/* There are a total of 82 entries in the algebraic variable array. There are a total of 22 entries in each of the rate and state variable arrays. There are a total of 83 entries in the constant variable array. */ /* * CONSTANTS[0] is I_hold in component interface (pA_per_pF). * CONSTANTS[1] is I_test in component interface (pA_per_pF). * CONSTANTS[2] is test_start in component interface (msec). * CONSTANTS[3] is test_end in component interface (msec). * ALGEBRAIC[0] is Ist in component interface (pA_per_pF). * VOI is time in component environment (msec). * ALGEBRAIC[81] is I_tot in component membrane_potential (pA_per_pF). * ALGEBRAIC[74] is I_Ca_tot in component membrane_potential (pA_per_pF). * STATES[0] is v in component membrane_potential (mV). * CONSTANTS[67] is Cm in component parameters (uF_per_cm2). * ALGEBRAIC[10] is ina in component I_Na (pA_per_pF). * ALGEBRAIC[16] is ical in component I_CaL (pA_per_pF). * ALGEBRAIC[21] is icat in component I_CaT (pA_per_pF). * ALGEBRAIC[22] is ib in component I_b (pA_per_pF). * ALGEBRAIC[28] is ik1 in component I_K1 (pA_per_pF). * ALGEBRAIC[34] is ik2 in component I_K2 (pA_per_pF). * ALGEBRAIC[39] is ika in component I_Ka (pA_per_pF). * ALGEBRAIC[44] is iBKa in component I_BKa (pA_per_pF). * ALGEBRAIC[49] is iBKab in component I_BKab (pA_per_pF). * ALGEBRAIC[54] is ih in component I_h (pA_per_pF). * ALGEBRAIC[59] is icl in component I_Cl (pA_per_pF). * ALGEBRAIC[61] is insna in component I_ns (pA_per_pF). * ALGEBRAIC[60] is insca in component I_ns (pA_per_pF). * ALGEBRAIC[62] is insk in component I_ns (pA_per_pF). * ALGEBRAIC[64] is inak in component I_NaK (pA_per_pF). * ALGEBRAIC[80] is inaca in component I_NaCa (pA_per_pF). * ALGEBRAIC[79] is J_tot in component Ca_Concentrations (mM_per_msec). * ALGEBRAIC[75] is J_Ca_mem in component Ca_Concentrations (mM_per_msec). * STATES[1] is cai in component Ca_Concentrations (mM). * ALGEBRAIC[72] is jnaca in component J_NaCa (mM_per_msec). * ALGEBRAIC[73] is jpmca in component J_PMCA (mM_per_msec). * CONSTANTS[62] is buff in component parameters (dimensionless). * CONSTANTS[63] is AV in component parameters (cm2_per_uL). * CONSTANTS[64] is zca in component parameters (dimensionless). * CONSTANTS[66] is frdy in component parameters (coulomb_per_mole). * ALGEBRAIC[76] is jcamem_plot in component Ca_Concentrations (M_per_msec). * ALGEBRAIC[77] is jpmca_plot in component Ca_Concentrations (M_per_msec). * ALGEBRAIC[78] is jnaca_plot in component Ca_Concentrations (M_per_msec). * CONSTANTS[4] is conversion in component Ca_Concentrations (mM_to_M). * CONSTANTS[11] is ki in component parameters (mM). * CONSTANTS[53] is nai in component parameters (mM). * CONSTANTS[56] is cli in component parameters (mM). * CONSTANTS[57] is ko in component parameters (mM). * CONSTANTS[12] is cao in component parameters (mM). * CONSTANTS[58] is nao in component parameters (mM). * CONSTANTS[60] is clo in component parameters (mM). * CONSTANTS[13] is mgo in component parameters (mM). * CONSTANTS[14] is zna in component parameters (dimensionless). * CONSTANTS[15] is zk in component parameters (dimensionless). * CONSTANTS[65] is R in component parameters (joule_per_kelvin_per_kilomole). * CONSTANTS[68] is temp in component parameters (kelvin). * CONSTANTS[16] is gna in component parameters (nS_per_pF). * CONSTANTS[17] is gcal in component parameters (nS_per_pF). * CONSTANTS[18] is ecal in component parameters (mV). * CONSTANTS[19] is kmca in component parameters (mM). * CONSTANTS[20] is gcat in component parameters (nS_per_pF). * CONSTANTS[21] is ecat in component parameters (mV). * CONSTANTS[22] is gkca in component parameters (nS_per_pF). * CONSTANTS[23] is gb in component parameters (nS_per_pF). * CONSTANTS[24] is gk1 in component parameters (nS_per_pF). * CONSTANTS[25] is gk2 in component parameters (nS_per_pF). * CONSTANTS[26] is gbka in component parameters (dimensionless). * CONSTANTS[27] is gbkab in component parameters (dimensionless). * CONSTANTS[28] is gka in component parameters (nS_per_pF). * CONSTANTS[29] is gcl in component parameters (nS_per_pF). * CONSTANTS[30] is gh in component parameters (nS_per_pF). * CONSTANTS[31] is gns in component parameters (nS_per_pF). * CONSTANTS[32] is PnsK in component parameters (dimensionless). * CONSTANTS[33] is PnsNa in component parameters (dimensionless). * CONSTANTS[34] is PnsCa in component parameters (dimensionless). * CONSTANTS[35] is PnsCs in component parameters (dimensionless). * CONSTANTS[36] is gnsCa in component parameters (dimensionless). * CONSTANTS[37] is gnsNa in component parameters (dimensionless). * CONSTANTS[38] is gnsK in component parameters (dimensionless). * CONSTANTS[39] is gnsCs in component parameters (dimensionless). * CONSTANTS[69] is ginak in component parameters (pA_per_pF). * CONSTANTS[74] is nakKmko in component parameters (mM). * CONSTANTS[76] is nakKmnai in component parameters (mM). * CONSTANTS[70] is PK in component parameters (dimensionless). * CONSTANTS[75] is PNa in component parameters (dimensionless). * CONSTANTS[40] is Jpmca in component parameters (mM_per_msec). * CONSTANTS[41] is Kmpmca in component parameters (mM). * CONSTANTS[42] is npmca in component parameters (dimensionless). * CONSTANTS[78] is Jnaca in component parameters (mM_per_msec). * CONSTANTS[43] is Kmallo in component parameters (mM). * CONSTANTS[44] is nallo in component parameters (dimensionless). * CONSTANTS[79] is ksat in component parameters (dimensionless). * CONSTANTS[80] is xgamma in component parameters (dimensionless). * CONSTANTS[45] is Kmnai in component parameters (mM). * CONSTANTS[46] is Kmcai in component parameters (mM). * CONSTANTS[47] is Kmnao in component parameters (mM). * CONSTANTS[48] is Kmcao in component parameters (mM). * CONSTANTS[49] is Fmax in component parameters (uN). * CONSTANTS[50] is FKm in component parameters (nM). * CONSTANTS[51] is Fn in component parameters (dimensionless). * ALGEBRAIC[1] is vFRT in component parameters (dimensionless). * CONSTANTS[71] is ena in component parameters (mV). * CONSTANTS[72] is ek in component parameters (mV). * CONSTANTS[77] is eh in component parameters (mV). * CONSTANTS[73] is ecl in component parameters (mV). * ALGEBRAIC[2] is enscc in component parameters (mV). * ALGEBRAIC[3] is wss in component Ca_dependent_Force (dimensionless). * ALGEBRAIC[4] is wtc in component Ca_dependent_Force (msec). * CONSTANTS[5] is conversion in component Ca_dependent_Force (nM_to_mM). * ALGEBRAIC[5] is Force in component Ca_dependent_Force (uN). * STATES[2] is w in component Ca_dependent_Force (dimensionless). * ALGEBRAIC[6] is mss in component I_Na (dimensionless). * ALGEBRAIC[7] is hss in component I_Na (dimensionless). * ALGEBRAIC[8] is mtc in component I_Na (msec). * ALGEBRAIC[9] is htc in component I_Na (msec). * STATES[3] is m in component I_Na (dimensionless). * STATES[4] is h in component I_Na (dimensionless). * ALGEBRAIC[12] is dss in component I_CaL (dimensionless). * ALGEBRAIC[13] is fss in component I_CaL (dimensionless). * ALGEBRAIC[11] is fca in component I_CaL (dimensionless). * ALGEBRAIC[14] is dtc in component I_CaL (msec). * CONSTANTS[52] is f1tc in component I_CaL (msec). * ALGEBRAIC[15] is f2tc in component I_CaL (msec). * STATES[5] is d in component I_CaL (dimensionless). * STATES[6] is f1 in component I_CaL (dimensionless). * STATES[7] is f2 in component I_CaL (dimensionless). * ALGEBRAIC[17] is bss in component I_CaT (dimensionless). * ALGEBRAIC[18] is gss in component I_CaT (dimensionless). * ALGEBRAIC[19] is btc in component I_CaT (msec). * ALGEBRAIC[20] is gtc in component I_CaT (msec). * STATES[8] is b in component I_CaT (dimensionless). * STATES[9] is g in component I_CaT (dimensionless). * ALGEBRAIC[23] is qss in component I_K1 (dimensionless). * ALGEBRAIC[24] is rss in component I_K1 (dimensionless). * ALGEBRAIC[25] is qtc in component I_K1 (msec). * ALGEBRAIC[26] is r1tc in component I_K1 (msec). * ALGEBRAIC[27] is r2tc in component I_K1 (msec). * STATES[10] is q in component I_K1 (dimensionless). * STATES[11] is r1 in component I_K1 (dimensionless). * STATES[12] is r2 in component I_K1 (dimensionless). * ALGEBRAIC[29] is pss in component I_K2 (dimensionless). * ALGEBRAIC[30] is kss in component I_K2 (dimensionless). * ALGEBRAIC[31] is ptc in component I_K2 (msec). * ALGEBRAIC[32] is k1tc in component I_K2 (msec). * ALGEBRAIC[33] is k2tc in component I_K2 (msec). * STATES[13] is p in component I_K2 (dimensionless). * STATES[14] is k1 in component I_K2 (dimensionless). * STATES[15] is k2 in component I_K2 (dimensionless). * ALGEBRAIC[35] is sss in component I_Ka (dimensionless). * ALGEBRAIC[36] is xss in component I_Ka (dimensionless). * ALGEBRAIC[37] is stc in component I_Ka (msec). * ALGEBRAIC[38] is xtc in component I_Ka (msec). * STATES[16] is s in component I_Ka (dimensionless). * STATES[17] is x in component I_Ka (dimensionless). * ALGEBRAIC[40] is xass_z in component I_BKa (dimensionless). * ALGEBRAIC[41] is xass_vh in component I_BKa (mV). * CONSTANTS[6] is conversion in component I_BKa (mM_to_M). * ALGEBRAIC[42] is xass in component I_BKa (dimensionless). * ALGEBRAIC[43] is xatc in component I_BKa (msec). * STATES[18] is xa in component I_BKa (dimensionless). * ALGEBRAIC[45] is xabss_z in component I_BKab (dimensionless). * ALGEBRAIC[46] is xabss_vh in component I_BKab (mV). * CONSTANTS[7] is conversion in component I_BKab (mM_to_M). * ALGEBRAIC[47] is xabss in component I_BKab (dimensionless). * ALGEBRAIC[48] is xabtc in component I_BKab (msec). * STATES[19] is xab in component I_BKab (dimensionless). * ALGEBRAIC[50] is yss in component I_h (dimensionless). * ALGEBRAIC[53] is ytc in component I_h (msec). * ALGEBRAIC[51] is ya in component I_h (per_msec). * ALGEBRAIC[52] is yb in component I_h (per_msec). * STATES[20] is y in component I_h (dimensionless). * ALGEBRAIC[57] is css in component I_Cl (dimensionless). * ALGEBRAIC[58] is ctc in component I_Cl (msec). * ALGEBRAIC[55] is K1cl in component I_Cl (mM). * ALGEBRAIC[56] is K2cl in component I_Cl (dimensionless). * STATES[21] is c in component I_Cl (dimensionless). * CONSTANTS[54] is fmg in component I_ns (dimensionless). * CONSTANTS[61] is gs_nao in component I_ns (dimensionless). * CONSTANTS[55] is gs_cao in component I_ns (dimensionless). * CONSTANTS[59] is gs_ko in component I_ns (dimensionless). * CONSTANTS[8] is tinyamount in component I_ns (mM). * ALGEBRAIC[63] is fnak in component I_NaK (dimensionless). * CONSTANTS[81] is knak in component I_NaK (dimensionless). * CONSTANTS[82] is nnak in component I_NaK (dimensionless). * CONSTANTS[9] is inaca_sign in component I_NaCa (dimensionless). * ALGEBRAIC[65] is f1naca in component J_NaCa (dimensionless). * ALGEBRAIC[66] is f2naca in component J_NaCa (dimensionless). * ALGEBRAIC[67] is fallo in component J_NaCa (dimensionless). * ALGEBRAIC[68] is naca_Eup in component J_NaCa (mM4). * ALGEBRAIC[69] is naca_Ed1 in component J_NaCa (dimensionless). * ALGEBRAIC[70] is naca_Ed2 in component J_NaCa (mM4). * ALGEBRAIC[71] is naca_Ed3 in component J_NaCa (mM4). * CONSTANTS[10] is jnaca_sign in component J_NaCa (dimensionless). * RATES[0] is d/dt v in component membrane_potential (mV). * RATES[1] is d/dt cai in component Ca_Concentrations (mM). * RATES[2] is d/dt w in component Ca_dependent_Force (dimensionless). * RATES[3] is d/dt m in component I_Na (dimensionless). * RATES[4] is d/dt h in component I_Na (dimensionless). * RATES[5] is d/dt d in component I_CaL (dimensionless). * RATES[6] is d/dt f1 in component I_CaL (dimensionless). * RATES[7] is d/dt f2 in component I_CaL (dimensionless). * RATES[8] is d/dt b in component I_CaT (dimensionless). * RATES[9] is d/dt g in component I_CaT (dimensionless). * RATES[10] is d/dt q in component I_K1 (dimensionless). * RATES[11] is d/dt r1 in component I_K1 (dimensionless). * RATES[12] is d/dt r2 in component I_K1 (dimensionless). * RATES[13] is d/dt p in component I_K2 (dimensionless). * RATES[14] is d/dt k1 in component I_K2 (dimensionless). * RATES[15] is d/dt k2 in component I_K2 (dimensionless). * RATES[16] is d/dt s in component I_Ka (dimensionless). * RATES[17] is d/dt x in component I_Ka (dimensionless). * RATES[18] is d/dt xa in component I_BKa (dimensionless). * RATES[19] is d/dt xab in component I_BKab (dimensionless). * RATES[20] is d/dt y in component I_h (dimensionless). * RATES[21] is d/dt c in component I_Cl (dimensionless). * There are a total of 2 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0; CONSTANTS[1] = -0.5; CONSTANTS[2] = 1000; CONSTANTS[3] = 3000; STATES[0] = -53.90915441282156; STATES[1] = 0.0001161881607214449; CONSTANTS[4] = 1000; CONSTANTS[5] = 1e-6; STATES[2] = 0.2345238135343783; STATES[3] = 0.1253518889572223; STATES[4] = 0.404599170710196; STATES[5] = 0.01036961357784695; STATES[6] = 0.9065941499695301; STATES[7] = 0.9065967263076083; STATES[8] = 0.508117603077852; STATES[9] = 0.03582573962705717; STATES[10] = 0.2060363247740295; STATES[11] = 0.1922244113609531; STATES[12] = 0.1932803618375963; STATES[13] = 