/* There are a total of 22 entries in the algebraic variable array. There are a total of 11 entries in each of the rate and state variable arrays. There are a total of 25 entries in the constant variable array. */ /* * CONSTANTS[0] is kappa_R_1a_cGMP in component BG_parameters (fmol_per_sec). * CONSTANTS[1] is kappa_R_1b_cGMP in component BG_parameters (fmol_per_sec). * CONSTANTS[2] is kappa_R_2a_cGMP in component BG_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_R_2b_cGMP in component BG_parameters (fmol_per_sec). * CONSTANTS[4] is kappa_R_1_sGC in component BG_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_R_2_sGC in component BG_parameters (fmol_per_sec). * CONSTANTS[6] is kappa_R_3_sGC in component BG_parameters (fmol_per_sec). * CONSTANTS[7] is kappa_R_4_sGC in component BG_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_R_DNO_sGC in component BG_parameters (fmol_per_sec). * CONSTANTS[9] is K_GTP in component BG_parameters (per_fmol). * CONSTANTS[10] is K_E5c in component BG_parameters (per_fmol). * CONSTANTS[11] is K_cGMP in component BG_parameters (per_fmol). * CONSTANTS[12] is K_PDE in component BG_parameters (per_fmol). * CONSTANTS[13] is K_GTP_E5c in component BG_parameters (per_fmol). * CONSTANTS[14] is K_cGMP_PDE in component BG_parameters (per_fmol). * CONSTANTS[15] is K_GMP in component BG_parameters (per_fmol). * CONSTANTS[16] is K_Eb in component BG_parameters (per_fmol). * CONSTANTS[17] is K_NO in component BG_parameters (per_fmol). * CONSTANTS[18] is K_E6c in component BG_parameters (per_fmol). * CONSTANTS[19] is K_NO_product in component BG_parameters (per_fmol). * VOI is t in component environment (second). * CONSTANTS[20] is vol_myo in component environment (pL). * STATES[0] is q_cGMP in component environment (fmol). * STATES[1] is q_GTP in component environment (fmol). * STATES[2] is q_E5c in component environment (fmol). * STATES[3] is q_PDE in component environment (fmol). * STATES[4] is q_GTP_E5c in component environment (fmol). * STATES[5] is q_cGMP_PDE in component environment (fmol). * STATES[6] is q_GMP in component environment (fmol). * STATES[7] is q_Eb in component environment (fmol). * STATES[8] is q_NO in component environment (fmol). * STATES[9] is q_E6c in component environment (fmol). * STATES[10] is q_NO_product in component environment (fmol). * ALGEBRAIC[7] is v_R_1a_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[8] is v_R_1b_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[9] is v_R_2a_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[10] is v_R_2b_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[17] is v_R_1_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[18] is v_R_2_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[19] is v_R_3_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[20] is v_R_4_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[21] is v_R_DNO_sGC in component sGC (fmol_per_sec). * CONSTANTS[21] is v_NO_generation in component environment (fmol_per_sec). * CONSTANTS[22] is R in component constants (J_per_K_per_mol). * CONSTANTS[23] is T in component constants (kelvin). * CONSTANTS[24] is F in component constants (C_per_mol). * ALGEBRAIC[0] is mu_GTP in component cGMP (J_per_mol). * ALGEBRAIC[1] is mu_E5c in component cGMP (J_per_mol). * ALGEBRAIC[2] is mu_cGMP in component cGMP (J_per_mol). * ALGEBRAIC[3] is mu_PDE in component cGMP (J_per_mol). * ALGEBRAIC[4] is mu_GTP_E5c in component cGMP (J_per_mol). * ALGEBRAIC[5] is mu_cGMP_PDE in component cGMP (J_per_mol). * ALGEBRAIC[6] is mu_GMP in component cGMP (J_per_mol). * ALGEBRAIC[11] is mu_Eb in component sGC (J_per_mol). * ALGEBRAIC[12] is mu_NO in component sGC (J_per_mol). * ALGEBRAIC[13] is mu_E6c in component sGC (J_per_mol). * ALGEBRAIC[14] is mu_E5c in component sGC (J_per_mol). * ALGEBRAIC[15] is mu_cGMP in component sGC (J_per_mol). * ALGEBRAIC[16] is mu_NO_product in component sGC (J_per_mol). * RATES[0] is d/dt q_cGMP in component environment (fmol). * RATES[1] is d/dt q_GTP in component environment (fmol). * RATES[2] is d/dt q_E5c in component environment (fmol). * RATES[3] is d/dt q_PDE in component environment (fmol). * RATES[4] is d/dt q_GTP_E5c in component environment (fmol). * RATES[5] is d/dt q_cGMP_PDE in component environment (fmol). * RATES[6] is d/dt q_GMP in component environment (fmol). * RATES[7] is d/dt q_Eb in component environment (fmol). * RATES[8] is d/dt q_NO in component environment (fmol). * RATES[9] is d/dt q_E6c in component environment (fmol). * RATES[10] is d/dt q_NO_product in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 192.663; CONSTANTS[1] = 0.00328297; CONSTANTS[2] = 56591.2; CONSTANTS[3] = 0.0110353; CONSTANTS[4] = 3.61127e+06; CONSTANTS[5] = 0.00328297; CONSTANTS[6] = 4.92446; CONSTANTS[7] = 0.0361127; CONSTANTS[8] = 0.01; CONSTANTS[9] = 17040; CONSTANTS[10] = 0.304602; CONSTANTS[11] = 1; CONSTANTS[12] = 17.6706; CONSTANTS[13] = 5190.42; CONSTANTS[14] = 35.3412; CONSTANTS[15] = 0.0051282; CONSTANTS[16] = 0.0276911; CONSTANTS[17] = 1; CONSTANTS[18] = 30.4602; CONSTANTS[19] = 0.1; CONSTANTS[20] = 1; STATES[0] = 1e-6; STATES[1] = 0.0005; STATES[2] = 1e-16; STATES[3] = 1e-10; STATES[4] = 1e-16; STATES[5] = 1e-16; STATES[6] = 1e-16; STATES[7] = 1e-6; STATES[8] = 0.00836; STATES[9] = 1e-16; STATES[10] = 