<?xml version="1.0"?>
<!--
This CellML file was generated on 18/04/2008 at 09:25:32 using:
COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
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<article>
<articleinfo>
<title>Modelling the Roles of Individual Current Systems in Ventricular Cells and in the SA Node</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model has been curated and unit checked by Alan Garny in collaboration with the model authors and it is known to run in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: This paper discusses the development of a cardiac sinoatrial (SA) node pacemaker model. The model successfully reconstructs the experimental action potentials at various concentrations of external Ca2+ and K+. Increasing the amplitude of L-type Ca2+ current (I(CaL)) prolongs the duration of the action potential and thereby slightly decreases the spontaneous rate. On the other hand, a negative voltage shift of I(CaL) gating by a few mV markedly increases the spontaneous rate. When the amplitude of sustained inward current (I(st)) is increased, the spontaneous rate is increased irrespective of the I(CaL) amplitude. Increasing [Ca2+](o) shortens the action potential and increases the spontaneous rate. When the spontaneous activity is stopped by decreasing I(CaL) amplitude, the resting potential is nearly constant (-35 mV) over 1-15 mM [K+](o) as observed in the experiment. This is because the conductance of the inward background non-selective cation current balances with the outward [K+](o)-dependent K+ conductance. The unique role of individual voltage- and time-dependent ion channels is clearly demonstrated and distinguished from that of the background current by calculating an instantaneous zero current potential ("lead potential") during the course of the spontaneous activity.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Role of Individual Ionic Current Systems in the SA Node Hypothesized by a Model Study, Sarai N, Matsuoka S, Kuratomi S, Ono K, and Noma A, 2003, <emphasis>The Japanese Journal of Physiology</emphasis>, 53, 125-134. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/12877768">PubMed ID: 12877768</ulink>
</para>
<informalfigure float="0" id="fig_SA_node_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>SA node cell diagram</title>
</objectinfo>
<imagedata fileref="matsuoka_san_2003.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the ionic components of the Matsuoka <emphasis>et al.</emphasis> 2003 SA node cell mathematical model. Unique to the SA node cells are the acetylecholine-activated K<superscript>+</superscript> current, I<subscript>KACh</subscript>, the hyperpolarisation-activated cation current, I<subscript>ha</subscript>, and the sustained inward current I<subscript>st</subscript>.</caption>
</informalfigure>
<informalfigure float="0" id="fig_reaction_kinetics">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction kinetics diagram</title>
</objectinfo>
<imagedata fileref="matsuoka_3_2003.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the reaction kinetics of the ion channel gates in the Matsuoka <emphasis>et al.</emphasis> 2003 mathematical models. A) The kinetics of the sodium channel voltage-dependent gate. B) The kinetics of the Na-Ca exchange pump. C) The kinetics of the Na-K pump. D) The kinetics of the inward rectifier K<superscript>+</superscript> current. E) The kinetics of the Ca<superscript>2+</superscript>-dependent gate of the L-type Ca<superscript>2+</superscript> channel. F) The kinetics of the ultra-slow gates of several ion channels. G) The kinetics of the SR Ca<superscript>2+</superscript> pump. H) The kinetics of the hyperpolarisation-activated cation current. I) The kinetics of the RyR channel in the SR.</caption>
</informalfigure>
</sect1>
</article>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>CF_K</ci>
<piecewise>
<piece>
<ci>Ki</ci>
<apply>
<eq/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>Ko</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="ATP_production">
<variable initial_value="4.929308214702568" name="ATPi" public_interface="out" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="dATPdt_NL" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Vi" public_interface="in" units="micrometre3"/>
<variable name="i_NaK" public_interface="in" units="picoA"/>
<variable name="i_SR_U" public_interface="in" units="picoA"/>
<variable initial_value="0.003" name="ProducingRate_Max" units="per_millisecond"/>
<variable initial_value="5" name="Adenosine_Total" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATPi</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>ProducingRate_Max</ci>
<apply>
<minus/>
<ci>Adenosine_Total</ci>
<ci>ATPi</ci>
</apply>
</apply>
<ci>dATPdt_NL</ci>
</apply>
<apply>
<divide/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>F</ci>
<ci>Vi</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>i_SR_U</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>F</ci>
<ci>Vi</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current">
<variable cmeta:id="sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA"/>
<variable name="i_Na_Na" public_interface="out" units="picoA"/>
<variable name="i_Na_K" public_interface="out" units="picoA"/>
<variable initial_value="12" name="P_Na" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="p_AP_Na" private_interface="in" units="dimensionless"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<plus/>
<ci>i_Na_Na</ci>
<ci>i_Na_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_Na</ci>
<apply>
<times/>
<ci>P_Na</ci>
<ci>CF_Na</ci>
<ci>p_AP_Na</ci>
<ci>y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
<ci>P_Na</ci>
<ci>CF_K</ci>
<ci>p_AP_Na</ci>
<ci>y</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_voltage_dependent_gate">
<variable initial_value="5.9898633533987405e-5" name="p_AP_Na" public_interface="out" units="dimensionless"/>
<variable name="p_RI_Na" units="dimensionless"/>
<variable initial_value="2.2262336890623873e-4" name="p_RP_Na" units="dimensionless"/>
<variable initial_value="0.9715915109181413" name="p_AI_Na" units="dimensionless"/>
<variable name="k_RP_AP" units="per_millisecond"/>
<variable name="k_AP_RP" units="per_millisecond"/>
<variable name="k_RI_AI" units="per_millisecond"/>
<variable name="k_AI_RI" units="per_millisecond"/>
<variable name="k_AP_AI" units="per_millisecond"/>
<variable initial_value="8.75e-5" name="k_AI_AP" units="per_millisecond"/>
<variable name="k_RP_RI" units="per_millisecond"/>
<variable name="k_RI_RP" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_RP_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_AP_Na</ci>
<ci>k_AP_RP</ci>
</apply>
<apply>
<times/>
<ci>p_RI_Na</ci>
<ci>k_RI_RP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_RP_Na</ci>
<apply>
<plus/>
<ci>k_RP_RI</ci>
<ci>k_RP_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AP_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RP_Na</ci>
<ci>k_RP_AP</ci>
</apply>
<apply>
<times/>
<ci>p_AI_Na</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AP_Na</ci>
<apply>
<plus/>
<ci>k_AP_RP</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AI_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RI_Na</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>p_AP_Na</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AI_Na</ci>
<apply>
<plus/>
<ci>k_AI_RI</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_RI_Na</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_RP_Na</ci>
</apply>
<ci>p_AP_Na</ci>
</apply>
<ci>p_AI_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_AP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_RP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">26</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AI_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1300</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.04</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_AI_AP</ci>
<ci>k_AP_RP</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>k_AP_AI</ci>
<ci>k_RP_AP</ci>
<ci>k_AI_RI</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_RP</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
<ci>k_RP_RI</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_ultra_slow_gate">
<variable initial_value="0.02691630436856424" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9000000000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.014</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4000</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA"/>
