Rendering of the source text

<?xml version="1.0"?>
<!--
This CellML file was generated on 27/08/2008 at 13:48:41 using:

COR (0.9.31.1027)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="stewart_2009" name="stewart_2009">

<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <author>
    <firstname>Penny</firstname>
          <surname>Noble</surname>
    <affiliation>
      <shortaffil>DPAG, University of Oxford</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
        This CellML version of the model has been checked in COR and OpenCell.  The units are consistent and the model runs to recreate the published results.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
In the paper described here, Philip Stewart and colleagues present a details of their newly developed model for the human Purkinje cell including validation against experimental data. Ionic mechanisms underlying the heterogeneity between
the Purkinje fibre and ventricular action potentials in humans and other species
were analysed. The newly developed Purkinje fibre cell model adds a new member
to the family of human cardiac cell models developed previously for the sino-atrial
node, atrial and ventricular cells, which can be incorporated into an anatomical
model of human heart with details of its electrophysiological heterogeneity and
anatomical complexity.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Mathematical models of the electrical action potential of Purkinje fibre cells, Philip Stewart, Oleg V. Aslanidi, Denis Noble, Penelope J. Noble, Mark R. Boyett, and Henggui Zhang, 2009, <emphasis>Philosophical Transactions of the Royal Society</emphasis>, 367, 2225-2255.  
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/19414454">PubMed ID: 19414454</ulink>

</para>
				
				<informalfigure float="0" id="fig_cell_diagram">
					<mediaobject>
						<imageobject>
							<imagedata fileref="stewart_2009.png"/>
						</imageobject>
					</mediaobject>
					<caption>A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Stewart et al. 2009 mathematical model of the human Purkinje fibres.</caption>
				</informalfigure>

</sect1>
</article>
</documentation> 


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         </apply>
         <apply>
            <eq/>
            <ci>beta_xr1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <ci>alpha_xr1</ci>
               <ci>beta_xr1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Xr1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr1_inf</ci>
                  <ci>Xr1</ci>
               </apply>
               <ci>tau_xr1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_time_dependent_potassium_current_Xr2_gate">
      <variable initial_value="0.313213286437995" name="Xr2" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="xr2_inf" units="dimensionless"/>
      <variable name="alpha_xr2" units="dimensionless"/>
      <variable name="beta_xr2" units="dimensionless"/>
      <variable name="tau_xr2" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr2_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">88</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_xr2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xr2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <ci>alpha_xr2</ci>
               <ci>beta_xr2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Xr2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr2_inf</ci>
                  <ci>Xr2</ci>
               </apply>
               <ci>tau_xr2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_time_dependent_potassium_current">
      <variable cmeta:id="slow_time_dependent_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.2352" name="g_Ks" units="nanoS_per_picoF"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Xs" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <apply>
                  <power/>
                  <ci>Xs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_time_dependent_potassium_current_Xs_gate">
      <variable initial_value="0.00953708522974789" name="Xs" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="xs_inf" units="dimensionless"/>
      <variable name="alpha_xs" units="dimensionless"/>
      <variable name="beta_xs" units="dimensionless"/>
      <variable name="tau_xs" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_xs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1400</cn>
               <apply>
                  <root/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                  <ci>alpha_xs</ci>
                  <ci>beta_xs</ci>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">80</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Xs</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs_inf</ci>
                  <ci>Xs</ci>
               </apply>
               <ci>tau_xs</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current">
      <variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="130.5744" name="g_Na" units="nanoS_per_picoF"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <variable name="j" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <ci>j</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_m_gate">
      <variable initial_value="0.0417391656294997" name="m" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="m_inf" units="dimensionless"/>
      <variable name="alpha_m" units="dimensionless"/>
      <variable name="beta_m" units="dimensionless"/>
      <variable name="tau_m" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>m_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">56.86</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.03</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">200</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <ci>alpha_m</ci>
               <ci>beta_m</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_inf</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_h_gate">
      <variable initial_value="0.190678733735145" name="h" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="h_inf" units="dimensionless"/>
      <variable name="alpha_h" units="per_millisecond"/>
      <variable name="beta_h" units="per_millisecond"/>
