function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =15; end % There are a total of 5 entries in each of the rate and state variable arrays. % There are a total of 13 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('t in component environment (second)'); LEGEND_CONSTANTS(:,1) = strpad('R in component environment (J_per_K_per_mol)'); LEGEND_CONSTANTS(:,2) = strpad('T in component environment (kelvin)'); LEGEND_CONSTANTS(:,3) = strpad('F in component environment (C_per_mol)'); LEGEND_CONSTANTS(:,4) = strpad('C_m in component environment (fF)'); LEGEND_STATES(:,1) = strpad('q_K_o in component environment (fmol)'); LEGEND_STATES(:,2) = strpad('q_K_i in component environment (fmol)'); LEGEND_STATES(:,3) = strpad('q_C_Kp in component environment (fmol)'); LEGEND_STATES(:,4) = strpad('q_O_Kp in component environment (fmol)'); LEGEND_ALGEBRAIC(:,12) = strpad('v_Kp in component Kp (fmol_per_sec)'); LEGEND_STATES(:,5) = strpad('q_mem in component environment (fC)'); LEGEND_ALGEBRAIC(:,14) = strpad('I_mem_Kp in component Kp (fA)'); LEGEND_CONSTANTS(:,5) = strpad('K_C_Kp in component Kp_parameters (per_fmol)'); LEGEND_CONSTANTS(:,6) = strpad('K_K_o in component Kp_parameters (per_fmol)'); LEGEND_CONSTANTS(:,7) = strpad('K_K_i in component Kp_parameters (per_fmol)'); LEGEND_CONSTANTS(:,8) = strpad('K_O_Kp in component Kp_parameters (per_fmol)'); LEGEND_CONSTANTS(:,9) = strpad('kappa_Kp in component Kp_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,10) = strpad('kappa_gKp in component Kp_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,11) = strpad('zK in component Kp_parameters (dimensionless)'); LEGEND_CONSTANTS(:,12) = strpad('z_f_Kp in component Kp_parameters (dimensionless)'); LEGEND_CONSTANTS(:,13) = strpad('z_r_Kp in component Kp_parameters (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('mu_K_o in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,4) = strpad('mu_K_i in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,2) = strpad('mu_C_Kp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,5) = strpad('mu_O_Kp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,8) = strpad('Am_Kp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,6) = strpad('Af_Kp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,9) = strpad('Ar_Kp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,7) = strpad('Af_gKp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,10) = strpad('Ar_gKp in component Kp (J_per_mol)'); LEGEND_ALGEBRAIC(:,11) = strpad('v_gKp in component Kp (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,13) = strpad('v_C_Kp in component Kp (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,15) = strpad('v_O_Kp in component Kp (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,1) = strpad('V_mem in component Kp (volt)'); LEGEND_RATES(:,1) = strpad('d/dt q_K_o in component environment (fmol)'); LEGEND_RATES(:,2) = strpad('d/dt q_K_i in component environment (fmol)'); LEGEND_RATES(:,5) = strpad('d/dt q_mem in component environment (fC)'); LEGEND_RATES(:,3) = strpad('d/dt q_C_Kp in component environment (fmol)'); LEGEND_RATES(:,4) = strpad('d/dt q_O_Kp in component environment (fmol)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 8.314; CONSTANTS(:,2) = 310; CONSTANTS(:,3) = 96485; CONSTANTS(:,4) = 153400; STATES(:,1) = 27.9828; STATES(:,2) = 5510; STATES(:,3) = 1.3813E-07; STATES(:,4) = 3.45317E-08; STATES(:,5) = -13039; CONSTANTS(:,5) = 41.6265; CONSTANTS(:,6) = 0.059344; CONSTANTS(:,7) = 0.0080926; CONSTANTS(:,8) = 145.607; CONSTANTS(:,9) = 252.3419; CONSTANTS(:,10) = 24.0195; CONSTANTS(:,11) = 1; CONSTANTS(:,12) = 0; CONSTANTS(:,13) = -4.4669; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = STATES(:,5)./CONSTANTS(:,4); ALGEBRAIC(:,8) = CONSTANTS(:,11).