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C C There are a total of 31 entries in the algebraic variable array. C There are a total of 12 entries in each of the rate and state variable arrays. C There are a total of 32 entries in the constant variable array. C C C VOI is time in component environment (second). C ALGBRC(1) is q_L_B1_init in component environment (fmol). C CONSTS(1) is q_R_B1_init in component environment (fmol). C CONSTS(2) is q_Gs_init in component environment (fmol). C CONSTS(3) is q_LR_B1_init in component environment (fmol). C CONSTS(4) is q_LR_B1Gs_init in component environment (fmol). C CONSTS(5) is q_B1d_init in component environment (fmol). C CONSTS(6) is q_BARK_init in component environment (fmol). C CONSTS(7) is q_LR_B1_BARK_init in component environment (fmol). C CONSTS(8) is q_LR_B1Gs_BARK_init in component environment (fmol). C CONSTS(9) is q_B1p_init in component environment (fmol). C CONSTS(10) is q_PKACI_init in component environment (fmol). C CONSTS(11) is q_R_PKACI_init in component environment (fmol). C ALGBRC(3) is q_L_B1 in component environment (fmol). C ALGBRC(2) is q_R_B1 in component environment (fmol). C ALGBRC(5) is q_Gs in component environment (fmol). C ALGBRC(7) is q_LR_B1 in component environment (fmol). C ALGBRC(9) is q_LR_B1Gs in component environment (fmol). C ALGBRC(11) is q_B1d in component environment (fmol). C ALGBRC(13) is q_BARK in component environment (fmol). C ALGBRC(15) is q_LR_B1_BARK in component environment (fmol). C ALGBRC(18) is q_LR_B1Gs_BARK in component environment (fmol). C ALGBRC(4) is q_B1p in component environment (fmol). C ALGBRC(6) is q_PKACI in component environment (fmol). C ALGBRC(8) is q_R_PKACI in component environment (fmol). C STATES(1) is q_L_B1 in component B1AR (fmol). C STATES(2) is q_R_B1 in component B1AR (fmol). C STATES(3) is q_Gs in component B1AR (fmol). C STATES(4) is q_LR_B1 in component B1AR (fmol). C STATES(5) is q_LR_B1Gs in component B1AR (fmol). C STATES(6) is q_B1d in component B1AR (fmol). C STATES(7) is q_BARK in component B1AR (fmol). C STATES(8) is q_LR_B1_BARK in component B1AR (fmol). C STATES(9) is q_LR_B1Gs_BARK in component B1AR (fmol). C STATES(10) is q_B1p in component B1AR (fmol). C STATES(11) is q_PKACI in component B1AR (fmol). C STATES(12) is q_R_PKACI in component B1AR (fmol). C CONSTS(12) is kappa_B11 in component B1AR_parameters (fmol_per_sec). C CONSTS(13) is kappa_B12 in component B1AR_parameters (fmol_per_sec). C CONSTS(14) is kappa_B21 in component B1AR_parameters (fmol_per_sec). C CONSTS(15) is kappa_B22 in component B1AR_parameters (fmol_per_sec). C CONSTS(16) is kappa_P1 in component B1AR_parameters (fmol_per_sec). C CONSTS(17) is kappa_P2 in component