K ATP protein knowledge page

About

Landing page for the ATP-sensitive potassium channel (K-ATP).

This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is activated by internal ATP. K-ATP is part of the inward rectifying (K-ir) family

Some isoforms are also G-protein regulated.

Pictures

kir2.2

Fig. 1. Visualisation of the KIR2.2 channel. Image from the RCSB PDB (RCSB.org) of PDB ID 1BNA (H.R. Drew, R.M. Wing, T. Takano, C. Broka, S. Tanaka, K. Itakura, R.E.Dickerson, Structure of a B-DNA dodecamer: conformation and dynamics (1981) Proc.Natl.Acad.Sci.USA 78: 2179-2183)

Subfamilies

The following list contains the known isoforms of K-ATP.

Variants within the human species
Channel name x Alias Gene Structure Interacts with
KCNJx 1 ROMK1 Uniprot 1 SMR 1  
  5 Kir3.4 Uniprot 5 SMR 5 G protein
  6 Kir3.2 Uniprot 6 SMR 6 G protein
  8 Kir6.1 Uniprot 8 SMR 8  
  10 Kir4.1/1.2 Uniprot 10 SMR 10  
  11 Kir6.2 Uniprot 11 PDB 11 ABCC9
  12 Kir2.2 Uniprot 12 SMR 12  
  14 kir2.4 Uniprot 14 SMR 14  
  15 Kir4.2/Kir1.3 Uniprot 15 SMR 15  
  18 kir2.6 Uniprot 18 SMR 18  
ABCC8 NA SUR1 Uniprot SUR1 PDB SUR1 KCNJ11
ABCC9 NA SUR2 Uniprot SUR2 SMR SUR2 KCNJ11

The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.

Literature

For further reading
Title Author
Potassium channels in the heart: structure, function and regulation Grandi et al.

Existing models

Link to other PMR workspaces or exposures
Title Author
BG_K_ATP S Fong
Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ Faber and Rudy

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.

Source
Derived from workspace K ATP protein knowledge page at changeset 6717ffbc8a2a.
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