<?xml version="1.0" encoding="utf-8"?>
<!--
A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology
***************************************************************************
The CellML code of this model was prepared by
YC Poh (email address: poh.yongcheng@gmail.com) using:
(1) COR (0.9.31.1409)
Copyright 2002-2012 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
&
(2) CellML 1.0 was used to generate this model
http://www.cellml.org/
***************************************************************************
Paper details:
Authors: Poh YC, Corrias A, Cheng N and Buist ML
PLoS ONE 7(8): e42385. doi:10.1371/journal.pone.0042385
Feedback & comments are welcomed
The C & Matlab versions of this model are available for download from
the Computational Bioengineering Laboratory (NUS) website:
http://www.bioeng.nus.edu.sg/compbiolab/
-->
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<bqs:subject_type>keyword</bqs:subject_type>
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<rdf:li>ion channel</rdf:li>
<rdf:li>small intestine</rdf:li>
<rdf:li>slow wave</rdf:li>
<rdf:li>gastrointestinal tract</rdf:li>
<rdf:li>electrophysiology</rdf:li>
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<bqs:Pubmed_id>22912702</bqs:Pubmed_id>
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<vCard:Other>Lindsay</vCard:Other>
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<dc:title>
A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology
</dc:title>
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<dcterms:W3CDTF>2012-09-15</dcterms:W3CDTF>
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<dc:title>PLoS ONE</dc:title>
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<unit units="litre"/>
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<units name="micromolar">
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<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
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<unit units="farad" prefix="pico"/>
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<units name="picoA">
<unit units="ampere" prefix="pico"/>
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<units name="millisecond">
<unit units="second" prefix="milli"/>
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<units name="millivolt2">
<unit units="volt" prefix="milli" exponent="2"/>
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<units name="nanoS">
<unit units="siemens" prefix="nano"/>
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<units name="per_millisecond">
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<units name="per_kelvin">
<unit units="kelvin" exponent="-1"/>
</units>
<component name="environment">
<variable name="time" units="millisecond" public_interface="out"/>
</component>
<component name="membrane">
<variable name="V" units="millivolt" initial_value="-73.5049651455872" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" initial_value="8.314" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="F" units="coulomb_per_millimole" initial_value="96.48534" public_interface="out"/>
<variable name="Cm" units="picoF" initial_value="50"/>
<variable name="I_stim" units="picoA" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="i_Na" units="picoA" public_interface="in"/>
<variable name="i_Ca_L" units="picoA" public_interface="in"/>
<variable name="i_Ca_T" units="picoA" public_interface="in"/>
<variable name="i_Kv" units="picoA" public_interface="in"/>
<variable name="i_BK" units="picoA" public_interface="in"/>
<variable name="i_NCX" units="picoA" public_interface="in"/>
<variable name="i_NaK" units="picoA" public_interface="in"/>
<variable name="i_NsK" units="picoA" public_interface="in"/>
<variable name="i_NsNa" units="picoA" public_interface="in"/>
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<eq/>
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<diff/>
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<times/>
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<divide/>
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<minus/>
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<variable name="t_slope" units="millisecond" initial_value="600"/>
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<variable name="f_2" units="millisecond" initial_value="300"/>
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<variable name="V_ICCamp" units="millivolt" initial_value="33.5"/>
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<times/>
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<divide/>
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<times/>
<ci>V_ICCamp</ci>
<ci>local_time</ci>
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<ci>f_2</ci>
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<lt/>
<ci>local_time</ci>
<ci>t_ICCpeak</ci>
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<apply>
<times/>
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<minus/>
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<divide/>
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<times/>
<ci>V_ICCamp</ci>
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<plus/>
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<times/>
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<divide/>
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<minus/>
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<minus/>