B1AR_parameters (fmol_per_sec). C CONSTS(18) is K_L_B1 in component B1AR_parameters (per_fmol). C CONSTS(19) is K_R_B1 in component B1AR_parameters (per_fmol). C CONSTS(20) is K_Gs in component B1AR_parameters (per_fmol). C CONSTS(21) is K_LR_B1 in component B1AR_parameters (per_fmol). C CONSTS(22) is K_LR_B1Gs in component B1AR_parameters (per_fmol). C CONSTS(23) is K_B1d in component B1AR_parameters (per_fmol). C CONSTS(24) is K_BARK in component B1AR_parameters (per_fmol). C CONSTS(25) is K_LR_B1_BARK in component B1AR_parameters (per_fmol). C CONSTS(26) is K_LR_B1Gs_BARK in component B1AR_parameters (per_fmol). C CONSTS(27) is K_B1p in component B1AR_parameters (per_fmol). C CONSTS(28) is K_PKACI in component B1AR_parameters (per_fmol). C CONSTS(29) is K_R_PKACI in component B1AR_parameters (per_fmol). C CONSTS(30) is R in component constants (J_per_K_per_mol). C CONSTS(31) is T in component constants (kelvin). C ALGBRC(28) is vB11 in component B1AR (fmol_per_sec). C ALGBRC(29) is vB12 in component B1AR (fmol_per_sec). C ALGBRC(30) is vB21 in component B1AR (fmol_per_sec). C ALGBRC(31) is vB22 in component B1AR (fmol_per_sec). C ALGBRC(17) is vP1 in component B1AR (fmol_per_sec). C ALGBRC(19) is vP2 in component B1AR (fmol_per_sec). C ALGBRC(20) is mu_L_B1 in component B1AR (J_per_mol). C ALGBRC(10) is mu_R_B1 in component B1AR (J_per_mol). C ALGBRC(21) is mu_Gs in component B1AR (J_per_mol). C ALGBRC(22) is mu_LR_B1 in component B1AR (J_per_mol). C ALGBRC(23) is mu_LR_B1Gs in component B1AR (J_per_mol). C ALGBRC(24) is mu_B1d in component B1AR (J_per_mol). C ALGBRC(25) is mu_BARK in component B1AR (J_per_mol). C ALGBRC(26) is mu_LR_B1_BARK in component B1AR (J_per_mol). C ALGBRC(27) is mu_LR_B1Gs_BARK in component B1AR (J_per_mol). C ALGBRC(12) is mu_B1p in component B1AR (J_per_mol). C ALGBRC(14) is mu_PKACI in component B1AR (J_per_mol). C ALGBRC(16) is mu_R_PKACI in component B1AR (J_per_mol). C CONSTS(32) is F in component constants (C_per_mol). C RATES(1) is d/dt q_L_B1 in component B1AR (fmol). C RATES(2) is d/dt q_R_B1 in component B1AR (fmol). C RATES(3) is d/dt q_Gs in component B1AR (fmol). C RATES(4) is d/dt q_LR_B1 in component B1AR (fmol). C RATES(6) is d/dt q_B1d in component B1AR (fmol). C RATES(7) is d/dt q_BARK in component B1AR (fmol). C RATES(8) is d/dt q_LR_B1_BARK in component B1AR (fmol). C RATES(5) is d/dt q_LR_B1Gs in component B1AR (fmol). C RATES(9) is d/dt q_LR_B1Gs_BARK in component B1AR (fmol). C RATES(10) is d/dt q_B1p in component B1AR (fmol). C RATES(11) is d/dt q_PKACI in component B1AR (fmol). C RATES(12) is d/dt q_R_PKACI in component B1AR (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.00005 CONSTS(2) = 0.00015 CONSTS(3) = 0 CONSTS(4) = 