rate of the F1F0 ATP synthase catalysed reaction
JF1F0
S
Dan
Luciani
rate of calcium flux out of the endoplasmic reticulum
Jer
mitochondrial inner membrane potential
delta_psi
ATPm
mitochondrial ATP
This is a CellML description of Bertram et al.'s 2007 mathematical model of the interaction between glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
JNaCa
calcium flux out of the mitochondria into the cytosol through the sodium-calcium ion exchanger
Jmem
rate of calcium flux across the plasma membrane
JGPDH
rate of the glyceride 3-P dehydrogenase reaction
JO
rate of oxygen consumption at the final stage of the electron transport chain
2007-11-01T17:17:08+13:00
Satin
S
Leslie
JHleak
proton leakage into the mitochodria down the proton gradient
JHres
flux through respiration-driven proton pumps
Bertram et al.'s 2007 mathematical model of the interaction between glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
mitochondrial NAD
NADm
calcium-activated potassium current
Ikca
Richard
Bertram
mitochondrial NADH
NADHm
keyword
cytosolic ATP
atp
Catherine
Lloyd
May
glucose 6-phosphate
G6P
17172305
Ica
voltage-dependent calcium current
Richard
Lawson
James
n
voltage-dependent potassium current n gate
rate of ATP-driven proton flux
rate of the glucokinase reaction
JGK
JHatp
JSERCA
rate of calcium flux into the endoplasmic reticulum through the SERCA pumps
Catherine
Lloyd
May
voltage-dependent calcium current m gate
m
The University of Auckland
The Bioengineering Institute
Jleak
rate of calcium leakage out of the endoplasmic reticulum
Updated curation status
endocrine
metabolism
pancreatic beta cell
glycolysis
mitochondria
insulin
rate of ADP and ATP flux through the adenine nucleotide translocator
JANT
rate of the phosphofructokinase reaction
JPFK
JPDH
rate of the pyruvate dehydrogenase reaction
This CellML model has been coded by translating the authors original XPPAUT .ode file, which can be found at http://www.math.fsu.edu/~bertram/software/islet/BJ_07/mitophan.ode . The model runs in PCEnv and is able to produce the published results. The parameters have been chosen to recreate the bursting behaviour seen in figures 3 and 4 of the original paper.
adp
cytosolic ADP concentration
Caer
calcium
The University of Auckland, Bioengineering Institute
2007-03-01
2007-08-08T00:00:00+00:00
Sherman
Arthur
100000
10
Morten
Pedersen
Gram
Juni
calcium flux into the mitochondria through a calcium uniporter
c.lloyd@auckland.ac.nz
600000
1555
1544
92
Intra- and inter-islet synchronization of metabolically driven insulin secretion
Ik
voltage-dependent potassium current
Cam
mitochondrial calcium concentration
Model has been fixed such that it now recreates the published results. This required a slight deviation from the equations in the published paper and the author's original .ODE code was used instead.
Biophysical Journal
fructose 1-6-bisphosphate
FBP
ADPm
mitochondrial ADP
c
cytosolic calcium
Jhyd
cytosolic hydrolysis of ATP
2009-05-15T16:19:11+12:00
fructose 6-phosphate
F6P
Catherine Lloyd
Ikatp
ATP-sensitive potassium current
Catherine Lloyd