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<times/>
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<variable name="E_Ca" units="millivolt" public_interface="out"/>
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<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
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<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="O_CaL" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>E_Ca</ci>
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<times/>
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<divide/>
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<times/>
<ci>R</ci>
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<times/>
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<ci>F</ci>
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<ln/>
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<divide/>
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<ci>i_Ca_L</ci>
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<times/>
<ci>g_CaL</ci>
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<minus/>
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<variable name="alpha" units="per_millisecond"/>
<variable name="beta" units="per_millisecond"/>
<variable name="alpha_0" units="per_millisecond"/>
<variable name="alpha_1" units="per_millisecond"/>
<variable name="alpha_2" units="per_millisecond"/>
<variable name="alpha_3" units="per_millisecond"/>
<variable name="beta_0" units="per_millisecond"/>
<variable name="beta_1" units="per_millisecond"/>
<variable name="beta_2" units="per_millisecond"/>
<variable name="beta_3" units="per_millisecond"/>
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<variable name="theta" units="per_millisecond"/>
<variable name="phi_s" units="per_millisecond"/>
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<variable name="omega_s" units="per_millisecond"/>
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<variable name="omega_fs" units="per_millisecond"/>
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<times/>
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<minus/>
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<times/>
<ci>T_correction_Ca</ci>
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<minus/>
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<ci>xi_f</ci>
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<exp/>
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<ci>T_correction_Ca</ci>
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<times/>
<ci>T_correction_Ca</ci>
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<divide/>
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<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">280</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_f</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>xi_f</ci>
<ci>phi_f</ci>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>psi_f</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_s</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>xi_s</ci>
<ci>phi_s</ci>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>psi_s</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_sf</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>psi_f</ci>
</apply>
<ci>xi_f</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_fs</ci>
<ci>psi_s</ci>
</apply>
<apply>
<eq/>
<ci>delta</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="per_millisecond">0.01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>theta</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="per_millisecond">4</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="millimolar">1</cn>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>norm</ci>
<apply>
<plus/>
<ci>C3</ci>
<ci>C2</ci>
<ci>C1</ci>
<ci>C0</ci>
<ci>C3Ca</ci>
<ci>C2Ca</ci>
<ci>C1Ca</ci>
<ci>C0Ca</ci>
<ci>O_CaL</ci>
<ci>ICa</ci>
<ci>IVs</ci>
<ci>IVf</ci>
<ci>IVsCa</ci>
<ci>IVfCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_3</ci>
<ci>beta_2</ci>
<ci>phi_s</ci>
<ci>phi_f</ci>
<ci>theta</ci>
</apply>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_f</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_s</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_2</ci>
<ci>beta_1</ci>
<ci>theta</ci>
</apply>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_2</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_0</ci>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_1</ci>
<ci>beta_0</ci>
<ci>theta</ci>
</apply>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_1</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>alpha_0</ci>
<ci>theta</ci>
</apply>
</apply>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_0</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_3</ci>
<ci>beta_2</ci>
<ci>phi_f</ci>
<ci>phi_s</ci>
<ci>delta</ci>
</apply>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_f</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_s</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_2</ci>
<ci>beta_1</ci>
<ci>delta</ci>
</apply>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_2</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_0</ci>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_1</ci>
<ci>beta_0</ci>
<ci>delta</ci>
</apply>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_1</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_0</ci>
<ci>delta</ci>
