/* There are a total of 69 entries in the algebraic variable array. There are a total of 22 entries in each of the rate and state variable arrays. There are a total of 63 entries in the constant variable array. */ /* * VOI is time in component Time (time_units). * CONSTANTS[0] is T in component Environment (Temperature_units). * CONSTANTS[1] is F in component Environment (F_units). * CONSTANTS[2] is R in component Environment (R_units). * CONSTANTS[3] is Ca_o in component Environment (millimolar). * CONSTANTS[4] is Na_o in component Environment (millimolar). * CONSTANTS[5] is K_o in component Environment (millimolar). * CONSTANTS[57] is FoRT in component Environment (inverse_voltage_units). * CONSTANTS[58] is RToF in component Environment (voltage_units). * CONSTANTS[6] is Cm in component membrane (capacitance_units). * STATES[0] is Vm in component membrane (voltage_units). * STATES[1] is Ca_i_peripheral in component membrane (millimolar). * STATES[2] is Ca_i_bulk in component membrane (millimolar). * STATES[3] is Ca_sr in component membrane (millimolar). * STATES[4] is Na_i in component membrane (millimolar). * STATES[5] is K_i in component membrane (millimolar). * ALGEBRAIC[43] is i_k1 in component i_k1 (current_units). * ALGEBRAIC[33] is i_to_fast in component i_to_fast (current_units). * ALGEBRAIC[36] is i_to_sustained in component i_to_sustained (current_units). * ALGEBRAIC[46] is i_kr in component i_kr (current_units). * ALGEBRAIC[48] is i_ks in component i_ks (current_units). * ALGEBRAIC[54] is i_kb in component i_kb (current_units). * ALGEBRAIC[52] is i_nak in component i_nak (current_units). * ALGEBRAIC[31] is i_cal in component i_cal (current_units). * ALGEBRAIC[25] is i_cat in component i_cat (current_units). * ALGEBRAIC[38] is i_na_fast in component i_na_fast (current_units). * ALGEBRAIC[40] is i_na_late in component i_na_late (current_units). * ALGEBRAIC[59] is i_pmca in component i_pmca (current_units). * ALGEBRAIC[58] is i_cab in component i_cab (current_units). * ALGEBRAIC[66] is i_f_na in component i_f_na (current_units). * ALGEBRAIC[62] is i_f_k in component i_f_k (current_units). * ALGEBRAIC[49] is i_naca in component i_naca (current_units). * ALGEBRAIC[56] is i_nab in component i_nab (current_units). * ALGEBRAIC[0] is i_stim in component membrane (current_units). * ALGEBRAIC[61] is i_rel_per in component i_rel_per (current_units). * ALGEBRAIC[63] is i_serca_per in component i_serca_per (current_units). * ALGEBRAIC[65] is i_serca_bulk in component i_serca_bulk (current_units). * ALGEBRAIC[68] is i_diff in component i_diff (current_units). * ALGEBRAIC[67] is i_leak in component i_leak (current_units). * CONSTANTS[60] is peripheral_volume in component membrane (volume_units). * CONSTANTS[59] is bulk_volume in component membrane (volume_units). * CONSTANTS[62] is diffusable_volume in component membrane (volume_units). * CONSTANTS[61] is sr_volume in component membrane (volume_units). * CONSTANTS[7] is cell_volume in component membrane (volume_units). * CONSTANTS[8] is bulk_fraction in component membrane (dimensionless). * CONSTANTS[9] is periphery_fraction in component membrane (dimensionless). * CONSTANTS[10] is sr_fraction in component membrane (dimensionless). * CONSTANTS[11] is stim_start in component membrane (time_units). * CONSTANTS[12] is stim_end in component membrane (time_units). * CONSTANTS[13] is stim_period in component membrane (time_units). * CONSTANTS[14] is stim_duration in component membrane (time_units). * CONSTANTS[15] is stim_amplitude