<variable name="i_CaL_Na" public_interface="out" units="picoA"/>
<variable name="i_CaL_Ca" public_interface="out" units="picoA"/>
<variable name="i_CaL_K" public_interface="out" units="picoA"/>
<variable name="p_open_CaL" private_interface="out" public_interface="out" units="dimensionless"/>
<variable name="CaDiadic" private_interface="in" public_interface="out" units="picoA"/>
<variable initial_value="2112" name="P_CaL" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_Ca" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="p_AP_CaL" private_interface="in" units="dimensionless"/>
<variable name="p_U" private_interface="in" units="dimensionless"/>
<variable name="p_UCa" private_interface="in" units="dimensionless"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<plus/>
<ci>i_CaL_Na</ci>
<ci>i_CaL_Ca</ci>
<ci>i_CaL_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca</ci>
<apply>
<times/>
<ci>P_CaL</ci>
<ci>CF_Ca</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0000185</cn>
<ci>P_CaL</ci>
<ci>CF_Na</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000365</cn>
<ci>P_CaL</ci>
<ci>CF_K</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open_CaL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<apply>
<plus/>
<ci>p_U</ci>
<ci>p_UCa</ci>
</apply>
<ci>y</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1.4</cn>
<ci>ATPi</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_voltage_dependent_gate">
<variable initial_value="0.010773205742759775" name="p_AP_CaL" public_interface="out" units="dimensionless"/>
<variable name="p_RI_CaL" units="dimensionless"/>
<variable initial_value="0.42833044151885075" name="p_RP_CaL" units="dimensionless"/>
<variable initial_value="0.5607106503080197" name="p_AI_CaL" units="dimensionless"/>
<variable name="k_RP_AP" units="per_millisecond"/>
<variable name="k_AP_RP" units="per_millisecond"/>
<variable name="k_RI_AI" units="per_millisecond"/>
<variable name="k_AI_RI" units="per_millisecond"/>
<variable initial_value="0.004" name="k_AP_AI" units="per_millisecond"/>
<variable initial_value="0.001" name="k_AI_AP" units="per_millisecond"/>
<variable name="k_RP_RI" units="per_millisecond"/>
<variable name="k_RI_RP" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_RP_CaL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<ci>k_AP_RP</ci>
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<apply>
<times/>
<ci>p_RI_CaL</ci>
<ci>k_RI_RP</ci>
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<apply>
<times/>
<ci>p_RP_CaL</ci>
<apply>
<plus/>
<ci>k_RP_RI</ci>
<ci>k_RP_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AP_CaL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RP_CaL</ci>
<ci>k_RP_AP</ci>
</apply>
<apply>
<times/>
<ci>p_AI_CaL</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<apply>
<plus/>
<ci>k_AP_RP</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AI_CaL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RI_CaL</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AI_CaL</ci>
<apply>
<plus/>
<ci>k_AI_RI</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_RI_CaL</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_AP_CaL</ci>
</apply>
<ci>p_RP_CaL</ci>
</apply>
<ci>p_AI_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_AP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.27</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<apply>
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<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_RP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">480</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
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</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0018</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AI_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2200000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_AI_AP</ci>
<ci>k_AP_RP</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>k_AP_AI</ci>
<ci>k_RP_AP</ci>
<ci>k_AI_RI</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_RP</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
<ci>k_RP_RI</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_Ca_dependent_gate">
<variable initial_value="0.018412749759150325" name="p_U" public_interface="out" units="dimensionless"/>
<variable initial_value="2.0870506374005444e-4" name="p_UCa" public_interface="out" units="dimensionless"/>
<variable name="iCaL" units="picoA"/>
<variable name="Cacm" units="millimolar"/>
<variable name="p_CCa" units="dimensionless"/>
<variable initial_value="0.05040310692927668" name="p_C" units="dimensionless"/>
<variable initial_value="0.0003" name="k_CCa_UCa" units="per_millisecond"/>
<variable initial_value="0.35" name="k_UCa_CCa" units="per_millisecond"/>
<variable initial_value="0.143" name="k_C_U" units="per_millisecond"/>
<variable initial_value="0.35" name="k_U_C" units="per_millisecond"/>
<variable name="k_UCa_U" units="per_millisecond"/>
<variable initial_value="6.954" name="k_U_UCa" units="per_millimolar_millisecond"/>
<variable initial_value="0.0042" name="k_CCa_C" units="per_millisecond"/>
<variable initial_value="6.954" name="k_C_CCa" units="per_millimolar_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<variable name="p_AP_CaL" public_interface="in" units="dimensionless"/>
<variable name="CaEffC" units="millimolar"/>
<variable name="CaEffU" units="millimolar"/>
<variable name="k_UUCa_Ca" units="per_millisecond"/>
<variable name="k_CCCa_Ca" units="per_millisecond"/>
<variable name="CaDiadic" public_interface="out" units="picoA"/>
<variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>iCaL</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picoA_per_millimolar">0.0676</cn>
<ci>CF_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CaDiadic</ci>
<apply>
<times/>
<ci>iCaL</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Cacm</ci>
<apply>
<minus/>
<ci>Cai</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar_per_picoA">0.3</cn>
<ci>iCaL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaEffC</ci>
<apply>
<times/>
<ci>Cacm</ci>
<ci>p_AP_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CaEffU</ci>
<apply>
<plus/>
<ci>CaEffC</ci>
<apply>
<times/>
<ci>Cai</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_AP_CaL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_UUCa_Ca</ci>
<apply>
<times/>
<ci>k_U_UCa</ci>
<ci>CaEffU</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_CCCa_Ca</ci>
<apply>
<times/>
<ci>k_C_CCa</ci>
<ci>CaEffC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_U</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_C</ci>
<ci>k_C_U</ci>
</apply>
<apply>
<times/>
<ci>p_UCa</ci>
<ci>k_UCa_U</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_U</ci>
<apply>
<plus/>
<ci>k_UUCa_Ca</ci>
<ci>k_U_C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_UCa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_U</ci>
<ci>k_UUCa_Ca</ci>
</apply>
<apply>
<times/>
<ci>p_CCa</ci>
<ci>k_CCa_UCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_UCa</ci>
<apply>
<plus/>
<ci>k_UCa_CCa</ci>
<ci>k_UCa_U</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_C</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_CCa</ci>
<ci>k_CCa_C</ci>
</apply>
<apply>
<times/>
<ci>p_U</ci>
<ci>k_U_C</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_C</ci>
<apply>
<plus/>
<ci>k_C_U</ci>
<apply>
<times/>
<ci>k_C_CCa</ci>
<ci>Cacm</ci>
<ci>p_AP_CaL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CCa</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_C</ci>
</apply>
<ci>p_U</ci>
</apply>
<ci>p_UCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_UCa_U</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_CCa_C</ci>
<ci>k_C_U</ci>
<ci>k_U_UCa</ci>
<ci>k_UCa_CCa</ci>
</apply>
<apply>
<times/>
<ci>k_U_C</ci>
<ci>k_C_CCa</ci>
<ci>k_CCa_UCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_ultra_slow_gate">
<variable initial_value="0.8256168329801671" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">250000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">58</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1800</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">66</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel">
<variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="picoA"/>
