Bingzheng, Zhenye, Liansong, 1990

Model Status

This CellML model is known to run in OpenCell and COR and can recreate the published results. The units have been checked and are consistent.

Model Structure

ABSTRACT: We propose a mathematical model for the regulation system of the secretion of glucocorticoids and determined the coefficients in the system of ordinary differential equations. Some results are calculated which agree with the experimental results.

The original paper reference is cited below:

A mathematical model of the regulation system of the secretion of glucocorticoids, Liu Bingzheng, Zhao Zhenye and Chen Liansong, 1990, Journal of Biological Physics, volume 17, issue 4, 221-233.

The HPA axis model has three compartments, namely the hypothalamus, pituitary and adrenals. Neural signals trigger CRF secretion by the hypothalamus. In turn, this signals to the pituitary to release ACTH which stimulates the adrenal gland to release cortisol. Cortisol acts on the hypothalamus and the pituitary to have a negative feedback effect on the release of CRH and ACTH respectively.