in component membrane (current_units). * ALGEBRAIC[1] is x_inf_Ttype in component x_Ttype (dimensionless). * CONSTANTS[16] is tau_x_Ttype in component x_Ttype (time_units). * STATES[6] is x_Ttype in component x_Ttype (dimensionless). * ALGEBRAIC[2] is y_inf_Ttype in component y_Ttype (dimensionless). * ALGEBRAIC[17] is tau_y_Ttype in component y_Ttype (time_units). * STATES[7] is y_Ttype in component y_Ttype (dimensionless). * ALGEBRAIC[16] is E_Ca in component i_cat (voltage_units). * CONSTANTS[17] is G_max_Ttype in component i_cat (conductance_units). * ALGEBRAIC[3] is x_inf_Ltype in component x_Ltype (dimensionless). * CONSTANTS[18] is tau_x_Ltype in component x_Ltype (time_units). * STATES[8] is x_Ltype in component x_Ltype (dimensionless). * ALGEBRAIC[4] is y_inf_Ltype in component y_Ltype (dimensionless). * ALGEBRAIC[18] is tau_y_Ltype in component y_Ltype (time_units). * STATES[9] is y_Ltype in component y_Ltype (dimensionless). * ALGEBRAIC[5] is y_ca_inf_Ltype in component y_ca_Ltype (dimensionless). * ALGEBRAIC[19] is tau_y_ca_Ltype in component y_ca_Ltype (time_units). * STATES[10] is y_ca_Ltype in component y_ca_Ltype (dimensionless). * ALGEBRAIC[28] is E_Ca in component i_cal (voltage_units). * CONSTANTS[19] is G_max_Ltype in component i_cal (conductance_units). * ALGEBRAIC[6] is x_inf_to_fast in component x_to_fast (dimensionless). * CONSTANTS[20] is tau_x_to_fast in component x_to_fast (time_units). * STATES[11] is x_to_fast in component x_to_fast (dimensionless). * ALGEBRAIC[7] is y_inf_to_fast in component y_to_fast (dimensionless). * CONSTANTS[21] is tau_y_to_fast in component y_to_fast (time_units). * STATES[12] is y_to_fast in component y_to_fast (dimensionless). * ALGEBRAIC[32] is E_k in component i_to_fast (voltage_units). * CONSTANTS[22] is G_max_to_fast in component i_to_fast (conductance_units). * ALGEBRAIC[34] is x_to_sustained in component x_to_sustained (dimensionless). * ALGEBRAIC[35] is E_k in component i_to_sustained (voltage_units). * CONSTANTS[23] is G_max_to_sustained in component i_to_sustained (conductance_units). * ALGEBRAIC[8] is x_inf_na_fast in component x_na_fast (dimensionless). * CONSTANTS[24] is tau_x_na_fast in component x_na_fast (time_units). * STATES[13] is x_na_fast in component x_na_fast (dimensionless). * ALGEBRAIC[9] is y_inf_na_fast in component y_na_fast (dimensionless). * CONSTANTS[25] is tau_y_na_fast in component y_na_fast (time_units). * STATES[14] is y_na_fast in component y_na_fast (dimensionless). * ALGEBRAIC[37] is E_na in component i_na_fast (voltage_units). * CONSTANTS[26] is G_max_na_fast in component i_na_fast (conductance_units). * ALGEBRAIC[10] is x_inf_na_late in component x_na_late (dimensionless). * CONSTANTS[27] is tau_x_na_late in component x_na_late (time_units). * STATES[15] is x_na_late in component x_na_late (dimensionless). * ALGEBRAIC[11] is y_inf_na_late in component y_na_late (dimensionless). * ALGEBRAIC[20] is tau_y_na_late in component y_na_late (time_units). * STATES[16] is y_na_late in component y_na_late (dimensionless). * ALGEBRAIC[39] is E_na in component i_na_late (voltage_units). * CONSTANTS[28] is G_max_na_late in component i_na_late (conductance_units). * ALGEBRAIC[41] is x_k1 in component x_k1 (dimensionless). * ALGEBRAIC[42] is E_k in component i_k1 (voltage_units). * CONSTANTS[29] is G_max_k1 in component i_k1 (conductance_units). * ALGEBRAIC[44] is x_kr in component x_kr (dimensionless). * ALGEBRAIC[12] is y_inf_kr in component y_kr (dimensionless). * ALGEBRAIC[29] is tau_y_kr in