<variable initial_value="612" name="P_CaT" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_T</ci>
<apply>
<times/>
<ci>P_CaT</ci>
<ci>CF_Ca</ci>
<ci>y1</ci>
<ci>y2</ci>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_y1_gate">
<variable initial_value="0.04679297803939428" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.019</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.6</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">250</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">40</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_y2_gate">
<variable initial_value="0.004220636800632867" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">62000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.1</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">30</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0006</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.7</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="st_channel">
<variable cmeta:id="st_channel_i_st" name="i_st" public_interface="out" units="picoA"/>
<variable name="i_st_Na" public_interface="out" units="picoA"/>
<variable name="i_st_K" public_interface="out" units="picoA"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<variable name="y3" private_interface="in" units="dimensionless"/>
<variable initial_value="0.236" name="P_st_Na" units="picoA_per_millimolar"/>
<variable initial_value="0.138" name="P_st_K" units="picoA_per_millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_st</ci>
<apply>
<plus/>
<ci>i_st_Na</ci>
<ci>i_st_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_st_Na</ci>
<apply>
<times/>
<ci>P_st_Na</ci>
<ci>CF_Na</ci>
<ci>y1</ci>
<ci>y2</ci>
<ci>y3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_st_K</ci>
<apply>
<times/>
<ci>P_st_K</ci>
<ci>CF_K</ci>
<ci>y1</ci>
<ci>y2</ci>
<ci>y3</ci>
</apply>
</apply>
</math>
</component>
<component name="st_channel_y1_gate">
<variable initial_value="0.5375825176280309" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">700</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">16</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">15</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="st_channel_y2_gate">
<variable initial_value="0.3404904569858008" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3100</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">700</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">95</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">50</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">700</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millimolar_millisecond">2.5</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="st_channel_y3_gate">
<variable initial_value="0.5596860236041188" name="y3" public_interface="out" units="dimensionless"/>
<variable name="alpha_y3" units="per_millisecond"/>
<variable name="beta_y3" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">400000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">60</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">700</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">60</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y3</ci>
<ci>y3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ha_channel">
<variable cmeta:id="ha_channel_i_ha" name="i_ha" public_interface="out" units="picoA"/>
<variable name="i_ha_Na" public_interface="out" units="picoA"/>
<variable name="i_ha_K" public_interface="out" units="picoA"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="C1" private_interface="in" units="dimensionless"/>
<variable name="C2" private_interface="in" units="dimensionless"/>
<variable initial_value="1.821" name="P_ha_Na" units="picoA_per_millimolar"/>
<variable initial_value="7.7286" name="P_ha_K" units="picoA_per_millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ha</ci>
<apply>
<plus/>
<ci>i_ha_Na</ci>
<ci>i_ha_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ha_Na</ci>
<apply>
<times/>
<ci>P_ha_Na</ci>
<ci>CF_Na</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>C1</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ha_K</ci>
<apply>
<times/>
<ci>P_ha_K</ci>
<ci>CF_K</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>C1</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ha_channel_voltage_dependent_gate">
<variable initial_value="7.531035735927369e-7" name="O1" units="dimensionless"/>
<variable initial_value="1.1957124194086763e-8" name="O2" units="dimensionless"/>
<variable name="O3" units="dimensionless"/>
<variable initial_value="0.9999616586460943" name="C1" public_interface="out" units="dimensionless"/>
<variable initial_value="3.757612529902994e-5" name="C2" public_interface="out" units="dimensionless"/>
<variable name="alpha" units="per_millisecond"/>
<variable name="beta" units="per_millisecond"/>
<variable name="mu" units="per_millisecond"/>
<variable name="lambda" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>beta</ci>
<ci>O2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha</ci>
<ci>beta</ci>
</apply>
<ci>O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>O1</ci>
</apply>
<apply>
<times/>
<ci>beta</ci>
<ci>O3</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha</ci>
<ci>beta</ci>
</apply>
<ci>O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>lambda</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>mu</ci>
<ci>C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>mu</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>beta</ci>
<ci>O1</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha</ci>
<ci>lambda</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O3</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>C1</ci>
</apply>
<ci>C2</ci>
</apply>
<ci>O1</ci>
</apply>
<ci>O2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3500</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45000000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">500</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">200</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>lambda</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.4</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA"/>
<variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
<variable name="g_K1" units="nanoS"/>
<variable initial_value="0.003125" name="P_K1_0" units="nanoS_per_picoF"/>
<variable name="fO" private_interface="out" units="dimensionless"/>
<variable name="fO2" units="dimensionless"/>
<variable name="fO3" units="dimensionless"/>
<variable name="fO4" units="dimensionless"/>
<variable name="fB" units="dimensionless"/>
<variable name="mu" units="per_millisecond"/>
<variable name="lambda" units="per_millisecond"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<ci>fO4</ci>
<ci>fO3</ci>
<ci>fO2</ci>
</apply>
<ci>y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>g_K1</ci>
<apply>
<times/>
<ci>P_K1_0</ci>
<ci>Cm</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fB</ci>
<apply>
<divide/>
<ci>mu</ci>
<apply>
<plus/>
<ci>mu</ci>
<ci>lambda</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO</ci>
<apply>
<divide/>
<ci>lambda</ci>
<apply>
<plus/>
<ci>mu</ci>
<ci>lambda</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>fB</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO3</ci>
<apply>
<times/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>fB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fO4</ci>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>mu</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.75</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.035</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.015</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">140</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>lambda</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.048</cn>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.064</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current_y_gate">
<variable initial_value="0.54434573606543" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="fO" public_interface="in" units="dimensionless"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00014</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.1</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">500</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current">
<variable cmeta:id="rapid_time_dependent_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA"/>
<variable name="g_Kr" units="nanoS"/>
