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/* There are a total of 40 entries in the algebraic variable array. There are a total of 11 entries in each of the rate and state variable arrays. There are a total of 24 entries in the constant variable array. */ /* * VOI is t in component environment (second). * CONSTANTS[0] is R in component environment (J_per_K_per_mol). * CONSTANTS[1] is T in component environment (kelvin). * CONSTANTS[2] is F in component environment (C_per_mol). * CONSTANTS[3] is C_m in component environment (fF). * STATES[0] is q_Ca_o in component environment (fmol). * STATES[1] is q_Ca_i in component environment (fmol). * STATES[2] is q_Na_o in component environment (fmol). * STATES[3] is q_Na_i in component environment (fmol). * STATES[4] is q_P1_NCX in component environment (fmol). * STATES[5] is q_P2_NCX in component environment (fmol). * STATES[6] is q_P3_NCX in component environment (fmol). * STATES[7] is q_P4_NCX in component environment (fmol). * STATES[8] is q_P5_NCX in component environment (fmol). * STATES[9] is q_P6_NCX in component environment (fmol). * ALGEBRAIC[29] is v_Ca_o_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[22] is v_Ca_i_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[33] is v_Na_o_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[19] is v_Na_i_NCX in component NCX (fmol_per_sec). * STATES[10] is q_mem in component environment (fC). * ALGEBRAIC[37] is I_mem_NCX in component NCX (fA). * CONSTANTS[4] is kappa_1_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_2_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[6] is kappa_3_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[7] is kappa_4_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_5_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[9] is kappa_6_NCX in component NCX_parameters (fmol_per_sec). * CONSTANTS[10] is K_1_NCX in component NCX_parameters (per_fmol). * CONSTANTS[11] is K_2_NCX in component NCX_parameters (per_fmol). * CONSTANTS[12] is K_3_NCX in component NCX_parameters (per_fmol). * CONSTANTS[13] is K_4_NCX in component NCX_parameters (per_fmol). * CONSTANTS[14] is K_5_NCX in component NCX_parameters (per_fmol). * CONSTANTS[15] is K_6_NCX in component NCX_parameters (per_fmol). * CONSTANTS[16] is K_Na_i in component NCX_parameters (per_fmol). * CONSTANTS[17] is K_Ca_i in component NCX_parameters (per_fmol). * CONSTANTS[18] is K_Na_o in component NCX_parameters (per_fmol). * CONSTANTS[19] is K_Ca_o in component NCX_parameters (per_fmol). * CONSTANTS[20] is nNa_o_NCX in component NCX_parameters (dimensionless). * CONSTANTS[21] is nNa_i_NCX in component NCX_parameters (dimensionless). * CONSTANTS[22] is zf_NCX in component NCX_parameters (dimensionless). * CONSTANTS[23] is zr_NCX in component NCX_parameters (dimensionless). * ALGEBRAIC[1] is mu_Ca_o in component NCX (J_per_mol). * ALGEBRAIC[2] is mu_Ca_i in component NCX (J_per_mol). * ALGEBRAIC[3] is mu_Na_o in component NCX (J_per_mol). * ALGEBRAIC[4] is mu_Na_i in component NCX (J_per_mol). * ALGEBRAIC[5] is mu_P1_NCX in component NCX (J_per_mol). * ALGEBRAIC[6] is mu_P2_NCX in component NCX (J_per_mol). * ALGEBRAIC[7] is mu_P3_NCX in component NCX (J_per_mol). * ALGEBRAIC[8] is mu_P4_NCX in component NCX (J_per_mol). * ALGEBRAIC[9] is mu_P5_NCX in component NCX (J_per_mol). * ALGEBRAIC[10] is mu_P6_NCX in component NCX (J_per_mol). * ALGEBRAIC[38] is v_P1_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[23] is v_P2_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[26] is v_P3_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[30] is v_P4_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[35] is v_P5_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[39] is v_P6_NCX in component NCX (fmol_per_sec). * ALGEBRAIC[11] is Af_r1 in component NCX (J_per_mol). * ALGEBRAIC[17] is Ar_r1 in component NCX (J_per_mol). * ALGEBRAIC[18] is v_r1 in component NCX (fmol_per_sec). * ALGEBRAIC[12] is Af_r2 in component NCX (J_per_mol). * ALGEBRAIC[20] is Ar_r2 in component NCX (J_per_mol). * ALGEBRAIC[21] is v_r2 