      <variable name="tau_h" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.55</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.43</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.057</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">2.7</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.3485</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.77</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.13</cn>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_h</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_h</ci>
                  <ci>beta_h</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_inf</ci>
                  <ci>h</ci>
               </apply>
               <ci>tau_h</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_j_gate">
      <variable initial_value="0.238219836154029" name="j" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="j_inf" units="dimensionless"/>
      <variable name="alpha_j" units="per_millisecond"/>
      <variable name="beta_j" units="per_millisecond"/>
      <variable name="tau_j" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>j_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.55</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.43</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">25428</cn>
                                 </apply>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millisecond">6.948   <sep/>
                                 -6</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.02424</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.6</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.057</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_j</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_j</ci>
                  <ci>beta_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>j_inf</ci>
                  <ci>j</ci>
               </apply>
               <ci>tau_j</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_b_Na" name="i_b_Na" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.00029" name="g_bna" units="nanoS_per_picoF"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_b_Na</ci>
            <apply>
               <times/>
               <ci>g_bna</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_current">
      <variable cmeta:id="L_type_Ca_current_i_CaL" name="i_CaL" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="3.98e-5" name="g_CaL" units="litre_per_farad_second"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_ss" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="d" private_interface="in" public_interface="out" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f2" private_interface="in" units="dimensionless"/>
      <variable name="fCass" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>g_CaL</ci>
                        <ci>d</ci>
                        <ci>f</ci>
                        <ci>f2</ci>
                        <ci>fCass</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
                        <ci>Ca_ss</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                                 </apply>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Ca_o</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                           </apply>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_current_d_gate">
      <variable initial_value="0.000287906256206415" name="d" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="d_inf" units="dimensionless"/>
      <variable name="alpha_d" units="dimensionless"/>
      <variable name="beta_d" units="dimensionless"/>
      <variable name="gamma_d" units="millisecond"/>
      <variable name="tau_d" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>d_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma_d</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                  <ci>alpha_d</ci>
                  <ci>beta_d</ci>
               </apply>
               <ci>gamma_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_inf</ci>
                  <ci>d</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_current_f_gate">
      <variable initial_value="0.989328560287987" name="f" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="f_inf" units="dimensionless"/>
      <variable name="tau_f" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1102.5</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">27</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_square">225</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">200</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">180</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">20</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_inf</ci>
                  <ci>f</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_current_f2_gate">
      <variable initial_value="0.995474890442185" name="f2" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="f2_inf" units="dimensionless"/>
      <variable name="tau_f2" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f2_inf</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.67</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.33</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">562</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">27</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_square">240</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">31</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">80</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f2_inf</ci>
                  <ci>f2</ci>
               </apply>
               <ci>tau_f2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_current_fCass_gate">
      <variable initial_value="0.999955429598213" name="fCass" public_interface="out" units="dimensionless"/>
      <variable name="Ca_ss" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="fCass_inf" units="dimensionless"/>
      <variable name="tau_fCass" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fCass_inf</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Ca_ss</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.05</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_fCass</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">80</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Ca_ss</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.05</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCass</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>fCass_inf</ci>
                  <ci>fCass</ci>
               </apply>
               <ci>tau_fCass</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_b_Ca" name="i_b_Ca" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.000592" name="g_bca" units="nanoS_per_picoF"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_b_Ca</ci>
            <apply>
               <times/>
               <ci>g_bca</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable cmeta:id="transient_outward_current_i_to" name="i_to" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.08184" name="g_to" units="nanoS_per_picoF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="s" private_interface="in" units="dimensionless"/>
      <variable name="r" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <ci>r</ci>
               <ci>s</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_s_gate">
      <variable initial_value="0.96386101799501" name="s" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="s_inf" units="dimensionless"/>
      <variable name="tau_s" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>s_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">27</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_s</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">85</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_square">320</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">5</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">42</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>s</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>s_inf</ci>
                  <ci>s</ci>
               </apply>
               <ci>tau_s</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_r_gate">
      <variable initial_value="0.00103618091196912" name="r" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="r_inf" units="dimensionless"/>
      <variable name="tau_r" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>r_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_r</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">10.45</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_square">1800</cn>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">7.3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>r</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>r_inf</ci>
                  <ci>r</ci>
               </apply>
               <ci>tau_r</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sustained_outward_current">
      <variable cmeta:id="sustained_outward_current_i_sus" name="i_sus" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.0227" name="g_sus" units="nanoS_per_picoF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="a" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_sus</ci>
            <apply>
               <times/>
               <ci>g_sus</ci>
               <ci>a</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump_current">
      <variable cmeta:id="sodium_potassium_pump_current_i_NaK" name="i_NaK" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="2.724" name="P_NaK" units="picoA_per_picoF"/>
      <variable initial_value="1" name="K_mk" units="millimolar"/>
      <variable initial_value="40" name="K_mNa" units="millimolar"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>P_NaK</ci>
                           <ci>K_o</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>K_o</ci>
                           <ci>K_mk</ci>
                        </apply>
                     </apply>
                     <ci>Na_i</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>Na_i</ci>
                     <ci>K_mNa</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0353</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchanger_current">
      <variable cmeta:id="sodium_calcium_exchanger_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="1000" name="K_NaCa" units="picoA_per_picoF"/>
      <variable initial_value="0.1" name="K_sat" units="dimensionless"/>
      <variable initial_value="2.5" name="alpha" units="dimensionless"/>
      <variable initial_value="0.35" name="gamma" units="dimensionless"/>
      <variable initial_value="1.38" name="Km_Ca" units="millimolar"/>
      <variable initial_value="87.5" name="Km_Nai" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>K_NaCa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>gamma</ci>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_i</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Ca_o</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_o</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Ca_i</ci>
                        <ci>alpha</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <power/>
                        <ci>Km_Nai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Na_o</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>Km_Ca</ci>
                     <ci>Ca_o</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>K_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_pump_current">
      <variable cmeta:id="calcium_pump_current_i_p_Ca" name="i_p_Ca" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.1238" name="g_pCa" units="picoA_per_picoF"/>
      <variable initial_value="0.0005" name="K_pCa" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>g_pCa</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ca_i</ci>
                  <ci>K_pCa</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="potassium_pump_current">
      <variable cmeta:id="potassium_pump_current_i_p_K" name="i_p_K" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.0146" name="g_pK" units="nanoS_per_picoF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>g_pK</ci>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_dynamics">
      <variable initial_value="0.000101878186157052" name="Ca_i" public_interface="out" units="millimolar"/>
      <variable initial_value="2" name="Ca_o" public_interface="out" units="millimolar"/>
      <variable initial_value="3.10836886659417" name="Ca_SR" units="millimolar"/>
      <variable initial_value="0.000446818714055411" name="Ca_ss" public_interface="out" units="millimolar"/>
      <variable name="i_rel" units="millimolar_per_millisecond"/>
      <variable name="i_up" units="millimolar_per_millisecond"/>
      <variable name="i_leak" units="millimolar_per_millisecond"/>
      <variable name="i_xfer" units="millimolar_per_millisecond"/>
      <variable name="O" units="dimensionless"/>
      <variable initial_value="0.991580051907845" name="R_prime" units="dimensionless"/>
      <variable name="k1" units="per_millimolar2_per_millisecond"/>
      <variable name="k2" units="per_millimolar_per_millisecond"/>
      <variable initial_value="0.15" name="k1_prime" units="per_millimolar2_per_millisecond"/>
      <variable initial_value="0.045" name="k2_prime" units="per_millimolar_per_millisecond"/>
      <variable initial_value="0.06" name="k3" units="per_millisecond"/>
      <variable initial_value="0.005" name="k4" units="per_millisecond"/>
      <variable initial_value="1.5" name="EC" units="millimolar"/>
      <variable initial_value="2.5" name="max_sr" units="dimensionless"/>
      <variable initial_value="1" name="min_sr" units="dimensionless"/>
      <variable name="kcasr" units="dimensionless"/>
      <variable initial_value="0.102" name="V_rel" units="per_millisecond"/>
      <variable initial_value="0.0038" name="V_xfer" units="per_millisecond"/>
      <variable initial_value="0.00025" name="K_up" units="millimolar"/>
      <variable initial_value="0.00036" name="V_leak" units="per_millisecond"/>
      <variable initial_value="0.006375" name="Vmax_up" units="millimolar_per_millisecond"/>
      <variable name="Ca_i_bufc" units="dimensionless"/>
      <variable name="Ca_sr_bufsr" units="dimensionless"/>
      <variable name="Ca_ss_bufss" units="dimensionless"/>
      <variable initial_value="0.2" name="Buf_c" units="millimolar"/>
      <variable initial_value="0.001" name="K_buf_c" units="millimolar"/>
      <variable initial_value="10" name="Buf_sr" units="millimolar"/>
      <variable initial_value="0.3" name="K_buf_sr" units="millimolar"/>
      <variable initial_value="0.4" name="Buf_ss" units="millimolar"/>
      <variable initial_value="0.00025" name="K_buf_ss" units="millimolar"/>
      <variable initial_value="0.001094" name="V_sr" units="micrometre3"/>
      <variable initial_value="5.468e-5" name="V_ss" units="micrometre3"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="V_c" public_interface="in" units="micrometre3"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="d" public_interface="in" units="dimensionless"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cm" public_interface="in" units="microF"/>
      <variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_p_Ca" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_b_Ca" public_interface="in" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_rel</ci>
            <apply>
               <times/>
               <ci>V_rel</ci>
               <ci>O</ci>
               <apply>
                  <minus/>
                  <ci>Ca_SR</ci>
                  <ci>Ca_ss</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <ci>Vmax_up</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <ci>K_up</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Ca_i</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>V_leak</ci>
               <apply>
                  <minus/>
                  <ci>Ca_SR</ci>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_xfer</ci>
            <apply>
               <times/>
               <ci>V_xfer</ci>
               <apply>
                  <minus/>
                  <ci>Ca_ss</ci>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>O</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>k1</ci>
                  <apply>
                     <power/>
                     <ci>Ca_ss</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <ci>R_prime</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>k3</ci>
                  <apply>
                     <times/>
                     <ci>k1</ci>
                     <apply>
                        <power/>
                        <ci>Ca_ss</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>R_prime</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>k2</ci>
                  </apply>
                  <ci>Ca_ss</ci>
                  <ci>R_prime</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k4</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>R_prime</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k1</ci>
            <apply>
               <divide/>
               <ci>k1_prime</ci>
               <ci>kcasr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k2</ci>
            <apply>
               <times/>
               <ci>k2_prime</ci>
               <ci>kcasr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kcasr</ci>
            <apply>
               <minus/>
               <ci>max_sr</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>max_sr</ci>
                     <ci>min_sr</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>EC</ci>
                           <ci>Ca_SR</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_i_bufc</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Buf_c</ci>
                        <ci>K_buf_c</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Ca_i</ci>
                           <ci>K_buf_c</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_sr_bufsr</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Buf_sr</ci>
                        <ci>K_buf_sr</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Ca_SR</ci>
                           <ci>K_buf_sr</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_ss_bufss</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Buf_ss</ci>
                        <ci>K_buf_ss</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Ca_ss</ci>
                           <ci>K_buf_ss</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_i</ci>
            </apply>
            <apply>
               <times/>
               <ci>Ca_i_bufc</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>i_leak</ci>
                              <ci>i_up</ci>
                           </apply>
                           <ci>V_sr</ci>
                        </apply>
                        <ci>V_c</ci>
                     </apply>
                     <ci>i_xfer</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_pA">1</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>i_b_Ca</ci>
                              <ci>i_p_Ca</ci>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>i_NaCa</ci>
                           </apply>
                        </apply>
                        <ci>Cm</ci>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                        <ci>V_c</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SR</ci>
            </apply>
            <apply>
               <times/>
               <ci>Ca_sr_bufsr</ci>
