/* There are a total of 16 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 35 entries in the constant variable array. */ /* * VOI is time in component time_s (second). * ALGEBRAIC[8] is V in component Vm (mV). * ALGEBRAIC[2] is p1 in component Vm (mV_per_s). * ALGEBRAIC[4] is p2 in component Vm (mV). * ALGEBRAIC[6] is t0 in component Vm (second). * CONSTANTS[0] is tss in component Vm (second). * CONSTANTS[1] is Nai in component control_para (mM). * CONSTANTS[2] is inhPump in component control_para (dimensionless). * CONSTANTS[3] is K_Cahalf in component control_para (mV). * STATES[0] is Cai in component Cai (mM). * ALGEBRAIC[15] is J_VOCC in component J_VOCC (mM_per_s). * ALGEBRAIC[10] is J_CaPump in component J_CaPump (mM_per_s). * ALGEBRAIC[13] is J_NaCa in component J_NaCa (mM_per_s). * ALGEBRAIC[0] is stress in component CB4HM (dimensionless). * ALGEBRAIC[1] is phosphorylation in component CB4HM (dimensionless). * CONSTANTS[4] is R in component constants (J_per_K_mol). * CONSTANTS[5] is F in component constants (C_per_mmol). * CONSTANTS[6] is T in component model_para (kelvin). * CONSTANTS[7] is Nao in component model_para (mM). * CONSTANTS[8] is Cao in component model_para (mM). * CONSTANTS[9] is V_cell in component model_para (fm3). * CONSTANTS[10] is V_Cahalf in component model_para (mV). * CONSTANTS[11] is g_mCa in component model_para (nS). * CONSTANTS[12] is V_pmax in component model_para (mM_per_s). * CONSTANTS[13] is n in component model_para (dimensionless). * CONSTANTS[14] is K_ph in component model_para (mM). * CONSTANTS[15] is K_NaCa in component model_para (mM). * CONSTANTS[16] is G_NaCa in component model_para (mM_per_s_mV). * CONSTANTS[17] is Cai_init in component initials (mM). * CONSTANTS[18] is n_M in component model_para (dimensionless). * CONSTANTS[19] is Ca_halfMLCK in component model_para (mM). * CONSTANTS[20] is M_init in component initials (dimensionless). * CONSTANTS[21] is Mp_init in component initials (dimensionless). * CONSTANTS[22] is AM_init in component initials (dimensionless). * CONSTANTS[23] is AMp_init in component initials (dimensionless). * CONSTANTS[24] is K_7 in component model_para (per_s). * CONSTANTS[25] is K_2 in component model_para (per_s). * CONSTANTS[26] is K_3 in component model_para (per_s). * ALGEBRAIC[9] is rho_vCa in component J_VOCC (dimensionless). * CONSTANTS[27] is Nai in component model_para (mM). * CONSTANTS[28] is K_Cahalf in component model_para (mV). * CONSTANTS[29] is inhPump in component model_para (dimensionless). * CONSTANTS[30] is z_Ca in component E_Ca (dimensionless). * ALGEBRAIC[11] is E in component Nernst_potential (mV). * CONSTANTS[31] is z_Na in component E_Na (dimensionless). * CONSTANTS[32] is E in component Nernst_potential (mV). * ALGEBRAIC[14] is I in component Ionic_currents (pA). * ALGEBRAIC[12] is V_mNaCa in component J_NaCa (mV). * ALGEBRAIC[5] is K_1 in component K_1 (per_s). * CONSTANTS[33] is K_4 in component CB4HM (per_s). * CONSTANTS[34] is K_5 in component CB4HM (per_s). * ALGEBRAIC[7] is K_6 in component CB4HM (per_s). * ALGEBRAIC[3] is norm in component CB4HM (dimensionless). * STATES[1] is M in component CB4HM (dimensionless). * STATES[2] is Mp in component CB4HM (dimensionless). * STATES[3] is AM in component CB4HM (dimensionless). * STATES[4] is AMp in component CB4HM (dimensionless). * RATES[0] is d/dt Cai in component Cai (mM). * RATES[1] is d/dt M in component CB4HM (dimensionless). * RATES[2] is d/dt Mp in component CB4HM (dimensionless). * RATES[3] is d/dt AM in component CB4HM (dimensionless). * RATES[4] is d/dt AMp in component CB4HM (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0; CONSTANTS[1] = 2.9836; CONSTANTS[2] = 1; CONSTANTS[3] = 11; CONSTANTS[4] = 8.314; CONSTANTS[5] = 96.48534; CONSTANTS[6] = 310; CONSTANTS[7] = 140; CONSTANTS[8] = 2; CONSTANTS[9] = 21; CONSTANTS[10] = -27; CONSTANTS[11] = 0.046842; CONSTANTS[12] = 5.1449e-4; CONSTANTS[13] = 1.9015; CONSTANTS[14] = 0.6e-3; CONSTANTS[15] = 7e-3; CONSTANTS[16] = 