/* There are a total of 5 entries in the algebraic variable array. There are a total of 11 entries in each of the rate and state variable arrays. There are a total of 35 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is IP3 in component IP3_dynamics (micromolar). * ALGEBRAIC[0] is j_IP3 in component IP3_dynamics (micromolar_micrometre_per_second). * CONSTANTS[0] is J_IP3 in component IP3_dynamics (micromolar_micrometre_per_second). * CONSTANTS[1] is k_0 in component IP3_dynamics (first_order_rate_constant). * CONSTANTS[2] is k_degr in component IP3_dynamics (first_order_rate_constant). * CONSTANTS[3] is IP3_0 in component IP3_dynamics (micromolar). * CONSTANTS[4] is Ca_ER in component ER (micromolar). * STATES[1] is Ca in component Calcium_dynamics (micromolar). * CONSTANTS[5] is alpha in component Calcium_dynamics (dimensionless). * ALGEBRAIC[1] is J_channel in component Channel_kinetics (flux). * ALGEBRAIC[2] is J_pump in component SERCA_pump_kinetics (flux). * ALGEBRAIC[3] is J_leak in component Leak (flux). * CONSTANTS[27] is R_buffering in component Calcium_buffering (flux). * CONSTANTS[6] is J_max in component Channel_kinetics (flux). * STATES[2] is h in component Channel_kinetics (dimensionless). * CONSTANTS[7] is K_act in component Channel_kinetics (micromolar). * CONSTANTS[8] is K_IP3 in component Channel_kinetics (micromolar). * CONSTANTS[9] is K_inh in component Channel_kinetics (micromolar). * CONSTANTS[10] is k_on in component Channel_kinetics (second_order_rate_constant). * CONSTANTS[11] is V_max in component SERCA_pump_kinetics (flux). * CONSTANTS[12] is K_p in component SERCA_pump_kinetics (micromolar). * CONSTANTS[13] is L in component Leak (flux). * CONSTANTS[14] is R1 in component Calcium_buffering (flux). * CONSTANTS[15] is R2 in component Calcium_buffering (flux). * STATES[3] is B1 in component Calcium_buffering (micromolar). * STATES[4] is B2 in component Calcium_buffering (micromolar). * STATES[5] is CaB1 in component Calcium_buffering (micromolar). * STATES[6] is CaB2 in component Calcium_buffering (micromolar). * STATES[7] is k1_on in component Calcium_buffering (second_order_rate_constant). * STATES[8] is k1_off in component Calcium_buffering (first_order_rate_constant). * STATES[9] is k2_on in component Calcium_buffering (second_order_rate_constant). * STATES[10] is k2_off in component Calcium_buffering (first_order_rate_constant). * CONSTANTS[16] is K1 in component Calcium_buffering (micromolar). * CONSTANTS[17] is K2 in component Calcium_buffering (micromolar). * CONSTANTS[18] is soma_or_neurite in component Plasma_membrane_extrusion_mechanisms (dimensionless). * ALGEBRAIC[4] is j_Ca in component Plasma_membrane_extrusion_mechanisms (micromolar_micrometre_per_second). * CONSTANTS[19] is gamma_0 in component Plasma_membrane_extrusion_mechanisms (micrometre_per_second). * CONSTANTS[30] is gamma in component Plasma_membrane_extrusion_mechanisms (micrometre_per_second). * CONSTANTS[28] is gamma_s in component Plasma_membrane_extrusion_mechanisms (micrometre_per_second). * CONSTANTS[29] is gamma_n in component Plasma_membrane_extrusion_mechanisms (micrometre_per_second). * CONSTANTS[20] is delta in component Plasma_membrane_extrusion_mechanisms (dimensionless). * CONSTANTS[21] is sigma in component Plasma_membrane_extrusion_mechanisms (per_micrometre). * CONSTANTS[22] is w_n in component Plasma_membrane_extrusion_mechanisms (dimensionless). * CONSTANTS[23] is w_s in component Plasma_membrane_extrusion_mechanisms (dimensionless). * CONSTANTS[24] is sigma_soma_2D in component Plasma_membrane_extrusion_mechanisms (per_micrometre). * CONSTANTS[25] is sigma_neurite_2D in component Plasma_membrane_extrusion_mechanisms (per_micrometre). * CONSTANTS[26] is Ca_c in component Plasma_membrane_extrusion_mechanisms (micromolar). * RATES[0] is d/dt IP3 in component IP3_dynamics (micromolar). * RATES[1] is d/dt Ca in component Calcium_dynamics (micromolar). * RATES[2] is d/dt h in component Channel_kinetics (dimensionless). * RATES[3] is d/dt B1 in component Calcium_buffering (micromolar). * RATES[5] is d/dt CaB1 in component Calcium_buffering (micromolar). * RATES[4] is d/dt B2 in component Calcium_buffering (micromolar). * RATES[6] is d/dt CaB2 in component Calcium_buffering (micromolar). * There are a total of 1 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 3.0; CONSTANTS[0] = 20.86; CONSTANTS[1] = 1.188; CONSTANTS[2] = 0.14; CONSTANTS[3] = 0.16; CONSTANTS[4] = 400.0; STATES[1] = 0.05; CONSTANTS[5] = 0.0; CONSTANTS[6] = 3500.0; STATES[2] = 0.8; CONSTANTS[7] = 0.3; CONSTANTS[8] = 0.8; CONSTANTS[9] = 0.2; CONSTANTS[10] = 2.7; CONSTANTS[11] = 3.75; CONSTANTS[12] = 0.27; CONSTANTS[13] = 0.1; CONSTANTS[14] = 0.1; CONSTANTS[15] = 0.1; STATES[3] = 450.0; STATES[4] = 75.0; STATES[5] = 0; STATES[6] = 0; CONSTANTS[16] = 10.0; CONSTANTS[17] = 0.24; CONSTANTS[18] = -1; CONSTANTS[19] = 8.0; CONSTANTS[20] = 1.45; CONSTANTS[21] = 0.263; CONSTANTS[22] = 0.377; CONSTANTS[23] = 0.623; CONSTANTS[24] = 0.132; CONSTANTS[25] = 0.479; CONSTANTS[26] = 0.2; CONSTANTS[27] = CONSTANTS[14]+CONSTANTS[15]; CONSTANTS[28] = ( CONSTANTS[19]*CONSTANTS[21])/( CONSTANTS[20]*CONSTANTS[25]*CONSTANTS[22]+ CONSTANTS[24]*CONSTANTS[23]); CONSTANTS[31] = CONSTANTS[14]; CONSTANTS[32] = - CONSTANTS[14]; CONSTANTS[33] = CONSTANTS[15]; CONSTANTS[34] = - CONSTANTS[15]; CONSTANTS[29] = ( CONSTANTS[19]*CONSTANTS[21]*CONSTANTS[20])/( CONSTANTS[20]*CONSTANTS[25]*CONSTANTS[22]+ CONSTANTS[24]*CONSTANTS[23]); CONSTANTS[30] = (CONSTANTS[18]<=0.00000 ? CONSTANTS[28] : CONSTANTS[29]); STATES[7] = 0.1001; STATES[8] = 0.1001; STATES[9] = 0.1001; STATES[10] = 0.1001; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - ( CONSTANTS[2]*(STATES[0] - CONSTANTS[3])); resid[1] = RATES[1] - CONSTANTS[5]*(ALGEBRAIC[1]+- ALGEBRAIC[2]+ALGEBRAIC[3])+CONSTANTS[27]; resid[2] = RATES[2] - CONSTANTS[10]*(CONSTANTS[9] - STATES[2]*(STATES[1]+CONSTANTS[9])); resid[3] = CONSTANTS[14] - - ( STATES[7]*STATES[1]*STATES[3])+ STATES[8]*STATES[5]; resid[4] = CONSTANTS[15] - - ( STATES[9]*STATES[1]*STATES[4])+ STATES[10]*STATES[6]; resid[5] = CONSTANTS[16] - STATES[8]/STATES[7]; resid[6] = CONSTANTS[17] - STATES[10]/STATES[9]; resid[7] = RATES[3] - CONSTANTS[31]; resid[8] = RATES[5] - CONSTANTS[32]; resid[9] = RATES[4] - CONSTANTS[33]; resid[10] = RATES[6] - CONSTANTS[34]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*exp( - CONSTANTS[1]*VOI); ALGEBRAIC[4] = (CONDVAR[0]>0.00000 ? CONSTANTS[30]*(STATES[1] - CONSTANTS[26]) : 0.00000); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[6]*pow( (STATES[0]/(STATES[0]+CONSTANTS[8]))*(STATES[1]/(STATES[1]+CONSTANTS[7]))*STATES[2], 3.00000)*(1.00000 - STATES[1]/CONSTANTS[4]); ALGEBRAIC[2] = CONSTANTS[11]*(pow(STATES[1], 2.00000)/(pow(STATES[1], 2.00000)+pow(CONSTANTS[12], 2.00000))); ALGEBRAIC[3] = CONSTANTS[13]*(1.00000 - STATES[1]/CONSTANTS[4]); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 0.0; SI[8] = 0.0; SI[9] = 0.0; SI[10] = 0.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = STATES[1] - CONSTANTS[26]; }