Colegrove, Albrecht, Friel, 2000

Model Status

This model can not be solved as it is unsuitably constrained.

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Model Structure

One of the central goals in the study of calcium signalling is to understand the basis of [Ca2+] dynamics. This is complicated by the fact that Ca2+ is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca2+ transport system and the rate of Ca2+ transport between these compartments can exhibit a complex non-linear dependence on free [Ca2+].

In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca2+ transport contributes to the redistribution of intracellular Ca2+ during and after depolarisation-evoked Ca2+ entry in sympathetic neurons. The total Ca2+ flux during the recovery phase following membrane depolarisation was divided into three components (see the figure below): one representing net Ca2+ extrusion across the plasma membrane (Jextru), one representing mitochondrial Ca2+ uptake via the uniporter (Juni) and one representing mitochondrial Ca2+ release via the Na+/Ca2+ exchanger (JNaCa). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .

The complete original paper reference is cited below:

Quantitative Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations , Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000, The Journal Of General Physiology , 115, 371-388. PubMed ID: 10694264

Schematic of the model indicating Ca2+ compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca2+ ion movement between the compartments.