C C There are a total of 37 entries in the algebraic variable array. C There are a total of 20 entries in each of the rate and state variable arrays. C There are a total of 144 entries in the constant variable array. C C C VOI is time in component environment (hour). C ALGBRC(5) is V_K in component membrane (nanoM). C ALGBRC(37) is fr in component membrane (hertz). C ALGBRC(1) is v_sPC in component membrane (flux). C ALGBRC(25) is Res in component membrane (gigaohm). C ALGBRC(19) is V_rest in component membrane (milliV). C ALGBRC(24) is V_reset in component membrane (milliV). C CONSTS(1) is V_theta in component membrane (milliV). C CONSTS(2) is Cm in component membrane (nanoF). C CONSTS(3) is R in component membrane (joule_per_mole_kelvin). C CONSTS(4) is T in component membrane (kelvin). C CONSTS(5) is T_abs in component membrane (kelvin). C CONSTS(6) is T_room in component membrane (kelvin). C CONSTS(7) is F in component membrane (coulomb_per_mole). C ALGBRC(6) is alpha in component membrane (dimensionless). C ALGBRC(2) is beta in component membrane (dimensionless). C ALGBRC(16) is beta_a in component membrane (dimensionless). C ALGBRC(17) is c in component membrane (dimensionless). C CONSTS(8) is P_Ca in component membrane (per_milliM). C ALGBRC(3) is P_K in component membrane (per_milliM). C CONSTS(9) is P_Na in component membrane (per_milliM). C CONSTS(10) is P_Cl in component membrane (per_milliM). C CONSTS(11) is v_PK in component membrane (per_milliM). C CONSTS(12) is npk in component membrane (dimensionless). C CONSTS(13) is K_PK in component membrane (per_nanoM2). C CONSTS(14) is V_R in component membrane (gigaohm). C CONSTS(15) is K_R in component membrane (milliV). C CONSTS(16) is Ca_ex in component membrane (microM). C CONSTS(17) is Na_ex in component membrane (milliM). C CONSTS(18) is K_ex in component membrane (milliM). C CONSTS(19) is Cl_ex in component membrane (milliM). C CONSTS(143) is Na_in in component membrane (milliM). C CONSTS(140) is K_in in component membrane (milliM). C CONSTS(142) is theta_Na in component membrane (dimensionless). C CONSTS(139) is theta_K in component membrane (dimensionless). C CONSTS(20) is E_Na_0 in component membrane (milliV). C CONSTS(141) is E_Na in component membrane (milliV). C CONSTS(21) is g_Na in component membrane (nanoS). C ALGBRC(8) is E_Ca in component membrane (milliV). C ALGBRC(12) is g_Ca in component membrane (nanoS). C ALGBRC(10) is g_K in component membrane (nanoS). C CONSTS(22) is g_K0 in component membrane (nanoS). C CONSTS(23) is v_gk in component membrane (nanoS). C CONSTS(24) is K_gk in component membrane (nanoM). C ALGBRC(13) is g_KCa in component membrane (nanoS). C CONSTS(25) is v_KCa in component membrane (nanoS). C CONSTS(26) is K_KCa in component membrane (per_nanoM). C CONSTS(27) is nkca in component membrane (dimensionless). C ALGBRC(30) is g_L in component membrane (nanoS). C CONSTS(28) is E_L_0 in component membrane (milliV). C CONSTS(144) is E_L in component membrane (milliV). C CONSTS(29) is E_K_0 in component membrane (milliV). C CONSTS(137) is E_K in component membrane (milliV). C ALGBRC(31) is g_ex in component membrane (nanoS). C CONSTS(30) is