# Size of variable arrays: sizeAlgebraic = 82 sizeStates = 22 sizeConstants = 83 from math import * from numpy import * def createLegends(): legend_states = [""] * sizeStates legend_rates = [""] * sizeStates legend_algebraic = [""] * sizeAlgebraic legend_voi = "" legend_constants = [""] * sizeConstants legend_constants[0] = "I_hold in component interface (pA_per_pF)" legend_constants[1] = "I_test in component interface (pA_per_pF)" legend_constants[2] = "test_start in component interface (msec)" legend_constants[3] = "test_end in component interface (msec)" legend_algebraic[0] = "Ist in component interface (pA_per_pF)" legend_voi = "time in component environment (msec)" legend_algebraic[79] = "I_tot in component membrane_potential (pA_per_pF)" legend_algebraic[61] = "I_Ca_tot in component membrane_potential (pA_per_pF)" legend_states[0] = "v in component membrane_potential (mV)" legend_constants[67] = "Cm in component parameters (uF_per_cm2)" legend_algebraic[42] = "ina in component I_Na (pA_per_pF)" legend_algebraic[49] = "ical in component I_CaL (pA_per_pF)" legend_algebraic[51] = "icat in component I_CaT (pA_per_pF)" legend_algebraic[52] = "ib in component I_b (pA_per_pF)" legend_algebraic[53] = "ik1 in component I_K1 (pA_per_pF)" legend_algebraic[54] = "ik2 in component I_K2 (pA_per_pF)" legend_algebraic[55] = "ika in component I_Ka (pA_per_pF)" legend_algebraic[56] = "iBKa in component I_BKa (pA_per_pF)" legend_algebraic[57] = "iBKab in component I_BKab (pA_per_pF)" legend_algebraic[58] = "ih in component I_h (pA_per_pF)" legend_algebraic[59] = "icl in component I_Cl (pA_per_pF)" legend_algebraic[63] = "insna in component I_ns (pA_per_pF)" legend_algebraic[60] = "insca in component I_ns (pA_per_pF)" legend_algebraic[65] = "insk in component I_ns (pA_per_pF)" legend_algebraic[67] = "inak in component I_NaK (pA_per_pF)" legend_algebraic[76] = "inaca in component I_NaCa (pA_per_pF)" legend_algebraic[80] = "J_tot in component Ca_Concentrations (mM_per_msec)" legend_algebraic[62] = "J_Ca_mem in component Ca_Concentrations (mM_per_msec)" legend_states[1] = "cai in component Ca_Concentrations (mM)" legend_algebraic[75] = "jnaca in component J_NaCa (mM_per_msec)" legend_algebraic[77] = "jpmca in component J_PMCA (mM_per_msec)" legend_constants[62] = "buff in component parameters (dimensionless)" legend_constants[63] = "AV in component parameters (cm2_per_uL)" legend_constants[64] = "zca in component parameters (dimensionless)" legend_constants[66] = "frdy in component parameters (coulomb_per_mole)" legend_algebraic[64] = "jcamem_plot in component Ca_Concentrations (M_per_msec)" legend_algebraic[81] = "jpmca_plot in component Ca_Concentrations (M_per_msec)" legend_algebraic[78] = "jnaca_plot in component Ca_Concentrations (M_per_msec)" legend_constants[4] = "conversion in component Ca_Concentrations (mM_to_M)" legend_constants[11] = "ki in component parameters (mM)" legend_constants[53] = "nai in component parameters (mM)" legend_constants[56] = "cli in component parameters (mM)" legend_constants[57] = "ko in component parameters (mM)" legend_constants[12] = "cao in component parameters (mM)" legend_constants[58] = "nao in component parameters (mM)" legend_constants[60] = "clo in component parameters (mM)" legend_constants[13] = "mgo in component parameters (mM)" legend_constants[14] = "zna in component parameters (dimensionless)" legend_constants[15] = "zk in component parameters (dimensionless)" legend_constants[65] = "R in component parameters (joule_per_kelvin_per_kilomole)" legend_constants[68] = "temp in component parameters (kelvin)" legend_constants[16] = "gna in component parameters (nS_per_pF)" legend_constants[17] = "gcal in component parameters (nS_per_pF)" legend_constants[18] = "ecal in component parameters (mV)" legend_constants[19] = "kmca in component parameters (mM)" legend_constants[20] = "gcat in component parameters (nS_per_pF)" legend_constants[21] = "ecat in component parameters (mV)" legend_constants[22] = "gkca in component parameters (nS_per_pF)" legend_constants[23] = "gb in component parameters (nS_per_pF)" legend_constants[24] = "gk1 in component parameters (nS_per_pF)" legend_constants[25] = "gk2 in component parameters (nS_per_pF)" legend_constants[26] = "gbka in component parameters (dimensionless)" legend_constants[27] = "gbkab in component parameters (dimensionless)" legend_constants[28] = "gka