5.7297e-5; CONSTANTS[17] = 0.1e-6; CONSTANTS[18] = 8.7613; CONSTANTS[19] = 256.98e-6; CONSTANTS[20] = 1; CONSTANTS[21] = 0; CONSTANTS[22] = 0; CONSTANTS[23] = 0; CONSTANTS[24] = 0.0378; CONSTANTS[25] = 1.2387; CONSTANTS[26] = 0.1419; CONSTANTS[27] = 2.9836; CONSTANTS[28] = 11; CONSTANTS[29] = 1; CONSTANTS[30] = 2; CONSTANTS[31] = 1; CONSTANTS[32] = (( CONSTANTS[4]*CONSTANTS[6])/( CONSTANTS[31]*CONSTANTS[5]))*log(CONSTANTS[7]/CONSTANTS[1]); CONSTANTS[33] = CONSTANTS[26]/4.00000; CONSTANTS[34] = CONSTANTS[25]; STATES[0] = CONSTANTS[17]; STATES[1] = CONSTANTS[20]; STATES[2] = CONSTANTS[21]; STATES[3] = CONSTANTS[22]; STATES[4] = CONSTANTS[23]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = (pow(STATES[0], CONSTANTS[18])/(pow(CONSTANTS[19], CONSTANTS[18])+pow(STATES[0], CONSTANTS[18])))*1.00000; ALGEBRAIC[3] = STATES[1]+STATES[2]+STATES[3]+STATES[4]; RATES[1] = ( - ALGEBRAIC[5]*STATES[1])/ALGEBRAIC[3]+( CONSTANTS[25]*STATES[2])/ALGEBRAIC[3]+( CONSTANTS[24]*STATES[3])/ALGEBRAIC[3]; RATES[2] = (( CONSTANTS[33]*STATES[4])/ALGEBRAIC[3]+( ALGEBRAIC[5]*STATES[1])/ALGEBRAIC[3]) - ( (CONSTANTS[25]+CONSTANTS[26])*STATES[2])/ALGEBRAIC[3]; ALGEBRAIC[7] = ALGEBRAIC[5]; RATES[3] = ( CONSTANTS[34]*STATES[4])/ALGEBRAIC[3] - ( (ALGEBRAIC[7]+CONSTANTS[24])*STATES[3])/ALGEBRAIC[3]; RATES[4] = (( CONSTANTS[26]*STATES[2])/ALGEBRAIC[3]+( ALGEBRAIC[7]*STATES[3])/ALGEBRAIC[3]) - ( (CONSTANTS[33]+CONSTANTS[34])*STATES[4])/ALGEBRAIC[3]; ALGEBRAIC[2] = (VOI - CONSTANTS[0]<0.474200 ? 0.00000 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? 0.250800 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? - 4.29660 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? 3.62830 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? 6.71270 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? 3.61510 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? - 6.84810 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? - 0.0369000 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2152 ? - 66.1632 : VOI - CONSTANTS[0]>=56.2152&&VOI - CONSTANTS[0]<62.2548 ? - 1.44560 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? - 0.155700 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? - 0.0623000 : 0.00000); ALGEBRAIC[4] = (VOI - CONSTANTS[0]<0.474200 ? - 63.0930 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? - 63.0930 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? - 60.7620 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? - 65.2270 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? - 60.7870 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? - 18.5270 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? - 13.2450 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? - 27.7300 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2152 ? - 28.9850 : VOI - CONSTANTS[0]>=56.2152&&VOI - CONSTANTS[0]<62.2548 ? - 49.5750 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? - 58.3060 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? - 61.4480 : - 63.4110); ALGEBRAIC[6] = (VOI - CONSTANTS[0]<0.474200 ? 0.00000 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? 0.474200 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? 9.76840 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? 10.8076 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? 12.0313 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? 18.3268 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? 19.7879 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? 21.9031 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2151 ? 55.9040 : VOI - CONSTANTS[0]>=56.2151&&VOI - CONSTANTS[0]<62.2548 ? 56.2151 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? 62.2548 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? 