</apply>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_0</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_CaL</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>beta_3</ci>
<ci>psi_f</ci>
<ci>psi_s</ci>
<ci>theta</ci>
</apply>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_f</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICa</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>beta_3</ci>
<ci>psi_f</ci>
<ci>psi_s</ci>
<ci>delta</ci>
</apply>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_f</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVs</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_s</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_s</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_fs</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_s</ci>
<ci>xi_s</ci>
<ci>omega_sf</ci>
<ci>theta</ci>
</apply>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVf</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_f</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_f</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_f</ci>
<ci>xi_f</ci>
<ci>omega_fs</ci>
<ci>theta</ci>
</apply>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_sf</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVsCa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_s</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_s</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_fs</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_s</ci>
<ci>xi_s</ci>
<ci>omega_sf</ci>
<ci>delta</ci>
</apply>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVfCa</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_f</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_f</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_f</ci>
<ci>xi_f</ci>
<ci>omega_fs</ci>
<ci>delta</ci>
</apply>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_sf</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel">
<variable name="i_Ca_T" units="picoA" public_interface="out"/>
<variable name="g_CaT" units="nanoS" initial_value="0.0425"/>
<variable name="E_Ca" units="millivolt" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="d_CaT" units="dimensionless" private_interface="in"/>
<variable name="f_CaT" units="dimensionless" private_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_T</ci>
<apply>
<times/>
<ci>g_CaT</ci>
<ci>d_CaT</ci>
<ci>f_CaT</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_d_gate">
<variable name="d_CaT" units="dimensionless" initial_value="0.0791635737410974" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="d_CaT_inf" units="dimensionless"/>
<variable name="tau_d_CaT" units="millisecond"/>
<variable name="T_correction_Ca" units="dimensionless"/>
<variable name="Q10Ca" units="dimensionless" initial_value="2.1"/>
<variable name="T" units="kelvin" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_Ca</ci>
<apply>
<power/>
<ci>Q10Ca</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d_CaT_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_CaT</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1.9058</cn>
<ci>T_correction_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_CaT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_CaT_inf</ci>
<ci>d_CaT</ci>
</apply>
<ci>tau_d_CaT</ci>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_f_gate">
<variable name="f_CaT" units="dimensionless" initial_value="0.377831534375835" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="f_CaT_inf" units="dimensionless"/>
<variable name="tau_f_CaT" units="millisecond"/>
<variable name="T_correction_Ca" units="dimensionless"/>
<variable name="Q10Ca" units="dimensionless" initial_value="2.1"/>
<variable name="T" units="kelvin" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_Ca</ci>
<apply>
<power/>
<ci>Q10Ca</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_CaT_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75.5</cn>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_CaT</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">0.38117</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">8.6</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">14.7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">900</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>T_correction_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_CaT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_CaT_inf</ci>
<ci>f_CaT</ci>
</apply>
<ci>tau_f_CaT</ci>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel">
<variable name="i_Kv" units="picoA" public_interface="out"/>
<variable name="g_Kv" units="nanoS" initial_value="1.0217"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="x_Kv" units="dimensionless" private_interface="in"/>
<variable name="y_Kv" units="dimensionless" private_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv</ci>
<apply>
<times/>
<ci>g_Kv</ci>
<ci>x_Kv</ci>
<ci>y_Kv</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel_x_gate">
<variable name="x_Kv" units="dimensionless" initial_value="0.14714161078933" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="x_Kv_inf" units="dimensionless"/>
<variable name="tau_x_Kv" units="millisecond"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="T_correction_K" units="dimensionless"/>
<variable name="Q10K" units="dimensionless" initial_value="3.1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_K</ci>
<apply>
<power/>