E_ex in component membrane (milliV). C CONSTS(31) is v_ex1 in component membrane (nanoS). C CONSTS(32) is v_ex2 in component membrane (nanoS). C CONSTS(33) is K_ex1 in component membrane (picoA_2_5). C CONSTS(34) is K_ex2 in component membrane (per_microM). C CONSTS(35) is nex1 in component membrane (dimensionless). C CONSTS(36) is nex2 in component membrane (dimensionless). C CONSTS(37) is g_inhib in component membrane (nanoS). C ALGBRC(26) is E_inhib in component membrane (milliV). C ALGBRC(14) is GABA in component membrane (nanoM). C CONSTS(38) is GABA0 in component membrane (nanoM). C CONSTS(39) is v_GABA in component membrane (nanoM). C CONSTS(40) is K_GABA in component membrane (nanoM). C ALGBRC(15) is Cl_in in component membrane (milliM). C CONSTS(41) is Cl0 in component membrane (milliM). C CONSTS(42) is v_Cl1 in component membrane (milliM). C CONSTS(43) is v_Cl2 in component membrane (milliM). C CONSTS(44) is K_Cl1 in component membrane (nanoM). C CONSTS(45) is K_Cl2 in component membrane (per_nanoM_0_2). C CONSTS(46) is nCl in component membrane (dimensionless). C ALGBRC(27) is i_Na in component membrane (picoA). C ALGBRC(29) is i_Na_abs in component membrane (picoA). C ALGBRC(21) is i_Ca in component membrane (picoA). C ALGBRC(22) is i_K in component membrane (picoA). C ALGBRC(23) is i_KCa in component membrane (picoA). C ALGBRC(32) is i_L in component membrane (picoA). C ALGBRC(33) is i_ex in component membrane (picoA). C ALGBRC(28) is i_inhib in component membrane (picoA). C ALGBRC(34) is I_star in component membrane (picoA). C ALGBRC(35) is R_star in component membrane (milliohm). C ALGBRC(36) is tau_m in component membrane (second). C ALGBRC(20) is theta in component membrane (milliV). C ALGBRC(18) is psi in component membrane (dimensionless). C CONSTS(47) is k_q in component membrane (per_kelvin). C CONSTS(48) is k_MK in component membrane (nanoM). C CONSTS(49) is V_MK in component membrane (nanoM). C CONSTS(50) is V_b in component membrane (nanoM). C CONSTS(51) is k_b in component membrane (dimensionless). C CONSTS(52) is K_D in component membrane (nanoM). C CONSTS(53) is v_sP0 in component membrane (flux). C CONSTS(54) is C_T in component membrane (flux). C CONSTS(55) is nca in component membrane (dimensionless). C CONSTS(56) is v_Ca in component membrane (nanoS). C CONSTS(57) is K_Ca in component membrane (nanoM_2_2). C CONSTS(58) is K_C in component membrane (nanoM). C STATES(1) is Ca_in in component Ca_in (microM). C STATES(2) is BC in component BC (nanoM). C STATES(3) is MP in component MP (nanoM). C STATES(4) is VIP in component VIP (nanoM). C STATES(5) is CC in component CC (nanoM). C STATES(6) is CB in component CB (nanoM). C CONSTS(59) is beta_IP3 in component Ca_in (dimensionless). C STATES(7) is Ca_store in component Ca_in (nanoM). C ALGBRC(7) is v0 in component Ca_in (microM_per_hour). C CONSTS(138) is v1 in component Ca_in (microM_per_hour). C ALGBRC(9) is v2 in component Ca_in (microM_per_hour). C ALGBRC(11) is v3 in component Ca_in (microM_per_hour). C CONSTS(60) is v_kk in component Ca_in (per_microM_per_hour). C CONSTS(61) is v_v0 in component Ca_in (microM_per_hour). C CONSTS(62) is