0.1174074734567931; STATES[14] = 0.9968385770271651; STATES[15] = 0.9968408069904307; STATES[16] = 0.0307583106982354; STATES[17] = 0.08785242843398365; CONSTANTS[6] = 1000.0; STATES[18] = 0.0003569126518797985; CONSTANTS[7] = 1000.0; STATES[19] = 0.002220456569762898; STATES[20] = 0.002604864867063448; STATES[21] = 0.0003764413740731269; CONSTANTS[8] = 1e-8; CONSTANTS[9] = -1; CONSTANTS[10] = -1; CONSTANTS[11] = 140.000; CONSTANTS[12] = 2.50000; CONSTANTS[13] = 0.500000; CONSTANTS[14] = 1.00000; CONSTANTS[15] = 1.00000; CONSTANTS[16] = 0.00000; CONSTANTS[17] = 0.600000; CONSTANTS[18] = 45.0000; CONSTANTS[19] = 0.00100000; CONSTANTS[20] = 0.0580000; CONSTANTS[21] = 42.0000; CONSTANTS[22] = 0.800000; CONSTANTS[23] = 0.00400000; CONSTANTS[24] = 0.520000; CONSTANTS[25] = 0.0320000; CONSTANTS[26] = 0.200000; CONSTANTS[27] = 0.100000; CONSTANTS[28] = 0.160000; CONSTANTS[29] = 0.187500; CONSTANTS[30] = 0.0542000; CONSTANTS[31] = 0.0123000; CONSTANTS[32] = 1.30000; CONSTANTS[33] = 0.900000; CONSTANTS[34] = 0.890000; CONSTANTS[35] = 1.00000; CONSTANTS[36] = 0.500000; CONSTANTS[37] = 1.00000; CONSTANTS[38] = 1.19000; CONSTANTS[39] = 1.60000; CONSTANTS[40] = 3.50000e-07; CONSTANTS[41] = 0.000500000; CONSTANTS[42] = 2.00000; CONSTANTS[43] = 0.000300000; CONSTANTS[44] = 4.00000; CONSTANTS[45] = 30.0000; CONSTANTS[46] = 0.00700000; CONSTANTS[47] = 87.5000; CONSTANTS[48] = 1.30000; CONSTANTS[49] = 3.00000; CONSTANTS[50] = 161.301; CONSTANTS[51] = 3.60205; CONSTANTS[52] = 12.0000; CONSTANTS[53] = 4.00000; CONSTANTS[54] = 0.108043+0.903902/(1.00000+pow(CONSTANTS[13]/0.281007, 1.29834)); CONSTANTS[55] = ( (1.00000/0.000525000)*0.0300000)/(1.00000+pow(150.000/(CONSTANTS[12]+CONSTANTS[8]), 2.00000)); CONSTANTS[56] = 46.0000; CONSTANTS[57] = 6.00000; CONSTANTS[58] = 130.000; CONSTANTS[59] = ( (1.00000/0.0123000)*0.0300000)/(1.00000+pow(150.000/(CONSTANTS[57]+CONSTANTS[8]), 2.00000)); CONSTANTS[60] = 130.000; CONSTANTS[61] = ( (1.00000/0.0123000)*0.0300000)/(1.00000+pow(150.000/(CONSTANTS[58]+CONSTANTS[8]), 2.00000)); CONSTANTS[62] = 0.0150000; CONSTANTS[63] = 4.00000; CONSTANTS[64] = 2.00000; CONSTANTS[65] = 8314.00; CONSTANTS[66] = 96485.0; CONSTANTS[67] = 1.00000; CONSTANTS[68] = 308.000; CONSTANTS[69] = 1.70000; CONSTANTS[70] = 1.00000; CONSTANTS[71] = (( CONSTANTS[65]*CONSTANTS[68])/CONSTANTS[66])*log(CONSTANTS[58]/CONSTANTS[53]); CONSTANTS[72] = (( CONSTANTS[65]*CONSTANTS[68])/CONSTANTS[66])*log(CONSTANTS[57]/CONSTANTS[11]); CONSTANTS[73] = (( CONSTANTS[65]*CONSTANTS[68])/CONSTANTS[66])*log(CONSTANTS[56]/CONSTANTS[60]); CONSTANTS[74] = 2.00000; CONSTANTS[75] = 0.350000; CONSTANTS[76] = 22.0000; CONSTANTS[77] = (( CONSTANTS[65]*CONSTANTS[68])/CONSTANTS[66])*log((CONSTANTS[57]+ (CONSTANTS[75]/CONSTANTS[70])*CONSTANTS[58])/(CONSTANTS[11]+ (CONSTANTS[75]/CONSTANTS[70])*CONSTANTS[53])); CONSTANTS[78] = 3.50000e-06; CONSTANTS[79] = 0.270000; CONSTANTS[80] = 0.350000; CONSTANTS[81] = 1.00000/(1.00000+pow(CONSTANTS[74]/CONSTANTS[57], 1.50000)); CONSTANTS[82] = 1.00000/(1.00000+pow(CONSTANTS[76]/CONSTANTS[53], 2.00000)); RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; RATES[10] = 0.1001; RATES[11] = 0.1001; RATES[12] = 0.1001; RATES[13] = 0.1001; RATES[14] = 0.1001; RATES[15] = 0.1001; RATES[16] = 0.1001; RATES[17] = 