in component NCX (fmol_per_sec). * ALGEBRAIC[13] is Af_r3 in component NCX (J_per_mol). * ALGEBRAIC[24] is Ar_r3 in component NCX (J_per_mol). * ALGEBRAIC[25] is v_r3 in component NCX (fmol_per_sec). * ALGEBRAIC[14] is Af_r4 in component NCX (J_per_mol). * ALGEBRAIC[27] is Ar_r4 in component NCX (J_per_mol). * ALGEBRAIC[28] is v_r4 in component NCX (fmol_per_sec). * ALGEBRAIC[15] is Af_r5 in component NCX (J_per_mol). * ALGEBRAIC[31] is Ar_r5 in component NCX (J_per_mol). * ALGEBRAIC[32] is v_r5 in component NCX (fmol_per_sec). * ALGEBRAIC[16] is Af_r6 in component NCX (J_per_mol). * ALGEBRAIC[34] is Ar_r6 in component NCX (J_per_mol). * ALGEBRAIC[36] is v_r6 in component NCX (fmol_per_sec). * ALGEBRAIC[0] is V_mem in component NCX (volt). * RATES[0] is d/dt q_Ca_o in component environment (fmol). * RATES[1] is d/dt q_Ca_i in component environment (fmol). * RATES[2] is d/dt q_Na_o in component environment (fmol). * RATES[3] is d/dt q_Na_i in component environment (fmol). * RATES[10] is d/dt q_mem in component environment (fC). * RATES[4] is d/dt q_P1_NCX in component environment (fmol). * RATES[5] is d/dt q_P2_NCX in component environment (fmol). * RATES[6] is d/dt q_P3_NCX in component environment (fmol). * RATES[7] is d/dt q_P4_NCX in component environment (fmol). * RATES[8] is d/dt q_P5_NCX in component environment (fmol). * RATES[9] is d/dt q_P6_NCX in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 8.314; CONSTANTS[1] = 310; CONSTANTS[2] = 96485; CONSTANTS[3] = 153400; STATES[0] = 9.3276; STATES[1] = 0.00456; STATES[2] = 725.48; STATES[3] = 380; STATES[4] = 0.000103509; STATES[5] = 0.000103509; STATES[6] = 0.000103509; STATES[7] = 0.000103509; STATES[8] = 0.000103509; STATES[9] = 0.000103509; STATES[10] = -13039; CONSTANTS[4] = 417309; CONSTANTS[5] = 1.39522e+07; CONSTANTS[6] = 472.755; CONSTANTS[7] = 1.39522e+07; CONSTANTS[8] = 417309; CONSTANTS[9] = 0.370405; CONSTANTS[10] = 2.93394e+08; CONSTANTS[11] = 14.1045; CONSTANTS[12] = 263471; CONSTANTS[13] = 2.39875e+06; CONSTANTS[14] = 2373.73; CONSTANTS[15] = 956.214; CONSTANTS[16] = 0.0137751; CONSTANTS[17] = 10.2446; CONSTANTS[18] = 0.470129; CONSTANTS[19] = 7572.91; CONSTANTS[20] = 3; CONSTANTS[21] = 3; CONSTANTS[22] = -0.55679; CONSTANTS[23] = 0.44321; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[11] = ALGEBRAIC[5]; ALGEBRAIC[4] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[16]*STATES[3]); ALGEBRAIC[6] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[17] = CONSTANTS[21]*ALGEBRAIC[4]+ALGEBRAIC[6]; ALGEBRAIC[18] = CONSTANTS[4]*(exp(ALGEBRAIC[11]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[17]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[19] = CONSTANTS[21]*ALGEBRAIC[18]; RATES[3] = ALGEBRAIC[19]; ALGEBRAIC[2] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[17]*STATES[1]); ALGEBRAIC[12] = ALGEBRAIC[6]+ALGEBRAIC[2]; ALGEBRAIC[7] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[12]*STATES[6]); ALGEBRAIC[20] = ALGEBRAIC[7]; ALGEBRAIC[21] = CONSTANTS[5]*(exp(ALGEBRAIC[12]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[20]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[22] = - ALGEBRAIC[21]; RATES[1] = ALGEBRAIC[22]; ALGEBRAIC[23] = ALGEBRAIC[18] - ALGEBRAIC[21]; RATES[5] = ALGEBRAIC[23]; ALGEBRAIC[13] = ALGEBRAIC[7]; ALGEBRAIC[8] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[13]*STATES[7]); ALGEBRAIC[24] = ALGEBRAIC[8]; ALGEBRAIC[25] = CONSTANTS[6]*(exp(ALGEBRAIC[13]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[24]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[26] = ALGEBRAIC[21] - ALGEBRAIC[25]; RATES[6] = ALGEBRAIC[26]; ALGEBRAIC[14] = ALGEBRAIC[8]; ALGEBRAIC[1] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[19]*STATES[0]); ALGEBRAIC[9] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[14]*STATES[8]); ALGEBRAIC[27] = ALGEBRAIC[9]+ALGEBRAIC[1]; ALGEBRAIC[28] = CONSTANTS[7]*(exp(ALGEBRAIC[14]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[27]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[29] = ALGEBRAIC[28]; RATES[0] = ALGEBRAIC[29]; ALGEBRAIC[30] = - ALGEBRAIC[28]+ALGEBRAIC[25]; RATES[7] = ALGEBRAIC[30]; ALGEBRAIC[3] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[18]*STATES[2]); ALGEBRAIC[15] = ALGEBRAIC[9]+ CONSTANTS[20]*ALGEBRAIC[3]; ALGEBRAIC[10] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[9]); ALGEBRAIC[31] = ALGEBRAIC[10]; ALGEBRAIC[32] = CONSTANTS[8]*(exp(ALGEBRAIC[15]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[31]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[33] = - CONSTANTS[20]*ALGEBRAIC[32]; RATES[2] = ALGEBRAIC[33]; ALGEBRAIC[35] = - ALGEBRAIC[32]+ALGEBRAIC[28]; RATES[8] = ALGEBRAIC[35]; ALGEBRAIC[0] = STATES[10]/CONSTANTS[3]; ALGEBRAIC[16] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[9])+ CONSTANTS[22]*CONSTANTS[2]*ALGEBRAIC[0]; ALGEBRAIC[34] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[10]*STATES[4])+ CONSTANTS[23]*CONSTANTS[2]*ALGEBRAIC[0]; ALGEBRAIC[36] = CONSTANTS[9]*(exp(ALGEBRAIC[16]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[34]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[37] = CONSTANTS[2]*( - CONSTANTS[22]*ALGEBRAIC[36]+ CONSTANTS[23]*ALGEBRAIC[36]); RATES[10] = ALGEBRAIC[37]; ALGEBRAIC[38] = ALGEBRAIC[36] - ALGEBRAIC[18]; RATES[4] = ALGEBRAIC[38]; ALGEBRAIC[39] = - ALGEBRAIC[36]+ALGEBRAIC[32]; RATES[9] = ALGEBRAIC[39]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[11] = ALGEBRAIC[5]; ALGEBRAIC[4] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[16]*STATES[3]); ALGEBRAIC[6] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[17] = CONSTANTS[21]*ALGEBRAIC[4]+ALGEBRAIC[6]; ALGEBRAIC[18] = CONSTANTS[4]*(exp(ALGEBRAIC[11]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[17]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[19] = CONSTANTS[21]*ALGEBRAIC[18]; ALGEBRAIC[2] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[17]*STATES[1]); ALGEBRAIC[12] = ALGEBRAIC[6]+ALGEBRAIC[2]; ALGEBRAIC[7] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[12]*STATES[6]); ALGEBRAIC[20] = ALGEBRAIC[7]; ALGEBRAIC[21] = CONSTANTS[5]*(exp(ALGEBRAIC[12]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[20]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[22] = - ALGEBRAIC[21]; ALGEBRAIC[23] = ALGEBRAIC[18] - ALGEBRAIC[21]; ALGEBRAIC[13] = ALGEBRAIC[7]; ALGEBRAIC[8] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[13]*STATES[7]); ALGEBRAIC[24] = ALGEBRAIC[8]; ALGEBRAIC[25] = CONSTANTS[6]*(exp(ALGEBRAIC[13]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[24]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[26] = ALGEBRAIC[21] - ALGEBRAIC[25]; ALGEBRAIC[14] = ALGEBRAIC[8]; ALGEBRAIC[1] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[19]*STATES[0]); ALGEBRAIC[9] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[14]*STATES[8]); ALGEBRAIC[27] = ALGEBRAIC[9]+ALGEBRAIC[1]; ALGEBRAIC[28] = CONSTANTS[7]*(exp(ALGEBRAIC[14]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[27]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[29] = ALGEBRAIC[28]; ALGEBRAIC[30] = - ALGEBRAIC[28]+ALGEBRAIC[25]; ALGEBRAIC[3] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[18]*STATES[2]); ALGEBRAIC[15] = ALGEBRAIC[9]+ CONSTANTS[20]*ALGEBRAIC[3]; ALGEBRAIC[10] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[9]); ALGEBRAIC[31] = ALGEBRAIC[10]; ALGEBRAIC[32] = CONSTANTS[8]*(exp(ALGEBRAIC[15]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[31]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[33] = - CONSTANTS[20]*ALGEBRAIC[32]; ALGEBRAIC[35] = - ALGEBRAIC[32]+ALGEBRAIC[28]; ALGEBRAIC[0] = STATES[10]/CONSTANTS[3]; ALGEBRAIC[16] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[9])+ CONSTANTS[22]*CONSTANTS[2]*ALGEBRAIC[0]; ALGEBRAIC[34] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[10]*STATES[4])+ CONSTANTS[23]*CONSTANTS[2]*ALGEBRAIC[0]; ALGEBRAIC[36] = CONSTANTS[9]*(exp(ALGEBRAIC[16]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[34]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[37] = CONSTANTS[2]*( - CONSTANTS[22]*ALGEBRAIC[36]+ CONSTANTS[23]*ALGEBRAIC[36]); ALGEBRAIC[38] = ALGEBRAIC[36] - ALGEBRAIC[18]; ALGEBRAIC[39] = - ALGEBRAIC[36]+ALGEBRAIC[32]; }