<variable initial_value="0.1045" name="P_Kr" units="nanoS_per_picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="E_K" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<variable name="y3" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
<ci>y1</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
<ci>y2</ci>
</apply>
</apply>
<ci>y3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>g_Kr</ci>
<apply>
<times/>
<ci>P_Kr</ci>
<ci>Cm</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y1_gate">
<variable initial_value="0.7520936568166604" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">160</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2500</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y2_gate">
<variable initial_value="0.6128486629679218" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1600</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y3_gate">
<variable initial_value="0.6786243213825371" name="y3" public_interface="out" units="dimensionless"/>
<variable name="alpha_y3" units="per_millisecond"/>
<variable name="beta_y3" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.35</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y3</ci>
<ci>y3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ACh_dependent_potassium_current">
<variable cmeta:id="ACh_dependent_potassium_current_i_KACh" name="i_KACh" public_interface="out" units="picoA"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<variable initial_value="4.32" name="g_ACh" units="nanoS"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KACh</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_ACh</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
<ci>y</ci>
</apply>
</apply>
</math>
</component>
<component name="ACh_dependent_potassium_current_y_gate">
<variable initial_value="0.018249236601344903" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable initial_value="0" name="ACh" units="millimolar"/>
<variable initial_value="0.0042" name="Km_ACh" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0002475</cn>
<apply>
<eq/>
<ci>ACh</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01232</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_ACh</ci>
<ci>ACh</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0002475</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0133</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_NSC_current">
<variable cmeta:id="background_NSC_current_i_bNSC" name="i_bNSC" public_interface="out" units="picoA"/>
<variable name="i_bNSC_Na" public_interface="out" units="picoA"/>
<variable name="i_bNSC_K" public_interface="out" units="picoA"/>
<variable initial_value="0.152" name="P_bNSC" units="picoA_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_bNSC</ci>
<apply>
<plus/>
<ci>i_bNSC_K</ci>
<ci>i_bNSC_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_bNSC_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
<ci>P_bNSC</ci>
<ci>CF_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_bNSC_Na</ci>
<apply>
<times/>
<ci>P_bNSC</ci>
<ci>CF_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="background_Kpl_current">
<variable cmeta:id="background_Kpl_current_i_Kpl" name="i_Kpl" public_interface="out" units="picoA"/>
<variable name="P_Kpl" units="nanoS_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kpl</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>P_Kpl</ci>
<ci>CF_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.0077</cn>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Kpl</ci>
<ci>CF_K</ci>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>P_Kpl</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoS_per_millimolar">0.007</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.16</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_lCa_current">
<variable name="i_lCa" public_interface="out" units="picoA"/>
<variable name="i_lCa_Na" public_interface="out" units="picoA"/>
<variable name="i_lCa_K" public_interface="out" units="picoA"/>
<variable initial_value="0.44" name="P_lCa" units="picoA_per_millimolar"/>
<variable name="p_open" units="dimensionless"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_lCa</ci>
<apply>
<plus/>
<ci>i_lCa_K</ci>
<ci>i_lCa_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_lCa_K</ci>
<apply>
<times/>
<ci>P_lCa</ci>
<ci>CF_K</ci>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_lCa_Na</ci>
<apply>
<times/>
<ci>P_lCa</ci>
<ci>CF_Na</ci>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0012</cn>
<ci>Cai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_KATP_current">
<variable cmeta:id="background_KATP_current_i_KATP" name="i_KATP" public_interface="out" units="picoA"/>
<variable name="p_open" units="dimensionless"/>
<variable name="gamma" units="nanoS"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable initial_value="0.0236" name="P_KATP" units="nanoS_per_picoF"/>
<variable initial_value="1000" name="N" units="picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KATP</ci>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<ci>P_KATP</ci>
<ci>N</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.24</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>ATPi</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_Cab_current">
<variable cmeta:id="background_Cab_current_i_Cab" name="i_Cab" public_interface="out" units="picoA"/>
<variable initial_value="0.008" name="P_Cab" units="picoA_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>P_Cab</ci>
<ci>CF_Ca</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger">
<variable cmeta:id="sodium_calcium_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="picoA"/>
<variable name="p_E2Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
<variable name="k1" private_interface="out" units="per_millisecond"/>
<variable name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="8.75" name="Km_Nai" units="millimolar"/>
<variable initial_value="87.5" name="Km_Nao" units="millimolar"/>
<variable initial_value="0.00138" name="Km_Cai" units="millimolar"/>
<variable initial_value="1.38" name="Km_Cao" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Cao" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<variable initial_value="6.81" name="P_NaCa" units="picoA_per_picoF"/>
<variable initial_value="0.32" name="Partition" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<ci>P_NaCa</ci>
<ci>Cm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Km_Cai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nao</ci>
<ci>Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Km_Cao</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Km_Cai</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Km_Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Km_Cao</ci>
<ci>Cao</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Km_Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Partition</ci>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Partition</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger_y_gate">
<variable initial_value="0.9218642754061908" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Na" public_interface="in" units="dimensionless"/>
<variable name="p_E2Na" public_interface="in" units="dimensionless"/>
<variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="picoA"/>
<variable name="p_E2Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1K" private_interface="out" units="dimensionless"/>
<variable name="p_E2K" private_interface="out" units="dimensionless"/>
<variable name="k1" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.04" name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.01" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.165" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="4.05" name="Km_Nai" units="millimolar"/>
<variable initial_value="69.8" name="Km_Nao" units="millimolar"/>
<variable initial_value="32.88" name="Km_Ki" units="millimolar"/>
<variable initial_value="0.258" name="Km_Ko" units="millimolar"/>
<variable initial_value="0.094" name="Km_ATP" units="millimolar"/>
<variable name="Nao_Eff" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<variable initial_value="21" name="P_NaK" units="picoA_per_picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Cm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ki</ci>
<ci>Km_Ki</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nao</ci>
<ci>Nao_Eff</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1K</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Ki</ci>