in component parameters (nS_per_pF)" legend_constants[29] = "gcl in component parameters (nS_per_pF)" legend_constants[30] = "gh in component parameters (nS_per_pF)" legend_constants[31] = "gns in component parameters (nS_per_pF)" legend_constants[32] = "PnsK in component parameters (dimensionless)" legend_constants[33] = "PnsNa in component parameters (dimensionless)" legend_constants[34] = "PnsCa in component parameters (dimensionless)" legend_constants[35] = "PnsCs in component parameters (dimensionless)" legend_constants[36] = "gnsCa in component parameters (dimensionless)" legend_constants[37] = "gnsNa in component parameters (dimensionless)" legend_constants[38] = "gnsK in component parameters (dimensionless)" legend_constants[39] = "gnsCs in component parameters (dimensionless)" legend_constants[69] = "ginak in component parameters (pA_per_pF)" legend_constants[74] = "nakKmko in component parameters (mM)" legend_constants[76] = "nakKmnai in component parameters (mM)" legend_constants[70] = "PK in component parameters (dimensionless)" legend_constants[75] = "PNa in component parameters (dimensionless)" legend_constants[40] = "Jpmca in component parameters (mM_per_msec)" legend_constants[41] = "Kmpmca in component parameters (mM)" legend_constants[42] = "npmca in component parameters (dimensionless)" legend_constants[78] = "Jnaca in component parameters (mM_per_msec)" legend_constants[43] = "Kmallo in component parameters (mM)" legend_constants[44] = "nallo in component parameters (dimensionless)" legend_constants[79] = "ksat in component parameters (dimensionless)" legend_constants[80] = "xgamma in component parameters (dimensionless)" legend_constants[45] = "Kmnai in component parameters (mM)" legend_constants[46] = "Kmcai in component parameters (mM)" legend_constants[47] = "Kmnao in component parameters (mM)" legend_constants[48] = "Kmcao in component parameters (mM)" legend_constants[49] = "Fmax in component parameters (uN)" legend_constants[50] = "FKm in component parameters (nM)" legend_constants[51] = "Fn in component parameters (dimensionless)" legend_algebraic[18] = "vFRT in component parameters (dimensionless)" legend_constants[71] = "ena in component parameters (mV)" legend_constants[72] = "ek in component parameters (mV)" legend_constants[77] = "eh in component parameters (mV)" legend_constants[73] = "ecl in component parameters (mV)" legend_algebraic[37] = "enscc in component parameters (mV)" legend_algebraic[1] = "wss in component Ca_dependent_Force (dimensionless)" legend_algebraic[19] = "wtc in component Ca_dependent_Force (msec)" legend_constants[5] = "conversion in component Ca_dependent_Force (nM_to_mM)" legend_algebraic[2] = "Force in component Ca_dependent_Force (uN)" legend_states[2] = "w in component Ca_dependent_Force (dimensionless)" legend_algebraic[3] = "mss in component I_Na (dimensionless)" legend_algebraic[4] = "hss in component I_Na (dimensionless)" legend_algebraic[20] = "mtc in component I_Na (msec)" legend_algebraic[21] = "htc in component I_Na (msec)" legend_states[3] = "m in component I_Na (dimensionless)" legend_states[4] = "h in component I_Na (dimensionless)" legend_algebraic[5] = "dss in component I_CaL (dimensionless)" legend_algebraic[6] = "fss in component I_CaL (dimensionless)" legend_algebraic[47] = "fca in component I_CaL (dimensionless)" legend_algebraic[22] = "dtc in component I_CaL (msec)" legend_constants[52] = "f1tc in component I_CaL (msec)" legend_algebraic[23] = "f2tc in component I_CaL (msec)" legend_states[5] = "d in component I_CaL (dimensionless)" legend_states[6] = "f1 in component I_CaL (dimensionless)" legend_states[7] = "f2 in component I_CaL (dimensionless)" legend_algebraic[7] = "bss in component I_CaT (dimensionless)" legend_algebraic[8] = "gss in component I_CaT (dimensionless)" legend_algebraic[24] = "btc in component I_CaT (msec)" legend_algebraic[25] = "gtc in component I_CaT (msec)" legend_states[8] = "b in component I_CaT (dimensionless)" legend_states[9] = "g in component I_CaT (dimensionless)" legend_algebraic[9] = "qss in component I_K1 (dimensionless)" legend_algebraic[10] = "rss in component I_K1 (dimensionless)" legend_algebraic[26] = "qtc in component I_K1 (msec)" legend_algebraic[27] = "r1tc in component I_K1 (msec)" legend_algebraic[28] = "r2tc in component I_K1 (msec)" legend_states[10] = "q in component I_K1 (dimensionless)" legend_states[11] = "r1 in component I_K1 (dimensionless)" legend_states[12] = "r2 in component I_K1 (dimensionless)" legend_algebraic[11] = "pss in component I_K2 (dimensionless)" legend_algebraic[12] = "kss in component I_K2 (dimensionless)" legend_algebraic[29] = "ptc in component I_K2 (msec)" legend_algebraic[30] = "k1tc in component I_K2 (msec)" legend_algebraic[31] = "k2tc in component I_K2 (msec)" legend_states[13] = "p in component I_K2 (dimensionless)" legend_states[14] = "k1 in component I_K2 (dimensionless)" legend_states[15] = "k2 in component I_K2 (dimensionless)" legend_algebraic[13] = "sss in component I_Ka (dimensionless)" legend_algebraic[14] = "xss in component I_Ka (dimensionless)" legend_algebraic[32] = "stc in component I_Ka (msec)" legend_algebraic[33] = "xtc in component I_Ka (msec)" legend_states[16] = "s in component I_Ka (dimensionless)" legend_states[17] = "x in component I_Ka (dimensionless)" legend_algebraic[15] = "xass_z in component I_BKa (dimensionless)" legend_algebraic[34] = "xass_vh in component I_BKa (mV)" legend_constants[6] = "conversion in component I_BKa (mM_to_M)" legend_algebraic[38] = "xass in component I_BKa (dimensionless)" legend_algebraic[43] = "xatc in component I_BKa (msec)" legend_states[18] = "xa in component I_BKa (dimensionless)" legend_algebraic[16] = "xabss_z in component I_BKab (dimensionless)" legend_algebraic[35] = "xabss_vh in component I_BKab (mV)" legend_constants[7] = "conversion in component I_BKab (mM_to_M)" legend_algebraic[39] = "xabss in component I_BKab (dimensionless)" legend_algebraic[44] = "xabtc in component I_BKab (msec)" legend_states[19] = "xab in component I_BKab (dimensionless)" legend_algebraic[17] = "yss in component I_h (dimensionless)" legend_algebraic[45] = "ytc in component I_h (msec)" legend_algebraic[36] = "ya in component I_h (per_msec)" legend_algebraic[40] = "yb in component I_h (per_msec)" legend_states[20] = "y in component I_h (dimensionless)" legend_algebraic[48] = "css in component I_Cl (dimensionless)" legend_algebraic[50] = "ctc in component I_Cl (msec)" legend_algebraic[41] = "K1cl in component I_Cl (mM)" legend_algebraic[46] = "K2cl in component I_Cl (dimensionless)" legend_states[21] = "c in component I_Cl (dimensionless)" legend_constants[54] = "fmg in component I_ns (dimensionless)" legend_constants[61] = "gs_nao in component I_ns (dimensionless)" legend_constants[55] = "gs_cao in component I_ns (dimensionless)" legend_constants[59] = "gs_ko in component I_ns (dimensionless)" legend_constants[8] = "tinyamount in component I_ns (mM)" legend_algebraic[66] = "fnak in component I_NaK (dimensionless)" legend_constants[81] = "knak in component I_NaK (dimensionless)" legend_constants[82] = "nnak in component I_NaK (dimensionless)" legend_constants[9] = "inaca_sign in component I_NaCa (dimensionless)" legend_algebraic[68] = "f1naca in component J_NaCa (dimensionless)" legend_algebraic[69] = "f2naca in component J_NaCa (dimensionless)" legend_algebraic[70] = "fallo in component J_NaCa (dimensionless)" legend_algebraic[71] = "naca_Eup in component J_NaCa (mM4)" legend_algebraic[72] = "naca_Ed1 in component J_NaCa (dimensionless)" legend_algebraic[73] = "naca_Ed2 in component J_NaCa (mM4)" legend_algebraic[74] = "naca_Ed3 in component J_NaCa (mM4)" legend_constants[10] = "jnaca_sign in component J_NaCa (dimensionless)" legend_rates[0] = "d/dt v in component membrane_potential (mV)" legend_rates[1] = "d/dt cai in component Ca_Concentrations (mM)" legend_rates[2] = "d/dt w in component Ca_dependent_Force (dimensionless)" legend_rates[3] = "d/dt m in component I_Na (dimensionless)" legend_rates[4] = "d/dt h in component I_Na (dimensionless)" legend_rates[5] = "d/dt d in component I_CaL (dimensionless)" legend_rates[6] = "d/dt f1 in component I_CaL (dimensionless)" legend_rates[7] = "d/dt f2 in component I_CaL (dimensionless)" legend_rates[8] = "d/dt b in component I_CaT (dimensionless)" legend_rates[9] = "d/dt g in component I_CaT (dimensionless)" legend_rates[10] = "d/dt q in component I_K1 (dimensionless)" legend_rates[11] = "d/dt r1 in component I_K1 (dimensionless)" legend_rates[12] = "d/dt r2 in component I_K1 (dimensionless)" legend_rates[13] = "d/dt p in component I_K2 (dimensionless)" legend_rates[14] = "d/dt k1 in component I_K2 (dimensionless)" legend_rates[15] = "d/dt k2 in component I_K2 (dimensionless)" legend_rates[16] = "d/dt s in component I_Ka (dimensionless)" legend_rates[17] = "d/dt x in component I_Ka (dimensionless)" legend_rates[18] = "d/dt xa in component I_BKa (dimensionless)" legend_rates[19] = "d/dt xab in component I_BKab (dimensionless)" legend_rates[20] = "d/dt y in component I_h (dimensionless)" legend_rates[21] = "d/dt c in component I_Cl (dimensionless)" return (legend_states, legend_algebraic, legend_voi, legend_constants) def initConsts(): constants = [0.0] * sizeConstants; states = [0.0] * sizeStates; constants[0] = 0 constants[1] = -0.5 constants[2] = 1000 constants[3] = 3000 states[0] = -53.90915441282156 states[1] = 0.0001161881607214449 constants[4] = 1000 constants[5] = 1e-6 states[2] = 0.2345238135343783 states[3] = 0.1253518889572223 states[4] = 0.404599170710196 states[5] = 0.01036961357784695 states[6] = 0.9065941499695301 states[7] = 0.9065967263076083 states[8] = 0.508117603077852 states[9] = 0.03582573962705717 states[10] = 0.2060363247740295 states[11] = 0.1922244113609531 states[12] = 0.1932803618375963 states[13] = 0.1174074734567931 states[14] = 0.9968385770271651 states[15] = 0.9968408069904307 states[16] = 0.0307583106982354 states[17] = 0.08785242843398365 constants[6] = 1000.0 states[18] = 0.0003569126518797985 constants[7] = 1000.0 states[19] = 0.002220456569762898 states[20] = 0.002604864867063448 states[21] = 0.0003764413740731269 constants[8] = 1e-8 constants[9] = -1 constants[10] = -1 constants[11] = 140.000 constants[12] = 2.50000 constants[13] = 0.500000 constants[14] = 1.00000 constants[15] = 1.00000 constants[16] = 0.00000 constants[17] = 0.600000 constants[18] = 45.0000 constants[19] = 0.00100000 constants[20] = 0.0580000 constants[21] = 42.0000 constants[22] = 0.800000 constants[23] = 0.00400000 constants[24] = 0.520000 constants[25] = 0.0320000 constants[26] = 0.200000 constants[27] = 0.100000 constants[28] = 0.160000 constants[29] = 0.187500 constants[30] = 0.0542000 constants[31] = 0.0123000 constants[32] = 1.30000 constants[33] = 0.900000 constants[34] = 0.890000 constants[35] = 1.00000 constants[36] = 0.500000 constants[37] = 1.00000 constants[38] = 1.19000 constants[39] = 1.60000 constants[40] = 3.50000e-07 constants[41] = 0.000500000 constants[42] = 2.00000 constants[43] = 0.000300000 constants[44] = 4.00000 constants[45] = 30.0000 constants[46] = 0.00700000 constants[47] = 87.5000 constants[48] = 1.30000 constants[49] = 3.00000 constants[50] = 161.301 constants[51] = 3.60205 constants[52] = 12.0000 constants[53] = 4.00000 constants[54] = 0.108043+0.903902/(1.00000+power(constants[13]/0.281007, 1.29834)) constants[55] = ((1.00000/0.000525000)*0.0300000)/(1.00000+power(150.000/(constants[12]+constants[8]), 2.00000)) constants[56] = 46.0000 constants[57] = 6.00000 constants[58] = 130.000 constants[59] = ((1.00000/0.0123000)*0.0300000)/(1.00000+power(150.000/(constants[57]+constants[8]), 2.00000)) constants[60] = 130.000 constants[61] = ((1.00000/0.0123000)*0.0300000)/(1.00000+power(150.000/(constants[58]+constants[8]), 2.00000)) constants[62] = 0.0150000 constants[63] = 4.00000 constants[64] = 2.00000 constants[65] = 8314.00 constants[66] = 96485.0 constants[67] = 1.00000 constants[68] = 308.000 constants[69] = 1.70000 constants[70] = 1.00000 constants[71] = ((constants[65]*constants[68])/constants[66])*log(constants[58]/constants[53]) constants[72] = ((constants[65]*constants[68])/constants[66])*log(constants[57]/constants[11]) constants[73] = ((constants[65]*constants[68])/constants[66])*log(constants[56]/constants[60]) constants[74] = 2.00000 constants[75] = 0.350000 constants[76] = 22.0000 constants[77] = ((constants[65]*constants[68])/constants[66])*log((constants[57]+(constants[75]/constants[70])*constants[58])/(constants[11]+(constants[75]/constants[70])*constants[53])) constants[78] = 3.50000e-06 constants[79] = 0.270000 constants[80] = 0.350000 constants[81] = 1.00000/(1.00000+power(constants[74]/constants[57], 1.50000)) constants[82] = 1.00000/(1.00000+power(constants[76]/constants[53], 2.00000)) return (states, constants) def computeRates(voi, states, constants): rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic algebraic[6] = 1.00000/(1.00000+exp((states[0]+38.0000)/7.00000)) rates[6] = (algebraic[6]-states[6])/constants[52] algebraic[1] = 1.00000/(1.00000+power((constants[50]*constants[5])/states[1], constants[51])) algebraic[19] = 