kf in component Ca_in (per_hour). C ALGBRC(4) is k in component Ca_in (per_microM_per_hour). C CONSTS(63) is nkk in component Ca_in (dimensionless). C CONSTS(64) is nv0 in component Ca_in (dimensionless). C CONSTS(65) is m in component Ca_in (dimensionless). C CONSTS(66) is n in component Ca_in (dimensionless). C CONSTS(67) is p in component Ca_in (dimensionless). C CONSTS(68) is v in component Ca_in (dimensionless). C CONSTS(69) is K_kk in component Ca_in (nanoM_0_1). C CONSTS(70) is K_v0 in component Ca_in (nanoM_4_5). C CONSTS(71) is K_2 in component Ca_in (microM). C CONSTS(72) is K_R in component Ca_in (microM). C CONSTS(73) is K_A in component Ca_in (microM). C CONSTS(74) is v_M1 in component Ca_in (microM_per_hour). C CONSTS(75) is v_M2 in component Ca_in (microM_per_hour). C CONSTS(76) is v_M3 in component Ca_in (microM_per_hour). C CONSTS(77) is v_VIP in component VIP (flux). C CONSTS(78) is K_VIP in component VIP (hertz_1_9). C CONSTS(79) is kd_VIP in component VIP (nanoM_0_8_per_hour). C CONSTS(80) is nd_VIP in component VIP (dimensionless). C CONSTS(81) is n_VIP in component VIP (dimensionless). C CONSTS(82) is vmP in component MP (flux). C CONSTS(83) is kdmp in component MP (first_order_rate_constant). C CONSTS(84) is KAP in component MP (nanoM). C CONSTS(85) is KmP in component MP (nanoM). C CONSTS(86) is n in component model_parameters (dimensionless). C STATES(8) is BN in component BN (nanoM). C STATES(9) is MC in component MC (nanoM). C CONSTS(87) is vsC in component MC (flux). C CONSTS(88) is vmC in component MC (flux). C CONSTS(89) is kdmc in component MC (first_order_rate_constant). C CONSTS(90) is KAC in component MC (nanoM). C CONSTS(91) is KmC in component MC (nanoM). C STATES(10) is MB in component MB (nanoM). C CONSTS(92) is vsB in component MB (flux). C CONSTS(93) is vmB in component MB (flux). C CONSTS(94) is kdmb in component MB (first_order_rate_constant). C CONSTS(95) is KIB in component MB (nanoM). C CONSTS(96) is KmB in component MB (nanoM). C CONSTS(97) is m in component model_parameters (dimensionless). C STATES(11) is PC in component PC (nanoM). C CONSTS(98) is ksP in component model_parameters (first_order_rate_constant). C CONSTS(99) is Kp in component model_parameters (nanoM). C CONSTS(100) is Kdp in component model_parameters (nanoM). C CONSTS(101) is k3 in component model_parameters (second_order_rate_constant). C CONSTS(102) is k4 in component model_parameters (first_order_rate_constant). C CONSTS(103) is kdn in component model_parameters (first_order_rate_constant). C CONSTS(104) is V1P in component model_parameters (flux). C CONSTS(105) is V2P in component model_parameters (flux). C STATES(12) is PCP in component PCP (nanoM). C STATES(13) is PCC in component PCC (nanoM). C CONSTS(106) is ksC in component model_parameters (first_order_rate_constant). C CONSTS(107) is kdnc in component model_parameters (first_order_rate_constant). C CONSTS(108) is V1C in component model_parameters (flux). C CONSTS(109) is V2C in component model_parameters (flux). C STATES(14) is CCP in component CCP (nanoM). C CONSTS(110) is vdPC in component model_parameters (flux). C CONSTS(111) is Kd in component