<ci>Q10K</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x_Kv_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">43</cn>
</apply>
</apply>
<cn cellml:units="millivolt">17.36</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_x_Kv</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">4.7803</cn>
<ci>T_correction_K</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_Kv</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_Kv_inf</ci>
<ci>x_Kv</ci>
</apply>
<ci>tau_x_Kv</ci>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel_y_gate">
<variable name="y_Kv" units="dimensionless" initial_value="0.99994773314105" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="y_Kv_inf" units="dimensionless"/>
<variable name="tau_y_Kv" units="millisecond"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="T_correction_K" units="dimensionless"/>
<variable name="Q10K" units="dimensionless" initial_value="3.1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_K</ci>
<apply>
<power/>
<ci>Q10K</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_Kv_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">44.9</cn>
</apply>
<cn cellml:units="millivolt">12.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y_Kv</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">763.7564</cn>
<ci>T_correction_K</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_Kv</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_Kv_inf</ci>
<ci>y_Kv</ci>
</apply>
<ci>tau_y_Kv</ci>
</apply>
</apply>
</math>
</component>
<component name="Calcium_voltage_activated_potassium_channel">
<variable name="i_BK" units="picoA" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="g_BK" units="nanoS" initial_value="80"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="O4" units="dimensionless" private_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_BK</ci>
<apply>
<times/>
<ci>g_BK</ci>
<ci>O4</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Calcium_voltage_activated_potassium_channel_states">
<variable name="C0" units="dimensionless" initial_value="0.48379087935899"/>
<variable name="C1" units="dimensionless" initial_value="0.385183559520031"/>
<variable name="C2" units="dimensionless" initial_value="0.115002824567753"/>
<variable name="C3" units="dimensionless" initial_value="0.0152602714149774"/>
<variable name="C4" units="dimensionless" initial_value="0.000759264410974374"/>
<variable name="O0" units="dimensionless" initial_value="6.94960798375172e-7"/>
<variable name="O1" units="dimensionless" initial_value="5.55636826398253e-8"/>
<variable name="O2" units="dimensionless" initial_value="2.85143702125325e-8"/>
<variable name="O3" units="dimensionless" initial_value="1.59832806123435e-6"/>
<variable name="O4" units="dimensionless" initial_value="1.82113764497095e-6" public_interface="out"/>
<variable name="alpha" units="per_millisecond"/>
<variable name="beta" units="per_millisecond"/>
<variable name="k_on" units="per_millisecond"/>
<variable name="k_off_C" units="per_millisecond"/>
<variable name="k_off_O" units="per_millisecond"/>
<variable name="k_C0O0" units="per_millisecond"/>
<variable name="k_C1O1" units="per_millisecond"/>
<variable name="k_C2O2" units="per_millisecond"/>
<variable name="k_C3O3" units="per_millisecond"/>
<variable name="k_C4O4" units="per_millisecond"/>
<variable name="k_O0C0" units="per_millisecond"/>
<variable name="k_O1C1" units="per_millisecond"/>
<variable name="k_O2C2" units="per_millisecond"/>
<variable name="k_O3C3" units="per_millisecond"/>
<variable name="k_O4C4" units="per_millisecond"/>
<variable name="k_C0C1" units="per_millisecond"/>
<variable name="k_C1C2" units="per_millisecond"/>
<variable name="k_C2C3" units="per_millisecond"/>
<variable name="k_C3C4" units="per_millisecond"/>
<variable name="k_C4C3" units="per_millisecond"/>
<variable name="k_C3C2" units="per_millisecond"/>
<variable name="k_C2C1" units="per_millisecond"/>
<variable name="k_C1C0" units="per_millisecond"/>
<variable name="k_O0O1" units="per_millisecond"/>
<variable name="k_O1O2" units="per_millisecond"/>
<variable name="k_O2O3" units="per_millisecond"/>
<variable name="k_O3O4" units="per_millisecond"/>
<variable name="k_O4O3" units="per_millisecond"/>
<variable name="k_O3O2" units="per_millisecond"/>
<variable name="k_O2O1" units="per_millisecond"/>
<variable name="k_O1O0" units="per_millisecond"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="norm" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">8.47188</cn>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_kelvin">1</cn>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">7.77556</cn>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_kelvin">1</cn>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_on</ci>
<cn cellml:units="per_millisecond">40633</cn>
</apply>
<apply>
<eq/>
<ci>k_off_C</ci>
<cn cellml:units="per_millisecond">11</cn>
</apply>
<apply>
<eq/>
<ci>k_off_O</ci>
<cn cellml:units="per_millisecond">1.1</cn>
</apply>
<apply>
<eq/>