4000.00*(0.234845+(1.00000-0.234845)/(1.00000+power(states[1]/(constants[50]*constants[5]), constants[51]))) rates[2] = (algebraic[1]-states[2])/algebraic[19] algebraic[3] = 1.00000/(1.00000+exp(-(states[0]+35.9584)/9.24013)) algebraic[20] = 0.250000+7.00000/(1.00000+exp((states[0]+38.0000)/10.0000)) rates[3] = (algebraic[3]-states[3])/algebraic[20] algebraic[4] = 1.00000/(1.00000+exp((states[0]+57.0000)/8.00000)) algebraic[21] = 0.900000+1002.85/(1.00000+power((states[0]+47.5000)/1.50000, 2.00000)) rates[4] = (algebraic[4]-states[4])/algebraic[21] algebraic[5] = 1.00000/(1.00000+exp(-(states[0]+22.0000)/7.00000)) algebraic[22] = 2.29000+5.70000/(1.00000+power((states[0]+29.9700)/9.00000, 2.00000)) rates[5] = (algebraic[5]-states[5])/algebraic[22] algebraic[23] = 90.9699*(1.00000-1.00000/((1.00000+exp((states[0]+13.9629)/45.3782))*(1.00000+exp(-(states[0]+9.49866)/3.39450)))) rates[7] = (algebraic[6]-states[7])/algebraic[23] algebraic[7] = 1.00000/(1.00000+exp(-(states[0]+54.2300)/9.88000)) algebraic[24] = 0.450000+3.90000/(1.00000+power((states[0]+66.0000)/26.0000, 2.00000)) rates[8] = (algebraic[7]-states[8])/algebraic[24] algebraic[8] = 0.0200000+0.980000/(1.00000+exp((states[0]+72.9780)/4.64000)) algebraic[25] = 150.000*(1.00000-1.00000/((1.00000+exp((states[0]-417.430)/203.180))*(1.00000+exp(-(states[0]+61.1100)/8.07000)))) rates[9] = (algebraic[8]-states[9])/algebraic[25] algebraic[9] = 0.978613/(1.00000+exp(-(states[0]+18.6736)/26.6606)) algebraic[26] = 500.000/(1.00000+power((states[0]+60.7100)/15.7900, 2.00000)) rates[10] = (algebraic[9]-states[10])/algebraic[26] algebraic[10] = 1.00000/(1.00000+exp((states[0]+63.0000)/6.30000)) algebraic[27] = 5000.00/(1.00000+power((states[0]+62.7133)/35.8611, 2.00000)) rates[11] = (algebraic[10]-states[11])/algebraic[27] algebraic[28] = 30000.0+220000./(1.00000+exp((states[0]+22.0000)/4.00000)) rates[12] = (algebraic[10]-states[12])/algebraic[28] algebraic[11] = 0.948000/(1.00000+exp(-(states[0]+17.9100)/18.4000)) algebraic[29] = 100.000/(1.00000+power((states[0]+64.1000)/28.6700, 2.00000)) rates[13] = (algebraic[11]-states[13])/algebraic[29] algebraic[12] = 1.00000/(1.00000+exp((states[0]+21.2000)/5.70000)) algebraic[30] = 1.00000e+06*(1.00000-1.00000/((1.00000+exp((states[0]-315.000)/50.0000))*(1.00000+exp(-(states[0]+74.9000)/8.00000)))) rates[14] = (algebraic[12]-states[14])/algebraic[30] algebraic[31] = 2.50000e+06*(1.00000-1.00000/((1.00000+exp((states[0]-132.868)/25.3992))*(1.00000+exp(-(states[0]+24.9203)/2.67915)))) rates[15] = (algebraic[12]-states[15])/algebraic[31] algebraic[13] = 1.00000/(1.00000+exp(-(states[0]+27.7900)/7.57000)) algebraic[32] = 17.0000/(1.00000+power((states[0]+20.5232)/35.0000, 2.00000)) rates[16] = (algebraic[13]-states[16])/algebraic[32] algebraic[14] = 0.0200000+0.980000/(1.00000+exp((states[0]+69.5000)/6.00000)) algebraic[33] = 7.50000+10.0000/(1.00000+power((states[0]+34.1765)/120.000, 2.00000)) rates[17] = (algebraic[14]-states[17])/algebraic[33] algebraic[15] = -0.749234/(1.00000+power((states[1]*constants[6]-0.0630535)/0.161942, 2.00000))+8.38384/(1.00000+power((states[1]*constants[6]+1538.29)/739.057, 2.00000)) algebraic[34] = 5011.47/(1.00000+power((states[1]*constants[6]+0.237503)/0.000239278, 0.422910))-37.5137 algebraic[38] = 1.00000/(1.00000+exp((-algebraic[15]*constants[66]*(states[0]-algebraic[34]))/(constants[65]*constants[68]))) algebraic[43] = 2.40914/(1.00000+power((states[0]-158.779)/-52.1497, 2.00000)) rates[18] = (algebraic[38]-states[18])/algebraic[43] algebraic[16] = -0.681249/(1.00000+power((states[1]*constants[7]-0.218988)/0.428335, 2.00000))+1.40001/(1.00000+power((states[1]*constants[7]+228.710)/684.946, 2.00000)) algebraic[35] = 8540.23/(1.00000+power((states[1]*constants[7]+0.401189)/0.00399115, 0.668054))-109.275 algebraic[39] = 1.00000/(1.00000+exp((-algebraic[16]*constants[66]*(states[0]-algebraic[35]))/(constants[65]*constants[68]))) algebraic[44] = 13.8049/(1.00000+power((states[0]-153.019)/66.4952, 2.00000)) rates[19] = (algebraic[39]-states[19])/algebraic[44] algebraic[17] = 1.00000/(1.00000+exp((states[0]+105.390)/8.65530)) algebraic[36] = 3.50000e-06*exp(-0.0497000*states[0]) algebraic[40] = 0.0400300*exp(0.0521100*states[0]) algebraic[45] = 1.00000/(algebraic[36]+algebraic[40]) rates[20] = (algebraic[17]-states[20])/algebraic[45] algebraic[18] = (states[0]*constants[66])/(constants[65]*constants[68]) algebraic[41] = 