0.0000508778 CONSTS(5) = 0 CONSTS(6) = 0.0228 CONSTS(7) = 0.0000508778 CONSTS(8) = 0.0000508778 CONSTS(9) = 0 CONSTS(10) = 0.000221209 CONSTS(11) = 0.008778 STATES(1) = 1e-16 STATES(2) = 1e-16 STATES(3) = 1e-16 STATES(4) = 1e-16 STATES(5) = 1e-16 STATES(6) = 1e-16 STATES(7) = 1e-16 STATES(8) = 1e-16 STATES(9) = 1e-16 STATES(10) = 1e-16 STATES(11) = 1e-16 STATES(12) = 1e-16 CONSTS(12) = 0.000282928 CONSTS(13) = 128604 CONSTS(14) = 0.000200356 CONSTS(15) = 91071.1 CONSTS(16) = 2.28764e-05 CONSTS(17) = 10398.4 CONSTS(18) = 2.90698e-08 CONSTS(19) = 1849.44 CONSTS(20) = 0.0410501 CONSTS(21) = 0.0242248 CONSTS(22) = 0.0342084 CONSTS(23) = 2.90698e-08 CONSTS(24) = 0.226042 CONSTS(25) = 0.226042 CONSTS(26) = 0.319199 CONSTS(27) = 1.13021e-09 CONSTS(28) = 7.19049e-05 CONSTS(29) = 2.79561 CONSTS(30) = 8.31 CONSTS(31) = 310 CONSTS(32) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = STATES(2)+CONSTS(1) ALGBRC(10) = CONSTS(30)*CONSTS(31)*log( CONSTS(19)*ALGBRC(2)) ALGBRC(6) = STATES(11)+CONSTS(10) ALGBRC(14) = CONSTS(30)*CONSTS(31)*log( CONSTS(28)*ALGBRC(6)) ALGBRC(8) = STATES(12)+CONSTS(11) ALGBRC(16) = CONSTS(30)*CONSTS(31)*log( CONSTS(29)*ALGBRC(8)) ALGBRC(17) = CONSTS(16)*(EXP((ALGBRC(10)+ALGBRC(14))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(16)/( CONSTS(30)*CONSTS(31)))) RATES(2) = - ALGBRC(17) RATES(10) = - ALGBRC(17) ALGBRC(4) = STATES(10)+CONSTS(9) ALGBRC(12) = CONSTS(30)*CONSTS(31)*log( CONSTS(27)*ALGBRC(4)) ALGBRC(19) = CONSTS(17)*(EXP(ALGBRC(16)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(14)+ALGBRC(12))/( CONSTS(30)*CONSTS(31)))) RATES(11) = ALGBRC(19) - ALGBRC(17) RATES(12) = ALGBRC(17) - ALGBRC(19) ALGBRC(7) = STATES(4)+CONSTS(3) ALGBRC(22) = CONSTS(30)*CONSTS(31)*log( CONSTS(21)*ALGBRC(7)) ALGBRC(13) = STATES(7)+CONSTS(6) ALGBRC(25) = CONSTS(30)*CONSTS(31)*log( CONSTS(24)*ALGBRC(13)) ALGBRC(15) = STATES(8)+CONSTS(7) ALGBRC(26) = CONSTS(30)*CONSTS(31)*log( CONSTS(25)*ALGBRC(15)) ALGBRC(28) = CONSTS(12)*(EXP((ALGBRC(22)+ALGBRC(25))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(26)/( CONSTS(30)*CONSTS(31)))) RATES(4) = - ALGBRC(28) ALGBRC(1) = TERNRY( sin( 2.00000* 3.14159265358979*VOI).GT.0.100000, 0.000100000, 1.00000e-06) ALGBRC(3) = STATES(1)+ALGBRC(1) ALGBRC(20) = CONSTS(30)*CONSTS(31)*log( CONSTS(18)*ALGBRC(3)) ALGBRC(11) = STATES(6)+CONSTS(5) ALGBRC(24) = CONSTS(30)*CONSTS(31)*log( CONSTS(23)*ALGBRC(11)) ALGBRC(29) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(25)+ALGBRC(24)+ALGBRC(20))/( CONSTS(30)*CONSTS(31)))) RATES(8) = ALGBRC(28) - ALGBRC(29) ALGBRC(9) = STATES(5)+CONSTS(4) ALGBRC(23) = CONSTS(30)*CONSTS(31)*log( CONSTS(22)*ALGBRC(9)) ALGBRC(18) = STATES(9)+CONSTS(8) ALGBRC(27) = CONSTS(30)*CONSTS(31)*log( CONSTS(26)*ALGBRC(18)