<ci>k_C0O0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02162</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1O1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000869</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2O2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0000281</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3O3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000781</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C4O4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.044324</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O0C0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">318.1084</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">144.1736</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">32.6594</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.095312</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O4C4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000106</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C0C1</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">4</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1C2</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">3</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2C3</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">2</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3C4</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C4C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1C0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O0O1</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">4</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1O2</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">3</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2O3</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">2</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3O4</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O4O3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3O2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2O1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1O0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>norm</ci>
<apply>
<plus/>
<ci>C0</ci>
<ci>C1</ci>
<ci>C2</ci>
<ci>C3</ci>
<ci>C4</ci>
<ci>O0</ci>
<ci>O1</ci>
<ci>O2</ci>
<ci>O3</ci>
<ci>O4</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_C4C3</ci>
<ci>k_C4O4</ci>
</apply>
</apply>
<ci>C4</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C3C4</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_O4C4</ci>
<ci>O4</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_C3C2</ci>
<ci>k_C3O3</ci>
<ci>k_C3C4</ci>
</apply>
</apply>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C2C3</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_O3C3</ci>
<ci>O3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C4C3</ci>
<ci>C4</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
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<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_C2C1</ci>
<ci>k_C2O2</ci>
<ci>k_C2C3</ci>
</apply>
</apply>
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<component name="Na_Ca_exchanger">
<variable name="i_NCX" units="picoA" public_interface="out"/>
<variable name="P_NCX" units="picoA" initial_value="1992.335"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="K_mCa" units="millimolar" initial_value="1.38"/>
<variable name="K_mNai" units="millimolar" initial_value="87.5"/>
<variable name="k_sat" units="dimensionless" initial_value="0.1"/>
<variable name="gamma" units="dimensionless" initial_value="0.35"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NCX</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P_NCX</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK" units="picoA" public_interface="out"/>
<variable name="P_NaK" units="picoA" initial_value="9.26"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="K_mK" units="millimolar" initial_value="1"/>
<variable name="K_mNa" units="millimolar" initial_value="40"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Ko</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>K_mK</ci>
</apply>
<apply>
<plus/>
<ci>K_mNa</ci>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0353</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_specific_Na_current">
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="i_NsNa" units="picoA" public_interface="out"/>
<variable name="g_NsNa" units="nanoS" initial_value="0.022488"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NsNa</ci>
<apply>
<times/>
<ci>g_NsNa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_specific_K_current">
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="i_NsK" units="picoA" public_interface="out"/>
<variable name="g_NsK" units="nanoS" initial_value="0.017512"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NsK</ci>
<apply>
<times/>
<ci>g_NsK</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ionic_concentrations">
<variable name="Nai" units="millimolar" initial_value="10.5731241425458" public_interface="out"/>
<variable name="Nao" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="153.604280337996" public_interface="out"/>
<variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
<variable name="Cai" units="millimolar" initial_value="5.38843941249284e-5" public_interface="out"/>
<variable name="Cao" units="millimolar" initial_value="2" public_interface="out"/>
<variable name="CRT_total" units="millimolar" initial_value="0.034"/>
<variable name="CaM_total" units="millimolar" initial_value="0.012"/>
<variable name="K_D_CRT" units="millimolar" initial_value="0.0009"/>
<variable name="K_D_CaM" units="millimolar4" initial_value="0.0001"/>
<variable name="n_CRT" units="dimensionless" initial_value="1"/>
<variable name="n_CaM" units="dimensionless" initial_value="4"/>
<variable name="V_myo" units="litre" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="i_Na" units="picoA" public_interface="in"/>