0.000600000*exp(2.53000*algebraic[18]) algebraic[46] = 0.100000*exp(-5.00000*algebraic[18]) algebraic[48] = 1.00000/(1.00000+algebraic[46]*(power(algebraic[41]/states[1], 2.00000)+algebraic[41]/states[1]+1.00000)) algebraic[50] = -160.000+210.000/(1.00000+exp((states[0]+4.56000)/11.6200))+170.000/(1.00000+exp(-(states[0]+25.5000)/11.6200)) rates[21] = (algebraic[48]-states[21])/algebraic[50] algebraic[0] = custom_piecewise([greater(voi , constants[2]) & less(voi , constants[3]), constants[1] , True, constants[0]]) algebraic[42] = constants[16]*states[3]*states[3]*states[3]*states[4]*(states[0]-constants[71]) algebraic[47] = 1.00000/(1.00000+power(states[1]/constants[19], 4.00000)) algebraic[49] = constants[17]*algebraic[47]*states[5]*states[5]*(0.800000*states[6]+0.200000*states[7])*(states[0]-constants[18]) algebraic[51] = constants[20]*states[8]*states[8]*states[9]*(states[0]-constants[21]) algebraic[52] = constants[23]*(states[0]-constants[72]) algebraic[53] = constants[24]*states[10]*states[10]*(0.380000*states[11]+0.630000*states[12])*(states[0]-constants[72]) algebraic[54] = constants[25]*states[13]*states[13]*(0.750000*states[14]+0.250000*states[15])*(states[0]-constants[72]) algebraic[55] = constants[28]*states[16]*states[17]*(states[0]-constants[72]) algebraic[56] = constants[22]*constants[26]*states[18]*(states[0]-constants[72]) algebraic[57] = constants[22]*constants[27]*states[19]*(states[0]-constants[72]) algebraic[58] = constants[30]*states[20]*(states[0]-constants[77]) algebraic[59] = constants[29]*states[21]*(states[0]-constants[73]) algebraic[37] = ((constants[65]*constants[68])/constants[66])*log((constants[32]*constants[57]+constants[33]*constants[58]+(4.00000*constants[34]*constants[12])/(1.00000+exp(algebraic[18])))/(constants[32]*constants[11]+constants[33]*constants[53]+(4.00000*constants[34]*states[1])/(1.00000+exp(algebraic[18])))) algebraic[63] = constants[54]*constants[61]*constants[37]*constants[31]*(states[0]-algebraic[37]) algebraic[60] = constants[54]*constants[55]*constants[36]*constants[31]*(states[0]-algebraic[37]) algebraic[65] = constants[54]*constants[59]*constants[38]*constants[31]*(states[0]-algebraic[37]) algebraic[66] = 1.00000/(1.00000+0.124500*exp(-0.100000*algebraic[18])+0.00219000*exp(constants[58]/49.7100)*exp(-1.90000*algebraic[18])) algebraic[67] = constants[69]*constants[81]*constants[82]*algebraic[66] algebraic[70] = 1.00000/(1.00000+power(constants[43]/states[1], constants[44])) algebraic[68] = exp((constants[80]-1.00000)*algebraic[18]) algebraic[69] = exp(constants[80]*algebraic[18]) algebraic[71] = (power(constants[53], 3.00000))*constants[12]*algebraic[69]-(power(constants[58], 3.00000))*states[1]*algebraic[68] algebraic[72] = 1.00000+constants[79]*algebraic[68] algebraic[73] = constants[48]*(power(constants[53], 3.00000))+(power(constants[47], 3.00000))*states[1]+(power(constants[45], 3.00000))*constants[12]*(1.00000+states[1]/constants[46]) algebraic[74] = constants[12]*(power(constants[53], 3.00000))+(power(constants[58], 3.00000))*states[1]+(power(constants[58], 3.00000))*constants[46]*(1.00000+power(constants[53]/constants[45], 3.00000)) algebraic[75] = (constants[10]*constants[78]*algebraic[70]*algebraic[71])/(algebraic[72]*(algebraic[73]+algebraic[74])) algebraic[76] = ((0.500000*constants[64]*constants[66])/(constants[63]*constants[67]*constants[62]))*constants[9]*algebraic[75] algebraic[79] = algebraic[42]+algebraic[58]+algebraic[76]+algebraic[67]+algebraic[49]+algebraic[51]+algebraic[59]+algebraic[53]+algebraic[54]+algebraic[55]+algebraic[56]+algebraic[57]+algebraic[63]+algebraic[65]+algebraic[60]+algebraic[52] rates[0] = -(algebraic[79]+algebraic[0]) algebraic[61] = algebraic[49]+algebraic[51]+algebraic[60] algebraic[62] = ((constants[63]*constants[67]*constants[62])/(constants[64]*constants[66]))*algebraic[61] algebraic[77] = constants[40]/(1.00000+power(constants[41]/states[1], constants[42])) algebraic[80] = algebraic[62]+algebraic[75]+algebraic[77] rates[1] = -algebraic[80] return(rates) def computeAlgebraic(constants, states, voi): algebraic = array([[0.0] * len(voi)] * sizeAlgebraic) states = array(states) voi = array(voi) algebraic[6] = 1.00000/(1.00000+exp((states[0]+38.0000)/7.00000)) algebraic[1] = 1.00000/(1.00000+power((constants[50]*constants[5])/states[1], constants[51])) algebraic[19] = 