component y_kr (time_units). * STATES[17] is y_kr in component y_kr (dimensionless). * ALGEBRAIC[21] is ykrv1 in component y_kr (rate_constants_units). * ALGEBRAIC[26] is ykrv2 in component y_kr (rate_constants_units). * ALGEBRAIC[45] is E_k in component i_kr (voltage_units). * CONSTANTS[30] is G_max_kr in component i_kr (conductance_units). * ALGEBRAIC[13] is x_inf_ks in component x_ks (dimensionless). * ALGEBRAIC[22] is tau_x_ks in component x_ks (time_units). * STATES[18] is x_ks in component x_ks (dimensionless). * ALGEBRAIC[27] is y_inf_ks in component y_ks (dimensionless). * ALGEBRAIC[30] is tau_y_ks in component y_ks (time_units). * STATES[19] is y_ks in component y_ks (dimensionless). * ALGEBRAIC[47] is E_k in component i_ks (voltage_units). * CONSTANTS[31] is G_max_ks in component i_ks (conductance_units). * CONSTANTS[32] is n_NaCa in component i_naca (dimensionless). * CONSTANTS[33] is g_NaCa in component i_naca (current_units). * CONSTANTS[34] is d_NaCa in component i_naca (dimensionless). * CONSTANTS[35] is gamma in component i_naca (dimensionless). * ALGEBRAIC[50] is x_nak in component x_nak (dimensionless). * ALGEBRAIC[51] is y_nak in component y_nak (dimensionless). * CONSTANTS[36] is g_nak in component i_nak (current_units). * ALGEBRAIC[53] is E_k in component i_kb (voltage_units). * CONSTANTS[37] is G_max_kb in component i_kb (conductance_units). * ALGEBRAIC[55] is E_na in component i_nab (voltage_units). * CONSTANTS[38] is G_max_nab in component i_nab (conductance_units). * ALGEBRAIC[57] is E_ca in component i_cab (voltage_units). * CONSTANTS[39] is G_max_cab in component i_cab (conductance_units). * CONSTANTS[40] is PMCA_max in component i_pmca (current_units). * CONSTANTS[41] is Kpmca in component i_pmca (millimolar). * CONSTANTS[42] is Hpmca in component i_pmca (dimensionless). * CONSTANTS[43] is G_f_k in component i_f_k (conductance_units). * ALGEBRAIC[60] is E_k in component i_f_k (voltage_units). * STATES[20] is y_gate_f_k in component y_gate_f_k (dimensionless). * CONSTANTS[44] is G_f_na in component i_f_na (conductance_units). * ALGEBRAIC[64] is E_na in component i_f_na (voltage_units). * STATES[21] is y_gate_f_na in component y_gate_f_na (dimensionless). * ALGEBRAIC[14] is y_inf_f_gate in component y_gate_f_k (dimensionless). * ALGEBRAIC[23] is tau_y_f_gate in component y_gate_f_k (time_units). * ALGEBRAIC[15] is y_inf_f_gate in component y_gate_f_na (dimensionless). * ALGEBRAIC[24] is tau_y_f_gate in component y_gate_f_na (time_units). * CONSTANTS[45] is REL_max in component i_rel_per (current_per_millimolar_units). * CONSTANTS[46] is Krel in component i_rel_per (millimolar). * CONSTANTS[47] is SERCA_max in component i_serca_per (current_units). * CONSTANTS[48] is Kmf in component i_serca_per (millimolar). * CONSTANTS[49] is Kmr in component i_serca_per (millimolar). * CONSTANTS[50] is H in component i_serca_per (dimensionless). * CONSTANTS[51] is SERCA_max in component i_serca_bulk (current_units). * CONSTANTS[52] is Kmf in component i_serca_bulk (millimolar). * CONSTANTS[53] is Kmr in component i_serca_bulk (millimolar). * CONSTANTS[54] is H in component i_serca_bulk (dimensionless). * CONSTANTS[55] is LEAK_max in component i_leak (current_per_millimolar_units). * CONSTANTS[56] is DIFF_max in component i_diff (current_per_millimolar_units). * RATES[0] is d/dt Vm in component membrane (voltage_units). * RATES[1] is d/dt Ca_i_peripheral in component membrane (millimolar). * RATES[2] is d/dt Ca_i_bulk in component membrane (millimolar). * RATES[3] is