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,4) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,7).*STATES(:,2)); ALGEBRAIC(:,5) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,8).*STATES(:,4)); ALGEBRAIC(:,6) = ALGEBRAIC(:,4)+ CONSTANTS(:,11).*CONSTANTS(:,3).*ALGEBRAIC(:,1)+ALGEBRAIC(:,5); ALGEBRAIC(:,3) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,6).*STATES(:,1)); ALGEBRAIC(:,9) = ALGEBRAIC(:,3)+ALGEBRAIC(:,5); ALGEBRAIC(:,12) = piecewise({ALGEBRAIC(:,8)==0.00000, CONSTANTS(:,9).*(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,9)./( CONSTANTS(:,1).*CONSTANTS(:,2)))) }, ((( CONSTANTS(:,9).*ALGEBRAIC(:,8))./( CONSTANTS(:,1).*CONSTANTS(:,2)))./(exp(ALGEBRAIC(:,8)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - 1.00000)).*(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,9)./( CONSTANTS(:,1).*CONSTANTS(:,2))))); RATES(:,1) = ALGEBRAIC(:,12); RATES(:,2) = - ALGEBRAIC(:,12); ALGEBRAIC(:,7) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,5).*STATES(:,3))+ CONSTANTS(:,12).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,10) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,8).*STATES(:,4))+ CONSTANTS(:,13).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,11) = CONSTANTS(:,10).*(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,10)./( CONSTANTS(:,1).*CONSTANTS(:,2)))); ALGEBRAIC(:,13) = - ALGEBRAIC(:,11); RATES(:,3) = ALGEBRAIC(:,13); ALGEBRAIC(:,14) = CONSTANTS(:,3).*(( - CONSTANTS(:,11).*ALGEBRAIC(:,12)+ CONSTANTS(:,13).*ALGEBRAIC(:,11)) - CONSTANTS(:,12).*ALGEBRAIC(:,11)); RATES(:,5) = ALGEBRAIC(:,14); ALGEBRAIC(:,15) = ALGEBRAIC(:,11) - (ALGEBRAIC(:,12) - ALGEBRAIC(:,12)); RATES(:,4) = ALGEBRAIC(:,15); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = STATES(:,5)./CONSTANTS(:,4); ALGEBRAIC(:,8) = CONSTANTS(:,11).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,4) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,7).*STATES(:,2)); ALGEBRAIC(:,5) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,8).*STATES(:,4)); ALGEBRAIC(:,6) = ALGEBRAIC(:,4)+ CONSTANTS(:,11).*CONSTANTS(:,3).*ALGEBRAIC(:,1)+ALGEBRAIC(:,5); ALGEBRAIC(:,3) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,6).*STATES(:,1)); ALGEBRAIC(:,9) = ALGEBRAIC(:,3)+ALGEBRAIC(:,5); ALGEBRAIC(:,12) = piecewise({ALGEBRAIC(:,8)==0.00000, CONSTANTS(:,9).*(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,9)./( CONSTANTS(:,1).*CONSTANTS(:,2)))) }, ((( CONSTANTS(:,9).*ALGEBRAIC(:,8))./( CONSTANTS(:,1).*CONSTANTS(:,2)))./(exp(ALGEBRAIC(:,8)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - 1.00000)).*(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,9)./( CONSTANTS(:,1).*CONSTANTS(:,2))))); ALGEBRAIC(:,7) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,5).*STATES(:,3))+ CONSTANTS(:,12).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,10) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,8).*STATES(:,4))+ CONSTANTS(:,13).*CONSTANTS(:,3).*ALGEBRAIC(:,1); ALGEBRAIC(:,11) = CONSTANTS(:,10).*(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,1).*CONSTANTS(:,2))) - exp(ALGEBRAIC(:,10)./( CONSTANTS(:,1).*CONSTANTS(:,2)))); ALGEBRAIC(:,13) = - ALGEBRAIC(:,11); ALGEBRAIC(:,14) = CONSTANTS(:,3).*(( - CONSTANTS(:,11).*ALGEBRAIC(:,12)+ CONSTANTS(:,13).*ALGEBRAIC(:,11)) - CONSTANTS(:,12).*ALGEBRAIC(:,11)); ALGEBRAIC(:,15) = ALGEBRAIC(:,11) - (ALGEBRAIC(:,12) - ALGEBRAIC(:,12)); ALGEBRAIC(:,2) = CONSTANTS(:,1).*CONSTANTS(:,2).*log( CONSTANTS(:,5).*STATES(:,3)); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end