C C There are a total of 17 entries in the algebraic variable array. C There are a total of 10 entries in each of the rate and state variable arrays. C There are a total of 19 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is C_6PG in component C_6PG (millimolar). C CONSTS(1) is mu in component model_constants (per_hour). C ALGBRC(4) is rG6PDH in component rG6PDH (flux). C ALGBRC(10) is r6PGDH in component r6PGDH (flux). C STATES(2) is C_Ru5P in component C_Ru5P (millimolar). C ALGBRC(12) is rRu5PE in component rRu5PE (flux). C ALGBRC(11) is rR5PI in component rR5PI (flux). C STATES(3) is C_R5P in component C_R5P (millimolar). C ALGBRC(13) is rTKL1 in component rTKL1 (flux). C ALGBRC(14) is rRPPK in component rRPPK (flux). C STATES(4) is C_X5P in component C_X5P (millimolar). C ALGBRC(16) is rTKL2 in component rTKL2 (flux). C STATES(5) is C_S7P in component C_S7P (millimolar). C ALGBRC(15) is rTAL in component rTAL (flux). C STATES(6) is C_E4P in component C_E4P (millimolar). C ALGBRC(17) is rPKDA in component rPKDA (flux). C STATES(7) is C_G6P in component C_G6P (millimolar). C ALGBRC(1) is dC_G6P_dt in component C_G6P (flux). C STATES(8) is C_NADP in component C_NADP (millimolar). C STATES(9) is C_NADPH in component C_NADPH (millimolar). C STATES(10) is C_MgATP in component C_MgATP (millimolar). C CONSTS(2) is K_NADP_1 in component rG6PDH (millimolar). C CONSTS(3) is Ki_NADPH_1 in component rG6PDH (millimolar). C CONSTS(4) is Ki_MgATP_1 in component rG6PDH (millimolar). C ALGBRC(2) is I_NADPH_1 in component rG6PDH (dimensionless). C ALGBRC(3) is I_MgATP_1 in component rG6PDH (dimensionless). C CONSTS(5) is rmax_G6PDH in component rG6PDH (flux). C CONSTS(6) is K_NADP_2 in component r6PGDH (millimolar). C CONSTS(7) is Ki_NADPH_2 in component r6PGDH (millimolar). C CONSTS(8) is Ki_MgATP_2 in component r6PGDH (millimolar). C ALGBRC(5) is I_NADPH_2 in component r6PGDH (dimensionless). C ALGBRC(7) is I_MgATP_2 in component r6PGDH (dimensionless). C CONSTS(9) is rmax_6PGDH in component r6PGDH (flux). C CONSTS(10) is rmax_R5PI in component rR5PI (millimole_per_second). C CONSTS(11) is rmax_Ru5PE in component rRu5PE (millimole_per_second). C CONSTS(12) is rmax_TKL1 in component rTKL1 (millimole_per_second). C CONSTS(13) is C_GAP in component model_constants (millimolar). C CONSTS(14) is rmax_TAL in component rTAL (millimole_per_second). C CONSTS(15) is rmax_TKL2 in component rTKL2 (millimole_per_second). C CONSTS(16) is K_PKDA in component rPKDA (millimolar). C CONSTS(17) is rmax_PKDA in component rPKDA (millimole_per_second). C CONSTS(18) is K_RPPK in component rRPPK (millimolar). C CONSTS(19) is rmax_RPPK in component rRPPK (millimole_per_second). C ALGBRC(8) is rHK in component rHK (flux). C ALGBRC(6) is qs in component model_constants (flux). C ALGBRC(9) is rPGI in component rPGI (flux). C RATES(1) is d/dt C_6PG in component C_6PG (millimolar). C RATES(2) is d/dt C_Ru5P in component C_Ru5P (millimolar). C RATES(3) is d/dt C_R5P in component C_R5P (millimolar). C RATES(4) is d/dt C_X5P in component C_X5P (millimolar). C RATES(5) is d/dt C_S7P in component C_S7P (millimolar). C RATES(6) is d/dt C_E4P in component C_E4P (millimolar). C RATES(7) is d/dt C_G6P in component C_G6P (millimolar). C RATES(8) is d/dt C_NADP in component C_NADP (millimolar). C RATES(9) is d/dt C_NADPH in component C_NADPH (millimolar). C RATES(10) is d/dt C_MgATP in component C_MgATP (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.25 CONSTS(1) = 1.0 STATES(2) = 0.033 STATES(3) = 0.118 STATES(4) = 0.041 STATES(5) = 0.082 STATES(6) = 0.029 STATES(7) = 