               <apply>
                  <minus/>
                  <ci>i_up</ci>
                  <apply>
                     <plus/>
                     <ci>i_rel</ci>
                     <ci>i_leak</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_ss</ci>
            </apply>
            <apply>
               <times/>
               <ci>Ca_ss_bufss</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_pA">1</cn>
                           </apply>
                           <ci>i_CaL</ci>
                           <ci>Cm</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                           <ci>V_ss</ci>
                           <ci>F</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>i_rel</ci>
                           <ci>V_sr</ci>
                        </apply>
                        <ci>V_ss</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_xfer</ci>
                        <ci>V_c</ci>
                     </apply>
                     <ci>V_ss</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_dynamics">
      <variable initial_value="8.80420286531673" name="Na_i" public_interface="out" units="millimolar"/>
      <variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cm" public_interface="in" units="microF"/>
      <variable name="V_c" public_interface="in" units="micrometre3"/>
      <variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_b_Na" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_f_Na" public_interface="in" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_pA">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_b_Na</ci>
                        <ci>i_f_Na</ci>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                     <ci>V_c</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <ci>Cm</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="potassium_dynamics">
      <variable initial_value="136.781894160227" name="K_i" public_interface="out" units="millimolar"/>
      <variable initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cm" public_interface="in" units="microF"/>
      <variable name="V_c" public_interface="in" units="micrometre3"/>
      <variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_to" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_sus" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_p_K" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_f_K" public_interface="in" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>K_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_pA">1</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>i_K1</ci>
                           <ci>i_to</ci>
                           <ci>i_f_K</ci>
                           <ci>i_sus</ci>
                           <ci>i_Kr</ci>
                           <ci>i_Ks</ci>
                           <ci>i_p_K</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>i_NaK</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
                     <ci>V_c</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <ci>Cm</ci>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="fast_sodium_current">
            <component_ref component="fast_sodium_current_m_gate"/>
            <component_ref component="fast_sodium_current_h_gate"/>
            <component_ref component="fast_sodium_current_j_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_current">
            <component_ref component="L_type_Ca_current_d_gate"/>
            <component_ref component="L_type_Ca_current_f_gate"/>
            <component_ref component="L_type_Ca_current_f2_gate"/>
            <component_ref component="L_type_Ca_current_fCass_gate"/>
         </component_ref>
         <component_ref component="inward_rectifier_potassium_current"/>
         <component_ref component="rapid_time_dependent_potassium_current">
            <component_ref component="rapid_time_dependent_potassium_current_Xr1_gate"/>
            <component_ref component="rapid_time_dependent_potassium_current_Xr2_gate"/>
         </component_ref>
         <component_ref component="slow_time_dependent_potassium_current">
            <component_ref component="slow_time_dependent_potassium_current_Xs_gate"/>
         </component_ref>
         <component_ref component="sodium_background_current"/>
         <component_ref component="calcium_background_current"/>
         <component_ref component="transient_outward_current">
            <component_ref component="transient_outward_current_s_gate"/>
            <component_ref component="transient_outward_current_r_gate"/>
         </component_ref>
         <component_ref component="hyperpolarization_activated_current">
            <component_ref component="hyperpolarization_activated_current_y_gate"/>
         </component_ref>
         <component_ref component="sustained_outward_current"/>
         <component_ref component="sodium_potassium_pump_current"/>
         <component_ref component="sodium_calcium_exchanger_current"/>
         <component_ref component="calcium_pump_current"/>
         <component_ref component="potassium_pump_current"/>
         <component_ref component="calcium_dynamics"/>
         <component_ref component="sodium_dynamics"/>
         <component_ref component="potassium_dynamics"/>
         <component_ref component="reversal_potentials"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_current">
         <component_ref component="L_type_Ca_current_d_gate"/>
         <component_ref component="L_type_Ca_current_f_gate"/>
         <component_ref component="L_type_Ca_current_f2_gate"/>
         <component_ref component="L_type_Ca_current_fCass_gate"/>
      </component_ref>
      <component_ref component="rapid_time_dependent_potassium_current">
         <component_ref component="rapid_time_dependent_potassium_current_Xr1_gate"/>
         <component_ref component="rapid_time_dependent_potassium_current_Xr2_gate"/>
      </component_ref>
      <component_ref component="slow_time_dependent_potassium_current">
         <component_ref component="slow_time_dependent_potassium_current_Xs_gate"/>
      </component_ref>
      <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_s_gate"/>
         <component_ref component="transient_outward_current_r_gate"/>
      </component_ref>
      <component_ref component="hyperpolarization_activated_current">