0.1001; RATES[18] = 0.1001; RATES[19] = 0.1001; RATES[20] = 0.1001; RATES[21] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - (ALGEBRAIC[81]+ALGEBRAIC[0]); resid[1] = RATES[1] - - ALGEBRAIC[79]; resid[2] = RATES[2] - (ALGEBRAIC[3] - STATES[2])/ALGEBRAIC[4]; resid[3] = RATES[3] - (ALGEBRAIC[6] - STATES[3])/ALGEBRAIC[8]; resid[4] = RATES[4] - (ALGEBRAIC[7] - STATES[4])/ALGEBRAIC[9]; resid[5] = RATES[5] - (ALGEBRAIC[12] - STATES[5])/ALGEBRAIC[14]; resid[6] = RATES[6] - (ALGEBRAIC[13] - STATES[6])/CONSTANTS[52]; resid[7] = RATES[7] - (ALGEBRAIC[13] - STATES[7])/ALGEBRAIC[15]; resid[8] = RATES[8] - (ALGEBRAIC[17] - STATES[8])/ALGEBRAIC[19]; resid[9] = RATES[9] - (ALGEBRAIC[18] - STATES[9])/ALGEBRAIC[20]; resid[10] = RATES[10] - (ALGEBRAIC[23] - STATES[10])/ALGEBRAIC[25]; resid[11] = RATES[11] - (ALGEBRAIC[24] - STATES[11])/ALGEBRAIC[26]; resid[12] = RATES[12] - (ALGEBRAIC[24] - STATES[12])/ALGEBRAIC[27]; resid[13] = RATES[13] - (ALGEBRAIC[29] - STATES[13])/ALGEBRAIC[31]; resid[14] = RATES[14] - (ALGEBRAIC[30] - STATES[14])/ALGEBRAIC[32]; resid[15] = RATES[15] - (ALGEBRAIC[30] - STATES[15])/ALGEBRAIC[33]; resid[16] = RATES[16] - (ALGEBRAIC[35] - STATES[16])/ALGEBRAIC[37]; resid[17] = RATES[17] - (ALGEBRAIC[36] - STATES[17])/ALGEBRAIC[38]; resid[18] = RATES[18] - (ALGEBRAIC[42] - STATES[18])/ALGEBRAIC[43]; resid[19] = RATES[19] - (ALGEBRAIC[47] - STATES[19])/ALGEBRAIC[48]; resid[20] = RATES[20] - (ALGEBRAIC[50] - STATES[20])/ALGEBRAIC[53]; resid[21] = RATES[21] - (ALGEBRAIC[57] - STATES[21])/ALGEBRAIC[58]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = CONSTANTS[49]*(STATES[2] - 0.234500); ALGEBRAIC[76] = ALGEBRAIC[75]*CONSTANTS[4]; ALGEBRAIC[77] = ALGEBRAIC[73]*CONSTANTS[4]; ALGEBRAIC[78] = ALGEBRAIC[72]*CONSTANTS[4]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>0.00000&&CONDVAR[1]<0.00000 ? CONSTANTS[1] : CONSTANTS[0]); ALGEBRAIC[3] = 1.00000/(1.00000+pow(( CONSTANTS[50]*CONSTANTS[5])/STATES[1], CONSTANTS[51])); ALGEBRAIC[4] = 4000.00*(0.234845+(1.00000 - 0.234845)/(1.00000+pow(STATES[1]/( CONSTANTS[50]*CONSTANTS[5]), CONSTANTS[51]))); ALGEBRAIC[6] = 1.00000/(1.00000+exp(- (STATES[0]+35.9584)/9.24013)); ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0]+57.0000)/8.00000)); ALGEBRAIC[8] = 0.250000+7.00000/(1.00000+exp((STATES[0]+38.0000)/10.0000)); ALGEBRAIC[9] = 0.900000+1002.85/(1.00000+pow((STATES[0]+47.5000)/1.50000, 2.00000)); ALGEBRAIC[12] = 1.00000/(1.00000+exp(- (STATES[0]+22.0000)/7.00000)); ALGEBRAIC[13] = 1.00000/(1.00000+exp((STATES[0]+38.0000)/7.00000)); ALGEBRAIC[14] = 2.29000+5.70000/(1.00000+pow((STATES[0]+29.9700)/9.00000, 2.00000)); ALGEBRAIC[15] = 90.9699*(1.00000 - 1.00000/( (1.00000+exp((STATES[0]+13.9629)/45.3782))*(1.00000+exp(- (STATES[0]+9.49866)/3.39450)))); ALGEBRAIC[17] = 1.00000/(1.00000+exp(- (STATES[0]+54.2300)/9.88000)); ALGEBRAIC[18] = 0.0200000+0.980000/(1.00000+exp((STATES[0]+72.9780)/4.64000)); ALGEBRAIC[19] = 0.450000+3.90000/(1.00000+pow((STATES[0]+66.0000)/26.0000, 2.00000)); ALGEBRAIC[20] = 150.000*(1.00000 - 1.00000/( (1.00000+exp((STATES[0] - 417.430)/203.180))*(1.00000+exp(- (STATES[0]+61.1100)/8.07000)))); ALGEBRAIC[23] = 0.978613/(1.00000+exp(- (STATES[0]+18.6736)/26.6606)); ALGEBRAIC[24] = 1.00000/(1.00000+exp((STATES[0]+63.0000)/6.30000)); ALGEBRAIC[25] = 