4000.00*(0.234845+(1.00000-0.234845)/(1.00000+power(states[1]/(constants[50]*constants[5]), constants[51]))) algebraic[3] = 1.00000/(1.00000+exp(-(states[0]+35.9584)/9.24013)) algebraic[20] = 0.250000+7.00000/(1.00000+exp((states[0]+38.0000)/10.0000)) algebraic[4] = 1.00000/(1.00000+exp((states[0]+57.0000)/8.00000)) algebraic[21] = 0.900000+1002.85/(1.00000+power((states[0]+47.5000)/1.50000, 2.00000)) algebraic[5] = 1.00000/(1.00000+exp(-(states[0]+22.0000)/7.00000)) algebraic[22] = 2.29000+5.70000/(1.00000+power((states[0]+29.9700)/9.00000, 2.00000)) algebraic[23] = 90.9699*(1.00000-1.00000/((1.00000+exp((states[0]+13.9629)/45.3782))*(1.00000+exp(-(states[0]+9.49866)/3.39450)))) algebraic[7] = 1.00000/(1.00000+exp(-(states[0]+54.2300)/9.88000)) algebraic[24] = 0.450000+3.90000/(1.00000+power((states[0]+66.0000)/26.0000, 2.00000)) algebraic[8] = 0.0200000+0.980000/(1.00000+exp((states[0]+72.9780)/4.64000)) algebraic[25] = 150.000*(1.00000-1.00000/((1.00000+exp((states[0]-417.430)/203.180))*(1.00000+exp(-(states[0]+61.1100)/8.07000)))) algebraic[9] = 0.978613/(1.00000+exp(-(states[0]+18.6736)/26.6606)) algebraic[26] = 500.000/(1.00000+power((states[0]+60.7100)/15.7900, 2.00000)) algebraic[10] = 1.00000/(1.00000+exp((states[0]+63.0000)/6.30000)) algebraic[27] = 5000.00/(1.00000+power((states[0]+62.7133)/35.8611, 2.00000)) algebraic[28] = 30000.0+220000./(1.00000+exp((states[0]+22.0000)/4.00000)) algebraic[11] = 0.948000/(1.00000+exp(-(states[0]+17.9100)/18.4000)) algebraic[29] = 100.000/(1.00000+power((states[0]+64.1000)/28.6700, 2.00000)) algebraic[12] = 1.00000/(1.00000+exp((states[0]+21.2000)/5.70000)) algebraic[30] = 1.00000e+06*(1.00000-1.00000/((1.00000+exp((states[0]-315.000)/50.0000))*(1.00000+exp(-(states[0]+74.9000)/8.00000)))) algebraic[31] = 2.50000e+06*(1.00000-1.00000/((1.00000+exp((states[0]-132.868)/25.3992))*(1.00000+exp(-(states[0]+24.9203)/2.67915)))) algebraic[13] = 1.00000/(1.00000+exp(-(states[0]+27.7900)/7.57000)) algebraic[32] = 17.0000/(1.00000+power((states[0]+20.5232)/35.0000, 2.00000)) algebraic[14] = 0.0200000+0.980000/(1.00000+exp((states[0]+69.5000)/6.00000)) algebraic[33] = 7.50000+10.0000/(1.00000+power((states[0]+34.1765)/120.000, 2.00000)) algebraic[15] = -0.749234/(1.00000+power((states[1]*constants[6]-0.0630535)/0.161942, 2.00000))+8.38384/(1.00000+power((states[1]*constants[6]+1538.29)/739.057, 2.00000)) algebraic[34] = 5011.47/(1.00000+power((states[1]*constants[6]+0.237503)/0.000239278, 0.422910))-37.5137 algebraic[38] = 1.00000/(1.00000+exp((-algebraic[15]*constants[66]*(states[0]-algebraic[34]))/(constants[65]*constants[68]))) algebraic[43] = 2.40914/(1.00000+power((states[0]-158.779)/-52.1497, 2.00000)) algebraic[16] = -0.681249/(1.00000+power((states[1]*constants[7]-0.218988)/0.428335, 2.00000))+1.40001/(1.00000+power((states[1]*constants[7]+228.710)/684.946, 2.00000)) algebraic[35] = 8540.23/(1.00000+power((states[1]*constants[7]+0.401189)/0.00399115, 0.668054))-109.275 algebraic[39] = 1.00000/(1.00000+exp((-algebraic[16]*constants[66]*(states[0]-algebraic[35]))/(constants[65]*constants[68]))) algebraic[44] = 13.8049/(1.00000+power((states[0]-153.019)/66.4952, 2.00000)) algebraic[17] = 1.00000/(1.00000+exp((states[0]+105.390)/8.65530)) algebraic[36] = 3.50000e-06*exp(-0.0497000*states[0]) algebraic[40] = 0.0400300*exp(0.0521100*states[0]) algebraic[45] = 1.00000/(algebraic[36]+algebraic[40]) algebraic[18] = (states[0]*constants[66])/(constants[65]*constants[68]) algebraic[41] = 0.000600000*exp(2.53000*algebraic[18]) algebraic[46] = 0.100000*exp(-5.00000*algebraic[18]) algebraic[48] = 1.00000/(1.00000+algebraic[46]*(power(algebraic[41]/states[1], 2.00000)+algebraic[41]/states[1]+1.00000)) algebraic[50] = -160.000+210.000/(1.00000+exp((states[0]+4.56000)/11.6200))+170.000/(1.00000+exp(-(states[0]+25.5000)/11.6200)) algebraic[0] = custom_piecewise([greater(voi , constants[2]) & less(voi , constants[3]), constants[1] , True, constants[0]]) algebraic[42] = constants[16]*states[3]*states[3]*states[3]*states[4]*(states[0]-constants[71]) algebraic[47] = 1.00000/(1.00000+power(states[1]/constants[19], 