         <component_ref component="hyperpolarization_activated_current_y_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarization_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_time_dependent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_time_dependent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="inward_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_background_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_calcium_exchanger_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="potassium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="reversal_potentials"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="hyperpolarization_activated_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_f" variable_2="i_f"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_time_dependent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_time_dependent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="transient_outward_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sustained_outward_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_sus" variable_2="i_sus"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="inward_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_calcium_exchanger_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_pump_current"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="potassium_pump_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_p_K" variable_2="i_p_K"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_dynamics"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="V_c" variable_2="V_c"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_dynamics"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="V_c" variable_2="V_c"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="potassium_dynamics"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="V_c" variable_2="V_c"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="hyperpolarization_activated_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="sodium_background_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="inward_rectifier_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="rapid_time_dependent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="transient_outward_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="sustained_outward_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="potassium_pump_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="slow_time_dependent_potassium_current"/>
      <map_variables variable_1="E_Ks" variable_2="E_Ks"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="calcium_background_current"/>
      <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="fast_sodium_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="calcium_dynamics"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="potassium_dynamics"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
   </connection>
   <connection>
      <map_components component_1="reversal_potentials" component_2="sodium_dynamics"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarization_activated_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_f_K" variable_2="i_f_K"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarization_activated_current" component_2="sodium_dynamics"/>
      <map_variables variable_1="i_f_Na" variable_2="i_f_Na"/>
   </connection>
   <connection>
      <map_components component_1="inward_rectifier_potassium_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="rapid_time_dependent_potassium_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="slow_time_dependent_potassium_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="sodium_dynamics"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="sodium_background_current" component_2="sodium_dynamics"/>
      <map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
      <map_variables variable_1="d" variable_2="d"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
   </connection>
   <connection>
      <map_components component_1="calcium_pump_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump_current" component_2="sodium_dynamics"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
   </connection>
   <connection>
      <map_components component_1="sodium_calcium_exchanger_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
   </connection>
   <connection>
      <map_components component_1="sodium_calcium_exchanger_current" component_2="sodium_dynamics"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarization_activated_current" component_2="hyperpolarization_activated_current_y_gate"/>
      <map_variables variable_1="y" variable_2="y"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_time_dependent_potassium_current" component_2="rapid_time_dependent_potassium_current_Xr1_gate"/>
      <map_variables variable_1="Xr1" variable_2="Xr1"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_time_dependent_potassium_current" component_2="rapid_time_dependent_potassium_current_Xr2_gate"/>
      <map_variables variable_1="Xr2" variable_2="Xr2"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="slow_time_dependent_potassium_current" component_2="slow_time_dependent_potassium_current_Xs_gate"/>
      <map_variables variable_1="Xs" variable_2="Xs"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="L_type_Ca_current_d_gate"/>
      <map_variables variable_1="d" variable_2="d"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="L_type_Ca_current_f_gate"/>
      <map_variables variable_1="f" variable_2="f"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="L_type_Ca_current_f2_gate"/>
      <map_variables variable_1="f2" variable_2="f2"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_current" component_2="L_type_Ca_current_fCass_gate"/>
      <map_variables variable_1="fCass" variable_2="fCass"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="transient_outward_current_s_gate"/>
      <map_variables variable_1="s" variable_2="s"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="transient_outward_current_r_gate"/>
      <map_variables variable_1="r" variable_2="r"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="sustained_outward_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_sus" variable_2="i_sus"/>
   </connection>
   <connection>
      <map_components component_1="potassium_pump_current" component_2="potassium_dynamics"/>
      <map_variables variable_1="i_p_K" variable_2="i_p_K"/>
   </connection>

   
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