0.9 STATES(8) = 0.168 STATES(9) = 0.168 STATES(10) = 2.3 CONSTS(2) = 0.116 CONSTS(3) = 1.702 CONSTS(4) = 0.33 CONSTS(5) = 44.19 CONSTS(6) = 1.848 CONSTS(7) = 0.055 CONSTS(8) = 0.109 CONSTS(9) = 0.654 CONSTS(10) = 0.57 CONSTS(11) = 0.85 CONSTS(12) = 3.24 CONSTS(13) = 0.064 CONSTS(14) = 3.0 CONSTS(15) = 10.5 CONSTS(16) = 0.0032 CONSTS(17) = 0.004 CONSTS(18) = 0.0034 CONSTS(19) = 0.003 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(8) = -1.48000/(9.17000+ 16.1000*VOI+ 0.480000*VOI ** 2.00000)+ (( 1.48000*VOI)/( (9.17000+ 16.1000*VOI+ 0.480000*VOI ** 2.00000)*(9.17000+ 16.1000*VOI+ 0.480000*VOI ** 2.00000)))*(16.1000+ 0.960000*VOI) RATES(9) = 0.516000/(25.3900+ 0.370000*VOI+ 0.500000*VOI ** 2.00000) - (( 0.516000*VOI)/( (25.3900+ 0.370000*VOI+ 0.500000*VOI ** 2.00000)*(25.3900+ 0.370000*VOI+ 0.500000*VOI ** 2.00000)))*(0.370000+ 1.00000*VOI) RATES(10) = 29.8300/(29.7700+ 13.4200*VOI+ 0.0500000*VOI ** 2.00000) - (( 29.8300*VOI)/( (29.7700+ 13.4200*VOI+ 0.0500000*VOI ** 2.00000)*(29.7700+ 13.4200*VOI+ 0.0500000*VOI ** 2.00000)))*(13.4200+ 0.100000*VOI) ALGBRC(1) = 44.1000/(48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)+ (( 44.1000*VOI)/( (48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)*(48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)))*(1.00000+ 0.900000*VOI) RATES(7) = ALGBRC(1) ALGBRC(2) = 1.00000+STATES(9)/CONSTS(3) ALGBRC(3) = 1.00000+STATES(10)/CONSTS(4) ALGBRC(4) = CONSTS(5)*(STATES(8)/( (STATES(8)+ CONSTS(2)*ALGBRC(2))*ALGBRC(3))) ALGBRC(5) = 1.00000+STATES(9)/CONSTS(7) ALGBRC(7) = 1.00000+STATES(10)/CONSTS(8) ALGBRC(10) = CONSTS(9)*(STATES(8)/( (STATES(8)+ CONSTS(6)*ALGBRC(5))*ALGBRC(7))) RATES(1) = ALGBRC(4) - (ALGBRC(10)+ CONSTS(1)*STATES(1)) ALGBRC(12) = 1.00000*CONSTS(11)*STATES(2) ALGBRC(11) = 1.00000*CONSTS(10)*STATES(2) RATES(2) = ALGBRC(10) - (ALGBRC(11)+ALGBRC(12)+ CONSTS(1)*STATES(2)) ALGBRC(13) = 1.00000*CONSTS(12)*STATES(4)*STATES(3) ALGBRC(14) = 1.00000*CONSTS(19)*(STATES(3)/(STATES(3)+CONSTS(18))) RATES(3) = ALGBRC(11) - (ALGBRC(13)+ALGBRC(14)+ CONSTS(1)*STATES(3)) ALGBRC(15) = 1.00000*CONSTS(14)*CONSTS(13)*STATES(5) RATES(5) = ALGBRC(13) - (ALGBRC(15)+ CONSTS(1)*STATES(5)) ALGBRC(16) = 1.00000*CONSTS(15)*STATES(6)*STATES(4) RATES(4) = ALGBRC(12) - (ALGBRC(13)+ALGBRC(16)+ CONSTS(1)*STATES(4)) ALGBRC(17) = 1.00000*CONSTS(17)*(STATES(6)/(STATES(6)+CONSTS(16))) RATES(6) = ALGBRC(15) - (ALGBRC(16)+ALGBRC(17)+ CONSTS(1)*STATES(6)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = 44.1000/(48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)+ (( 44.1000*VOI)/( (48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)*(48.0000+ 1.00000*VOI+ 0.450000*VOI ** 2.00000)))*(1.00000+ 0.900000*VOI) ALGBRC(2) = 1.00000+STATES(9)/CONSTS(3) ALGBRC(3) = 1.00000+STATES(10)/CONSTS(4) ALGBRC(4) = CONSTS(5)*(STATES(8)/( (STATES(8)+ CONSTS(2)*ALGBRC(2))*ALGBRC(3))) ALGBRC(5) = 1.00000+STATES(9)/CONSTS(7) ALGBRC(7) = 1.00000+STATES(10)/CONSTS(8) ALGBRC(10) = CONSTS(9)*(STATES(8)/( (STATES(8)+ CONSTS(6)*ALGBRC(5))*ALGBRC(7))) ALGBRC(12) = 1.00000*CONSTS(11)*STATES(2) ALGBRC(11) = 1.00000*CONSTS(10)*STATES(2) ALGBRC(13) = 1.00000*CONSTS(12)*STATES(4)*STATES(3) ALGBRC(14) = 1.00000*CONSTS(19)*(STATES(3)/(STATES(3)+CONSTS(18))) ALGBRC(15) = 1.00000*CONSTS(14)*CONSTS(13)*STATES(5) ALGBRC(16) = 1.00000*CONSTS(15)*STATES(6)*STATES(4) ALGBRC(17) = 1.00000*CONSTS(17)*(STATES(6)/(STATES(6)+CONSTS(16))) ALGBRC(6) = TERNRY(VOI.LT.0.00000, 0.131000, 0.546000) ALGBRC(8) = ALGBRC(6) ALGBRC(9) = ALGBRC(6) - (ALGBRC(4)+ CONSTS(1)*STATES(7)+ALGBRC(1)) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END