C C There are a total of 0 entries in the algebraic variable array. C There are a total of 11 entries in each of the rate and state variable arrays. C There are a total of 15 entries in the constant variable array. C C C VOI is t in component environment (s). C CONSTS(1) is kf8 in component PIPtoDAG (per_s). C CONSTS(2) is kf9 in component PIPtoDAG (per_s). C CONSTS(3) is km6 in component PIPtoDAG (um). C CONSTS(4) is Vmax6 in component PIPtoDAG (per_s). C CONSTS(5) is km7 in component PIPtoDAG (um). C CONSTS(6) is Vmax7 in component PIPtoDAG (per_s). C STATES(1) is PIP2 in component PIPtoDAG (um). C STATES(2) is DAG in component PIPtoDAG (um). C STATES(3) is IP3 in component PIPtoDAG (um). C STATES(4) is CaPLC in component PLC (um). C STATES(5) is CaGqPLC in component PLC (um). C STATES(6) is Inositol in component PIPtoDAG (um). C STATES(7) is PC in component PIPtoDAG (um). C CONSTS(7) is kf1 in component PLC (per_um_s). C CONSTS(8) is kb1 in component PLC (per_s). C CONSTS(9) is kf2 in component PLC (per_um_s). C CONSTS(10) is kb2 in component PLC (per_s). C CONSTS(11) is kf3 in component PLC (per_um_s). C CONSTS(12) is kb3 in component PLC (per_s). C CONSTS(13) is kf4 in component PLC (per_um_s). C CONSTS(14) is kb4 in component PLC (per_s). C CONSTS(15) is kf5 in component PLC (per_s). C STATES(8) is PLC in component PLC (um). C STATES(9) is Gq in component PLC (um). C STATES(10) is Ca in component PLC (um). C STATES(11) is GqPLC in component PLC (um). C RATES(1) is d/dt PIP2 in component PIPtoDAG (um). C RATES(2) is d/dt DAG in component PIPtoDAG (um). C RATES(3) is d/dt IP3 in component PIPtoDAG (um). C RATES(7) is d/dt PC in component PIPtoDAG (um). C RATES(6) is d/dt Inositol in component PIPtoDAG (um). C RATES(8) is d/dt PLC in component PLC (um). C RATES(9) is d/dt Gq in component PLC (um). C RATES(10) is d/dt Ca in component PLC (um). C RATES(11) is d/dt GqPLC in component PLC (um). C RATES(4) is d/dt CaPLC in component PLC (um). C RATES(5) is d/dt CaGqPLC in component PLC (um). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.15 CONSTS(2) = 2.5 CONSTS(3) = 5 CONSTS(4) = 48 CONSTS(5) = 19.84166667 CONSTS(6) = 10 STATES(1) = 10 STATES(2) = 0 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 0 STATES(7) = 0 CONSTS(7) = 0.000005 CONSTS(8) = 1 CONSTS(9) = 0.0000042 CONSTS(10) = 1 CONSTS(11) = 0.00005 CONSTS(12) = 1 CONSTS(13) = 0.0000042 CONSTS(14) = 1 CONSTS(15) = 0.0133 STATES(8) = 0.8 STATES(9) = 0.15 STATES(10) = 0.1 STATES(11) = 0 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( - STATES(4)*CONSTS(6)*STATES(1))/(CONSTS(5)+STATES(1)) - ( STATES(5)*CONSTS(4)*STATES(1))/(CONSTS(3)+STATES(1)) RATES(2) = ( STATES(4)*CONSTS(6)*STATES(1))/(CONSTS(5)+STATES(1)) - CONSTS(1)*STATES(2) RATES(3) = ( STATES(5)*CONSTS(4)*STATES(1))/(CONSTS(3)+STATES(1)) - CONSTS(2)*STATES(3) RATES(7) = CONSTS(1)*STATES(2) RATES(6) = CONSTS(2)*STATES(3) RATES(8) = (( - STATES(8)*STATES(10)*CONSTS(7)+ STATES(4)*CONSTS(8)) - STATES(8)*STATES(9)*CONSTS(9))+ STATES(11)*CONSTS(10) RATES(9) = ( - STATES(8)*STATES(9)*CONSTS(9)+ STATES(11)*CONSTS(10)+ STATES(5)*CONSTS(14)) - STATES(4)*STATES(9)*CONSTS(13) RATES(10) = (( - STATES(8)*STATES(10)*CONSTS(7)+ STATES(4)*CONSTS(8)) - STATES(10)*STATES(11)*CONSTS(11))+ STATES(5)*CONSTS(12) RATES(11) = (( STATES(8)*STATES(9)*CONSTS(9) - STATES(11)*CONSTS(10)) - STATES(10)*STATES(11)*CONSTS(11))+ STATES(5)*CONSTS(12) RATES(4) = (( STATES(8)*STATES(10)*CONSTS(7) - STATES(4)*CONSTS(8))+ STATES(5)*CONSTS(15)+ STATES(5)*CONSTS(14)) - STATES(4)*STATES(9)*CONSTS(13) RATES(5) = ((( STATES(11)*STATES(10)*CONSTS(11) - STATES(5)*CONSTS(12))+ STATES(4)*STATES(9)*CONSTS(13)) - STATES(5)*CONSTS(14)) - STATES(5)*CONSTS(15) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RETURN END