) ALGBRC(30) = CONSTS(14)*(EXP((ALGBRC(23)+ALGBRC(25))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(27)/( CONSTS(30)*CONSTS(31)))) RATES(5) = - ALGBRC(30) ALGBRC(5) = STATES(3)+CONSTS(2) ALGBRC(21) = CONSTS(30)*CONSTS(31)*log( CONSTS(20)*ALGBRC(5)) ALGBRC(31) = CONSTS(15)*(EXP(ALGBRC(27)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(25)+ALGBRC(24)+ALGBRC(20)+ALGBRC(21))/( CONSTS(30)*CONSTS(31)))) RATES(1) = ALGBRC(29)+ALGBRC(31) RATES(3) = ALGBRC(31) RATES(6) = ALGBRC(29)+ALGBRC(31) RATES(7) = ((ALGBRC(29)+ALGBRC(31)) - ALGBRC(28)) - ALGBRC(30) RATES(9) = ALGBRC(30) - ALGBRC(31) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = STATES(2)+CONSTS(1) ALGBRC(10) = CONSTS(30)*CONSTS(31)*log( CONSTS(19)*ALGBRC(2)) ALGBRC(6) = STATES(11)+CONSTS(10) ALGBRC(14) = CONSTS(30)*CONSTS(31)*log( CONSTS(28)*ALGBRC(6)) ALGBRC(8) = STATES(12)+CONSTS(11) ALGBRC(16) = CONSTS(30)*CONSTS(31)*log( CONSTS(29)*ALGBRC(8)) ALGBRC(17) = CONSTS(16)*(EXP((ALGBRC(10)+ALGBRC(14))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(16)/( CONSTS(30)*CONSTS(31)))) ALGBRC(4) = STATES(10)+CONSTS(9) ALGBRC(12) = CONSTS(30)*CONSTS(31)*log( CONSTS(27)*ALGBRC(4)) ALGBRC(19) = CONSTS(17)*(EXP(ALGBRC(16)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(14)+ALGBRC(12))/( CONSTS(30)*CONSTS(31)))) ALGBRC(7) = STATES(4)+CONSTS(3) ALGBRC(22) = CONSTS(30)*CONSTS(31)*log( CONSTS(21)*ALGBRC(7)) ALGBRC(13) = STATES(7)+CONSTS(6) ALGBRC(25) = CONSTS(30)*CONSTS(31)*log( CONSTS(24)*ALGBRC(13)) ALGBRC(15) = STATES(8)+CONSTS(7) ALGBRC(26) = CONSTS(30)*CONSTS(31)*log( CONSTS(25)*ALGBRC(15)) ALGBRC(28) = CONSTS(12)*(EXP((ALGBRC(22)+ALGBRC(25))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(26)/( CONSTS(30)*CONSTS(31)))) ALGBRC(1) = TERNRY( sin( 2.00000* 3.14159265358979*VOI).GT.0.100000, 0.000100000, 1.00000e-06) ALGBRC(3) = STATES(1)+ALGBRC(1) ALGBRC(20) = CONSTS(30)*CONSTS(31)*log( CONSTS(18)*ALGBRC(3)) ALGBRC(11) = STATES(6)+CONSTS(5) ALGBRC(24) = CONSTS(30)*CONSTS(31)*log( CONSTS(23)*ALGBRC(11)) ALGBRC(29) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(25)+ALGBRC(24)+ALGBRC(20))/( CONSTS(30)*CONSTS(31)))) ALGBRC(9) = STATES(5)+CONSTS(4) ALGBRC(23) = CONSTS(30)*CONSTS(31)*log( CONSTS(22)*ALGBRC(9)) ALGBRC(18) = STATES(9)+CONSTS(8) ALGBRC(27) = CONSTS(30)*CONSTS(31)*log( CONSTS(26)*ALGBRC(18)) ALGBRC(30) = CONSTS(14)*(EXP((ALGBRC(23)+ALGBRC(25))/( CONSTS(30)*CONSTS(31))) - EXP(ALGBRC(27)/( CONSTS(30)*CONSTS(31)))) ALGBRC(5) = STATES(3)+CONSTS(2) ALGBRC(21) = CONSTS(30)*CONSTS(31)*log( CONSTS(20)*ALGBRC(5)) ALGBRC(31) = CONSTS(15)*(EXP(ALGBRC(27)/( CONSTS(30)*CONSTS(31))) - EXP((ALGBRC(25)+ALGBRC(24)+ALGBRC(20)+ALGBRC(21))/( CONSTS(30)*CONSTS(31)))) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END