500.000/(1.00000+pow((STATES[0]+60.7100)/15.7900, 2.00000)); ALGEBRAIC[26] = 5000.00/(1.00000+pow((STATES[0]+62.7133)/35.8611, 2.00000)); ALGEBRAIC[27] = 30000.0+220000./(1.00000+exp((STATES[0]+22.0000)/4.00000)); ALGEBRAIC[29] = 0.948000/(1.00000+exp(- (STATES[0]+17.9100)/18.4000)); ALGEBRAIC[30] = 1.00000/(1.00000+exp((STATES[0]+21.2000)/5.70000)); ALGEBRAIC[31] = 100.000/(1.00000+pow((STATES[0]+64.1000)/28.6700, 2.00000)); ALGEBRAIC[32] = 1.00000e+06*(1.00000 - 1.00000/( (1.00000+exp((STATES[0] - 315.000)/50.0000))*(1.00000+exp(- (STATES[0]+74.9000)/8.00000)))); ALGEBRAIC[33] = 2.50000e+06*(1.00000 - 1.00000/( (1.00000+exp((STATES[0] - 132.868)/25.3992))*(1.00000+exp(- (STATES[0]+24.9203)/2.67915)))); ALGEBRAIC[35] = 1.00000/(1.00000+exp(- (STATES[0]+27.7900)/7.57000)); ALGEBRAIC[36] = 0.0200000+0.980000/(1.00000+exp((STATES[0]+69.5000)/6.00000)); ALGEBRAIC[37] = 17.0000/(1.00000+pow((STATES[0]+20.5232)/35.0000, 2.00000)); ALGEBRAIC[38] = 7.50000+10.0000/(1.00000+pow((STATES[0]+34.1765)/120.000, 2.00000)); ALGEBRAIC[40] = - 0.749234/(1.00000+pow(( STATES[1]*CONSTANTS[6] - 0.0630535)/0.161942, 2.00000))+8.38384/(1.00000+pow(( STATES[1]*CONSTANTS[6]+1538.29)/739.057, 2.00000)); ALGEBRAIC[41] = 5011.47/(1.00000+pow(( STATES[1]*CONSTANTS[6]+0.237503)/0.000239278, 0.422910)) - 37.5137; ALGEBRAIC[42] = 1.00000/(1.00000+exp(( - ALGEBRAIC[40]*CONSTANTS[66]*(STATES[0] - ALGEBRAIC[41]))/( CONSTANTS[65]*CONSTANTS[68]))); ALGEBRAIC[43] = 2.40914/(1.00000+pow((STATES[0] - 158.779)/- 52.1497, 2.00000)); ALGEBRAIC[45] = - 0.681249/(1.00000+pow(( STATES[1]*CONSTANTS[7] - 0.218988)/0.428335, 2.00000))+1.40001/(1.00000+pow(( STATES[1]*CONSTANTS[7]+228.710)/684.946, 2.00000)); ALGEBRAIC[46] = 8540.23/(1.00000+pow(( STATES[1]*CONSTANTS[7]+0.401189)/0.00399115, 0.668054)) - 109.275; ALGEBRAIC[47] = 1.00000/(1.00000+exp(( - ALGEBRAIC[45]*CONSTANTS[66]*(STATES[0] - ALGEBRAIC[46]))/( CONSTANTS[65]*CONSTANTS[68]))); ALGEBRAIC[48] = 13.8049/(1.00000+pow((STATES[0] - 153.019)/66.4952, 2.00000)); ALGEBRAIC[50] = 1.00000/(1.00000+exp((STATES[0]+105.390)/8.65530)); ALGEBRAIC[51] = 3.50000e-06*exp( - 0.0497000*STATES[0]); ALGEBRAIC[52] = 0.0400300*exp( 0.0521100*STATES[0]); ALGEBRAIC[53] = 1.00000/(ALGEBRAIC[51]+ALGEBRAIC[52]); ALGEBRAIC[1] = ( STATES[0]*CONSTANTS[66])/( CONSTANTS[65]*CONSTANTS[68]); ALGEBRAIC[55] = 0.000600000*exp( 2.53000*ALGEBRAIC[1]); ALGEBRAIC[56] = 0.100000*exp( - 5.00000*ALGEBRAIC[1]); ALGEBRAIC[57] = 1.00000/(1.00000+ ALGEBRAIC[56]*(pow(ALGEBRAIC[55]/STATES[1], 2.00000)+ALGEBRAIC[55]/STATES[1]+1.00000)); ALGEBRAIC[58] = - 160.000+210.000/(1.00000+exp((STATES[0]+4.56000)/11.6200))+170.000/(1.00000+exp(- (STATES[0]+25.5000)/11.6200)); ALGEBRAIC[11] = 1.00000/(1.00000+pow(STATES[1]/CONSTANTS[19], 4.00000)); ALGEBRAIC[16] = CONSTANTS[17]*ALGEBRAIC[11]*STATES[5]*STATES[5]*( 0.800000*STATES[6]+ 0.200000*STATES[7])*(STATES[0] - CONSTANTS[18]); ALGEBRAIC[21] = CONSTANTS[20]*STATES[8]*STATES[8]*STATES[9]*(STATES[0] - CONSTANTS[21]); ALGEBRAIC[2] = (( CONSTANTS[65]*CONSTANTS[68])/CONSTANTS[66])*log(( CONSTANTS[32]*CONSTANTS[57]+ CONSTANTS[33]*CONSTANTS[58]+( 4.00000*CONSTANTS[34]*CONSTANTS[12])/(1.00000+exp(ALGEBRAIC[1])))/( CONSTANTS[32]*CONSTANTS[11]+ CONSTANTS[33]*CONSTANTS[53]+( 