/* There are a total of 5 entries in the algebraic variable array. There are a total of 2 entries in each of the rate and state variable arrays. There are a total of 17 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is x1 in component x1 (picomole). * CONSTANTS[14] is k in component k (flux). * ALGEBRAIC[4] is lambda_Ca in component lambda_Ca (per_minute). * CONSTANTS[0] is lambda1 in component model_parameters (per_minute). * CONSTANTS[15] is A in component A (per_minute). * CONSTANTS[16] is B in component B (per_minute). * ALGEBRAIC[1] is Ca in component Ca (millimolar). * ALGEBRAIC[3] is S in component S (millimolar). * ALGEBRAIC[2] is m_Ca in component m_Ca (dimensionless). * CONSTANTS[1] is m1 in component model_parameters (dimensionless). * CONSTANTS[2] is m2 in component model_parameters (dimensionless). * CONSTANTS[3] is beta in component model_parameters (litre_per_millimole). * CONSTANTS[4] is R in component model_parameters (millimolar). * STATES[1] is x2 in component x2 (picomole). * ALGEBRAIC[0] is PTH in component x2 (picomole). * CONSTANTS[5] is lambda2 in component model_parameters (per_minute). * CONSTANTS[6] is Ca_0 in component model_parameters (millimolar). * CONSTANTS[7] is Ca_1 in component model_parameters (millimolar). * CONSTANTS[8] is alpha in component model_parameters (per_minute). * CONSTANTS[9] is t0 in component model_parameters (minute). * CONSTANTS[10] is x1_n in component model_parameters (picomole). * CONSTANTS[11] is x2_n in component model_parameters (picomole). * CONSTANTS[12] is x2_max in component model_parameters (picomole). * CONSTANTS[13] is x2_min in component model_parameters (picomole). * RATES[0] is d/dt x1 in component x1 (picomole). * RATES[1] is d/dt x2 in component x2 (picomole). * There are a total of 1 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.00; CONSTANTS[0] = 0.0125; CONSTANTS[1] = 112.5200; CONSTANTS[2] = 15.00; CONSTANTS[3] = 1e6; CONSTANTS[4] = 1.2162; STATES[1] = 0.00; CONSTANTS[5] = 0.5595; CONSTANTS[6] = 1.255; CONSTANTS[7] = 0.1817; CONSTANTS[8] = 0.0442; CONSTANTS[9] = 575.0; CONSTANTS[10] = 490.7800; CONSTANTS[11] = 6.6290; CONSTANTS[12] = 14.0430; CONSTANTS[13] = 0.6697; CONSTANTS[14] = CONSTANTS[5]*CONSTANTS[11]+ CONSTANTS[0]*CONSTANTS[10]; CONSTANTS[15] = ( CONSTANTS[0]*CONSTANTS[5]*CONSTANTS[12])/(CONSTANTS[14] - CONSTANTS[5]*CONSTANTS[12]); CONSTANTS[16] = ( CONSTANTS[0]*CONSTANTS[5]*CONSTANTS[13])/(CONSTANTS[14] - CONSTANTS[5]*CONSTANTS[13]); RATES[0] = 0.1001; RATES[1] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - CONSTANTS[14] - ( ALGEBRAIC[4]*STATES[0]+ CONSTANTS[0]*STATES[0]); resid[1] = RATES[1] - ALGEBRAIC[4]*STATES[0] - CONSTANTS[5]*STATES[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[1]/2.75000; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = (CONDVAR[0]<0.00000 ? CONSTANTS[6] : CONSTANTS[6] - CONSTANTS[7]*(1.00000 - exp( - CONSTANTS[8]*(VOI - CONSTANTS[9])))); ALGEBRAIC[2] = CONSTANTS[1]/(1.00000+exp( - CONSTANTS[3]*(CONSTANTS[4] - ALGEBRAIC[1])))+CONSTANTS[2]; ALGEBRAIC[3] = CONSTANTS[6]*pow(- (( CONSTANTS[10]*CONSTANTS[16] - CONSTANTS[5]*CONSTANTS[11])/( CONSTANTS[10]*CONSTANTS[15] - CONSTANTS[5]*CONSTANTS[11])), 1.00000/ALGEBRAIC[2]); ALGEBRAIC[4] = (CONSTANTS[15] - CONSTANTS[16])/(1.00000+pow(ALGEBRAIC[1]/ALGEBRAIC[3], ALGEBRAIC[2]))+CONSTANTS[16]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[9]; }