4.00000)) algebraic[49] = constants[17]*algebraic[47]*states[5]*states[5]*(0.800000*states[6]+0.200000*states[7])*(states[0]-constants[18]) algebraic[51] = constants[20]*states[8]*states[8]*states[9]*(states[0]-constants[21]) algebraic[52] = constants[23]*(states[0]-constants[72]) algebraic[53] = constants[24]*states[10]*states[10]*(0.380000*states[11]+0.630000*states[12])*(states[0]-constants[72]) algebraic[54] = constants[25]*states[13]*states[13]*(0.750000*states[14]+0.250000*states[15])*(states[0]-constants[72]) algebraic[55] = constants[28]*states[16]*states[17]*(states[0]-constants[72]) algebraic[56] = constants[22]*constants[26]*states[18]*(states[0]-constants[72]) algebraic[57] = constants[22]*constants[27]*states[19]*(states[0]-constants[72]) algebraic[58] = constants[30]*states[20]*(states[0]-constants[77]) algebraic[59] = constants[29]*states[21]*(states[0]-constants[73]) algebraic[37] = ((constants[65]*constants[68])/constants[66])*log((constants[32]*constants[57]+constants[33]*constants[58]+(4.00000*constants[34]*constants[12])/(1.00000+exp(algebraic[18])))/(constants[32]*constants[11]+constants[33]*constants[53]+(4.00000*constants[34]*states[1])/(1.00000+exp(algebraic[18])))) algebraic[63] = constants[54]*constants[61]*constants[37]*constants[31]*(states[0]-algebraic[37]) algebraic[60] = constants[54]*constants[55]*constants[36]*constants[31]*(states[0]-algebraic[37]) algebraic[65] = constants[54]*constants[59]*constants[38]*constants[31]*(states[0]-algebraic[37]) algebraic[66] = 1.00000/(1.00000+0.124500*exp(-0.100000*algebraic[18])+0.00219000*exp(constants[58]/49.7100)*exp(-1.90000*algebraic[18])) algebraic[67] = constants[69]*constants[81]*constants[82]*algebraic[66] algebraic[70] = 1.00000/(1.00000+power(constants[43]/states[1], constants[44])) algebraic[68] = exp((constants[80]-1.00000)*algebraic[18]) algebraic[69] = exp(constants[80]*algebraic[18]) algebraic[71] = (power(constants[53], 3.00000))*constants[12]*algebraic[69]-(power(constants[58], 3.00000))*states[1]*algebraic[68] algebraic[72] = 1.00000+constants[79]*algebraic[68] algebraic[73] = constants[48]*(power(constants[53], 3.00000))+(power(constants[47], 3.00000))*states[1]+(power(constants[45], 3.00000))*constants[12]*(1.00000+states[1]/constants[46]) algebraic[74] = constants[12]*(power(constants[53], 3.00000))+(power(constants[58], 3.00000))*states[1]+(power(constants[58], 3.00000))*constants[46]*(1.00000+power(constants[53]/constants[45], 3.00000)) algebraic[75] = (constants[10]*constants[78]*algebraic[70]*algebraic[71])/(algebraic[72]*(algebraic[73]+algebraic[74])) algebraic[76] = ((0.500000*constants[64]*constants[66])/(constants[63]*constants[67]*constants[62]))*constants[9]*algebraic[75] algebraic[79] = algebraic[42]+algebraic[58]+algebraic[76]+algebraic[67]+algebraic[49]+algebraic[51]+algebraic[59]+algebraic[53]+algebraic[54]+algebraic[55]+algebraic[56]+algebraic[57]+algebraic[63]+algebraic[65]+algebraic[60]+algebraic[52] algebraic[61] = algebraic[49]+algebraic[51]+algebraic[60] algebraic[62] = ((constants[63]*constants[67]*constants[62])/(constants[64]*constants[66]))*algebraic[61] algebraic[77] = constants[40]/(1.00000+power(constants[41]/states[1], constants[42])) algebraic[80] = algebraic[62]+algebraic[75]+algebraic[77] algebraic[2] = constants[49]*(states[2]-0.234500) algebraic[64] = algebraic[62]*constants[4] algebraic[78] = algebraic[75]*constants[4] algebraic[81] = algebraic[77]*constants[4] return algebraic def custom_piecewise(cases): """Compute result of a piecewise function""" return select(cases[0::2],cases[1::2]) def solve_model(): """Solve model with ODE solver""" from scipy.integrate import ode # Initialise constants and state variables (init_states, constants) = initConsts() # Set timespan to solve over voi = linspace(0, 10, 500) # Construct ODE object to solve r = ode(computeRates) r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1) r.set_initial_value(init_states, voi[0]) r.set_f_params(constants) # Solve model states = array([[0.0] * len(voi)] * sizeStates) states[:,0] = init_states for (i,t) in enumerate(voi[1:]): if r.successful(): r.integrate(t) states[:,i+1] = r.y else: break # Compute algebraic variables algebraic = computeAlgebraic(constants, states, voi) return (voi, states, algebraic) def plot_model(voi, states, algebraic): """Plot variables against variable of integration""" import pylab (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends() pylab.figure(1) pylab.plot(voi,vstack((states,algebraic)).T) pylab.xlabel(legend_voi) pylab.legend(legend_states + legend_algebraic, loc='best') pylab.show() if __name__ == "__main__": (voi, states, algebraic) = solve_model() plot_model(voi, states, algebraic)