About this model

This is a Functional Cell Unit for adenylyl cyclase metabolism in the cardiac cell.

This is a composite module, composed of several individual modules, and merged together in a modular fashion.

  • Ligands for beta-1 adrenergic and muscarinic receptors.
  • Change in molar amount of cyclic AMP.

Model status

The current CellML implementation runs in OpenCOR.

Model overview

All components are presented in bond-graph form. Components are made by converting an existing kinetic model and translating into bond-graph form.

Components of the model

Components of the model.

A description of the process to find bond-graph parameter is shown in the folder parameter_finder, which relies on the:

  1. stoichiometry of system
  2. kinetic constants for forward/reverse reactions
  • If not already, all reactions are made reversible by assigning a small value to the reverse direction.
  1. linear algebra script.

Here, this solve process is performed in Python.

Modular description


CellML divides the mathematical model into distinct components, which are able to be re-used in other composite models. These CellML components are:

Origin of kinetic model components
Source Components
Saucerman et al. GPCR-β 1AR, cAMP
Iancu et al. GPCR-M2

Each of these blocks is itself a CellML model, complete with bond-graph parameters appropriate for the isolated system.