<ci>Ki</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Km_Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2K</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Ko</ci>
<ci>Ko</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nao_Eff</ci>
<ci>Km_Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.37</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_ATP</ci>
<ci>ATPi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Nao_Eff</ci>
<apply>
<times/>
<ci>Nao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_y_gate">
<variable initial_value="0.6755031143352256" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Na" public_interface="in" units="dimensionless"/>
<variable name="p_E2Na" public_interface="in" units="dimensionless"/>
<variable name="p_E1K" public_interface="in" units="dimensionless"/>
<variable name="p_E2K" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_calcium_pump">
<variable name="i_SR_U" public_interface="out" units="picoA"/>
<variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E1" private_interface="out" units="dimensionless"/>
<variable name="p_E2" private_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="k1" private_interface="out" units="per_millisecond"/>
<variable name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.01" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.08" name="Km_CaSR" units="millimolar"/>
<variable initial_value="0.0008" name="Km_CaCyto" units="millimolar"/>
<variable initial_value="0.1" name="Km_ATP" units="millimolar"/>
<variable initial_value="4875" name="i_max" units="picoA"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_U</ci>
<apply>
<times/>
<ci>i_max</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Ca</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Ca</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_CaSR</ci>
<ci>Caup</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_CaCyto</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_E1Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_E2Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_ATP</ci>
<ci>ATPi</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_calcium_pump_y_gate">
<variable initial_value="0.8709732600283433" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E1" public_interface="in" units="dimensionless"/>
<variable name="p_E2" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Ca</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Ca</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RyR_channel">
<variable cmeta:id="RyR_channel_i_RyR" name="i_RyR" public_interface="out" units="picoA"/>
<variable initial_value="1860" name="P_RyR" units="picoA_per_millimolar"/>
<variable name="k1" units="per_millisecond"/>
<variable name="k2" units="per_millisecond"/>
<variable name="k3" units="per_millisecond"/>
<variable initial_value="0.000849" name="k4" units="per_millisecond"/>
<variable initial_value="0.011424172905335395" name="p_open_RyR" units="dimensionless"/>
<variable initial_value="0.007354039651246729" name="p_close_RyR" units="dimensionless"/>
<variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Carel" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable initial_value="-3" name="Diadid_Factor" units="per_picoA_millisecond"/>
<variable name="CaDiadic" public_interface="in" units="picoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_RyR</ci>
<apply>
<times/>
<ci>P_RyR</ci>
<apply>
<minus/>
<ci>Carel</ci>
<ci>Cai</ci>
</apply>
<ci>p_open_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_open_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>p_close_RyR</ci>
<ci>k1</ci>
</apply>
<apply>
<times/>
<ci>p_open_RyR</ci>
<ci>k2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_close_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>p_open_RyR</ci>
<ci>p_close_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>k1</ci>
<ci>k4</ci>
</apply>
<ci>p_close_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">280000</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Diadid_Factor</ci>
<ci>CaDiadic</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.36</cn>
<ci>Carel</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000377</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Carel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_T_current">
<variable name="i_SR_T" public_interface="out" units="picoA"/>
<variable initial_value="11.58" name="P_SR_T" units="picoA_per_millimolar"/>
<variable name="Carel" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_T</ci>
<apply>
<times/>
<ci>P_SR_T</ci>
<apply>
<minus/>
<ci>Caup</ci>
<ci>Carel</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_L_current">
<variable name="i_SR_L" public_interface="out" units="picoA"/>
<variable initial_value="13.77" name="P_SR_L" units="picoA_per_millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_L</ci>
<apply>
<times/>
<ci>P_SR_L</ci>
<apply>
<minus/>
<ci>Caup</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_concentrations_in_SR">
<variable initial_value="5.185011336959393" name="Ca_Total" units="millimolar"/>
<variable name="Carel" public_interface="out" units="millimolar"/>
<variable cmeta:id="Ca_concentrations_in_SR_Caup" initial_value="3.539652240305415" name="Caup" public_interface="out" units="millimolar"/>
<variable initial_value="1.50795" name="V_rel" units="micrometre3"/>
<variable initial_value="3.769875" name="V_up" units="micrometre3"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="i_SR_L" public_interface="in" units="picoA"/>
<variable name="i_SR_T" public_interface="in" units="picoA"/>
<variable name="i_RyR" public_interface="in" units="picoA"/>
<variable name="i_SR_U" public_interface="in" units="picoA"/>
<variable initial_value="10" name="CSQN_max" units="millimolar"/>
<variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
<variable name="b1" units="millimolar"/>
<variable name="c1" units="millimolar2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>b1</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>CSQN_max</ci>
<ci>Ca_Total</ci>
</apply>
<ci>K_mCSQN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>c1</ci>
<apply>
<times/>
<ci>K_mCSQN</ci>
<ci>Ca_Total</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Carel</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>b1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>c1</ci>
</apply>
</apply>
</apply>
<ci>b1</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Total</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>i_SR_T</ci>
<ci>i_RyR</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Caup</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>i_SR_U</ci>
</apply>
<ci>i_SR_T</ci>
</apply>
<ci>i_SR_L</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NL_model">
<variable name="dCaidt" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="dATPdt" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="EffFraction" units="dimensionless"/>
<variable initial_value="0.24298053499618683" name="pCa" units="dimensionless"/>
<variable initial_value="0.02896443650702234" name="pCaCB" units="dimensionless"/>
<variable initial_value="0.0020275353474589783" name="pCB" units="dimensionless"/>
<variable name="p" units="dimensionless"/>
<variable initial_value="0.007" name="T_t" units="millimolar"/>
<variable name="Q_a" units="per_millisecond"/>
<variable name="Q_b" units="per_millisecond"/>
<variable name="Q_r" units="per_millisecond"/>
<variable name="Q_d" units="per_millisecond"/>
<variable name="Q_d1" units="per_millisecond"/>
<variable name="Q_d2" units="per_millisecond"/>
<variable initial_value="39" name="Y_1" units="per_millimolar_millisecond"/>
<variable initial_value="0.0039" name="Y_2" units="per_millisecond"/>
<variable initial_value="0.03" name="Y_3" units="per_millisecond"/>
<variable initial_value="0.12" name="Y_4" units="per_millisecond"/>
<variable initial_value="0.027" name="Y_d" units="millisecond_per_micrometre2"/>
<variable initial_value="0.03" name="Z_1" units="per_millisecond"/>
<variable initial_value="0.0039" name="Z_2" units="per_millisecond"/>
<variable initial_value="1560" name="Z_3" units="per_millimolar_millisecond"/>
<variable name="h" units="micrometre"/>
<variable initial_value="1.17" name="L_a" units="micrometre"/>
<variable initial_value="0.9602399999150041" name="L" units="micrometre"/>
<variable name="ForceCB" units="mN_per_mm2"/>
