/* There are a total of 9 entries in the algebraic variable array. There are a total of 16 entries in each of the rate and state variable arrays. There are a total of 14 entries in the constant variable array. */ /* * VOI is time in component environment (day). * STATES[0] is B0 in component B0 (cells_per_GC). * CONSTANTS[0] is pr in component kinetic_parameters (dimensionless). * CONSTANTS[1] is mu in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[2] is rho in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[3] is delta_B in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[4] is CT_star in component CT_star (cells_per_GC). * STATES[1] is B1 in component B1 (cells_per_GC). * ALGEBRAIC[5] is alpha_B in component alpha_B (dimensionless). * STATES[2] is B2 in component B2 (cells_per_GC). * STATES[3] is B3 in component B3 (cells_per_GC). * STATES[4] is B4 in component B4 (cells_per_GC). * STATES[5] is B5 in component B5 (cells_per_GC). * STATES[6] is B6 in component B6 (cells_per_GC). * STATES[7] is B7 in component B7 (cells_per_GC). * STATES[8] is B8 in component B8 (cells_per_GC). * STATES[9] is B9 in component B9 (cells_per_GC). * STATES[10] is B10 in component B10 (cells_per_GC). * ALGEBRAIC[0] is B_sum in component centroblasts_sum (cells_per_GC). * STATES[11] is C in component C (cells_per_GC). * CONSTANTS[4] is d in component C (first_order_rate_constant). * STATES[12] is C_star in component C_star (cells_per_GC). * ALGEBRAIC[3] is CA in component CA (cells_per_GC). * ALGEBRAIC[1] is C_starsum in component centrocytes_sum (cells_per_GC). * STATES[13] is M in component M (cells_per_GC). * STATES[14] is A in component A (cells_per_GC). * CONSTANTS[5] is z in component A (first_order_rate_constant). * CONSTANTS[6] is u in component A (dimensionless). * ALGEBRAIC[2] is log_A in component A (dimensionless). * STATES[15] is T in component T (cells_per_GC). * CONSTANTS[7] is p in component T (first_order_rate_constant). * CONSTANTS[8] is sigma in component T (first_order_rate_constant). * CONSTANTS[9] is delta_T in component T (first_order_rate_constant). * ALGEBRAIC[6] is alpha_T in component alpha_T (dimensionless). * CONSTANTS[10] is SA in component CA (dimensionless). * CONSTANTS[11] is ST in component CT_star (dimensionless). * CONSTANTS[12] is KB in component alpha_B (dimensionless). * CONSTANTS[13] is KT in component alpha_T (dimensionless). * ALGEBRAIC[7] is total in component total (cells_per_GC). * ALGEBRAIC[8] is log_total in component total (dimensionless). * RATES[0] is d/dt B0 in component B0 (cells_per_GC). * RATES[1] is d/dt B1 in component B1 (cells_per_GC). * RATES[2] is d/dt B2 in component B2 (cells_per_GC). * RATES[3] is d/dt B3 in component B3 (cells_per_GC). * RATES[4] is d/dt B4 in component B4 (cells_per_GC). * RATES[5] is d/dt B5 in component B5 (cells_per_GC). * RATES[6] is d/dt B6 in component B6 (cells_per_GC). * RATES[7] is d/dt B7 in component B7 (cells_per_GC). * RATES[8] is d/dt B8 in component B8 (cells_per_GC). * RATES[9] is d/dt B9 in component B9 (cells_per_GC). * RATES[10] is d/dt B10 in component B10 (cells_per_GC). * RATES[11] is d/dt C in component C (cells_per_GC). * RATES[12] is d/dt C_star in component C_star (cells_per_GC). * RATES[13] is d/dt M in component M (cells_per_GC). * RATES[14] is d/dt A in component A (cells_per_GC). * RATES[15] is d/dt T in component T (cells_per_GC). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 3; CONSTANTS[0] = 0.15; CONSTANTS[1] = 3; CONSTANTS[2] = 4; CONSTANTS[3] = 0.8; STATES[1] = 0; STATES[2] = 0; STATES[3] = 0; STATES[4] = 0; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0; STATES[10] = 0; STATES[11] = 0; CONSTANTS[4] = 2; STATES[12] = 0; STATES[13] = 0; STATES[14] = 500; CONSTANTS[5] = 0.02; CONSTANTS[6] = 0.15; STATES[15] = 0; CONSTANTS[7] = 2; CONSTANTS[8] = 5; CONSTANTS[9] = 0.8; CONSTANTS[10] = 500; CONSTANTS[11] = 50; CONSTANTS[12] = 1e4; CONSTANTS[13] = 100; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; RATES[10] = 0.1001; RATES[11] = 0.1001; RATES[12] = 0.1001; RATES[13] = 0.1001; RATES[14] = 0.1001; RATES[15] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - CONSTANTS[0]*CONSTANTS[1]*ALGEBRAIC[4] - ( CONSTANTS[2]*STATES[0]+ CONSTANTS[3]*STATES[0]); resid[1] = RATES[1] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[0] - ( CONSTANTS[2]*STATES[1]+ CONSTANTS[3]*STATES[1]); resid[2] = RATES[2] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[1] - ( CONSTANTS[2]*STATES[2]+ CONSTANTS[3]*STATES[2]); resid[3] = RATES[3] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[2] - ( CONSTANTS[2]*STATES[3]+ CONSTANTS[3]*STATES[3]); resid[4] = RATES[4] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[3] - ( CONSTANTS[2]*STATES[4]+ CONSTANTS[3]*STATES[4]); resid[5] = RATES[5] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[4] - ( CONSTANTS[2]*STATES[5]+ CONSTANTS[3]*STATES[5]); resid[6] = RATES[6] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[5] - ( CONSTANTS[2]*STATES[6]+ CONSTANTS[3]*STATES[6]); resid[7] = RATES[7] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[6] - ( CONSTANTS[2]*STATES[7]+ CONSTANTS[3]*STATES[7]); resid[8] = RATES[8] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[7] - ( CONSTANTS[2]*STATES[8]+ CONSTANTS[3]*STATES[8]); resid[9] = RATES[9] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[8] - ( CONSTANTS[2]*STATES[9]+ CONSTANTS[3]*STATES[9]); resid[10] = RATES[10] - CONSTANTS[2]*(1.00000+ALGEBRAIC[5])*STATES[9] - ( CONSTANTS[2]*STATES[10]+ CONSTANTS[3]*STATES[10]); resid[11] = RATES[11] - CONSTANTS[4]*CONSTANTS[2]*STATES[10]*1.00000 - CONSTANTS[1]*STATES[11]; resid[12] = RATES[12] - CONSTANTS[1]*ALGEBRAIC[3] - CONSTANTS[1]*STATES[12]; resid[13] = RATES[13] - (1.00000 - CONSTANTS[0])*CONSTANTS[1]*ALGEBRAIC[4]; resid[14] = RATES[14] - - CONSTANTS[5]*STATES[14] - CONSTANTS[6]*ALGEBRAIC[3]*1.00000; resid[15] = RATES[15] - ( CONSTANTS[8]*1.00000+ CONSTANTS[7]*ALGEBRAIC[6]*ALGEBRAIC[4]) - CONSTANTS[9]*STATES[15]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = STATES[11]+STATES[12]; ALGEBRAIC[2] = arbitrary_log(STATES[14]/1.00000, 10); ALGEBRAIC[7] = ALGEBRAIC[0]+ALGEBRAIC[1]; ALGEBRAIC[8] = arbitrary_log(ALGEBRAIC[7]/1.00000+1.00000e-12, 10); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = ( STATES[11]*STATES[14])/( CONSTANTS[10]*1.00000+STATES[14]); ALGEBRAIC[4] = ( STATES[12]*STATES[15])/( CONSTANTS[11]*1.00000+STATES[12]); ALGEBRAIC[0] = STATES[1]+STATES[1]+STATES[3]+STATES[4]+STATES[5]+STATES[6]+STATES[6]+STATES[7]+STATES[8]+STATES[9]+STATES[10]; ALGEBRAIC[5] = CONSTANTS[12]/(CONSTANTS[12]+ALGEBRAIC[0]/1.00000); ALGEBRAIC[6] = CONSTANTS[13]/(CONSTANTS[13]+STATES[15]/1.00000); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[11] = 1.0; SI[12] = 1.0; SI[13] = 1.0; SI[14] = 1.0; SI[15] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }