K ATP protein knowledge page
About
Landing page for the ATP-sensitive potassium channel (K-ATP).
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is inhibited by internal ATP. K-ATP is part of the inward rectifying (K-ir) family
All K-ATP channels are composed of four pore-forming channel subunits Kir6, and four regulatory sulfonylurea receptor SUR subunits.
Subfamilies
The following list contains the known isoforms of K-ATP.
| Channel name | Alias | Gene | Structure | Interacts with |
|---|---|---|---|---|
| KCNJ8 | Kir6.1 | Uniprot 8 | SMR 8 | ABCC9 |
| KCNJ11 | Kir6.2 | Uniprot 11 | PDB 11 | ABCC8 |
| ABCC8 | SUR1 | Uniprot SUR1 | PDB SUR1 | KCNJ11 |
| ABCC9 | SUR2 | Uniprot SUR2 | SMR SUR2 | KCNJ8 |
The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.
Literature
| Title | Author |
|---|---|
| KATP Channel Function: More than Meets the Eye | Shyng |
| 'KATP Channels and Cardiovascular Disease: Suddenly a Syndrome <https://doi.org/10.1161/CIRCRESAHA.112.300514> | Singh and Grange |
Existing models
| Title | Author |
|---|---|
| BG_K_ATP | S Fong |
| Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ | Faber and Rudy |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.