NKE knowledge page

About

Landing page for the sodium potassium pump NKE. Other name for these proteins: NKA, Na-K-ATPase.

NKE helps maintain resting membrane potential through helping establish the sodium and potassium concentration gradients across the membrane.

NKE is thought to be a heterodimer - made of the active alpha subunit protein, which catalyses the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This is assembled with the regulatory beta subunit.

Pictures

NKE_pic

Subfamilies

The following list contains a portion of all subfamilies that can compose the NKE.

Variants within the human species
Channel name Alias Gene Structure
ATP1A1   Uniprot A1 PDB A1
ATP1A2   Uniprot A2 SMR A2
ATP1A3   Uniprot A3 PDB A3
ATP1A4   Uniprot A4 SMR A4
ATP1B1   Uniprot B1 PDB B1
ATP1B2   Uniprot B2 SMR B2
ATP1B3   Uniprot B3 SMR B3
ATP1C ATNG, FXYD2 Uniprot 1C PDB 1C
FXYD3   Uniprot FXYD3 SMR FXYD3

Existing models

Link to other PMR workspaces or exposures
Title Author
BG_NaK S Fong
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^ C Clancy and Y Rudy
Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ M Pan et al.
A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ C Luo and Y Rudy

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.

Other annotations

Item Database
Sodium:potassium-exchanging ATPase complex Gene Ontology Complex
P-type sodium:potassium-exchanging transporter activity Gene Ontology activity
Source
Derived from workspace NKE knowledge page at changeset 0436f633b9cf.
Collaboration
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