d/dt Ca_sr in component membrane (millimolar). * RATES[5] is d/dt K_i in component membrane (millimolar). * RATES[4] is d/dt Na_i in component membrane (millimolar). * RATES[6] is d/dt x_Ttype in component x_Ttype (dimensionless). * RATES[7] is d/dt y_Ttype in component y_Ttype (dimensionless). * RATES[8] is d/dt x_Ltype in component x_Ltype (dimensionless). * RATES[9] is d/dt y_Ltype in component y_Ltype (dimensionless). * RATES[10] is d/dt y_ca_Ltype in component y_ca_Ltype (dimensionless). * RATES[11] is d/dt x_to_fast in component x_to_fast (dimensionless). * RATES[12] is d/dt y_to_fast in component y_to_fast (dimensionless). * RATES[13] is d/dt x_na_fast in component x_na_fast (dimensionless). * RATES[14] is d/dt y_na_fast in component y_na_fast (dimensionless). * RATES[15] is d/dt x_na_late in component x_na_late (dimensionless). * RATES[16] is d/dt y_na_late in component y_na_late (dimensionless). * RATES[17] is d/dt y_kr in component y_kr (dimensionless). * RATES[18] is d/dt x_ks in component x_ks (dimensionless). * RATES[19] is d/dt y_ks in component y_ks (dimensionless). * RATES[20] is d/dt y_gate_f_k in component y_gate_f_k (dimensionless). * RATES[21] is d/dt y_gate_f_na in component y_gate_f_na (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 310.0; CONSTANTS[1] = 96485.3415; CONSTANTS[2] = 8314.472; CONSTANTS[3] = 2.0; CONSTANTS[4] = 140; CONSTANTS[5] = 5.4; CONSTANTS[6] = 69.0; STATES[0] = -88.34; STATES[1] = 0.00001; STATES[2] = 0.000032; STATES[3] = 0.17; STATES[4] = 6.7; STATES[5] = 140; CONSTANTS[7] = 13266.5; CONSTANTS[8] = 0.6; CONSTANTS[9] = 0.2; CONSTANTS[10] = 0.06; CONSTANTS[11] = 700; CONSTANTS[12] = 9000000; CONSTANTS[13] = 500; CONSTANTS[14] = 0.5; CONSTANTS[15] = -4320.0; CONSTANTS[16] = 1.0; STATES[6] = 0.001337; STATES[7] = 0.01; CONSTANTS[17] = 0.9; CONSTANTS[18] = 0.7; STATES[8] = 0.000003; STATES[9] = 0.1; STATES[10] = 0.7; CONSTANTS[19] = 5.4; CONSTANTS[20] = 5.0; STATES[11] = 0.0; CONSTANTS[21] = 350.0; STATES[12] = 0.7; CONSTANTS[22] = 10.0; CONSTANTS[23] = 3.0; CONSTANTS[24] = 0.005; STATES[13] = 0.000007; CONSTANTS[25] = 2.0; STATES[14] = 0.978861; CONSTANTS[26] = 1140.0; CONSTANTS[27] = 15.0; STATES[15] = 0.000012; STATES[16] = 0.864489; CONSTANTS[28] = 2.0; CONSTANTS[29] = 20.0; STATES[17] = 0.25; CONSTANTS[30] = 1.5; STATES[18] = 1.0; STATES[19] = 0.0; CONSTANTS[31] = 3.0; CONSTANTS[32] = 3; CONSTANTS[33] = 0.001; CONSTANTS[34] = 0.001; CONSTANTS[35] = 0.5; CONSTANTS[36] = 442.2; CONSTANTS[37] = 0.01; CONSTANTS[38] = 0.01; CONSTANTS[39] = 0.0001; CONSTANTS[40] = 5.0; CONSTANTS[41] = 0.0001; CONSTANTS[42] = 1.5; CONSTANTS[43] = 0.188709677; STATES[20] = 0.011099; CONSTANTS[44] = 0.045290323; STATES[21] = 0.011099; CONSTANTS[45] = 2500.0; CONSTANTS[46] = 0.001; CONSTANTS[47] = 120.0; CONSTANTS[48] = 0.000246; CONSTANTS[49] = 1.7; CONSTANTS[50] = 1.6; CONSTANTS[51] = 120.0; CONSTANTS[52] = 0.000246; CONSTANTS[53] = 1.7; CONSTANTS[54] = 1.6; CONSTANTS[55] = 10.0; CONSTANTS[56] = 5000.0; CONSTANTS[57] = CONSTANTS[1]/( CONSTANTS[2]*CONSTANTS[0]); CONSTANTS[58] = ( CONSTANTS[2]*CONSTANTS[0])/CONSTANTS[1]; CONSTANTS[59] = CONSTANTS[8]*CONSTANTS[7]; CONSTANTS[60] = CONSTANTS[9]*CONSTANTS[7]; CONSTANTS[61] = CONSTANTS[10]*CONSTANTS[7]; CONSTANTS[62] = (CONSTANTS[8]+CONSTANTS[9])*CONSTANTS[7]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0]+47.8000)/-5.50000)); RATES[6] = (ALGEBRAIC[1] - STATES[6])/CONSTANTS[16]; ALGEBRAIC[3] = 1.00000/(1.00000+exp((STATES[0]+14.6000)/-5.50000)); RATES[8] = (ALGEBRAIC[3] - STATES[8])/CONSTANTS[18]; ALGEBRAIC[6] = 