4.00000*CONSTANTS[34]*STATES[1])/(1.00000+exp(ALGEBRAIC[1])))); ALGEBRAIC[60] = CONSTANTS[54]*CONSTANTS[55]*CONSTANTS[36]*CONSTANTS[31]*(STATES[0] - ALGEBRAIC[2]); ALGEBRAIC[74] = ALGEBRAIC[16]+ALGEBRAIC[21]+ALGEBRAIC[60]; ALGEBRAIC[75] = (( CONSTANTS[63]*CONSTANTS[67]*CONSTANTS[62])/( CONSTANTS[64]*CONSTANTS[66]))*ALGEBRAIC[74]; ALGEBRAIC[67] = 1.00000/(1.00000+pow(CONSTANTS[43]/STATES[1], CONSTANTS[44])); ALGEBRAIC[65] = exp( (CONSTANTS[80] - 1.00000)*ALGEBRAIC[1]); ALGEBRAIC[66] = exp( CONSTANTS[80]*ALGEBRAIC[1]); ALGEBRAIC[68] = pow(CONSTANTS[53], 3.00000)*CONSTANTS[12]*ALGEBRAIC[66] - pow(CONSTANTS[58], 3.00000)*STATES[1]*ALGEBRAIC[65]; ALGEBRAIC[69] = 1.00000+ CONSTANTS[79]*ALGEBRAIC[65]; ALGEBRAIC[70] = CONSTANTS[48]*pow(CONSTANTS[53], 3.00000)+ pow(CONSTANTS[47], 3.00000)*STATES[1]+ pow(CONSTANTS[45], 3.00000)*CONSTANTS[12]*(1.00000+STATES[1]/CONSTANTS[46]); ALGEBRAIC[71] = CONSTANTS[12]*pow(CONSTANTS[53], 3.00000)+ pow(CONSTANTS[58], 3.00000)*STATES[1]+ pow(CONSTANTS[58], 3.00000)*CONSTANTS[46]*(1.00000+pow(CONSTANTS[53]/CONSTANTS[45], 3.00000)); ALGEBRAIC[72] = ( CONSTANTS[10]*CONSTANTS[78]*ALGEBRAIC[67]*ALGEBRAIC[68])/( ALGEBRAIC[69]*(ALGEBRAIC[70]+ALGEBRAIC[71])); ALGEBRAIC[73] = CONSTANTS[40]/(1.00000+pow(CONSTANTS[41]/STATES[1], CONSTANTS[42])); ALGEBRAIC[79] = ALGEBRAIC[75]+ALGEBRAIC[72]+ALGEBRAIC[73]; ALGEBRAIC[10] = CONSTANTS[16]*STATES[3]*STATES[3]*STATES[3]*STATES[4]*(STATES[0] - CONSTANTS[71]); ALGEBRAIC[22] = CONSTANTS[23]*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[28] = CONSTANTS[24]*STATES[10]*STATES[10]*( 0.380000*STATES[11]+ 0.630000*STATES[12])*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[34] = CONSTANTS[25]*STATES[13]*STATES[13]*( 0.750000*STATES[14]+ 0.250000*STATES[15])*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[39] = CONSTANTS[28]*STATES[16]*STATES[17]*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[44] = CONSTANTS[22]*CONSTANTS[26]*STATES[18]*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[49] = CONSTANTS[22]*CONSTANTS[27]*STATES[19]*(STATES[0] - CONSTANTS[72]); ALGEBRAIC[54] = CONSTANTS[30]*STATES[20]*(STATES[0] - CONSTANTS[77]); ALGEBRAIC[59] = CONSTANTS[29]*STATES[21]*(STATES[0] - CONSTANTS[73]); ALGEBRAIC[61] = CONSTANTS[54]*CONSTANTS[61]*CONSTANTS[37]*CONSTANTS[31]*(STATES[0] - ALGEBRAIC[2]); ALGEBRAIC[62] = CONSTANTS[54]*CONSTANTS[59]*CONSTANTS[38]*CONSTANTS[31]*(STATES[0] - ALGEBRAIC[2]); ALGEBRAIC[63] = 1.00000/(1.00000+ 0.124500*exp( - 0.100000*ALGEBRAIC[1])+ 0.00219000*exp(CONSTANTS[58]/49.7100)*exp( - 1.90000*ALGEBRAIC[1])); ALGEBRAIC[64] = CONSTANTS[69]*CONSTANTS[81]*CONSTANTS[82]*ALGEBRAIC[63]; ALGEBRAIC[80] = (( 0.500000*CONSTANTS[64]*CONSTANTS[66])/( CONSTANTS[63]*CONSTANTS[67]*CONSTANTS[62]))*CONSTANTS[9]*ALGEBRAIC[72]; ALGEBRAIC[81] = ALGEBRAIC[10]+ALGEBRAIC[54]+ALGEBRAIC[80]+ALGEBRAIC[64]+ALGEBRAIC[16]+ALGEBRAIC[21]+ALGEBRAIC[59]+ALGEBRAIC[28]+ALGEBRAIC[34]+ALGEBRAIC[39]+ALGEBRAIC[44]+ALGEBRAIC[49]+ALGEBRAIC[61]+ALGEBRAIC[62]+ALGEBRAIC[60]+ALGEBRAIC[22]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[11] = 1.0; SI[12] = 1.0; SI[13] = 1.0; SI[14] = 1.0; SI[15] = 1.0; SI[16] = 1.0; SI[17] = 1.0; SI[18] = 1.0; SI[19] = 1.0; SI[20] = 1.0; SI[21] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[2]; CONDVAR[1] = VOI - CONSTANTS[3]; }