82.4299 : 0.00000); ALGEBRAIC[8] = ALGEBRAIC[2]*((VOI - ALGEBRAIC[6]) - CONSTANTS[0])+ALGEBRAIC[4]; ALGEBRAIC[9] = 1.00000/(1.00000+exp((CONSTANTS[10] - ALGEBRAIC[8])/CONSTANTS[3])); ALGEBRAIC[11] = (( CONSTANTS[4]*CONSTANTS[6])/( CONSTANTS[30]*CONSTANTS[5]))*log(CONSTANTS[8]/STATES[0]); ALGEBRAIC[14] = CONSTANTS[11]*ALGEBRAIC[9]*(ALGEBRAIC[8] - ALGEBRAIC[11]); ALGEBRAIC[15] = - ALGEBRAIC[14]/( 2.00000*CONSTANTS[9]*CONSTANTS[5]); ALGEBRAIC[10] = ( - CONSTANTS[12]*pow(STATES[0], CONSTANTS[13]))/(pow(CONSTANTS[14], CONSTANTS[13])+pow(STATES[0], CONSTANTS[13])); ALGEBRAIC[12] = 3.00000*CONSTANTS[32] - 2.00000*ALGEBRAIC[11]; ALGEBRAIC[13] = (( CONSTANTS[16]*STATES[0])/(STATES[0]+CONSTANTS[15]))*(ALGEBRAIC[8] - ALGEBRAIC[12]); RATES[0] = ALGEBRAIC[15]+ CONSTANTS[2]*ALGEBRAIC[10]+ALGEBRAIC[13]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = (pow(STATES[0], CONSTANTS[18])/(pow(CONSTANTS[19], CONSTANTS[18])+pow(STATES[0], CONSTANTS[18])))*1.00000; ALGEBRAIC[3] = STATES[1]+STATES[2]+STATES[3]+STATES[4]; ALGEBRAIC[7] = ALGEBRAIC[5]; ALGEBRAIC[2] = (VOI - CONSTANTS[0]<0.474200 ? 0.00000 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? 0.250800 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? - 4.29660 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? 3.62830 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? 6.71270 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? 3.61510 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? - 6.84810 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? - 0.0369000 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2152 ? - 66.1632 : VOI - CONSTANTS[0]>=56.2152&&VOI - CONSTANTS[0]<62.2548 ? - 1.44560 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? - 0.155700 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? - 0.0623000 : 0.00000); ALGEBRAIC[4] = (VOI - CONSTANTS[0]<0.474200 ? - 63.0930 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? - 63.0930 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? - 60.7620 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? - 65.2270 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? - 60.7870 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? - 18.5270 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? - 13.2450 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? - 27.7300 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2152 ? - 28.9850 : VOI - CONSTANTS[0]>=56.2152&&VOI - CONSTANTS[0]<62.2548 ? - 49.5750 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? - 58.3060 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? - 61.4480 : - 63.4110); ALGEBRAIC[6] = (VOI - CONSTANTS[0]<0.474200 ? 0.00000 : VOI - CONSTANTS[0]>=0.474200&&VOI - CONSTANTS[0]<9.76840 ? 0.474200 : VOI - CONSTANTS[0]>=9.76840&&VOI - CONSTANTS[0]<10.8076 ? 9.76840 : VOI - CONSTANTS[0]>=10.8076&&VOI - CONSTANTS[0]<12.0313 ? 10.8076 : VOI - CONSTANTS[0]>=12.0313&&VOI - CONSTANTS[0]<18.3268 ? 12.0313 : VOI - CONSTANTS[0]>=18.3268&&VOI - CONSTANTS[0]<19.7879 ? 18.3268 : VOI - CONSTANTS[0]>=19.7879&&VOI - CONSTANTS[0]<21.9031 ? 19.7879 : VOI - CONSTANTS[0]>=21.9031&&VOI - CONSTANTS[0]<55.9040 ? 21.9031 : VOI - CONSTANTS[0]>=55.9040&&VOI - CONSTANTS[0]<56.2151 ? 55.9040 : VOI - CONSTANTS[0]>=56.2151&&VOI - CONSTANTS[0]<62.2548 ? 56.2151 : VOI - CONSTANTS[0]>=62.2548&&VOI - CONSTANTS[0]<82.4301 ? 62.2548 : VOI - CONSTANTS[0]>=82.4301&&VOI - CONSTANTS[0]<113.961 ? 82.4299 : 0.00000); ALGEBRAIC[8] = ALGEBRAIC[2]*((VOI - ALGEBRAIC[6]) - CONSTANTS[0])+ALGEBRAIC[4]; ALGEBRAIC[9] = 1.00000/(1.00000+exp((CONSTANTS[10] - ALGEBRAIC[8])/CONSTANTS[3])); ALGEBRAIC[11] = (( CONSTANTS[4]*CONSTANTS[6])/( CONSTANTS[30]*CONSTANTS[5]))*log(CONSTANTS[8]/STATES[0]); ALGEBRAIC[14] = CONSTANTS[11]*ALGEBRAIC[9]*(ALGEBRAIC[8] - ALGEBRAIC[11]); ALGEBRAIC[15] = - ALGEBRAIC[14]/( 2.00000*CONSTANTS[9]*CONSTANTS[5]); ALGEBRAIC[10] = ( - CONSTANTS[12]*pow(STATES[0], CONSTANTS[13]))/(pow(CONSTANTS[14], CONSTANTS[13])+pow(STATES[0], CONSTANTS[13])); ALGEBRAIC[12] = 3.00000*CONSTANTS[32] - 2.00000*ALGEBRAIC[11]; ALGEBRAIC[13] = (( CONSTANTS[16]*STATES[0])/(STATES[0]+CONSTANTS[15]))*(ALGEBRAIC[8] - ALGEBRAIC[12]); ALGEBRAIC[0] = STATES[4]+STATES[3]; ALGEBRAIC[1] = STATES[4]+STATES[2]; }