<variable name="i_Kv" units="picoA" public_interface="in"/>
<variable name="i_BK" units="picoA" public_interface="in"/>
<variable name="i_NCX" units="picoA" public_interface="in"/>
<variable name="i_NaK" units="picoA" public_interface="in"/>
<variable name="i_NsK" units="picoA" public_interface="in"/>
<variable name="i_NsNa" units="picoA" public_interface="in"/>
<variable name="i_Ca_L" units="picoA" public_interface="in"/>
<variable name="i_Ca_T" units="picoA" public_interface="in"/>
<variable name="I_stim" units="picoA" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_myo</ci>
<cn type="e-notation" cellml:units="litre">3.5 <sep/>
-12</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="second">1</cn>
</apply>
<cn type="e-notation" cellml:units="millisecond">1 <sep/>
15</cn>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_NsNa</ci>
<apply>
<times/>
<ci>i_NCX</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-15</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Kv</ci>
<ci>i_BK</ci>
<ci>i_NsK</ci>
<ci>I_stim</ci>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-15</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Ca_L</ci>
<ci>i_Ca_T</ci>
</apply>
<apply>
<times/>
<ci>i_NCX</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>n_CRT</ci>
<ci>CRT_total</ci>
<ci>K_D_CRT</ci>
<apply>
<power/>
<ci>Cai</ci>
<apply>
<minus/>
<ci>n_CRT</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>Cai</ci>
<ci>n_CRT</ci>
</apply>
<ci>K_D_CRT</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>n_CaM</ci>
<ci>CaM_total</ci>
<ci>K_D_CaM</ci>
<apply>
<power/>
<ci>Cai</ci>
<apply>
<minus/>
<ci>n_CaM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>Cai</ci>
<ci>n_CaM</ci>
</apply>
<ci>K_D_CaM</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="I_stim"/>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_states"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="voltage_dep_K_channel">
<component_ref component="voltage_dep_K_channel_x_gate"/>
<component_ref component="voltage_dep_K_channel_y_gate"/>
</component_ref>
<component_ref component="Calcium_voltage_activated_potassium_channel">
<component_ref component="Calcium_voltage_activated_potassium_channel_states"/>
</component_ref>
<component_ref component="sodium_current">
<component_ref component="Na_channel_states"/>
</component_ref>
<component_ref component="Na_Ca_exchanger"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="non_specific_Na_current"/>
<component_ref component="non_specific_K_current"/>
<component_ref component="ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_states"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="voltage_dep_K_channel">
<component_ref component="voltage_dep_K_channel_x_gate"/>
<component_ref component="voltage_dep_K_channel_y_gate"/>
</component_ref>
<component_ref component="Calcium_voltage_activated_potassium_channel">
<component_ref component="Calcium_voltage_activated_potassium_channel_states"/>
</component_ref>
<component_ref component="sodium_current">
<component_ref component="Na_channel_states"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_stim" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="I_stim"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="voltage_dep_K_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kv" variable_2="i_Kv"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Calcium_voltage_activated_potassium_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_BK" variable_2="i_BK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NCX" variable_2="i_NCX"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_Na_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NsNa" variable_2="i_NsNa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NsK" variable_2="i_NsK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ionic_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="I_stim" component_2="ionic_concentrations"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_Kv" variable_2="i_Kv"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_BK" variable_2="i_BK"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="i_NCX" variable_2="i_NCX"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="non_specific_Na_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NsNa" variable_2="i_NsNa"/>
</connection>
<connection>
<map_components component_1="non_specific_K_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_NsK" variable_2="i_NsK"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_states"/>
<map_variables variable_1="O_CaL" variable_2="O_CaL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_d_gate"/>
<map_variables variable_1="d_CaT" variable_2="d_CaT"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_f_gate"/>
<map_variables variable_1="f_CaT" variable_2="f_CaT"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="voltage_dep_K_channel_x_gate"/>
<map_variables variable_1="x_Kv" variable_2="x_Kv"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="voltage_dep_K_channel_y_gate"/>
<map_variables variable_1="y_Kv" variable_2="y_Kv"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="Calcium_voltage_activated_potassium_channel_states"/>
<map_variables variable_1="O4" variable_2="O4"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="Na_channel_states"/>
<map_variables variable_1="O_Na" variable_2="O_Na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>