<variable initial_value="0.9552449999150041" name="X" units="micrometre"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="NewCBF" units="mN_per_mm2_micrometre"/>
<variable name="CBBound" units="millimolar"/>
<variable initial_value="140000" name="KForceEC" units="mN_per_mm2_micrometre5"/>
<variable initial_value="0.97" name="ZeroForceEL" units="micrometre"/>
<variable initial_value="200" name="KForceLinearEc" units="mN_per_mm2_micrometre"/>
<variable initial_value="1800000" name="ForceFactor" units="mN_per_mm2_micrometre_millimolar"/>
<variable name="ForceEcomp" units="mN_per_mm2"/>
<variable initial_value="1.2" name="B" units="per_millisecond"/>
<variable initial_value="0.005" name="h_c" units="micrometre"/>
<variable name="ForceExt" units="mN_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h</ci>
<apply>
<minus/>
<ci>L</ci>
<ci>X</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>pCa</ci>
</apply>
<ci>pCaCB</ci>
</apply>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_b</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_1</ci>
<ci>Cai</ci>
<ci>p</ci>
</apply>
<apply>
<times/>
<ci>Z_1</ci>
<ci>pCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EffFraction</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_micrometre2">20</cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<ci>L</ci>
<ci>L_a</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_a</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_2</ci>
<ci>pCa</ci>
<ci>EffFraction</ci>
</apply>
<apply>
<times/>
<ci>Z_2</ci>
<ci>pCaCB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_r</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_3</ci>
<ci>pCaCB</ci>
</apply>
<apply>
<times/>
<ci>Z_3</ci>
<ci>pCB</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d</ci>
<apply>
<times/>
<ci>Y_4</ci>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d1</ci>
<apply>
<times/>
<ci>Y_d</ci>
<apply>
<power/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d2</ci>
<apply>
<times/>
<ci>Y_d</ci>
<apply>
<power/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>pCaCB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCa</ci>
</apply>
<apply>
<minus/>
<ci>Q_b</ci>
<ci>Q_a</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCaCB</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>Q_a</ci>
<ci>Q_r</ci>
</apply>
<ci>Q_d2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCB</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>Q_r</ci>
<ci>Q_d</ci>
</apply>
<ci>Q_d1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCaidt</ci>
<apply>
<times/>
<ci>T_t</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Q_d2</ci>
<ci>Q_r</ci>
</apply>
<ci>Q_b</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dATPdt</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.4</cn>
</apply>
<ci>pCaCB</ci>
<ci>T_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CBBound</ci>
<apply>
<times/>
<ci>T_t</ci>
<apply>
<plus/>
<ci>pCaCB</ci>
<ci>pCB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NewCBF</ci>
<apply>
<times/>
<ci>ForceFactor</ci>
<ci>CBBound</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceEcomp</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KForceEC</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>ZeroForceEL</ci>
<ci>L</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
</apply>
</apply>
<apply>
<times/>
<ci>KForceLinearEc</ci>
<apply>
<minus/>
<ci>ZeroForceEL</ci>
<ci>L</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceCB</ci>
<apply>
<times/>
<ci>NewCBF</ci>
<ci>h</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceExt</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>ForceEcomp</ci>
</apply>
<ci>ForceCB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<apply>
<times/>
<ci>B</ci>
<apply>
<minus/>
<ci>h</ci>
<ci>h_c</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="internal_concentrations"/>
<component name="intracellular_currents"/>
<component name="transmembrane_currents"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="internal_concentrations">
<component_ref component="internal_ion_concentrations"/>
<component_ref component="Ca_concentrations_in_SR"/>
<component_ref component="constant_field_equations"/>
<component_ref component="ATP_production"/>
<component_ref component="NL_model"/>
</component_ref>
<component_ref component="transmembrane_currents">
<component_ref component="sodium_current">
<component_ref component="sodium_current_voltage_dependent_gate"/>
<component_ref component="sodium_current_ultra_slow_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
<component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
<component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_y1_gate"/>
<component_ref component="T_type_Ca_channel_y2_gate"/>
</component_ref>
<component_ref component="st_channel">
<component_ref component="st_channel_y1_gate"/>
<component_ref component="st_channel_y2_gate"/>
<component_ref component="st_channel_y3_gate"/>
</component_ref>
<component_ref component="ha_channel">
<component_ref component="ha_channel_voltage_dependent_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
</component_ref>
<component_ref component="ACh_dependent_potassium_current">
<component_ref component="ACh_dependent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="background_NSC_current"/>
<component_ref component="background_Kpl_current"/>
<component_ref component="background_lCa_current"/>
<component_ref component="background_Cab_current"/>
<component_ref component="background_KATP_current"/>
<component_ref component="sodium_calcium_exchanger">
<component_ref component="sodium_calcium_exchanger_y_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump">
<component_ref component="sodium_potassium_pump_y_gate"/>
</component_ref>
</component_ref>
<component_ref component="intracellular_currents">
<component_ref component="SR_calcium_pump">
<component_ref component="SR_calcium_pump_y_gate"/>
</component_ref>
<component_ref component="RyR_channel"/>
<component_ref component="SR_T_current"/>
<component_ref component="SR_L_current"/>
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_voltage_dependent_gate"/>
<component_ref component="sodium_current_ultra_slow_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
<component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
<component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_y1_gate"/>
<component_ref component="T_type_Ca_channel_y2_gate"/>
</component_ref>
<component_ref component="st_channel">
<component_ref component="st_channel_y1_gate"/>
<component_ref component="st_channel_y2_gate"/>
<component_ref component="st_channel_y3_gate"/>
</component_ref>
<component_ref component="ha_channel">
<component_ref component="ha_channel_voltage_dependent_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
</component_ref>
<component_ref component="ACh_dependent_potassium_current">
<component_ref component="ACh_dependent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="sodium_calcium_exchanger">
<component_ref component="sodium_calcium_exchanger_y_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump">
<component_ref component="sodium_potassium_pump_y_gate"/>
</component_ref>
<component_ref component="SR_calcium_pump">
<component_ref component="SR_calcium_pump_y_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="st_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ha_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_T_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_L_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ACh_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_NSC_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_Kpl_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_lCa_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_KATP_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_Cab_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="RyR_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="NL_model" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="internal_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="constant_field_equations"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ATP_production"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_Ca_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="st_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_st" variable_2="i_st"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ha_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_ha" variable_2="i_ha"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ACh_dependent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="i_KACh" variable_2="i_KACh"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_NSC_current"/>
