBRAIC[1])*CONSTANTS[7]*CONSTANTS[0]; #undef VOI #undef CONSTANTS #undef RATES #undef STATES #undef ALGEBRAIC #undef pret } void rootfind_0(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC, int* pret) { static double p[3] = {57.064,39.9701,0.699673}; double bp[3], work[LM_DIF_WORKSZ(3, 3)]; struct rootfind_info rfi; rfi.aVOI = VOI; rfi.aCONSTANTS = CONSTANTS; rfi.aRATES = RATES; rfi.aSTATES = STATES; rfi.aALGEBRAIC = ALGEBRAIC; rfi.aPRET = pret; do_levmar(objfunc_0, p, bp, work, pret, 3, &rfi); ALGEBRAIC[4] = p[0]; ALGEBRAIC[5] = p[1]; ALGEBRAIC[6] = p[2]; }