Model Mathematics

\frac{d}{d time} (pRB) = (k1 \frac{E2F1}{km1 + E2F1} \frac{j11}{j11 pRB} \frac{j61}{j61 pRBp} - (k16 pRB CycDa)) + k61 pRBp - (phi_pRB pRB)

\frac{d}{d time} (E2F1) = kp + k2 \frac{a^{2} + {E2F1}^{2}}{{km2}^{2} + {E2F1}^{2}} \frac{j12}{j12 + pRBp} \frac{j62}{j62 + pRBp} - (phi_E2F1 E2F1)

\frac{d}{d time} (CycDa) = \frac{k34 CycDi CycDa}{km4 + CycDa} - (k34 CycDa) - (phi_CycDa CycDa)

\frac{d}{d time} (CycDi) = k3 AP1 + k23 E2F1 \frac{j13}{j13 + pRB} \frac{j63}{j63 + pRBp} + k43 CycDa - (k34 CycDi \frac{CycDa}{km4 + CycDa}) - (phi_CycDi CycDi)

\frac{d}{d time} (AP1) = Fm + k25 E2F1 \frac{j15}{j15 + pRB} \frac{j65}{j65 + pRBp} - (phi_AP1 AP1)

\frac{d}{d time} (pRBp) = (k16 pRB CycDa - (k61 pRBp) - (k67 pRBp CycEa)) + k76 pRBpp - (phi_pRBp pRBp)

\frac{d}{d time} (pRBpp) = k67 pRBp CycEa - (k76 pRBpp) - (phi_pRBpp pRBpp)

\frac{d}{d time} (CycEi) = k28 E2F1 \frac{j18}{j18 + pRB} \frac{j68}{j68 + pRBp} + k98 CycEa - (k89 CycEi \frac{CycEa}{km9 + CycEa}) - (phi_CycEi CycEi)

\frac{d}{d time} (CycEa) = k89 CycEi \frac{CycEa}{km9 + CycEa} - (k98 CycEa) - (phi_CycEa CycEa)