model_parameters (nanoM). C CONSTS(112) is vdCC in component model_parameters (flux). C CONSTS(113) is k1 in component model_parameters (first_order_rate_constant). C CONSTS(114) is k2 in component model_parameters (first_order_rate_constant). C CONSTS(115) is V1PC in component model_parameters (flux). C CONSTS(116) is V2PC in component model_parameters (flux). C STATES(15) is PCCP in component PCCP (nanoM). C STATES(16) is PCN in component PCN (nanoM). C CONSTS(117) is k7 in component model_parameters (second_order_rate_constant). C CONSTS(118) is k8 in component model_parameters (first_order_rate_constant). C CONSTS(119) is V3PC in component model_parameters (flux). C CONSTS(120) is V4PC in component model_parameters (flux). C STATES(17) is PCNP in component PCNP (nanoM). C STATES(18) is IN in component IN (nanoM). C CONSTS(121) is vdPCC in component model_parameters (flux). C CONSTS(122) is vdPCN in component model_parameters (flux). C CONSTS(123) is ksB in component model_parameters (first_order_rate_constant). C CONSTS(124) is k5 in component model_parameters (first_order_rate_constant). C CONSTS(125) is k6 in component model_parameters (first_order_rate_constant). C CONSTS(126) is V1B in component model_parameters (flux). C CONSTS(127) is V2B in component model_parameters (flux). C STATES(19) is BCP in component BCP (nanoM). C CONSTS(128) is vdBC in component model_parameters (flux). C CONSTS(129) is V3B in component model_parameters (flux). C CONSTS(130) is V4B in component model_parameters (flux). C STATES(20) is BNP in component BNP (nanoM). C CONSTS(131) is vdBN in component model_parameters (flux). C CONSTS(132) is vdIN in component model_parameters (flux). C CONSTS(133) is K1CB in component CB (nanoM). C CONSTS(134) is K2CB in component CB (nanoM). C CONSTS(135) is WT in component CB (hour). C CONSTS(136) is vP in component CB (nanoM). C RATES(1) is d/dt Ca_in in component Ca_in (microM). C RATES(7) is d/dt Ca_store in component Ca_in (nanoM). C RATES(4) is d/dt VIP in component VIP (nanoM). C RATES(3) is d/dt MP in component MP (nanoM). C RATES(9) is d/dt MC in component MC (nanoM). C RATES(10) is d/dt MB in component MB (nanoM). C RATES(11) is d/dt PC in component PC (nanoM). C RATES(5) is d/dt CC in component CC (nanoM). C RATES(12) is d/dt PCP in component PCP (nanoM). C RATES(14) is d/dt CCP in component CCP (nanoM). C RATES(13) is d/dt PCC in component PCC (nanoM). C RATES(16) is d/dt PCN in component PCN (nanoM). C RATES(15) is d/dt PCCP in component PCCP (nanoM). C RATES(17) is d/dt PCNP in component PCNP (nanoM). C RATES(2) is d/dt BC in component BC (nanoM). C RATES(19) is d/dt BCP in component BCP (nanoM). C RATES(8) is d/dt BN in component BN (nanoM). C RATES(20) is d/dt BNP in component BNP (nanoM). C RATES(18) is d/dt IN in component IN (nanoM). C RATES(6) is d/dt CB in component CB (nanoM). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 20.0 CONSTS(2) = 5.0 CONSTS(3) = 8.314 CONSTS(4) = 37 CONSTS(5) = 273.15 CONSTS(6) = 22 CONSTS(7) = 96485 CONSTS(8) = 0.05 CONSTS(9) = 0.036 CONSTS(10) = 0.3 CONSTS(11) = 1.9 CONSTS(12) = -2.0 CONSTS(13) = 1.0 CONSTS(14) = 0.41 CONSTS(15) = 34.0 CONSTS(16) = 5.0 CONSTS(17) = 145.0 CONSTS(18) = 1.0 CONSTS(19) = 114.5 CONSTS(20) = 45.0 CONSTS(21) = 36.0 CONSTS(22) = 9.7 CONSTS(23) = 10.0 CONSTS(24) = 10.0 CONSTS(25) = 3.0 CONSTS(26) = 0.16 CONSTS(27) = -1.0 CONSTS(28) = -29.0 CONSTS(29) = -97.0 CONSTS(30) = 0.0 CONSTS(31) = 105.0 CONSTS(32) = 4.4 CONSTS(33) = 574050000.0 CONSTS(34) = 1.0 CONSTS(35) = 2.5 CONSTS(36) = -1.0 CONSTS(37) = 12.3 CONSTS(38) = 0.2 CONSTS(39) = 19.0 CONSTS(40) = 3.0 CONSTS(41) = 1.0 CONSTS(42) = 15.5 CONSTS(43) = 19.0 CONSTS(44) = 4.0 CONSTS(45) = 1.0 CONSTS(46) = -0.2 CONSTS(47) = 8.75e-5 CONSTS(48) = 2.9 CONSTS(49) = 5.0 CONSTS(50) = 2.0 CONSTS(51) = 2.0 CONSTS(52) = 0.08 CONSTS(53) = 1.0 CONSTS(54) = 1.6 CONSTS(55) = 2.2 CONSTS(56) = 12.3 CONSTS(57) = 22.0 CONSTS(58) = 0.15 STATES(1) = 0.1 STATES(2) = 2.41 STATES(3) = 2.8 STATES(4) = 0.0 STATES(5) = 12.0 STATES(6) = 0.12 CONSTS(59) = 0.5 STATES(7) = 0.1 CONSTS(60) = 3.3 CONSTS(61) = 0.09 CONSTS(62) = 0.001 CONSTS(63) = 0.1 CONSTS(64) = 4.5 CONSTS(65) = 6.0 CONSTS(66) = 2.2 CONSTS(67) = 4.2 CONSTS(68) = 2.0 CONSTS(69) = 0.02 CONSTS(70) = 4.5 CONSTS(71) = 5.0 CONSTS(72) = 3.0 CONSTS(73) = 0.67 CONSTS(74) = 0.0003 CONSTS(75) = 149.5 CONSTS(76) = 400.0 CONSTS(77) = 0.5 CONSTS(78) = 15.0 CONSTS(79) = 0.5 CONSTS(80) = 0.2 CONSTS(81) = 1.9 CONSTS(82) = 1.1 CONSTS(83) = 0.01 CONSTS(84) = 0.6 CONSTS(85) = 0.31 CONSTS(86) = 4.0 STATES(8) = 1.94 STATES(9) = 2.0 CONSTS(87) = 1.1 CONSTS(88) = 1.0 CONSTS(89) = 0.01 CONSTS(90) = 0.6 CONSTS(91) = 0.4 STATES(10) = 7.94 CONSTS(92) = 1.0 CONSTS(93) = 0.8 CONSTS(94) = 0.01 CONSTS(95) = 2.2 CONSTS(96) = 0.4 CONSTS(97) = 2.0 STATES(11) = 0.4 CONSTS(98) = 0.6 CONSTS(99) = 0.1 CONSTS(100) = 0.1 CONSTS(101) = 0.4 CONSTS(102) = 0.2 CONSTS(103) = 0.01 CONSTS(104) = 0.4 CONSTS(105) = 0.3 STATES(12) = 0.13 STATES(13) = 1.26 CONSTS(106) = 1.6 CONSTS(107) = 0.12 CONSTS(108) = 0.6 CONSTS(109) = 0.1 STATES(14) = 9.0 CONSTS(110) = 0.7 CONSTS(111) = 0.3 CONSTS(112) = 0.7 CONSTS(113) = 0.45 CONSTS(114) = 0.2 CONSTS(115) = 0.4 CONSTS(116) = 0.1 STATES(15) = 0.2 STATES(16) = 0.16 CONSTS(117) = 0.5 CONSTS(118) = 0.1 CONSTS(119) = 0.4 CONSTS(120) = 0.1 STATES(17) = 0.091 STATES(18) = 0.05 CONSTS(121) = 0.7 CONSTS(122) = 0.7 CONSTS(123) = 0.12 CONSTS(124) = 0.4 CONSTS(125) = 0.2 CONSTS(126) = 0.5 CONSTS(127) = 0.1 STATES(19) = 0.48 CONSTS(128) = 0.5 CONSTS(129) = 0.5 CONSTS(130) = 0.2 STATES(20) = 0.32 CONSTS(131) = 0.6 CONSTS(132) = 0.8 CONSTS(133) = 0.01 CONSTS(134) = 0.01 CONSTS(135) = 1.0 CONSTS(136) = 1.0 CONSTS(137) = ( CONSTS(29)*(CONSTS(4)+CONSTS(5)))/(CONSTS(6)+CONSTS(5)) CONSTS(138) = CONSTS(74)*CONSTS(59) CONSTS(139) = EXP(CONSTS(137)/( CONSTS(47)*(CONSTS(4)+CONSTS(5))*1000.00)) CONSTS(140) = CONSTS(18)/CONSTS(139) CONSTS(141) = ( CONSTS(20)*(CONSTS(4)+CONSTS(5)))/(CONSTS(6)+CONSTS(5)) CONSTS(142) = EXP(CONSTS(141)/( CONSTS(47)*(CONSTS(4)+CONSTS(5))*1000.00)) CONSTS(143) = CONSTS(17)/CONSTS(142) CONSTS(144) = ( CONSTS(28)*(CONSTS(4)+CONSTS(5)))/(CONSTS(6)+CONSTS(5)) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(9) = CONSTS(87)*(STATES(8) ** CONSTS(86)/(CONSTS(90) ** CONSTS(86)+STATES(8) ** CONSTS(86))) - ( CONSTS(88)*(STATES(9)/(CONSTS(91)+STATES(9)))+ CONSTS(89)*STATES(9)) RATES(10) = CONSTS(92)*(CONSTS(95) ** CONSTS(97)/(CONSTS(95) ** CONSTS(97)+STATES(8) ** CONSTS(97))) - ( CONSTS(93)*(STATES(10)/(CONSTS(96)+STATES(10)))+ CONSTS(94)*STATES(10)) RATES(11) = ( CONSTS(98)*STATES(3)+ CONSTS(105)*(STATES(12)/(CONSTS(100)+STATES(12)))+ CONSTS(102)*STATES(13)) - ( CONSTS(104)*(STATES(11)/(CONSTS(99)+STATES(11)))+ CONSTS(101)*STATES(11)*STATES(5)+ CONSTS(103)*STATES(11)) RATES(5) = ( CONSTS(106)*STATES(9)+ CONSTS(109)*(STATES(14)/(CONSTS(100)+STATES(14)))+ CONSTS(102)*STATES(13)) - ( CONSTS(108)*(STATES(5)/(CONSTS(99)+STATES(5)))+ CONSTS(101)*STATES(11)*STATES(5)+ CONSTS(107)*STATES(5)) RATES(12) = CONSTS(104)*(STATES(11)/(CONSTS(99)+STATES(11))) - ( CONSTS(105)*(STATES(12)/(CONSTS(100)+STATES(12)))+ CONSTS(110)*(STATES(12)/(CONSTS(111)+STATES(12)))+ CONSTS(103)*STATES(12)) RATES(14) = CONSTS(108)*(STATES(5)/(CONSTS(99)+STATES(5))) - ( CONSTS(109)*(STATES(14)/(CONSTS(100)+STATES(14)))+ CONSTS(112)*(STATES(14)/(CONSTS(111)+STATES(14)))+ CONSTS(103)*STATES(14)) RATES(13) = ( CONSTS(116)*(STATES(15)/(CONSTS(100)+STATES(15)))+ CONSTS(101)*STATES(11)*STATES(5)+ CONSTS(114)*STATES(16)) - ( CONSTS(115)*(STATES(13)/(CONSTS(99)+STATES(13)))+ CONSTS(102)*STATES(13)+ CONSTS(113)*STATES(13)+ CONSTS(103)*STATES(13)) RATES(16) = ( CONSTS(120)*(STATES(17)/(CONSTS(100)+STATES(17)))+ CONSTS(113)*STATES(13)+ CONSTS(118)*STATES(18)) - ( CONSTS(119)*(STATES(16)/(CONSTS(99)+STATES(16)))+ CONSTS(114)*STATES(16)+ CONSTS(117)*STATES(8)*STATES(16)+ CONSTS(103)*STATES(16)) RATES(15) = CONSTS(115)*(STATES(13)/(CONSTS(99)+STATES(13))) - ( CONSTS(116)*(STATES(15)/(CONSTS(100)+STATES(15)))+ CONSTS(121)*(STATES(15)/(CONSTS(111)+STATES(15)))+ CONSTS(103)*STATES(15)) RATES(17) = CONSTS(119)*(STATES(16)/(CONSTS(99)+STATES(16))) - ( CONSTS(120)*(STATES(17)/(CONSTS(100)+STATES(17)))+ CONSTS(122)*(STATES(17)/(CONSTS(111)+STATES(17)))+ CONSTS(103)*STATES(17)) RATES(2) = ( CONSTS(127)*(STATES(19)/(CONSTS(100)+STATES(19)))+ CONSTS(125)*STATES(8)+ CONSTS(123)*STATES(10)) - ( CONSTS(126)*(STATES(2)/(CONSTS(99)+STATES(2)))+ CONSTS(124)*STATES(2)+ CONSTS(103)*STATES(2)) RATES(19) = CONSTS(126)*(STATES(2)/(CONSTS(99)+STATES(2))) - ( CONSTS(127)*(STATES(19)/(CONSTS(100)+STATES(19)))+ CONSTS(128)*(STATES(19)/(CONSTS(111)+STATES(19)))+ CONSTS(103)*STATES(19)) RATES(8) = ( CONSTS(130)*(STATES(20)/(CONSTS(100)+STATES(20)))+ CONSTS(124)*STATES(2)+ CONSTS(118)*STATES(18)) - ( CONSTS(129)*(STATES(8)/(CONSTS(99)+STATES(8)))+ CONSTS(125)*STATES(8)+ CONSTS(117)*STATES(8)*STATES(16)+ CONSTS(103)*STATES(8)) RATES(20) = CONSTS(129)*(STATES(8)/(CONSTS(99)+STATES(8))) - ( CONSTS(130)*(STATES(20)/(CONSTS(100)+STATES(20)))+ CONSTS(131)*(STATES(20)/(CONSTS(111)+STATES(20)))+ CONSTS(103)*STATES(20)) RATES(18) = CONSTS(117)*STATES(8)*STATES(16) - ( CONSTS(118)*STATES(18)+ CONSTS(132)*(STATES(18)/(CONSTS(111)+STATES(18)))+ CONSTS(103)*STATES(18)) ALGBRC(1) = CONSTS(53)+( CONSTS(54)*STATES(6))/(CONSTS(58)+STATES(6)) RATES(3) = ALGBRC(1)*(STATES(8) ** CONSTS(86)/(CONSTS(84) ** CONSTS(86)+STATES(8) ** CONSTS(86))) - ( CONSTS(82)*(STATES(3)/(CONSTS(85)+STATES(3)))+ CONSTS(83)*STATES(3)) ALGBRC(2) = STATES(4)/(STATES(4)+CONSTS(52)) ALGBRC(5) = ( CONSTS(49)*STATES(1))/(CONSTS(48)+STATES(1))+( CONSTS(50)*ALGBRC(2))/(CONSTS(51)+ALGBRC(2)) RATES(6) = (( ALGBRC(5)*(1.00000 - STATES(6)))/((CONSTS(133)+1.00000) - STATES(6)) - ( CONSTS(136)*STATES(6))/(CONSTS(134)+STATES(6)))/CONSTS(135) ALGBRC(7) = CONSTS(61)*(STATES(2) ** CONSTS(64)/(CONSTS(70)+STATES(2) ** CONSTS(64))) ALGBRC(9) = CONSTS(75)*(STATES(1) ** CONSTS(66)/(CONSTS(71) ** CONSTS(66)+STATES(1) ** CONSTS(66))) ALGBRC(11) = CONSTS(76)*(STATES(7) ** CONSTS(65)/(CONSTS(72) ** CONSTS(65)+STATES(7) ** CONSTS(65)))*(STATES(1) ** CONSTS(67)/(CONSTS(73) ** CONSTS(67)+STATES(1) ** CONSTS(67))) ALGBRC(4) = CONSTS(60)*(STATES(5) ** CONSTS(63)/(CONSTS(69)+STATES(5) ** CONSTS(63))) RATES(1) = (ALGBRC(7)+CONSTS(138)+ALGBRC(11)+ CONSTS(62)*STATES(7)) - (ALGBRC(9)+ ALGBRC(4)*STATES(1) ** CONSTS(68)) RATES(7) = ALGBRC(9) - (ALGBRC(11)+ CONSTS(62)*STATES(7)) ALGBRC(3) = CONSTS(11)*(STATES(2) ** CONSTS(12)/(CONSTS(13)+STATES(2) ** CONSTS(12))) ALGBRC(6) = 4.00000*CONSTS(8)*STATES(1)*0.00100000+ ALGBRC(3)*CONSTS(140)+ CONSTS(9)*CONSTS(143)+ CONSTS(10)*CONSTS(19) ALGBRC(14) = CONSTS(38)+( CONSTS(39)*STATES(4))/(CONSTS(40)+STATES(4)) ALGBRC(15) = CONSTS(41)+ CONSTS(42)*(STATES(3)/(CONSTS(44)+STATES(3)))+ CONSTS(43)*(ALGBRC(14) ** CONSTS(46)/(CONSTS(45)+ALGBRC(14) ** CONSTS(46))) ALGBRC(16) = ( ALGBRC(3)*CONSTS(140)+ CONSTS(9)*CONSTS(143)+ CONSTS(10)*CONSTS(19)) - ( ALGBRC(3)*CONSTS(18)+ CONSTS(9)*CONSTS(17)+ CONSTS(10)*ALGBRC(15)) ALGBRC(17) = - ( ALGBRC(3)*CONSTS(18)+ 4.00000*CONSTS(8)*CONSTS(16)*0.00100000+ CONSTS(9)*CONSTS(17)+ CONSTS(10)*ALGBRC(15)) ALGBRC(18) = ( (ALGBRC(16) ** 2.00000 - 4.00000*ALGBRC(6)*ALGBRC(17)) ** (1.0 / 2) - ALGBRC(16))/( 2.00000*ALGBRC(6)) ALGBRC(19) = (( CONSTS(3)*(CONSTS(4)+CONSTS(5)))/CONSTS(7))*log(ALGBRC(18))*1000.00 ALGBRC(24) = ALGBRC(19)+4.00000 ALGBRC(8) = (( CONSTS(47)*(CONSTS(4)+CONSTS(5)))/2.00000)*log(CONSTS(16)/STATES(1))*1000.00 ALGBRC(12) = CONSTS(56)*(STATES(3) ** CONSTS(55)/(CONSTS(57)+STATES(3) ** CONSTS(55))) ALGBRC(10) = CONSTS(22)+ CONSTS(23)*(STATES(3)/(CONSTS(24)+STATES(3))) ALGBRC(13) = CONSTS(25)*(STATES(5) ** CONSTS(27)/(CONSTS(26)+STATES(5) ** CONSTS(27))) ALGBRC(25) = CONSTS(14)*(ALGBRC(19)/(CONSTS(15)+ALGBRC(19))) ALGBRC(30) = 1.00000/ALGBRC(25) ALGBRC(27) = CONSTS(21)*(ALGBRC(19) - CONSTS(141)) ALGBRC(29) = ALGBRC(27) ** 2.00000 ** (1.0 / 2) ALGBRC(31) = CONSTS(31)*(ALGBRC(29) ** CONSTS(35)/(CONSTS(33)+ALGBRC(29) ** CONSTS(35)))+ CONSTS(32)*(STATES(1) ** CONSTS(36)/(CONSTS(34)+STATES(1) ** CONSTS(36))) ALGBRC(26) = - CONSTS(47)*(CONSTS(4)+CONSTS(5))*log(CONSTS(19)/ALGBRC(15))*1000.00 ALGBRC(34) = ( CONSTS(21)*CONSTS(141)+ ALGBRC(12)*ALGBRC(8)+ ALGBRC(10)*CONSTS(137)+ ALGBRC(30)*CONSTS(144)+ ALGBRC(13)*CONSTS(137)) - ( CONSTS(37)*ALGBRC(26)+ ALGBRC(31)*CONSTS(30)) ALGBRC(35) = 