<map_variables variable_1="i_bNSC" variable_2="i_bNSC"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_Kpl_current"/>
<map_variables variable_1="i_Kpl" variable_2="i_Kpl"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_lCa_current"/>
<map_variables variable_1="i_lCa" variable_2="i_lCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_KATP_current"/>
<map_variables variable_1="i_KATP" variable_2="i_KATP"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_Cab_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_concentrations_in_SR"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="constant_field_equations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="NL_model"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="dCaidt_NL" variable_2="dCaidt"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="constant_field_equations"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="time_independent_potassium_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="background_Kpl_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="background_KATP_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_lCa_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_lCa_Na" variable_2="i_lCa_Na"/>
<map_variables variable_1="i_lCa_K" variable_2="i_lCa_K"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="SR_calcium_pump"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_SR_U" variable_2="i_SR_U"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="RyR_channel"/>
<map_variables variable_1="i_RyR" variable_2="i_RyR"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="SR_L_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_SR_L" variable_2="i_SR_L"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="sodium_current"/>
<map_variables variable_1="i_Na_Na" variable_2="i_Na_Na"/>
<map_variables variable_1="i_Na_K" variable_2="i_Na_K"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="L_type_Ca_channel"/>
<map_variables variable_1="i_CaL_Na" variable_2="i_CaL_Na"/>
<map_variables variable_1="i_CaL_Ca" variable_2="i_CaL_Ca"/>
<map_variables variable_1="i_CaL_K" variable_2="i_CaL_K"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="T_type_Ca_channel"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="st_channel"/>
<map_variables variable_1="i_st_Na" variable_2="i_st_Na"/>
<map_variables variable_1="i_st_K" variable_2="i_st_K"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="ha_channel"/>
<map_variables variable_1="i_ha_Na" variable_2="i_ha_Na"/>
<map_variables variable_1="i_ha_K" variable_2="i_ha_K"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="time_independent_potassium_current"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="ACh_dependent_potassium_current"/>
<map_variables variable_1="i_KACh" variable_2="i_KACh"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_NSC_current"/>
<map_variables variable_1="i_bNSC" variable_2="i_bNSC"/>
<map_variables variable_1="i_bNSC_Na" variable_2="i_bNSC_Na"/>
<map_variables variable_1="i_bNSC_K" variable_2="i_bNSC_K"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_Kpl_current"/>
<map_variables variable_1="i_Kpl" variable_2="i_Kpl"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_KATP_current"/>
<map_variables variable_1="i_KATP" variable_2="i_KATP"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_Cab_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="sodium_current"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="L_type_Ca_channel"/>
<map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="T_type_Ca_channel"/>
<map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="st_channel"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="ha_channel"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="background_NSC_current"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="background_Kpl_current"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="background_lCa_current"/>
<map_variables variable_1="CF_Na" variable_2="CF_Na"/>
<map_variables variable_1="CF_K" variable_2="CF_K"/>
</connection>
<connection>
<map_components component_1="constant_field_equations" component_2="background_Cab_current"/>
<map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="NL_model"/>
<map_variables variable_1="dATPdt_NL" variable_2="dATPdt"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="L_type_Ca_channel"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="background_KATP_current"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="sodium_potassium_pump"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="SR_calcium_pump"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
<map_variables variable_1="i_SR_U" variable_2="i_SR_U"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="internal_ion_concentrations"/>
<map_variables variable_1="Vi" variable_2="Vi"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="ACh_dependent_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="background_KATP_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="SR_calcium_pump"/>
<map_variables variable_1="Caup" variable_2="Caup"/>
<map_variables variable_1="i_SR_U" variable_2="i_SR_U"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="RyR_channel"/>
<map_variables variable_1="p_open_CaL" variable_2="p_open_CaL"/>
<map_variables variable_1="CaDiadic" variable_2="CaDiadic"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="RyR_channel"/>
<map_variables variable_1="Carel" variable_2="Carel"/>
<map_variables variable_1="i_RyR" variable_2="i_RyR"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="SR_T_current"/>
<map_variables variable_1="Caup" variable_2="Caup"/>
<map_variables variable_1="Carel" variable_2="Carel"/>
<map_variables variable_1="i_SR_T" variable_2="i_SR_T"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="SR_L_current"/>
<map_variables variable_1="Caup" variable_2="Caup"/>
<map_variables variable_1="i_SR_L" variable_2="i_SR_L"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_voltage_dependent_gate"/>
<map_variables variable_1="p_AP_Na" variable_2="p_AP_Na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_ultra_slow_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_voltage_dependent_gate"/>
<map_variables variable_1="p_AP_CaL" variable_2="p_AP_CaL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel_Ca_dependent_gate" component_2="L_type_Ca_channel_voltage_dependent_gate"/>
<map_variables variable_1="p_AP_CaL" variable_2="p_AP_CaL"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_Ca_dependent_gate"/>
<map_variables variable_1="p_U" variable_2="p_U"/>
<map_variables variable_1="p_UCa" variable_2="p_UCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CF_Ca" variable_2="CF_Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="CaDiadic" variable_2="CaDiadic"/>
<map_variables variable_1="p_open_CaL" variable_2="p_open_CaL"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_ultra_slow_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_y1_gate"/>
<map_variables variable_1="y1" variable_2="y1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_y2_gate"/>
<map_variables variable_1="y2" variable_2="y2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="st_channel" component_2="st_channel_y1_gate"/>
<map_variables variable_1="y1" variable_2="y1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="st_channel" component_2="st_channel_y2_gate"/>
<map_variables variable_1="y2" variable_2="y2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="st_channel" component_2="st_channel_y3_gate"/>
<map_variables variable_1="y3" variable_2="y3"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="ha_channel" component_2="ha_channel_voltage_dependent_gate"/>
<map_variables variable_1="C1" variable_2="C1"/>
<map_variables variable_1="C2" variable_2="C2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_y_gate"/>
<map_variables variable_1="fO" variable_2="fO"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="rapid_time_dependent_potassium_current" component_2="rapid_time_dependent_potassium_current_y1_gate"/>
<map_variables variable_1="y1" variable_2="y1"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="rapid_time_dependent_potassium_current" component_2="rapid_time_dependent_potassium_current_y2_gate"/>