1.00000/(1.00000+exp((STATES[0]+-7.00000)/-9.00000)); RATES[11] = (ALGEBRAIC[6] - STATES[11])/CONSTANTS[20]; ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0]+27.5000)/8.00000)); RATES[12] = (ALGEBRAIC[7] - STATES[12])/CONSTANTS[21]; ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+25.0000)/-5.00000)); RATES[13] = (ALGEBRAIC[8] - STATES[13])/CONSTANTS[24]; ALGEBRAIC[9] = 1.00000/(1.00000+exp((STATES[0]+69.0000)/3.96000)); RATES[14] = (ALGEBRAIC[9] - STATES[14])/CONSTANTS[25]; ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+30.0000)/-5.00000)); RATES[15] = (ALGEBRAIC[10] - STATES[15])/CONSTANTS[27]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+67.9000)/3.87000)); ALGEBRAIC[17] = 1.42271*exp( -0.0511900*STATES[0]); RATES[7] = (ALGEBRAIC[2] - STATES[7])/ALGEBRAIC[17]; ALGEBRAIC[4] = 1.00000/(1.00000+exp((STATES[0]+31.0000)/5.54000)); ALGEBRAIC[18] = 25.1000/(0.0400000+ 0.700000*exp( -1.00000*pow( 0.0280000*(STATES[0]+14.5000), 2.00000))); RATES[9] = (ALGEBRAIC[4] - STATES[9])/ALGEBRAIC[18]; ALGEBRAIC[5] = 0.400000+0.600000/(1.00000+pow(STATES[1]/0.000100000, 2.00000)); ALGEBRAIC[19] = 2.00000+80.0000/(1.00000+pow(STATES[1]/0.000100000, 2.00000)); RATES[10] = (ALGEBRAIC[5] - STATES[10])/ALGEBRAIC[19]; ALGEBRAIC[11] = 0.100000+0.900000/(1.00000+exp((STATES[0]+75.6000)/6.30000)); ALGEBRAIC[20] = 120.000+ 1.00000*exp((STATES[0]+100.000)/25.0000); RATES[16] = (ALGEBRAIC[11] - STATES[16])/ALGEBRAIC[20]; ALGEBRAIC[13] = 1.00000/(1.00000+exp((STATES[0] - 1.50000)/-16.7000)); ALGEBRAIC[22] = (fabs(STATES[0]+30.0000)<0.0145000 ? 417.946 : 1.00000/(( 7.19000e-05*(STATES[0]+30.0000))/(1.00000 - exp( -0.148000*(STATES[0]+30.0000)))+( 0.000131000*(STATES[0]+30.0000))/(exp( 0.0687000*(STATES[0]+30.0000)) - 1.00000))); RATES[18] = (ALGEBRAIC[13] - STATES[18])/ALGEBRAIC[22]; ALGEBRAIC[14] = 1.00000/(1.00000+exp((STATES[0]+109.000)/10.0000)); ALGEBRAIC[23] = 6000.00/(exp( -1.00000*(2.90000+ 0.0400000*STATES[0]))+exp( 1.00000*(3.60000+ 0.110000*STATES[0]))); RATES[20] = (ALGEBRAIC[14] - STATES[20])/ALGEBRAIC[23]; ALGEBRAIC[15] = 1.00000/(1.00000+exp((STATES[0]+109.000)/10.0000)); ALGEBRAIC[24] = 6000.00/(exp( -1.00000*(2.90000+ 0.0400000*STATES[0]))+exp( 1.00000*(3.60000+ 0.110000*STATES[0]))); RATES[21] = (ALGEBRAIC[15] - STATES[21])/ALGEBRAIC[24]; ALGEBRAIC[12] = 1.00000/(1.00000+exp((STATES[0]+50.0000)/-7.50000)); ALGEBRAIC[21] = (fabs(STATES[0]+7.00000)>0.00100000 ? ( 0.00138000*1.00000*(STATES[0]+7.00000))/(1.00000 - exp( -0.123000*(STATES[0]+7.00000))) : 0.00138000/0.123000); ALGEBRAIC[26] = (fabs(STATES[0]+10.0000)>0.00100000 ? ( 6.10000e-05*1.00000*(STATES[0]+10.0000))/(exp( 0.145000*(STATES[0]+10.0000)) - 1.00000) : 0.000610000/0.145000); ALGEBRAIC[29] = 1.00000/(ALGEBRAIC[21]+ALGEBRAIC[26]); RATES[17] = (ALGEBRAIC[12] - STATES[17])/ALGEBRAIC[29]; ALGEBRAIC[27] = ALGEBRAIC[13]; ALGEBRAIC[30] = 4.00000*ALGEBRAIC[22]; RATES[19] = (ALGEBRAIC[27] - STATES[19])/ALGEBRAIC[30]; ALGEBRAIC[41] = 1.00000/(1.00000+exp((92.0000+STATES[0])/10.0000)); ALGEBRAIC[42] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[43] = CONSTANTS[29]*pow(CONSTANTS[5]/5.40000, 0.800000)*ALGEBRAIC[41]*(STATES[0] - ALGEBRAIC[42]); ALGEBRAIC[32] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[33] = CONSTANTS[22]*STATES[11]*STATES[12]*(STATES[0] - ALGEBRAIC[32]); ALGEBRAIC[34] = 1.00000/(1.00000+exp((5.00000 - STATES[0])/17.0000)); ALGEBRAIC[35] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[36] = CONSTANTS[23]*ALGEBRAIC[34]*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[44] = 