1.00000/((CONSTS(21)+ALGBRC(10)+ALGBRC(30)+ALGBRC(12)+ALGBRC(13)) - (CONSTS(37)+ALGBRC(31))) ALGBRC(36) = CONSTS(2)*ALGBRC(35) ALGBRC(20) = ALGBRC(19)+CONSTS(1) ALGBRC(37) = -1.00000/( ALGBRC(36)*log((ALGBRC(20) - ALGBRC(35)*ALGBRC(34))/(ALGBRC(24) - ALGBRC(35)*ALGBRC(34)))) RATES(4) = CONSTS(77)*(ALGBRC(37) ** CONSTS(81)/(CONSTS(78)+ALGBRC(37) ** CONSTS(81))) - CONSTS(79)*STATES(4) ** CONSTS(80) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(53)+( CONSTS(54)*STATES(6))/(CONSTS(58)+STATES(6)) ALGBRC(2) = STATES(4)/(STATES(4)+CONSTS(52)) ALGBRC(5) = ( CONSTS(49)*STATES(1))/(CONSTS(48)+STATES(1))+( CONSTS(50)*ALGBRC(2))/(CONSTS(51)+ALGBRC(2)) ALGBRC(7) = CONSTS(61)*(STATES(2) ** CONSTS(64)/(CONSTS(70)+STATES(2) ** CONSTS(64))) ALGBRC(9) = CONSTS(75)*(STATES(1) ** CONSTS(66)/(CONSTS(71) ** CONSTS(66)+STATES(1) ** CONSTS(66))) ALGBRC(11) = CONSTS(76)*(STATES(7) ** CONSTS(65)/(CONSTS(72) ** CONSTS(65)+STATES(7) ** CONSTS(65)))*(STATES(1) ** CONSTS(67)/(CONSTS(73) ** CONSTS(67)+STATES(1) ** CONSTS(67))) ALGBRC(4) = CONSTS(60)*(STATES(5) ** CONSTS(63)/(CONSTS(69)+STATES(5) ** CONSTS(63))) ALGBRC(3) = CONSTS(11)*(STATES(2) ** CONSTS(12)/(CONSTS(13)+STATES(2) ** CONSTS(12))) ALGBRC(6) = 4.00000*CONSTS(8)*STATES(1)*0.00100000+ ALGBRC(3)*CONSTS(140)+ CONSTS(9)*CONSTS(143)+ CONSTS(10)*CONSTS(19) ALGBRC(14) = CONSTS(38)+( CONSTS(39)*STATES(4))/(CONSTS(40)+STATES(4)) ALGBRC(15) = CONSTS(41)+ CONSTS(42)*(STATES(3)/(CONSTS(44)+STATES(3)))+ CONSTS(43)*(ALGBRC(14) ** CONSTS(46)/(CONSTS(45)+ALGBRC(14) ** CONSTS(46))) ALGBRC(16) = ( ALGBRC(3)*CONSTS(140)+ CONSTS(9)*CONSTS(143)+ CONSTS(10)*CONSTS(19)) - ( ALGBRC(3)*CONSTS(18)+ CONSTS(9)*CONSTS(17)+ CONSTS(10)*ALGBRC(15)) ALGBRC(17) = - ( ALGBRC(3)*CONSTS(18)+ 4.00000*CONSTS(8)*CONSTS(16)*0.00100000+ CONSTS(9)*CONSTS(17)+ CONSTS(10)*ALGBRC(15)) ALGBRC(18) = ( (ALGBRC(16) ** 2.00000 - 4.00000*ALGBRC(6)*ALGBRC(17)) ** (1.0 / 2) - ALGBRC(16))/( 2.00000*ALGBRC(6)) ALGBRC(19) = (( CONSTS(3)*(CONSTS(4)+CONSTS(5)))/CONSTS(7))*log(ALGBRC(18))*1000.00 ALGBRC(24) = ALGBRC(19)+4.00000 ALGBRC(8) = (( CONSTS(47)*(CONSTS(4)+CONSTS(5)))/2.00000)*log(CONSTS(16)/STATES(1))*1000.00 ALGBRC(12) = CONSTS(56)*(STATES(3) ** CONSTS(55)/(CONSTS(57)+STATES(3) ** CONSTS(55))) ALGBRC(10) = CONSTS(22)+ CONSTS(23)*(STATES(3)/(CONSTS(24)+STATES(3))) ALGBRC(13) = CONSTS(25)*(STATES(5) ** CONSTS(27)/(CONSTS(26)+STATES(5) ** CONSTS(27))) ALGBRC(25) = CONSTS(14)*(ALGBRC(19)/(CONSTS(15)+ALGBRC(19))) ALGBRC(30) = 1.00000/ALGBRC(25) ALGBRC(27) = CONSTS(21)*(ALGBRC(19) - CONSTS(141)) ALGBRC(29) = ALGBRC(27) ** 2.00000 ** (1.0 / 2) ALGBRC(31) = CONSTS(31)*(ALGBRC(29) ** CONSTS(35)/(CONSTS(33)+ALGBRC(29) ** CONSTS(35)))+ CONSTS(32)*(STATES(1) ** CONSTS(36)/(CONSTS(34)+STATES(1) ** CONSTS(36))) ALGBRC(26) = - CONSTS(47)*(CONSTS(4)+CONSTS(5))*log(CONSTS(19)/ALGBRC(15))*1000.00 ALGBRC(34) = ( CONSTS(21)*CONSTS(141)+ ALGBRC(12)*ALGBRC(8)+ ALGBRC(10)*CONSTS(137)+ ALGBRC(30)*CONSTS(144)+ ALGBRC(13)*CONSTS(137)) - ( CONSTS(37)*ALGBRC(26)+ ALGBRC(31)*CONSTS(30)) ALGBRC(35) = 1.00000/((CONSTS(21)+ALGBRC(10)+ALGBRC(30)+ALGBRC(12)+ALGBRC(13)) - (CONSTS(37)+ALGBRC(31))) ALGBRC(36) = CONSTS(2)*ALGBRC(35) ALGBRC(20) = ALGBRC(19)+CONSTS(1) ALGBRC(37) = -1.00000/( ALGBRC(36)*log((ALGBRC(20) - ALGBRC(35)*ALGBRC(34))/(ALGBRC(24) - ALGBRC(35)*ALGBRC(34)))) ALGBRC(21) = ALGBRC(12)*(ALGBRC(19) - ALGBRC(8)) ALGBRC(22) = ALGBRC(10)*(ALGBRC(19) - CONSTS(137)) ALGBRC(23) = ALGBRC(13)*(ALGBRC(19) - CONSTS(137)) ALGBRC(28) = CONSTS(37)*(ALGBRC(19) - ALGBRC(26)) ALGBRC(32) = ALGBRC(30)*(ALGBRC(19) - CONSTS(144)) ALGBRC(33) = ALGBRC(31)*(ALGBRC(19) - CONSTS(30)) RETURN END