1e-16; CONSTANTS[21] = 0.000114; CONSTANTS[22] = 8.31; CONSTANTS[23] = 310; CONSTANTS[24] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[1] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[10]*STATES[2]); ALGEBRAIC[4] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[13]*STATES[4]); ALGEBRAIC[7] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[4]/( CONSTANTS[22]*CONSTANTS[23]))); RATES[1] = - ALGEBRAIC[7]; ALGEBRAIC[2] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[11]*STATES[0]); ALGEBRAIC[8] = CONSTANTS[1]*(exp(ALGEBRAIC[4]/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[22]*CONSTANTS[23]))); RATES[4] = ALGEBRAIC[7] - ALGEBRAIC[8]; ALGEBRAIC[3] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[12]*STATES[3]); ALGEBRAIC[5] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[14]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[3])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[5]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[6] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[15]*STATES[6]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[5]+ALGEBRAIC[2])/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[6]+ALGEBRAIC[3])/( CONSTANTS[22]*CONSTANTS[23]))); RATES[3] = - ALGEBRAIC[9]+ALGEBRAIC[10]; RATES[5] = ALGEBRAIC[9] - ALGEBRAIC[10]; RATES[6] = ALGEBRAIC[10]; ALGEBRAIC[11] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[16]*STATES[7]); ALGEBRAIC[12] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[17]*STATES[8]); ALGEBRAIC[13] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[18]*STATES[9]); ALGEBRAIC[17] = CONSTANTS[4]*(exp((ALGEBRAIC[11]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[13]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[14] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[10]*STATES[2]); ALGEBRAIC[18] = CONSTANTS[5]*(exp(ALGEBRAIC[13]/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[14]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[19] = CONSTANTS[6]*(exp((ALGEBRAIC[13]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[14]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23]))); RATES[9] = (ALGEBRAIC[17] - ALGEBRAIC[18]) - ALGEBRAIC[19]; ALGEBRAIC[15] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[11]*STATES[0]); ALGEBRAIC[20] = CONSTANTS[7]*(exp((ALGEBRAIC[14]+ ALGEBRAIC[15]*2.00000)/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[11]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23]))); RATES[0] = ((ALGEBRAIC[8] - ALGEBRAIC[9]) - ALGEBRAIC[10]) - 2.00000*ALGEBRAIC[20]; RATES[2] = (- ALGEBRAIC[7]+ALGEBRAIC[8]+ALGEBRAIC[18]+ALGEBRAIC[19]) - ALGEBRAIC[20]; RATES[7] = - ALGEBRAIC[17]+ALGEBRAIC[20]; ALGEBRAIC[16] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[19]*STATES[10]); ALGEBRAIC[21] = CONSTANTS[8]*(exp(ALGEBRAIC[12]/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[16]/( CONSTANTS[22]*CONSTANTS[23]))); RATES[8] = ((- ALGEBRAIC[17]+ALGEBRAIC[20]) - ALGEBRAIC[21])+CONSTANTS[21]; RATES[10] = ALGEBRAIC[21]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[1] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[10]*STATES[2]); ALGEBRAIC[4] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[13]*STATES[4]); ALGEBRAIC[7] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[4]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[2] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[11]*STATES[0]); ALGEBRAIC[8] = CONSTANTS[1]*(exp(ALGEBRAIC[4]/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[3] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[12]*STATES[3]); ALGEBRAIC[5] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[14]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[3])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[5]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[6] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[15]*STATES[6]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[5]+ALGEBRAIC[2])/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[6]+ALGEBRAIC[3])/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[11] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[16]*STATES[7]); ALGEBRAIC[12] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[17]*STATES[8]); ALGEBRAIC[13] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[18]*STATES[9]); ALGEBRAIC[17] = CONSTANTS[4]*(exp((ALGEBRAIC[11]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[13]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[14] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[10]*STATES[2]); ALGEBRAIC[18] = CONSTANTS[5]*(exp(ALGEBRAIC[13]/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[14]/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[19] = CONSTANTS[6]*(exp((ALGEBRAIC[13]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[14]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[15] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[11]*STATES[0]); ALGEBRAIC[20] = CONSTANTS[7]*(exp((ALGEBRAIC[14]+ ALGEBRAIC[15]*2.00000)/( CONSTANTS[22]*CONSTANTS[23])) - exp((ALGEBRAIC[11]+ALGEBRAIC[12])/( CONSTANTS[22]*CONSTANTS[23]))); ALGEBRAIC[16] = CONSTANTS[22]*CONSTANTS[23]*log( CONSTANTS[19]*STATES[10]); ALGEBRAIC[21] = CONSTANTS[8]*(exp(ALGEBRAIC[12]/( CONSTANTS[22]*CONSTANTS[23])) - exp(ALGEBRAIC[16]/( CONSTANTS[22]*CONSTANTS[23]))); }