1.00000/(1.00000+exp((33.0000+STATES[0])/22.4000)); ALGEBRAIC[45] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[46] = CONSTANTS[30]*pow(CONSTANTS[5]/5.40000, 1.00000)*ALGEBRAIC[44]*STATES[17]*(STATES[0] - ALGEBRAIC[45]); ALGEBRAIC[47] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[48] = CONSTANTS[31]*STATES[18]*STATES[19]*(STATES[0] - ALGEBRAIC[47]); ALGEBRAIC[53] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[54] = CONSTANTS[37]*(STATES[0] - ALGEBRAIC[53]); ALGEBRAIC[50] = 1.00000/(1.00000+exp((STATES[0]+80.0000)/-45.0000)); ALGEBRAIC[51] = 1.00000/(1.00000+exp((STATES[0]+0.00000)/125.000)); ALGEBRAIC[52] = CONSTANTS[36]*ALGEBRAIC[50]*ALGEBRAIC[51]*(1.00000/(1.00000+pow(1.90000/CONSTANTS[5], 1.45000)))*(1.00000/(1.00000+pow(31.9800/STATES[4], 1.00000))); ALGEBRAIC[60] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[62] = CONSTANTS[43]*STATES[20]*(STATES[0] - ALGEBRAIC[60]); ALGEBRAIC[0] = (VOI>=CONSTANTS[11]&&VOI<=CONSTANTS[12]&&(VOI - CONSTANTS[11]) - floor((VOI - CONSTANTS[11])/CONSTANTS[13])*CONSTANTS[13]<=CONSTANTS[14] ? CONSTANTS[15] : 0.00000); RATES[5] = ( ( -1.00000*ALGEBRAIC[33]+ -1.00000*ALGEBRAIC[36]+ -1.00000*ALGEBRAIC[46]+ -1.00000*ALGEBRAIC[48]+ -1.00000*ALGEBRAIC[43]+ -1.00000*ALGEBRAIC[54]+ -1.00000*ALGEBRAIC[62]+ -1.00000*ALGEBRAIC[0]+ 2.00000*ALGEBRAIC[52])*1000.00)/( CONSTANTS[1]*CONSTANTS[62]); ALGEBRAIC[28] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[31] = CONSTANTS[19]*STATES[8]*STATES[9]*STATES[10]*(STATES[0] - ALGEBRAIC[28]); ALGEBRAIC[16] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[25] = CONSTANTS[17]*STATES[6]*STATES[7]*(STATES[0] - ALGEBRAIC[16]); ALGEBRAIC[37] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[38] = CONSTANTS[26]*STATES[13]*STATES[14]*(STATES[0] - ALGEBRAIC[37]); ALGEBRAIC[39] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[40] = CONSTANTS[28]*STATES[15]*STATES[16]*(STATES[0] - ALGEBRAIC[39]); ALGEBRAIC[59] = CONSTANTS[40]*(1.00000/(1.00000+pow(CONSTANTS[41]/STATES[1], CONSTANTS[42]))); ALGEBRAIC[57] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[58] = CONSTANTS[39]*(STATES[0] - ALGEBRAIC[57]); ALGEBRAIC[64] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[66] = CONSTANTS[44]*STATES[21]*(STATES[0] - ALGEBRAIC[64]); ALGEBRAIC[49] = ( 512.009*CONSTANTS[33]*( exp(( CONSTANTS[35]*(CONSTANTS[32] - 2.00000)*STATES[0])/CONSTANTS[58])*pow(STATES[4], CONSTANTS[32])*CONSTANTS[3] - STATES[1]*exp(( (CONSTANTS[35] - 1.00000)*(CONSTANTS[32] - 2.00000)*STATES[0])/CONSTANTS[58])*pow(CONSTANTS[4], CONSTANTS[32])))/( (1.00000+ CONSTANTS[34]*( STATES[1]*pow(CONSTANTS[4], CONSTANTS[32])+ CONSTANTS[3]*pow(STATES[4], CONSTANTS[32])))*(1.00000+STATES[1]/0.00690000)); ALGEBRAIC[55] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[56] = CONSTANTS[38]*(STATES[0] - ALGEBRAIC[55]); RATES[0] = (( - 1.00000*1.00000)/CONSTANTS[6])*(ALGEBRAIC[43]+ALGEBRAIC[33]+ALGEBRAIC[36]+ALGEBRAIC[46]+ALGEBRAIC[48]+ALGEBRAIC[54]+ALGEBRAIC[52]+ALGEBRAIC[31]+ALGEBRAIC[25]+ALGEBRAIC[38]+ALGEBRAIC[40]+ALGEBRAIC[59]+ALGEBRAIC[58]+ALGEBRAIC[66]+ALGEBRAIC[62]+ALGEBRAIC[49]+ALGEBRAIC[56]+ALGEBRAIC[0]); ALGEBRAIC[61] = CONSTANTS[45]*(STATES[3]/(1.00000+pow(CONSTANTS[46]/STATES[1], 2.00000))); ALGEBRAIC[63] = CONSTANTS[47]*((pow(STATES[1]/CONSTANTS[48], CONSTANTS[50]) - pow(STATES[3]/CONSTANTS[49], CONSTANTS[50]))/(1.00000+pow(STATES[1]/CONSTANTS[48], CONSTANTS[50])+pow(STATES[3]/CONSTANTS[49], CONSTANTS[50]))); ALGEBRAIC[65] = CONSTANTS[51]*((pow(STATES[2]/CONSTANTS[52], CONSTANTS[54]) - pow(STATES[3]/CONSTANTS[53], CONSTANTS[54]))/(1.00000+pow(STATES[2]/CONSTANTS[52], CONSTANTS[54])+pow(STATES[3]/CONSTANTS[53], CONSTANTS[54]))); ALGEBRAIC[67] = CONSTANTS[55]*(STATES[3] - STATES[2]); RATES[3] = ( ( -1.00000*ALGEBRAIC[61]+ -1.00000*ALGEBRAIC[67]+ALGEBRAIC[65]+ALGEBRAIC[63])*1000.00)/( 2.00000*CONSTANTS[1]*CONSTANTS[61]); RATES[4] = ( ( -1.00000*ALGEBRAIC[38]+ -1.00000*ALGEBRAIC[40]+ -3.00000*ALGEBRAIC[52]+ -3.00000*ALGEBRAIC[49]+ -1.00000*ALGEBRAIC[66]+ -1.00000*ALGEBRAIC[56])*1000.00)/( CONSTANTS[1]*CONSTANTS[62]); ALGEBRAIC[68] = CONSTANTS[56]*(STATES[1] - STATES[2]); RATES[1] = ( ( -1.00000*ALGEBRAIC[31]+ -1.00000*ALGEBRAIC[25]+ -1.00000*ALGEBRAIC[58]+ 1.00000*ALGEBRAIC[61]+ -1.00000*ALGEBRAIC[63]+ -1.00000*ALGEBRAIC[68]+ 2.00000*ALGEBRAIC[49]+ -1.00000*ALGEBRAIC[59])*1000.00)/( 2.00000*CONSTANTS[1]*CONSTANTS[60]); RATES[2] = ( ( -1.00000*ALGEBRAIC[65]+ALGEBRAIC[68]+ALGEBRAIC[67])*1000.00)/( 2.00000*CONSTANTS[1]*CONSTANTS[59]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0]+47.8000)/-5.50000)); ALGEBRAIC[3] = 1.00000/(1.00000+exp((STATES[0]+14.6000)/-5.50000)); ALGEBRAIC[6] = 1.00000/(1.00000+exp((STATES[0]+-7.00000)/-9.00000)); ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0]+27.5000)/8.00000)); ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+25.0000)/-5.00000)); ALGEBRAIC[9] = 1.00000/(1.00000+exp((STATES[0]+69.0000)/3.96000)); ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+30.0000)/-5.00000)); ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+67.9000)/3.87000)); ALGEBRAIC[17] = 1.42271*exp( -0.0511900*STATES[0]); ALGEBRAIC[4] = 1.00000/(1.00000+exp((STATES[0]+31.0000)/5.54000)); ALGEBRAIC[18] = 25.1000/(0.0400000+ 0.700000*exp( -1.00000*pow( 0.0280000*(STATES[0]+14.5000), 2.00000))); ALGEBRAIC[5] = 0.400000+0.600000/(1.00000+pow(STATES[1]/0.000100000, 2.00000)); ALGEBRAIC[19] = 2.00000+80.0000/(1.00000+pow(STATES[1]/0.000100000, 2.00000)); ALGEBRAIC[11] = 0.100000+0.900000/(1.00000+exp((STATES[0]+75.6000)/6.30000)); ALGEBRAIC[20] = 120.000+ 1.00000*exp((STATES[0]+100.000)/25.0000); ALGEBRAIC[13] = 1.00000/(1.00000+exp((STATES[0] - 1.50000)/-16.7000)); ALGEBRAIC[22] = (fabs(STATES[0]+30.0000)<0.0145000 ? 417.946 : 1.00000/(( 7.19000e-05*(STATES[0]+30.0000))/(1.00000 - exp( -0.148000*(STATES[0]+30.0000)))+( 0.000131000*(STATES[0]+30.0000))/(exp( 0.0687000*(STATES[0]+30.0000)) - 1.00000))); ALGEBRAIC[14] = 1.00000/(1.00000+exp((STATES[0]+109.000)/10.0000)); ALGEBRAIC[23] = 6000.00/(exp( -1.00000*(2.90000+ 0.0400000*STATES[0]))+exp( 1.00000*(3.60000+ 0.110000*STATES[0]))); ALGEBRAIC[15] = 1.00000/(1.00000+exp((STATES[0]+109.000)/10.0000)); ALGEBRAIC[24] = 6000.00/(exp( -1.00000*(2.90000+ 0.0400000*STATES[0]))+exp( 1.00000*(3.60000+ 0.110000*STATES[0]))); ALGEBRAIC[12] = 1.00000/(1.00000+exp((STATES[0]+50.0000)/-7.50000)); ALGEBRAIC[21] = (fabs(STATES[0]+7.00000)>0.00100000 ? ( 0.00138000*1.00000*(STATES[0]+7.00000))/(1.00000 - exp( -0.123000*(STATES[0]+7.00000))) : 0.00138000/0.123000); ALGEBRAIC[26] = (fabs(STATES[0]+10.0000)>0.00100000 ? ( 6.10000e-05*1.00000*(STATES[0]+10.0000))/(exp( 0.145000*(STATES[0]+10.0000)) - 1.00000) : 0.000610000/0.145000); ALGEBRAIC[29] = 1.00000/(ALGEBRAIC[21]+ALGEBRAIC[26]); ALGEBRAIC[27] = ALGEBRAIC[13]; ALGEBRAIC[30] = 4.00000*ALGEBRAIC[22]; ALGEBRAIC[41] = 1.00000/(1.00000+exp((92.0000+STATES[0])/10.0000)); ALGEBRAIC[42] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[43] = CONSTANTS[29]*pow(CONSTANTS[5]/5.40000, 