<map_variables variable_1="y2" variable_2="y2"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="rapid_time_dependent_potassium_current" component_2="rapid_time_dependent_potassium_current_y3_gate"/>
<map_variables variable_1="y3" variable_2="y3"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="ACh_dependent_potassium_current" component_2="ACh_dependent_potassium_current_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="sodium_calcium_exchanger_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="p_E1Na" variable_2="p_E1Na"/>
<map_variables variable_1="p_E2Na" variable_2="p_E2Na"/>
<map_variables variable_1="p_E1Ca" variable_2="p_E1Ca"/>
<map_variables variable_1="p_E2Ca" variable_2="p_E2Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="k1" variable_2="k1"/>
<map_variables variable_1="k2" variable_2="k2"/>
<map_variables variable_1="k3" variable_2="k3"/>
<map_variables variable_1="k4" variable_2="k4"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="sodium_potassium_pump_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="p_E1Na" variable_2="p_E1Na"/>
<map_variables variable_1="p_E2Na" variable_2="p_E2Na"/>
<map_variables variable_1="p_E1K" variable_2="p_E1K"/>
<map_variables variable_1="p_E2K" variable_2="p_E2K"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="k1" variable_2="k1"/>
<map_variables variable_1="k2" variable_2="k2"/>
<map_variables variable_1="k3" variable_2="k3"/>
<map_variables variable_1="k4" variable_2="k4"/>
</connection>
<connection>
<map_components component_1="SR_calcium_pump" component_2="SR_calcium_pump_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="p_E1" variable_2="p_E1"/>
<map_variables variable_1="p_E2" variable_2="p_E2"/>
<map_variables variable_1="p_E1Ca" variable_2="p_E1Ca"/>
<map_variables variable_1="p_E2Ca" variable_2="p_E2Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="k1" variable_2="k1"/>
<map_variables variable_1="k2" variable_2="k2"/>
<map_variables variable_1="k3" variable_2="k3"/>
<map_variables variable_1="k4" variable_2="k4"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#6e5f5a9b-c3ae-47af-a0f2-e891f93882c9"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="rdf:#a801e602-f130-4b7d-96cd-2cac6dca8bfc"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Kyoichi</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Ono</Family></rdf:Description><rdf:Description rdf:about="rdf:#60bc95b4-fb7c-496f-a1b7-9dd972fbb269"><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#20dc1a9e-ff85-4f4c-bcd5-23e8643e087b"/></Journal><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">134</last_page><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#8b6d74c8-2998-4853-b5e6-5dbbf0d5adf2"/></issued><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">125</first_page><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Role of individual ionic current systems in the SA node hypothesized by a model study</title><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#9823d0a5-b70f-4482-8a2d-3e421b1c751a"/></creator><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">53</volume></rdf:Description><rdf:Description rdf:about="rdf:#de1723bc-3f17-4b69-90c0-b782e1534431"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"/><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Alan</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Garny</Family></rdf:Description><rdf:Description rdf:about="rdf:#8e31f3d8-5606-4e07-a3a6-744826a1558c"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#5a599278-11a0-48a1-a704-34325018a51a"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#367ff835-464e-4b22-821a-1e57a17193ce"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Satoshi</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Matsuoka</Family></rdf:Description><rdf:Description rdf:about="rdf:#6eec5db2-3068-4e26-9d4b-4c2595eb58a5"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#daa5fe56-d897-4ee3-a596-5d67df892feb"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n1"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n2"/></boundIntervals></rdf:Description><rdf:Description rdf:nodeID="n3"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n4"/></subject></rdf:Description><rdf:Description rdf:nodeID="n5"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type><rdf:_2 xml:lang="en">electrophysiology</rdf:_2><rdf:_3 xml:lang="en">Sinoatrial Node</rdf:_3><rdf:_1 xml:lang="en">cardiac</rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#46258b39-d69c-401f-a9bd-7e8cbf75855f"><rdf:value xml:lang="en">This model has been curated and unit checked by Alan Garny in collaboration with the model authors and it is known to run in COR to reproduce the published results.</rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#6e5f5a9b-c3ae-47af-a0f2-e891f93882c9"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#daa5fe56-d897-4ee3-a596-5d67df892feb"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Shinobu</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Kuratomi</Family></rdf:Description><rdf:Description rdf:nodeID="n4"><rdf:value><rdf:Description rdf:nodeID="n5"/></rdf:value><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type></rdf:Description><rdf:Description rdf:about="rdf:#d948840d-91dc-4ecf-aa56-32d131a16e08"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#bc7b3242-ab7a-4258-ada1-a3c3e0d4b52a"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#9823d0a5-b70f-4482-8a2d-3e421b1c751a"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_5><rdf:Description rdf:about="rdf:#8e31f3d8-5606-4e07-a3a6-744826a1558c"/></rdf:_5><rdf:_4><rdf:Description rdf:about="rdf:#5a59f5d0-da3f-4d81-b2cc-dc417c3a127c"/></rdf:_4><rdf:_2><rdf:Description rdf:about="rdf:#72a398f8-31b6-4185-bbf7-590ac5a409a5"/></rdf:_2><rdf:_3><rdf:Description rdf:about="rdf:#6eec5db2-3068-4e26-9d4b-4c2595eb58a5"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#d948840d-91dc-4ecf-aa56-32d131a16e08"/></rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#3345c4e1-0139-471d-930d-db4cf451afe5"><rdf:value xml:lang="en">alan.garny@dpag.ox.ac.uk</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#5a599278-11a0-48a1-a704-34325018a51a"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Akinori</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Noma</Family></rdf:Description><rdf:Description rdf:about="rdf:#f08edf10-6424-4e21-8b2d-9843ba28aac4"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">University of Oxford</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"/></rdf:Description><rdf:Description rdf:about="rdf:#065a75f4-4177-43af-90b1-c9674c3da294"><N 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xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#50983908-da88-4d81-9bdb-c74304de3160"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#de1723bc-3f17-4b69-90c0-b782e1534431"/></N><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#f08edf10-6424-4e21-8b2d-9843ba28aac4"/></ORG><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#3345c4e1-0139-471d-930d-db4cf451afe5"/></EMAIL></rdf:Description><rdf:Description rdf:about="rdf:#2977acf1-7221-4043-9e08-b53f0d2b15bc"><rdf:value xml:lang="en">Worked with the original model authors and used their source code to get the CellML version of the model running to recreate the published results.</rdf:value><modified xmlns="http://purl.org/dc/terms/"><rdf:Description 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rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest></rdf:Description><rdf:Description rdf:about="rdf:#de8cde51-f104-40f0-a2be-b2c06b9c9a88"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"/></rdf:Description><rdf:Description rdf:about="rdf:#bc7b3242-ab7a-4258-ada1-a3c3e0d4b52a"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Nobuaki</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Sarai</Family></rdf:Description><rdf:Description rdf:about=""><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#53e38f0d-973f-4108-84f9-b72c20ca785e"/></created><cmeta:comment><rdf:Description rdf:about="rdf:#46258b39-d69c-401f-a9bd-7e8cbf75855f"/></cmeta:comment><cmeta:modification><rdf:Description rdf:about="rdf:#2977acf1-7221-4043-9e08-b53f0d2b15bc"/></cmeta:modification><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description 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