0.800000)*ALGEBRAIC[41]*(STATES[0] - ALGEBRAIC[42]); ALGEBRAIC[32] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[33] = CONSTANTS[22]*STATES[11]*STATES[12]*(STATES[0] - ALGEBRAIC[32]); ALGEBRAIC[34] = 1.00000/(1.00000+exp((5.00000 - STATES[0])/17.0000)); ALGEBRAIC[35] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[36] = CONSTANTS[23]*ALGEBRAIC[34]*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[44] = 1.00000/(1.00000+exp((33.0000+STATES[0])/22.4000)); ALGEBRAIC[45] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[46] = CONSTANTS[30]*pow(CONSTANTS[5]/5.40000, 1.00000)*ALGEBRAIC[44]*STATES[17]*(STATES[0] - ALGEBRAIC[45]); ALGEBRAIC[47] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[48] = CONSTANTS[31]*STATES[18]*STATES[19]*(STATES[0] - ALGEBRAIC[47]); ALGEBRAIC[53] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[54] = CONSTANTS[37]*(STATES[0] - ALGEBRAIC[53]); ALGEBRAIC[50] = 1.00000/(1.00000+exp((STATES[0]+80.0000)/-45.0000)); ALGEBRAIC[51] = 1.00000/(1.00000+exp((STATES[0]+0.00000)/125.000)); ALGEBRAIC[52] = CONSTANTS[36]*ALGEBRAIC[50]*ALGEBRAIC[51]*(1.00000/(1.00000+pow(1.90000/CONSTANTS[5], 1.45000)))*(1.00000/(1.00000+pow(31.9800/STATES[4], 1.00000))); ALGEBRAIC[60] = CONSTANTS[58]*log(CONSTANTS[5]/STATES[5]); ALGEBRAIC[62] = CONSTANTS[43]*STATES[20]*(STATES[0] - ALGEBRAIC[60]); ALGEBRAIC[0] = (VOI>=CONSTANTS[11]&&VOI<=CONSTANTS[12]&&(VOI - CONSTANTS[11]) - floor((VOI - CONSTANTS[11])/CONSTANTS[13])*CONSTANTS[13]<=CONSTANTS[14] ? CONSTANTS[15] : 0.00000); ALGEBRAIC[28] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[31] = CONSTANTS[19]*STATES[8]*STATES[9]*STATES[10]*(STATES[0] - ALGEBRAIC[28]); ALGEBRAIC[16] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[25] = CONSTANTS[17]*STATES[6]*STATES[7]*(STATES[0] - ALGEBRAIC[16]); ALGEBRAIC[37] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[38] = CONSTANTS[26]*STATES[13]*STATES[14]*(STATES[0] - ALGEBRAIC[37]); ALGEBRAIC[39] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[40] = CONSTANTS[28]*STATES[15]*STATES[16]*(STATES[0] - ALGEBRAIC[39]); ALGEBRAIC[59] = CONSTANTS[40]*(1.00000/(1.00000+pow(CONSTANTS[41]/STATES[1], CONSTANTS[42]))); ALGEBRAIC[57] = 0.500000*CONSTANTS[58]*log(CONSTANTS[3]/STATES[1]); ALGEBRAIC[58] = CONSTANTS[39]*(STATES[0] - ALGEBRAIC[57]); ALGEBRAIC[64] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[66] = CONSTANTS[44]*STATES[21]*(STATES[0] - ALGEBRAIC[64]); ALGEBRAIC[49] = ( 512.009*CONSTANTS[33]*( exp(( CONSTANTS[35]*(CONSTANTS[32] - 2.00000)*STATES[0])/CONSTANTS[58])*pow(STATES[4], CONSTANTS[32])*CONSTANTS[3] - STATES[1]*exp(( (CONSTANTS[35] - 1.00000)*(CONSTANTS[32] - 2.00000)*STATES[0])/CONSTANTS[58])*pow(CONSTANTS[4], CONSTANTS[32])))/( (1.00000+ CONSTANTS[34]*( STATES[1]*pow(CONSTANTS[4], CONSTANTS[32])+ CONSTANTS[3]*pow(STATES[4], CONSTANTS[32])))*(1.00000+STATES[1]/0.00690000)); ALGEBRAIC[55] = CONSTANTS[58]*log(CONSTANTS[4]/STATES[4]); ALGEBRAIC[56] = CONSTANTS[38]*(STATES[0] - ALGEBRAIC[55]); ALGEBRAIC[61] = CONSTANTS[45]*(STATES[3]/(1.00000+pow(CONSTANTS[46]/STATES[1], 2.00000))); ALGEBRAIC[63] = CONSTANTS[47]*((pow(STATES[1]/CONSTANTS[48], CONSTANTS[50]) - pow(STATES[3]/CONSTANTS[49], CONSTANTS[50]))/(1.00000+pow(STATES[1]/CONSTANTS[48], CONSTANTS[50])+pow(STATES[3]/CONSTANTS[49], CONSTANTS[50]))); ALGEBRAIC[65] = CONSTANTS[51]*((pow(STATES[2]/CONSTANTS[52], CONSTANTS[54]) - pow(STATES[3]/CONSTANTS[53], CONSTANTS[54]))/(1.00000+pow(STATES[2]/CONSTANTS[52], CONSTANTS[54])+pow(STATES[3]/CONSTANTS[53], CONSTANTS[54]))); ALGEBRAIC[67] = CONSTANTS[55]*(STATES[3] - STATES[2]); ALGEBRAIC[68] = CONSTANTS[56]*(STATES[1] - STATES[2]); }